Adel K El-Naggar

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. pmc MicroRNA profiling of salivary adenoid cystic carcinoma: association of miR-17-92 upregulation with poor outcome
    Yoshitsugu Mitani
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 8:e66778. 2013
  2. doi request reprint p16 expression as a surrogate marker for HPV-related oropharyngeal carcinoma: a guide for interpretative relevance and consistency
    Adel K El-Naggar
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Head Neck 34:459-61. 2012
  3. pmc Sinonasal neuroendocrine carcinoma: impact of differentiation status on response and outcome
    Anna Likhacheva
    Department of Radian Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Head Neck Oncol 3:32. 2011
  4. pmc The future of medical diagnostics: review paper
    Waseem K Jerjes
    Head and Neck Optical Diagnostics Society Council, International Society of Minimally Invasive Diagnostics, University College London, London, UK
    Head Neck Oncol 3:38. 2011
  5. pmc Rheumatoid arthritis mimicking metastatic squamous cell carcinoma
    Fernando Gomez-Rivera
    Otorhinolaryngology Head and Neck Surgery Otolaryngology, The University of Houston Health Science Center, Houston, Texas, USA
    Head Neck Oncol 3:26. 2011
  6. pmc At the frontiers of surgery: review
    Tahwinder Upile
    The Head and Neck Optical Diagnostics Society Council, Head and Neck Centre, University College Hospital, 250 Euston Road, London, NW1 2PG, UK
    Head Neck Oncol 3:7. 2011
  7. pmc Head & neck optical diagnostics: vision of the future of surgery
    Tahwinder Upile
    The Head and Neck Optical Diagnostics Society Council, Head and Neck Centre, University College Hospital, 250 Euston Road, London, NW1 2PG, UK
    Head Neck Oncol 1:25. 2009
  8. pmc Head & Neck Oncology: purpose, scope and goals-charting the future
    Adel K El-Naggar
    Head Neck Oncol 1:1. 2009
  9. ncbi request reprint Pathobiology of head and neck squamous tumorigenesis
    Adel K El-Naggar
    The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 085, Houston, Texas, USA
    Curr Cancer Drug Targets 7:606-12. 2007
  10. ncbi request reprint Anaplastic ameloblastic fibrosarcoma arising from recurrent ameloblastic fibroma: restricted molecular abnormalities of certain genes to the malignant transformation
    Michelle D Williams
    Department of Pathology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 104:72-5. 2007

Collaborators

Detail Information

Publications119 found, 100 shown here

  1. pmc MicroRNA profiling of salivary adenoid cystic carcinoma: association of miR-17-92 upregulation with poor outcome
    Yoshitsugu Mitani
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 8:e66778. 2013
    ....
  2. doi request reprint p16 expression as a surrogate marker for HPV-related oropharyngeal carcinoma: a guide for interpretative relevance and consistency
    Adel K El-Naggar
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Head Neck 34:459-61. 2012
    ..This perspective addresses the conceptual and practical issues associated with the p16 expression analysis and provides a broad outline for its application and evaluation in patients with oropharyngeal carcinoma...
  3. pmc Sinonasal neuroendocrine carcinoma: impact of differentiation status on response and outcome
    Anna Likhacheva
    Department of Radian Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Head Neck Oncol 3:32. 2011
    ..The impact of tumor differentiation on the behavior and response of sinonasal neuroendocrine carcinoma is unknown...
  4. pmc The future of medical diagnostics: review paper
    Waseem K Jerjes
    Head and Neck Optical Diagnostics Society Council, International Society of Minimally Invasive Diagnostics, University College London, London, UK
    Head Neck Oncol 3:38. 2011
    ..The meeting included 2 sections: oral communication sessions running in parallel to the IPA programme and poster presentation sessions combined with the IPA and EPPM posters sessions...
  5. pmc Rheumatoid arthritis mimicking metastatic squamous cell carcinoma
    Fernando Gomez-Rivera
    Otorhinolaryngology Head and Neck Surgery Otolaryngology, The University of Houston Health Science Center, Houston, Texas, USA
    Head Neck Oncol 3:26. 2011
    ..The clinician should be aware that, in a patient with a neck mass, in the presence of active RA, rheumatoid nodules should be part of the differential diagnosis...
  6. pmc At the frontiers of surgery: review
    Tahwinder Upile
    The Head and Neck Optical Diagnostics Society Council, Head and Neck Centre, University College Hospital, 250 Euston Road, London, NW1 2PG, UK
    Head Neck Oncol 3:7. 2011
    ..We review the salient advances in the field and propose further directions of investigation...
