G M Edelman

Summary

Affiliation: The Neurosciences Institute
Country: USA

Publications

  1. pmc Biology of consciousness
    Gerald M Edelman
    The Neurosciences Institute San Diego CA, USA
    Front Psychol 2:4. 2011
  2. pmc Degeneracy and complexity in biological systems
    G M Edelman
    The Neurosciences Institute, La Jolla, CA 92121, USA
    Proc Natl Acad Sci U S A 98:13763-8. 2001
  3. pmc Naturalizing consciousness: a theoretical framework
    Gerald M Edelman
    Neurosciences Institute, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 100:5520-4. 2003
  4. ncbi request reprint Learning in and from brain-based devices
    Gerald M Edelman
    Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Science 318:1103-5. 2007
  5. ncbi request reprint Consciousness and complexity
    G Tononi
    Neurosciences Institute, 10640 John J Hopkins Drive, San Diego, CA 92121, USA
    Science 282:1846-51. 1998
  6. ncbi request reprint Connectivity and complexity: the relationship between neuroanatomy and brain dynamics
    O Sporns
    The Neurosciences Institute, San Diego, CA 92121, USA
    Neural Netw 13:909-22. 2000
  7. ncbi request reprint Theoretical neuroanatomy and the connectivity of the cerebral cortex
    O Sporns
    The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Behav Brain Res 135:69-74. 2002
  8. pmc Retrospective and prospective responses arising in a modeled hippocampus during maze navigation by a brain-based device
    Jason G Fleischer
    Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 104:3556-61. 2007
  9. pmc Measures of degeneracy and redundancy in biological networks
    G Tononi
    The Neurosciences Institute, 10640 John J Hopkins Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 96:3257-62. 1999
  10. pmc Identification of two short internal ribosome entry sites selected from libraries of random oligonucleotides
    G C Owens
    The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 98:1471-6. 2001

