Michael B Elowitz

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. pmc Modeling a synthetic multicellular clock: repressilators coupled by quorum sensing
    Jordi Garcia-Ojalvo
    Center for Applied Mathematics, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 101:10955-60. 2004
  2. ncbi request reprint Stochastic gene expression in a single cell
    Michael B Elowitz
    Laboratory of Cancer Biology, Center for Studies in Physics and Biology, Rockefeller University, New York, NY 10021, USA
    Science 297:1183-6. 2002
  3. pmc Intrinsic and extrinsic contributions to stochasticity in gene expression
    Peter S Swain
    Center for Studies in Physics and Biology and Laboratory for Cancer Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 99:12795-800. 2002
  4. pmc The presence of p53 mutations in human osteosarcomas correlates with high levels of genomic instability
    Michael Overholtzer
    Laboratory of Cancer Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 100:11547-52. 2003
  5. ncbi request reprint Combinatorial synthesis of genetic networks
    Calin C Guet
    Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Science 296:1466-70. 2002
  6. ncbi request reprint Tunability and noise dependence in differentiation dynamics
    Gürol M Süel
    Green Center Division for Systems Biology and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 315:1716-9. 2007
  7. pmc A fluctuation method to quantify in vivo fluorescence data
    Nitzan Rosenfeld
    Department of Molecular Biology, Weizmann Institute of Science, Rehovot, Israel
    Biophys J 91:759-66. 2006
  8. ncbi request reprint An excitable gene regulatory circuit induces transient cellular differentiation
    Gürol M Süel
    Division of Biology and Department of Applied Physics, California Institute of Technology, Pasadena, California 91125, USA
    Nature 440:545-50. 2006
  9. ncbi request reprint Gene regulation at the single-cell level
    Nitzan Rosenfeld
    Departments of Molecular Cell Biology and Physics of Complex Systems, Weizmann Institute of Science, Rehovot, 76100, Israel
    Science 307:1962-5. 2005
  10. ncbi request reprint Negative autoregulation speeds the response times of transcription networks
    Nitzan Rosenfeld
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Mol Biol 323:785-93. 2002

Collaborators

  • Eric D Siggia
  • Peter S Swain
  • Arnold J Levine
  • Jonathan Dworkin
  • Nitzan Rosenfeld
  • Gürol M Süel
  • Jordi Garcia-Ojalvo
  • Uri Alon
  • Long Cai
  • Robert Sidney Cox
  • Jonathan W Young
  • Michael Overholtzer
  • Calin C Guet
  • Chiraj K Dalal
  • Michael G Surette
  • Rajan P Kulkarni
  • Theodore J Perkins
  • Louisa M Liberman
  • Steven H Strogatz
  • Xin Yan Lu
  • Reyna Favis
  • Richard Gorlick
  • Francis Barany
  • Marc Ladanyi
  • Pulivarthi H Rao
  • Weihong Hsing
  • Stanislas Leibler

Detail Information

Publications13

  1. pmc Modeling a synthetic multicellular clock: repressilators coupled by quorum sensing
    Jordi Garcia-Ojalvo
    Center for Applied Mathematics, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 101:10955-60. 2004
    ..As such, the particular system of coupled genetic oscillators considered here might be a good candidate to provide the first quantitative example of a synchronization transition in a population of biological oscillators...
  2. ncbi request reprint Stochastic gene expression in a single cell
    Michael B Elowitz
    Laboratory of Cancer Biology, Center for Studies in Physics and Biology, Rockefeller University, New York, NY 10021, USA
    Science 297:1183-6. 2002
    ..These results establish a quantitative foundation for modeling noise in genetic networks and reveal how low intracellular copy numbers of molecules can fundamentally limit the precision of gene regulation...
  3. pmc Intrinsic and extrinsic contributions to stochasticity in gene expression
    Peter S Swain
    Center for Studies in Physics and Biology and Laboratory for Cancer Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 99:12795-800. 2002
    ..All results are confirmed by stochastic simulation using plausible parameters for Escherichia coli...
  4. pmc The presence of p53 mutations in human osteosarcomas correlates with high levels of genomic instability
    Michael Overholtzer
    Laboratory of Cancer Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 100:11547-52. 2003
    ..These results demonstrate that the inactivation of p53 in osteosarcomas directly by mutation versus indirectly by HDM2 amplification may have different cellular consequences with respect to the stability of the genome...
  5. ncbi request reprint Combinatorial synthesis of genetic networks
    Calin C Guet
    Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Science 296:1466-70. 2002
    ..Combinatorial synthesis provides an alternative approach for studying biological networks, as well as an efficient method for producing diverse phenotypes in vivo...
  6. ncbi request reprint Tunability and noise dependence in differentiation dynamics
    Gürol M Süel
    Green Center Division for Systems Biology and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 315:1716-9. 2007
    ..Together, the data reveal a noise-dependent circuit that is remarkably resilient and tunable in terms of its dynamic behavior...
  7. pmc A fluctuation method to quantify in vivo fluorescence data
    Nitzan Rosenfeld
    Department of Molecular Biology, Weizmann Institute of Science, Rehovot, Israel
    Biophys J 91:759-66. 2006
    ..Our technique should provide a quantitative internal calibration to systems biology studies of both synthetic and endogenous cellular networks...
  8. ncbi request reprint An excitable gene regulatory circuit induces transient cellular differentiation
    Gürol M Süel
    Division of Biology and Department of Applied Physics, California Institute of Technology, Pasadena, California 91125, USA
    Nature 440:545-50. 2006
    ..Excitable dynamics driven by noise naturally generate stochastic and transient responses, thereby providing an ideal mechanism for competence regulation...
  9. ncbi request reprint Gene regulation at the single-cell level
    Nitzan Rosenfeld
    Departments of Molecular Cell Biology and Physics of Complex Systems, Weizmann Institute of Science, Rehovot, 76100, Israel
    Science 307:1962-5. 2005
    ..Thus, biochemical parameters, noise, and slowly varying cellular states together determine the effective single-cell GRF. These results can form a basis for quantitative modeling of natural gene circuits and for design of synthetic ones...
  10. ncbi request reprint Negative autoregulation speeds the response times of transcription networks
    Nitzan Rosenfeld
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Mol Biol 323:785-93. 2002
    ..This agrees with an analytical solution of a mathematical model for negative autoregulation. This may help in understanding the function of negative autoregulation, which appears in over 40% of known transcription factors in E.coli...
  11. pmc Accurate prediction of gene feedback circuit behavior from component properties
    Nitzan Rosenfeld
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    Mol Syst Biol 3:143. 2007
    ..This demonstration that quantitative characterization of regulatory elements can predict the behavior of genetic circuits supports a fundamental requirement of synthetic biology...
  12. pmc Programming gene expression with combinatorial promoters
    Robert Sidney Cox
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Mol Syst Biol 3:145. 2007
    ..Using these results, we identified heuristic rules for programming gene expression with combinatorial promoters...
  13. pmc Frequency-modulated nuclear localization bursts coordinate gene regulation
    Long Cai
    Howard Hughes Medical Institute, Division of Biology and Department of Applied Physics, California Institute of Technology, M C 114 96, Pasadena, California 91125, USA
    Nature 455:485-90. 2008
    ....