  7. pmc Head & neck optical diagnostics: vision of the future of surgery
    Tahwinder Upile
    The Head and Neck Optical Diagnostics Society Council, Head and Neck Centre, University College Hospital, 250 Euston Road, London, NW1 2PG, UK
    Head Neck Oncol 1:25. 2009
    ..We are fortunate that this is indeed a possibility and may fundamentally change current clinical and surgical practice to improve our patients' lives...
  8. pmc Head & Neck Oncology: purpose, scope and goals-charting the future
    Adel K El-Naggar
    Head Neck Oncol 1:1. 2009
    ..Despite the many advances in diagnosis and therapy, there has been little change in the prognosis for most cancers of the head and neck in the last 50 years, so what is the point of yet another journal? Well, it is not all bad news...
  9. ncbi request reprint Pathobiology of head and neck squamous tumorigenesis
    Adel K El-Naggar
    The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 085, Houston, Texas, USA
    Curr Cancer Drug Targets 7:606-12. 2007
    ..Targeting these events for biological and therapeutic approaches is a desirable goal for future effective treatment of patients with this cancer...
  10. ncbi request reprint Anaplastic ameloblastic fibrosarcoma arising from recurrent ameloblastic fibroma: restricted molecular abnormalities of certain genes to the malignant transformation
    Michelle D Williams
    Department of Pathology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 104:72-5. 2007
    ..Biomarker analysis showed alterations of the p53 and c-KIT genes restricted to the sarcomatous component. The biological implications of these findings in the future management of these tumors are discussed...
  11. ncbi request reprint Clear cell hidradenoma of the skin--a third tumor type with a t(11;19)-associated TORC1-MAML2 gene fusion: Genes Chromosomes Cancer. 2005;43:202-205
    Adel K El-Naggar
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Adv Anat Pathol 13:80-2. 2006
  12. ncbi request reprint Differential expression profiling of head and neck squamous carcinoma: significance in their phenotypic and biological classification
    Adel K El-Naggar
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, TX 77030, USA
    Oncogene 21:8206-19. 2002
    ....
  13. ncbi request reprint Association between the V109G polymorphism of the p27 gene and the risk and progression of oral squamous cell carcinoma
    Guojun Li
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Clin Cancer Res 10:3996-4002. 2004
    ..We hypothesized that this p27 T109G polymorphism is associated with squamous cell carcinoma of the head and neck (SCCHN) risk...
  14. pmc DeltaNp63 overexpression, alone and in combination with other biomarkers, predicts the development of oral cancer in patients with leukoplakia
    Pierre Saintigny
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Clin Cancer Res 15:6284-91. 2009
    ..DeltaNp63 is an early oncoprotein associated with mucosal tumorigenesis. The purpose of this study was to assess DeltaNp63 expression in OPL and its role as a marker of oral cancer risk...
  15. ncbi request reprint Association of a p73 exon 2 G4C14-to-A4T14 polymorphism with risk of squamous cell carcinoma of the head and neck
    Guojun Li
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 25:1911-6. 2004
    ..70; 95% CI, 1.19-2.43), women (1.61; 1.09-2.37), current smokers (1.77; 1.25-2.51) and patients with oral cancer (1.54; 1.15-2.07). Our results suggest that this p73 polymorphism may be a risk marker for genetic susceptibility to SCCHN...
  16. ncbi request reprint Genetic polymorphisms in DNA base-excision repair genes ADPRT, XRCC1, and APE1 and the risk of squamous cell carcinoma of the head and neck
    Chunying Li
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer 110:867-75. 2007
    ....
  17. ncbi request reprint Potentially functional single nucleotide polymorphisms in the core nucleotide excision repair genes and risk of squamous cell carcinoma of the head and neck
    Jiaze An
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Unit 1365, 1155 Pressler, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 16:1633-8. 2007
    ..These findings suggest that these potentially functional SNPs may collectively contribute to susceptibility to SCCHN. These findings need to be validated in larger, independent studies...
  18. ncbi request reprint Differential expressions of cyclin-dependent kinase inhibitors (p27 and p21) and their relation to p53 and Ki-67 in oral squamous tumorigenesis
    Hong Ran Choi
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Oncol 22:409-14. 2003
    ....
  19. ncbi request reprint Differential expression of p53 gene family members p63 and p73 in head and neck squamous tumorigenesis
    Hong Ran Choi
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Hum Pathol 33:158-64. 2002
    ....
  20. doi request reprint Genetic and expression analysis of HER-2 and EGFR genes in salivary duct carcinoma: empirical and therapeutic significance
    Michelle D Williams
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Clin Cancer Res 16:2266-74. 2010
    ..Because of the potential utilization of these markers as treatment targets, we evaluated protein and gene status by several techniques to determine complementary value...
  21. ncbi request reprint Differential expression of hormonal and growth factor receptors in salivary duct carcinomas: biologic significance and potential role in therapeutic stratification of patients
    Michelle D Williams
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Am J Surg Pathol 31:1645-52. 2007
    ....