Collaborators

Detail Information

Publications48

  1. pmc Biology of consciousness
    Gerald M Edelman
    The Neurosciences Institute San Diego CA, USA
    Front Psychol 2:4. 2011
    ..We examine the constraints on causal analyses of consciousness and suggest that there is now sufficient evidence to consider the design and construction of a conscious artifact...
  2. pmc Degeneracy and complexity in biological systems
    G M Edelman
    The Neurosciences Institute, La Jolla, CA 92121, USA
    Proc Natl Acad Sci U S A 98:13763-8. 2001
    ..Furthermore, it is both necessary for, and an inevitable outcome of, natural selection...
  3. pmc Naturalizing consciousness: a theoretical framework
    Gerald M Edelman
    Neurosciences Institute, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 100:5520-4. 2003
    ..To place these properties within a biological framework requires a theory based on a set of evolutionary and developmental principles. This paper describes such a theory, which aims to provide a unifying account of conscious phenomena...
  4. ncbi request reprint Learning in and from brain-based devices
    Gerald M Edelman
    Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Science 318:1103-5. 2007
    ..These machines would combine the learning ability of BBDs with explicitly programmed control systems...
  5. ncbi request reprint Consciousness and complexity
    G Tononi
    Neurosciences Institute, 10640 John J Hopkins Drive, San Diego, CA 92121, USA
    Science 282:1846-51. 1998
    ..Applying measures of neural integration and complexity, together with an analysis of extensive neurological data, leads to a testable proposal-the dynamic core hypothesis-about the properties of the neural substrate of consciousness...
  6. ncbi request reprint Connectivity and complexity: the relationship between neuroanatomy and brain dynamics
    O Sporns
    The Neurosciences Institute, San Diego, CA 92121, USA
    Neural Netw 13:909-22. 2000
    ..Our theoretical findings offer new insight into the intricate relationship between connectivity and complexity in the nervous system...
  7. ncbi request reprint Theoretical neuroanatomy and the connectivity of the cerebral cortex
    O Sporns
    The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Behav Brain Res 135:69-74. 2002
    ..The combined structural and functional analysis outlined in this chapter provides insight into the large-scale functional organization of distributed cortical systems...
  8. pmc Retrospective and prospective responses arising in a modeled hippocampus during maze navigation by a brain-based device
    Jason G Fleischer
    Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 104:3556-61. 2007
    ..Moreover, journey-dependent activity was driven more strongly by hippocampal influence than journey-independent activity...
  9. pmc Measures of degeneracy and redundancy in biological networks
    G Tononi
    The Neurosciences Institute, 10640 John J Hopkins Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 96:3257-62. 1999
    ..These measures promise to be useful in characterizing and understanding the functional robustness and adaptability of biological networks...
  10. pmc Identification of two short internal ribosome entry sites selected from libraries of random oligonucleotides
    G C Owens
    The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 98:1471-6. 2001
    ..The ability to identify IRES modules with specific expression properties may be useful in the design of vectors for biotechnology and gene therapy...
  11. ncbi request reprint Spike-timing dynamics of neuronal groups
    Eugene M Izhikevich
    The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Cereb Cortex 14:933-44. 2004
    ..Localized coherent input resulted in shifts of receptive and projective fields in the model similar to those observed in vivo...
  12. ncbi request reprint Visual binding through reentrant connectivity and dynamic synchronization in a brain-based device
    Anil K Seth
    The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Cereb Cortex 14:1185-99. 2004
    ....
  13. ncbi request reprint Neural reapportionment: an hypothesis to account for the function of sleep
    Joseph A Gally
    The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
    C R Biol 327:721-7. 2004
    ..Experimental approaches that might be utilized to test these hypotheses are suggested...
  14. pmc Characterizing functional hippocampal pathways in a brain-based device as it solves a spatial memory task
    Jeffrey L Krichmar
    The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 102:2111-6. 2005
    ..Thus, in the model, different functional pathways influence place field activity and, hence, behavior during navigation...
  15. ncbi request reprint Brain-based devices for the study of nervous systems and the development of intelligent machines
    Jeffrey L Krichmar
    The Neurosciences Institute, 10640 John J Hopkins Drive, San Diego, CA 92121, USA
    Artif Life 11:63-77. 2005
    ..Although the principal focus of developing BBDs has been to test theories of brain function, this type of modeling may also provide a basis for robotic design and practical applications...
  16. ncbi request reprint Spatial navigation and causal analysis in a brain-based device modeling cortical-hippocampal interactions
    Jeffrey L Krichmar
    The Neurosciences Institute, 10640 John J Hopkins Drive, San Diego, CA 92121, USA
    Neuroinformatics 3:197-221. 2005
    ..Moreover, this causal time series analysis may be useful in analyzing networks in general...
  17. ncbi request reprint Single-trial discrimination of truthful from deceptive responses during a game of financial risk using alpha-band MEG signals
    Anil K Seth
    The Neurosciences Institute, San Diego, CA 92121, USA
    Neuroimage 32:465-76. 2006
    ..Our results raise the possibility that alpha power modulation during deception may reflect risk management and/or cognitive control...
  18. pmc Large-scale model of mammalian thalamocortical systems
    Eugene M Izhikevich
    The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 105:3593-8. 2008
    ..We describe spontaneous activity, sensitivity to changes in individual neurons, emergence of waves and rhythms, and functional connectivity on different scales...
  19. ncbi request reprint Embodied models of delayed neural responses: spatiotemporal categorization and predictive motor control in brain based devices
    Jeffrey L McKinstry
    The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Neural Netw 21:553-61. 2008
    ..In both tasks, biologically inspired neural simulations with delayed neural responses were critical for successful behavior by the device...
  20. ncbi request reprint Caffeine stimulates cytochrome oxidase expression and activity in the striatum in a sexually dimorphic manner
    Frederick S Jones
    The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego CA 92121, USA
    Mol Pharmacol 74:673-84. 2008
    ....
  21. pmc A cerebellar model for predictive motor control tested in a brain-based device
    Jeffrey L McKinstry
    The Neurosciences Institute, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 103:3387-92. 2006
