Scott Edwards

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. pmc Escalation of drug self-administration as a hallmark of persistent addiction liability
    Scott Edwards
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Behav Pharmacol 24:356-62. 2013
  2. pmc Evidence that vasopressin V1b receptors mediate the transition to excessive drinking in ethanol-dependent rats
    Scott Edwards
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Addict Biol 17:76-85. 2012
  3. pmc Development of mechanical hypersensitivity in rats during heroin and ethanol dependence: alleviation by CRF₁ receptor antagonism
    Scott Edwards
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA, USA
    Neuropharmacology 62:1142-51. 2012
  4. pmc Dynamic vaccine blocks relapse to compulsive intake of heroin
    Joel E Schlosburg
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 110:9036-41. 2013
  5. pmc Developing a vaccine against multiple psychoactive targets: a case study of heroin
    G Neilm Stowe
    Departments of Chemistry and Immunology, The Skaggs Institute for Chemical Biology and Worm Institute of Research and Medicine WIRM, The Scripps Research Institute, La Jolla, California 92037, USA
    CNS Neurol Disord Drug Targets 10:865-75. 2011
  6. pmc Corticotropin-releasing factor (CRF) and α 2 adrenergic receptors mediate heroin withdrawal-potentiated startle in rats
    Paula E Park
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Int J Neuropsychopharmacol 16:1867-75. 2013
  7. pmc A vaccine strategy that induces protective immunity against heroin
    G Neil Stowe
    Department of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Med Chem 54:5195-204. 2011
  8. pmc Addiction as a stress surfeit disorder
    George F Koob
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30 2400, La Jolla, CA 92037, USA Electronic address
    Neuropharmacology 76:370-82. 2014
  9. pmc Kappa opioid receptor-mediated dysregulation of gamma-aminobutyric acidergic transmission in the central amygdala in cocaine addiction
    Marsida Kallupi
    School of Pharmacy, Pharmacology Unit, University of Camerino, Camerino, Italy Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California
    Biol Psychiatry 74:520-8. 2013
  10. pmc Levels of neural progenitors in the hippocampus predict memory impairment and relapse to drug seeking as a function of excessive methamphetamine self-administration
    Patrick Recinto
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA
    Neuropsychopharmacology 37:1275-87. 2012

Collaborators

Detail Information

Publications13

  1. pmc Escalation of drug self-administration as a hallmark of persistent addiction liability
    Scott Edwards
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Behav Pharmacol 24:356-62. 2013
    ..g. epigenetic) neuroadaptations generated by operant drug intake escalation models will continue to provide mechanisms and therapeutic interventions for reversing the aberrant neuroplasticity underlying addiction. ..
  2. pmc Evidence that vasopressin V1b receptors mediate the transition to excessive drinking in ethanol-dependent rats
    Scott Edwards
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Addict Biol 17:76-85. 2012
    ..Together, our data suggest a key role for vasopressin/V(1b) R signaling in the transition to ethanol dependence...
  3. pmc Development of mechanical hypersensitivity in rats during heroin and ethanol dependence: alleviation by CRF₁ receptor antagonism
    Scott Edwards
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA, USA
    Neuropharmacology 62:1142-51. 2012
    ..This article is part of a Special Issue entitled 'Post-Traumatic Stress Disorder'...
  4. pmc Dynamic vaccine blocks relapse to compulsive intake of heroin
    Joel E Schlosburg
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 110:9036-41. 2013
    ..Thus, our vaccine represents a promising adjunct therapy for heroin addiction, providing continuous heroin antagonism, requiring minimal medical monitoring and patient compliance...
  5. pmc Developing a vaccine against multiple psychoactive targets: a case study of heroin
    G Neilm Stowe
    Departments of Chemistry and Immunology, The Skaggs Institute for Chemical Biology and Worm Institute of Research and Medicine WIRM, The Scripps Research Institute, La Jolla, California 92037, USA
    CNS Neurol Disord Drug Targets 10:865-75. 2011
    ..In addition, we detail different strategies employed in the design of immunoconjugates for a vaccine-based therapy for heroin addiction treatment...
  6. pmc Corticotropin-releasing factor (CRF) and α 2 adrenergic receptors mediate heroin withdrawal-potentiated startle in rats
    Paula E Park
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Int J Neuropsychopharmacol 16:1867-75. 2013
    ....
  7. pmc A vaccine strategy that induces protective immunity against heroin
    G Neil Stowe
    Department of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Med Chem 54:5195-204. 2011
    ..Importantly, both the antinociceptive effects of heroin and acquisition of heroin self-administration were blocked in rats vaccinated using the heroin-like hapten...
  8. pmc Addiction as a stress surfeit disorder
    George F Koob
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30 2400, La Jolla, CA 92037, USA Electronic address
    Neuropharmacology 76:370-82. 2014
    ..This article is part of a Special Issue entitled 'NIDA 40th Anniversary Issue'...
  9. pmc Kappa opioid receptor-mediated dysregulation of gamma-aminobutyric acidergic transmission in the central amygdala in cocaine addiction
    Marsida Kallupi
    School of Pharmacy, Pharmacology Unit, University of Camerino, Camerino, Italy Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California
    Biol Psychiatry 74:520-8. 2013
    ..Studies have demonstrated an enhanced dynorphin/kappa-opioid receptor (KOR) system following repeated cocaine exposure, but few reports have focused on neuroadaptations within the central amygdala (CeA)...
  10. pmc Levels of neural progenitors in the hippocampus predict memory impairment and relapse to drug seeking as a function of excessive methamphetamine self-administration
    Patrick Recinto
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA
    Neuropsychopharmacology 37:1275-87. 2012
    ....
  11. pmc A role for the endocannabinoid system in the increased motivation for cocaine in extended-access conditions
    Laura Orio
    Committee on Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 29:4846-57. 2009
    ..These results suggest that neuroadaptations in the endogenous cannabinoid system may be part of the neuroplasticity associated with the development of cocaine addiction...
  12. pmc Long-lasting reduction in hippocampal neurogenesis by alcohol consumption in adolescent nonhuman primates
    Michael A Taffe
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 107:11104-9. 2010
    ..This lasting effect, observed 2 mo after alcohol discontinuation, may underlie the deficits in hippocampus-associated cognitive tasks that are observed in alcoholics...
  13. pmc Experimental psychiatric illness and drug abuse models: from human to animal, an overview
    Scott Edwards
    Committee on the Neurobiology of Addictive Disorders, Pearson Center for Alcoholism and Addiction Research, The Scripps Research Institute, La Jolla, CA, USA
    Methods Mol Biol 829:31-48. 2012
    ..Collaborative relationships between basic neuroscience and clinical modeling could greatly benefit the development of new and better models, in addition to facilitating medications development...