  22. ncbi request reprint Identifying the estrogen receptor coactivator PELP1 in autophagosomes
    Kazufumi Ohshiro
    Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Res 67:8164-71. 2007
    ....
  23. ncbi request reprint Implications of methylation patterns of cancer genes in salivary gland tumors
    Michelle D Williams
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Clin Cancer Res 12:7353-8. 2006
    ..We investigated the methylation status and protein expression of four tumor suppressor genes to determine their role in salivary gland tumorigenesis...
  24. ncbi request reprint CRTC1/MAML2 fusion transcript in high grade mucoepidermoid carcinomas of salivary and thyroid glands and Warthin's tumors: implications for histogenesis and biologic behavior
    Yamilet Tirado
    Department of Pathology, University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    Genes Chromosomes Cancer 46:708-15. 2007
    ....
  25. pmc Reduced DNA repair capacity for removing tobacco carcinogen-induced DNA adducts contributes to risk of head and neck cancer but not tumor characteristics
    Li E Wang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 16:764-74. 2010
    ..In this study, we investigated the associations between genetically determined DNA repair capacity (DRC) for removing tobacco-induced DNA adducts and risk of SCCHN and tumor characteristics...
  26. ncbi request reprint Concomitant inhibition of epidermal growth factor and vascular endothelial growth factor receptor tyrosine kinases reduces growth and metastasis of human salivary adenoid cystic carcinoma in an orthotopic nude mouse model
    Maher N Younes
    Department of Head and Neck Surgery, Unit 441, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 4009, USA
    Mol Cancer Ther 5:2696-705. 2006
    ..These data show that EGFR and VEGFR can be molecular targets for therapy of salivary ACC...
  27. ncbi request reprint Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome
    Gene A Lang
    Department of Molecular Genetics, Section of Cancer Genetics, The University of Texas MD Anderson Cancer Center and The University of Texas Graduate School of Biomedical Sciences, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cell 119:861-72. 2004
    ..These results provide in vivo validation for the gain-of-function properties of certain p53 missense mutations and suggest a mechanistic basis for these phenotypes...
  28. pmc Genetic variants in selected pre-microRNA genes and the risk of squamous cell carcinoma of the head and neck
    Zhensheng Liu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 116:4753-60. 2010
    ..The authors hypothesized that common polymorphisms in pre-miRNAs are associated individually and (more likely) collectively with the risk of squamous cell carcinoma of the head and neck (SCCHN)...
  29. ncbi request reprint Vandetanib inhibits growth of adenoid cystic carcinoma in an orthotopic nude mouse model
    Sungweon Choi
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Clin Cancer Res 14:5081-9. 2008
    ....
  30. ncbi request reprint Prediction of neck dissection requirement after definitive radiotherapy for head-and-neck squamous cell carcinoma
    Juliette Thariat
    Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 82:e367-74. 2012
    ....
  31. ncbi request reprint Dual epidermal growth factor receptor and vascular endothelial growth factor receptor inhibition with NVP-AEE788 for the treatment of aggressive follicular thyroid cancer
    Maher N Younes
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Clin Cancer Res 12:3425-34. 2006
    ....
  32. ncbi request reprint Sinonasal malignancies with neuroendocrine differentiation: patterns of failure according to histologic phenotype
    David I Rosenthal
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer 101:2567-73. 2004
    ..The authors reviewed their institutional experience to determine whether sinonasal neuroendocrine tumors of different histologies have distinct clinical characteristics that warrant individualized treatment approaches...
  33. pmc Expression and regulation of the ΔN and TAp63 isoforms in salivary gland tumorigenesis clinical and experimental findings
    Yoshitsugu Mitani
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
    Am J Pathol 179:391-9. 2011
    ....
  34. ncbi request reprint Outcomes after radiotherapy for basaloid squamous cell carcinoma of the head and neck: a case-control study
    Juliette Thariat
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 112:2698-709. 2008
    ..Its poorer prognosis compared with common SCC remains controversial. The authors investigated the outcomes of patients with BSCC who received radiotherapy and compared them with the outcomes of patients with SCC...
  35. doi request reprint Human papillomavirus & WHO type I nasopharyngeal carcinoma
    Emily J Lo
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Laryngoscope 120:S185. 2010
    ..Given the rise in oropharyngeal tumors positive for high risk human papillomavirus (HPV) and the unique biology of WHO type INPC, we chose to examine the relationship between HPV and WHO type I NPC...
  36. ncbi request reprint A miRNA signature associated with human metastatic medullary thyroid carcinoma
    Libero Santarpia
    Departments of Endocrine Neoplasia and Hormonal Disorders Experimental Therapeutics Urology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA Department of Oncology, The University of Naples, Naples, Italy Department of Pathology, Centro Oncologico Fiorentino, Sesto Fiorentino, Florence, Italy Verna and Marrs McLean Department of Biochemistry and Molecular Biology Baylor College of Medicine, Houston, Texas, USA Department of Oncology, Istituto Toscano Tumori, Hospital of Prato, Prato, Italy Department of Gynecologic Oncology, Center for RNA Interference and Non coding RNAs, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA Department of Endocrinology, University of Messina, Messina, Italy Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA Department of Internal Medicine, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Endocr Relat Cancer 20:809-23. 2013
    ..Our data identify a robust miRNA signature associated with metastatic MTC and distinct biological processes, e.g., TGFβ signalling pathway, providing new potential insights into the mechanisms of MTC metastasis...
  37. ncbi request reprint Residual nodal disease in patients with advanced-stage oropharyngeal squamous cell carcinoma treated with definitive radiation therapy and posttreatment neck dissection: Association with locoregional recurrence, distant metastasis, and decreased survival
    Vlad C Sandulache
    Bobby R Alford Department of Otolaryngology Head and Neck Surgery, Baylor College of Medicine, Houston, Texas
    Head Neck 35:1454-60. 2013
    ..Oropharyngeal squamous cell carcinoma (OPSCC) is increasing in frequency. We reviewed patients with advanced-stage OPSCC treated with chemoradiation to assess the impact of residual neck disease on survival...
  38. doi request reprint Epithelial to mesenchymal transition in head and neck squamous carcinoma: association of Src activation with E-cadherin down-regulation, vimentin expression, and aggressive tumor features
    Mahitosh Mandal
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cancer 112:2088-100. 2008
    ..In the current study, the expressions of several factors associated with the induction of EMT in HNSC cell lines and tumor specimens were investigated to define their functional and pathologic role in HNSC...
  39. ncbi request reprint Differential expression of p63 isotypes (DeltaN and TA) in salivary gland neoplasms: biological and diagnostic implications
    Shin ichiro Maruya
    Department of Pathology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Hum Pathol 36:821-7. 2005
    ....
  40. ncbi request reprint Growth-inhibitory effects of human anti-insulin-like growth factor-I receptor antibody (A12) in an orthotopic nude mouse model of anaplastic thyroid carcinoma
    Zhuoying Wang
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, 77030 4009, USA
    Clin Cancer Res 12:4755-65. 2006
    ..We therefore evaluated whether the IGF-IR could serve as a potential target for therapy of anaplastic thyroid carcinoma (ATC)...
  41. doi request reprint Quantitative promoter hypermethylation analysis of cancer-related genes in salivary gland carcinomas: comparison with methylation-specific PCR technique and clinical significance
    Eung Seok Lee
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Clin Cancer Res 14:2664-72. 2008
    ....
  42. ncbi request reprint Single-nucleotide polymorphisms at the TP53-binding or responsive promoter regions of BAX and BCL2 genes and risk of squamous cell carcinoma of the head and neck
    Kexin Chen
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Carcinogenesis 28:2008-12. 2007
    ..Our data suggest that the risk of SCCHN may be associated with these two SNPs of BAX and BCL2 promoter regions, particularly among TP53 heterozygotes. Larger studies are needed to validate these findings...
  43. ncbi request reprint Cyclin D1 genotype, response to biochemoprevention, and progression rate to upper aerodigestive tract cancer
    Julie G Izzo
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    J Natl Cancer Inst 95:198-205. 2003
    ....
  44. ncbi request reprint In vitro benzo[a]pyrene diol epoxide-induced DNA damage and chromosomal aberrations in primary lymphocytes, smoking, and risk of squamous cell carcinoma of the head and neck
    Ping Xiong
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Int J Cancer 121:2735-40. 2007
    ..Further validation studies are warranted...
  45. ncbi request reprint Novel estrogen receptor coactivator PELP1/MNAR gene and ERbeta expression in salivary duct adenocarcinoma: potential therapeutic targets
    Ratna K Vadlamudi
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Hum Pathol 36:670-5. 2005
    ..Our results indicate that PELP1 / MNAR and ER beta are coexpressed in most SDCs and may play a role in the pathobiology of these tumors...
  46. ncbi request reprint Suppression of type I interferon signaling proteins is an early event in squamous skin carcinogenesis
    John L Clifford
    Departments of Clinical Cancer Prevention, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 8:2067-72. 2002
    ..Our previous preliminary studies suggested suppression of some or all of the ISGF-3 proteins in skin SCC...
  47. pmc The six-nucleotide deletion/insertion variant in the CASP8 promoter region is inversely associated with risk of squamous cell carcinoma of the head and neck
    Chunying Li
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Cancer Prev Res (Phila) 3:246-53. 2010
    ..Further validation by population-based case-control studies and rigorous mechanistic studies is warranted...
  48. ncbi request reprint Polymorphisms of FAS and FAS ligand genes involved in the death pathway and risk and progression of squamous cell carcinoma of the head and neck
    Zhengdong Zhang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 12:5596-602. 2006
    ....
  49. ncbi request reprint Polymorphic TP53BP1 and TP53 gene interactions associated with risk of squamous cell carcinoma of the head and neck
    Kexin Chen
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 13:4300-5. 2007
    ....
  50. ncbi request reprint Loss of Fhit expression in head and neck squamous cell carcinoma and its potential clinical implication
    Shyh Kuan Tai
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 10:5554-7. 2004
    ....
  51. pmc Phase II trial of induction chemotherapy followed by surgery for squamous cell carcinoma of the oral tongue in young adults
    Merrill S Kies
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Head Neck 34:1255-62. 2012
    ..We conducted a phase II clinical trial of induction chemotherapy followed by surgery ± radiotherapy for squamous cell carcinoma of the oral tongue (SCCOT) in young adults...
  52. ncbi request reprint Identification of insulin-like growth factor binding protein-3 as a farnesyl transferase inhibitor SCH66336-induced negative regulator of angiogenesis in head and neck squamous cell carcinoma
    Seung Hyun Oh
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Clin Cancer Res 12:653-61. 2006
    ..These findings suggest that IGFBP-3 could be a primary target for antitumor activities of FTIs and that IGFBP-3 is an effective therapeutic approach against angiogenesis in HNSCC...
  53. pmc Gene expression profiling predicts the development of oral cancer
    Pierre Saintigny
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Cancer Prev Res (Phila) 4:218-29. 2011
    ..Our results show that gene expression profiles may improve the prediction of oral cancer risk in OPL patients and the significant genes identified may serve as potential targets for oral cancer chemoprevention...
  54. doi request reprint CRTC1/MAML2 fusion transcript in Warthin's tumor and mucoepidermoid carcinoma: evidence for a common genetic association
    Diana Bell
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Genes Chromosomes Cancer 47:309-14. 2008
    ..This article contains Supplementary Material available at http://www.interscience.wiley.com/jpages/1045-2257/suppmat...
  55. ncbi request reprint Insulin-like growth factor receptor as a therapeutic target in head and neck cancer
    Christopher J Barnes
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 13:4291-9. 2007
    ..The present study was undertaken to determine the effects of anti-IGF-IR therapeutic targeting on cell signaling and cancer cell phenotypes in squamous cell carcinomas of the head and neck (SCCHN)...
  56. ncbi request reprint Repair capacity for UV light induced DNA damage associated with risk of nonmelanoma skin cancer and tumor progression
    Li E Wang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 13:6532-9. 2007
    ..To examine the role of suboptimal DNA repair capacity (DRC) for UV light-induced DNA damage in the development of nonmelanoma skin cancer (NMSC) and tumor progression...
  57. pmc Epidermal growth factor receptor expression and gene copy number in the risk of oral cancer
    Mohammed Taoudi Benchekroun
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, USA
    Cancer Prev Res (Phila) 3:800-9. 2010
    ..A formalin-fixed, paraffin-embedded OPL biopsy specimen was collected from each of 162 patients in a randomized controlled clinical trial. We assessed EGFR expression by immunohistochemistry with two..
  58. ncbi request reprint Molecular and clinicopathologic comparisons of head and neck squamous carcinoma variants: common and distinctive features of biological significance
    Hong Ran Choi
    Department of Pathology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Am J Surg Pathol 28:1299-310. 2004
    ....
  59. ncbi request reprint Expression of LEKTI domains 6-9' in the baculovirus expression system: recombinant LEKTI domains 6-9' inhibit trypsin and subtilisin A
    Arumugam Jayakumar
    Department of Head and Neck Surgery, University of Texas, M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 4095, USA
    Protein Expr Purif 35:93-101. 2004
    ..Taking LEKTI6-9' as an example, the BEVS should facilitate the structure-function analysis of naturally occurring processed LEKTI forms that have physiological relevance...
  60. doi request reprint Molecular and phenotypic analysis of poorly differentiated sinonasal neoplasms: an integrated approach for early diagnosis and classification
    Brett Cordes
    Bobby R Alford Department of Otolaryngology Head and Neck Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Pathol 40:283-92. 2009
    ....
  61. pmc Functional variants of the NEIL1 and NEIL2 genes and risk and progression of squamous cell carcinoma of the oral cavity and oropharynx
    Xiadong Zhai
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 14:4345-52. 2008
    ..To date, only one reported study has investigated the association between NEIL1 and NEIL2 polymorphisms and cancer risk...
  62. doi request reprint Podoplanin: a novel marker for oral cancer risk in patients with oral premalignancy
    Hidetoshi Kawaguchi
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    J Clin Oncol 26:354-60. 2008
    ..The purpose of this study is to determine a role of podoplanin in predicting oral cancer development in patients with OPL...
  63. ncbi request reprint Effect of initial treatment on disease outcome for patients with submandibular gland carcinoma
    Scott M Kaszuba
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 441, Houston, TX 77030, USA
    Arch Otolaryngol Head Neck Surg 133:546-50. 2007
    ..To elucidate the effect on outcome of initial surgical enucleation with or without definitive surgical resection and radiation therapy for patients with submandibular gland carcinoma...
  64. pmc A single nucleotide polymorphism in the alcohol dehydrogenase 7 gene (alanine to glycine substitution at amino acid 92) is associated with the risk of squamous cell carcinoma of the head and neck
    Sheng Wei
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Cancer 116:2984-92. 2010
    ....
  65. ncbi request reprint Compliance with quality assurance measures in patients treated for early oral tongue cancer
    Amy C Hessel
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 116:3408-16. 2010
    ..The objective of this study was to identify measurable parameters that provide quality data for assessing how well cancer care adheres to accepted treatment guidelines and is delivered to any given patient with oral tongue cancer...
  66. ncbi request reprint Sorafenib inhibits the angiogenesis and growth of orthotopic anaplastic thyroid carcinoma xenografts in nude mice
    Seungwon Kim
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    Mol Cancer Ther 6:1785-92. 2007
    ..Given the lack of curative options for patients with ATC, sorafenib warrants further study as a therapeutic agent against ATC...
  67. ncbi request reprint The prognostic role of loss of insulin-like growth factor-binding protein-3 expression in head and neck carcinogenesis
    Vassiliki A Papadimitrakopoulou
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Cancer Lett 239:136-43. 2006
    ....
  68. pmc Differential gene expression profiling of aggressive and nonaggressive follicular carcinomas
    Michelle D Williams
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Hum Pathol 42:1213-20. 2011
    ..Such genes may be used in future prospective validation studies to establish clinically useful and complementary diagnostic markers...
  69. ncbi request reprint A phase II study of gefitinib for aggressive cutaneous squamous cell carcinoma of the head and neck
    Carol M Lewis
    Department of Head and Neck Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 18:1435-46. 2012
    ..To determine the disease control rate and toxicity of treating patients with aggressive cutaneous squamous cell carcinoma (CSCC) with neoadjuvant gefitinib...
  70. ncbi request reprint Effects of the integrin-linked kinase inhibitor QLT0267 on squamous cell carcinoma of the head and neck
    Maher N Younes
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, USA
    Arch Otolaryngol Head Neck Surg 133:15-23. 2007
    ..To study the expression of integrin-linked kinase (ILK) in human squamous cell carcinoma of the head and neck (SCCHN) tumor specimens and cell lines and the efficacy of the novel small molecule QLT0267...
  71. doi request reprint Intensity-modulated radiotherapy for cervical node squamous cell carcinoma metastases from unknown head-and-neck primary site: M. D. Anderson Cancer Center outcomes and patterns of failure
    Steven J Frank
    Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 78:1005-10. 2010
    ....
  72. ncbi request reprint Molecular signatures associated with clinical outcome in patients with high-risk head-and-neck squamous cell carcinoma treated by surgery and radiation
    Uma Giri
    Department of Experimental Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Int J Radiat Oncol Biol Phys 64:670-7. 2006
    ..This study examined whether gene expression patterns developed from tumors from surgicopathologic, criteria-defined, high-risk HNSCC patients could be correlated with clinical outcomes, namely, metastasis or nonrecurrent disease...
  73. pmc High rate of BRAF and RET/PTC dual mutations associated with recurrent papillary thyroid carcinoma
    Ying C Henderson
    Department of Head and Neck Surgery, Pathology, and Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 15:485-91. 2009
    ..PTC usually possesses BRAF mutation or RET/PTC rearrangements. The mutation status of patients with recurrent PTC has never been characterized in a large population...
  74. pmc A novel functional variant (-842G>C) in the PIN1 promoter contributes to decreased risk of squamous cell carcinoma of the head and neck by diminishing the promoter activity
    Jiachun Lu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 30:1717-21. 2009
    ..Large prospective studies of diverse ethnic groups and diverse cancer sites are warranted to validate our findings...
  75. ncbi request reprint Phosphatidylinositol 3-kinase/akt and ras/raf-mitogen-activated protein kinase pathway mutations in anaplastic thyroid cancer
    Libero Santarpia
    Department of Endocrine Neoplasia and Hormonal Disorders, Unit 435, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030 4009, USA
    J Clin Endocrinol Metab 93:278-84. 2008
    ..The Ras/Raf-MAPK and the phosphatidylinositol 3-kinase/Akt signaling pathways play critical roles in DTC tumorigenesis, but their roles in the pathogenesis of ATC are poorly defined...
  76. ncbi request reprint Epidermal growth factor receptor copy number alterations correlate with poor clinical outcome in patients with head and neck squamous cancer
    Stephane Temam
    Molecular Biology Laboratory and Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Oncol 25:2164-70. 2007
    ..Recent studies showed that EGFR inhibitors are effective for patients with HNSCC. This study analyzed the genetic nature of EGFR gene in HNSCC and its clinical correlations...
  77. ncbi request reprint Clinical significance of insulin-like growth factor-binding protein-3 expression in stage I non-small cell lung cancer
    Yoon Soo Chang
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 8:3796-802. 2002
    ..These results suggest that IGFBP-3 functions as a tumor suppressor and plays an important role in determining biological aggressiveness in early NSCLC...
  78. ncbi request reprint Extent of extracapsular spread: a critical prognosticator in oral tongue cancer
    Jayson S Greenberg
    The Bobby R Alford Department of Otorhinolaryngology and Communicative Sciences, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer 97:1464-70. 2003
    ..The purpose of this review was to determine if the degree of ECS impacts distant metastasis rates and survival...
  79. ncbi request reprint Management of nonsinonasal neuroendocrine carcinomas of the head and neck
    Jerry L Barker
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 98:2322-8. 2003
    ..The authors undertook a retrospective study to gain insights into the spectrum of clinicopathologic characteristics, patterns of failure, and optimal management of patients with this disease...
  80. ncbi request reprint Inhibition of serine proteinases plasmin, trypsin, subtilisin A, cathepsin G, and elastase by LEKTI: a kinetic analysis
    Kenji Mitsudo
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030 4095, USA
    Biochemistry 42:3874-81. 2003
    ..Thus, LEKTI is likely to be a major physiological inhibitor of multiple serine proteinases...
  81. pmc Inhibition of the Ras/Raf/MEK/ERK and RET kinase pathways with the combination of the multikinase inhibitor sorafenib and the farnesyltransferase inhibitor tipifarnib in medullary and differentiated thyroid malignancies
    David S Hong
    Department of Investigational Cancer Therapeutics, Division of Cancer Medicine, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Clin Endocrinol Metab 96:997-1005. 2011
    ..We tested sorafenib, a B-Raf, RET, and vascular endothelial growth factor receptor kinase inhibitor, combined with tipifarnib, a farnesyltransferase inhibitor that inactivates Ras and other farnesylated proteins...
  82. pmc Phase I trial of a combination of the multikinase inhibitor sorafenib and the farnesyltransferase inhibitor tipifarnib in advanced malignancies
    David S Hong
    Division of Cancer Medicine, Department of Investigational Therapeutics Phase 1 Program, Unit 455, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Clin Cancer Res 15:7061-8. 2009
    ....
  83. ncbi request reprint Disparity in pathologic and clinical lymph node staging in oral tongue carcinoma. Implication for therapeutic decision making
    Jayson S Greenberg
    The Bobby R Alford Department of Otorhinolaryngology and Communicative Sciences, Baylor College of Medicine, Houston, Texas 77030 4009, USA
    Cancer 98:508-15. 2003
    ..The authors hypothesized that pathologic lymph node staging (pN) would be a more reliable predictor of treatment outcomes than clinical lymph node staging (cN)...
  84. doi request reprint Medullary thyroid cancer: targeting the RET kinase pathway with sorafenib/tipifarnib
    David Hong
    Department of Investigational Therapeutics Phase I Program, Unit 455, Division of Cancer Medicine, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cancer Ther 7:1001-6. 2008
    ....
  85. ncbi request reprint Induction of p53-regulated genes and tumor regression in lung cancer patients after intratumoral delivery of adenoviral p53 (INGN 201) and radiation therapy
    Stephen G Swisher
    Department of Thoracic and Cardiovascular Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 9:93-101. 2003
    ..We designed a prospective single arm Phase II study to evaluate the feasibility and mechanisms of apoptosis induction after Ad-p53 (INGN 201) gene transfer and radiation therapy in patients with non-small cell lung cancer...
  86. ncbi request reprint Mortality risk from squamous cell skin cancer
    Gary L Clayman
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    J Clin Oncol 23:759-65. 2005
    ..To identify nonmelanoma skin cancer patients with squamous cell carcinoma (SCC) who are at greatest risk of disease-specific mortality...
  87. ncbi request reprint Fenretinide activity in retinoid-resistant oral leukoplakia
    Scott M Lippman
    Department of Clinical Cancer Prevention, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Clin Cancer Res 12:3109-14. 2006
    ....
  88. ncbi request reprint Olfactory neuroblastoma: the 22-year experience at one comprehensive cancer center
    Eduardo M Diaz
    Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 441, Houston, TX 77030, USA
    Head Neck 27:138-49. 2005
    ..There is no universally accepted staging system, and treatment approaches lack uniformity. We present one institution's experience with this tumor and the results of therapy...
  89. doi request reprint Salivary flow rates measured during radiation therapy in head and neck cancer patients: a pilot study assessing salivary sediment formation
    Mark S Chambers
    Department of Head and Neck Surgery, Department of Radiation Oncology, M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    J Prosthet Dent 100:142-6. 2008
    ..Determining the impact that salivary sediments have on measured salivary flow rates during radiation is important for management of patients...
  90. doi request reprint Four patients with cutaneous metastases from medullary thyroid cancer
    Libero Santarpia
    Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Thyroid 18:901-5. 2008
    ..The appearing of cutaneous metastasis is a negative prognostic factor since all the patients here described died within one year from the diagnosis of cutaneous metastases...
  91. doi request reprint Pilot randomized phase II study of celecoxib in oral premalignant lesions
    Vassiliki A Papadimitrakopoulou
    Department of Thoracic Head, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 14:2095-101. 2008
    ..In this pilot randomized phase II study, we evaluated the efficacy and safety of the COX-2 inhibitor celecoxib in patients with oral premalignant lesions (OPL)...
  92. ncbi request reprint Differential methylation status of tumor-associated genes in head and neck squamous carcinoma: incidence and potential implications
    Shin ichiro Maruya
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 10:3825-30. 2004
    ..Concurrent methylation analysis of multiple, functionally distinct genes may provide important information on their differential alterations and potential association in head and neck squamous carcinogenesis...
  93. ncbi request reprint No Association between hOGG1 Ser326Cys polymorphism and risk of squamous cell carcinoma of the head and neck
    Zhengdong Zhang
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Cancer Epidemiol Biomarkers Prev 13:1081-3. 2004
  94. ncbi request reprint Parathyroid carcinoma: a 22-year experience
    Naifa L Busaidy
    joint Baylor College of Medicine The University of Texas M D Anderson Cancer Center Training Program in Endocrinology, Diabetes, and Metabolism, Houston, Texas, USA
    Head Neck 26:716-26. 2004
    ..Treatment strategies generally derive from clinical and anecdotal experiences. We report our experience with this entity...
  95. pmc Combined effects of the p53 codon 72 and p73 G4C14-to-A4T14 polymorphisms on the risk of HPV16-associated oral cancer in never-smokers
    Xingming Chen
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 29:2120-5. 2008
    ..22-106.0) than did HPV16-seronegative never-smokers in the low-risk group. These findings suggest that the combined variants of p53 and p73 significantly increase the risk of HPV16-associated oral cancer, especially among never-smokers...
  96. pmc p21 delays tumor onset by preservation of chromosomal stability
    Juan A Barboza
    Department of Cancer Genetics and Pathology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:19842-7. 2006
    ..Thus, p21 coupled p53-dependent checkpoint control and preservation of chromosomal stability, and cooperated with apoptosis in suppressing tumor onset in mice...
  97. ncbi request reprint In vitro benzo[a]pyrene diol epoxide-induced DNA adducts and risk of squamous cell carcinoma of head and neck
    Donghui Li
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 67:5628-34. 2007
    ..In conclusion, we confirmed the previously reported association between in vitro BPDE-induced DNA adduct levels and SCCHN risk, and the assay may help identify individuals at high risk of developing smoking-related cancers...
  98. ncbi request reprint Pre-analytic saliva processing affect proteomic results and biomarker screening of head and neck squamous carcinoma
    Kazufumi Ohshiro
    Department of Pathology, The University of Texas, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Int J Oncol 30:743-9. 2007
    ....
  99. ncbi request reprint Endodermal sinus tumor of the paranasal sinuses
    Anupam Mishra
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Head Neck 30:539-43. 2008
    ..We report a rare case of endodermal sinus tumor (EST) of the paranasal sinus in a 59-year-old man with a 6-week history of nasal obstruction...
  100. pmc High resolution array-comparative genomic hybridization profiling reveals deoxyribonucleic acid copy number alterations associated with medullary thyroid carcinoma
    Lei Ye
    Department of Endocrine Neoplasia and Hormonal Disorders, Unit 433, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    J Clin Endocrinol Metab 93:4367-72. 2008
    ..Activating mutations in the RET protooncogene have been demonstrated in multiple endocrine neoplasia 2 and sporadic medullary thyroid carcinoma (MTC). However, the complete genetic etiology underlying MTC tumorigenesis remains unclear...
  101. doi request reprint An orthotopic murine model of sinonasal malignancy
    Alexander Gelbard
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    Clin Cancer Res 14:7348-57. 2008
    ....