    ..The system described here prompts several hypotheses about the relationship between perception and motor control and may be useful in the development of general-purpose motor learning systems for machines...
  22. ncbi request reprint Biochemistry and the sciences of recognition
    Gerald M Edelman
    Neurosciences Institute and the Scripps Research Institute, San Diego, California 92121, USA
    J Biol Chem 279:7361-9. 2004
  23. pmc The power of human brain magnetoencephalographic signals can be modulated up or down by changes in an attentive visual task
    Yanqing Chen
    The Neurosciences Institute, 10640 John Jay Hopkins Drive, La Jolla, CA 92121, USA
    Proc Natl Acad Sci U S A 100:3501-6. 2003
    ..These results may reflect relative differences in the synchronization and desynchronization of responding neuronal populations...
  24. ncbi request reprint Machine psychology: autonomous behavior, perceptual categorization and conditioning in a brain-based device
    Jeffrey L Krichmar
    W M Keck Laboratory, The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Cereb Cortex 12:818-30. 2002
    ..These devices also provide the groundwork for the development of intelligent machines that follow neurobiological rather than computational principles in their construction...
  25. ncbi request reprint Theoretical neuroanatomy: relating anatomical and functional connectivity in graphs and cortical connection matrices
    O Sporns
    The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Cereb Cortex 10:127-41. 2000
    ..We hypothesize that adaptation to rich sensory environments and motor demands requires complex dynamics and that these dynamics are supported by neuroanatomical motifs that are characteristic of the cerebral cortex...
  26. pmc The brain-derived neurotrophic factor enhances synthesis of Arc in synaptoneurosomes
    Yong Yin
    Department of Neurobiology, The Scripps Research Institute and The Skaggs Institute for Chemical Biology, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:2368-73. 2002
    ..The results suggest there is a synergy between neurotrophic and ionotropic mechanisms that may influence the specificity and duration of changes in synaptic efficacy at glutamatergic synapses...
  27. pmc Investigating neural correlates of conscious perception by frequency-tagged neuromagnetic responses
    G Tononi
    The Neurosciences Institute, 10640 John J Hopkins Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 95:3198-203. 1998
    ..The results demonstrate a correlation between the conscious perception of a visual stimulus and the synchronous activity of large populations of neurons as reflected by steady-state neuromagnetic responses...
  28. pmc A binding site for homeodomain and Pax proteins is necessary for L1 cell adhesion molecule gene expression by Pax-6 and bone morphogenetic proteins
    R Meech
    Department of Neurobiology, The Scripps Research Institute and The Skaggs Institute for Chemical Biology, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 96:2420-5. 1999
    ..Collectively, our experiments indicate that the HPD regulates L1 expression in neural tissues via homeodomain and Pax proteins and is likely to be a target of BMP signaling during development...
  29. pmc Transcript leader regions of two Saccharomyces cerevisiae mRNAs contain internal ribosome entry sites that function in living cells
    W Zhou
    Department of Neurobiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 98:1531-6. 2001
    ..Both YAP1 and p150 leaders contain several complementary sequence matches to yeast 18S rRNA. The findings are discussed in terms of our understanding of internal initiation in higher eukaryotes...
  30. pmc Cultured rat hippocampal neural progenitors generate spontaneously active neural networks
    Sanjay K Mistry
    Department of Neurobiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:1621-6. 2002
    ..We conclude that mitogenic growth factors can synergize with N-CAM or neurotrophins to generate spontaneously active neural networks from neural progenitors...
  31. ncbi request reprint Schizophrenia and the mechanisms of conscious integration
    G Tononi
    The Neurosciences Institute, 10640 John J Hopkins Drive, San Diego, CA, USA
    Brain Res Brain Res Rev 31:391-400. 2000
    ..The possibility is raised that disruption of re-entrant interactions among cortical areas may contribute to the pathophysiology of schizophrenia...
  32. ncbi request reprint Solution structure of the third immunoglobulin domain of the neural cell adhesion molecule N-CAM: can solution studies define the mechanism of homophilic binding?
    A R Atkins
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Mol Biol 311:161-72. 2001
    ....
  33. pmc Theories and measures of consciousness: an extended framework
    Anil K Seth
    Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 103:10799-804. 2006
    ..Given that some aspects of consciousness are likely to resist quantification altogether, we conclude that a satisfactory theory is likely to be one that combines both qualitative and quantitative elements...
  34. ncbi request reprint BDNF induces widespread changes in synaptic protein content and up-regulates components of the translation machinery: an analysis using high-throughput proteomics
    Lujian Liao
    Departments of Cell Biology and Neurobiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Proteome Res 6:1059-71. 2007
    ..The data demonstrate that BDNF increases the synthesis of a wide variety of synaptic proteins and suggest that the neurotrophin may enhance the translational capacity of synapses...
  35. ncbi request reprint Developmentally regulated expression of the cold-inducible RNA-binding motif protein 3 in euthermic rat brain
    Julie Pilotte
    Department of Neurobiology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Brain Res 1258:12-24. 2009
    ....
  36. pmc Dendritic spines elongate after stimulation of group 1 metabotropic glutamate receptors in cultured hippocampal neurons
    Peter W Vanderklish
    Department of Neurobiology, The Scripps Research Institute 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:1639-44. 2002
    ..The results suggest that in vivo activation of group 1 mGluRs by synaptically released glutamate affects spine shape in a protein synthesis-dependent manner...
  37. ncbi request reprint Differential translation and fragile X syndrome
    P W Vanderklish
    Department of Neurobiology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Genes Brain Behav 4:360-84. 2005
    ..We discuss several potential mechanisms for differential translation and the notion that FXS represents an exaggeration of one 'channel' in a set of translation-dependent consolidation responses...
  38. ncbi request reprint Efficient marking of neural stem cell-derived neurons with a modified murine embryonic stem cell virus, MESV2
    G C Owens
    The Neurosciences Institute, San Diego, CA 92121, USA
    Gene Ther 9:1044-8. 2002
    ..Both of these viruses efficiently transduced neural stem cells isolated from embryonic rat hippocampus, and robust EGFP expression was observed in neurons derived from these cells following differentiation in vitro...
  39. pmc Differential regulation by multiple promoters of the gene encoding the neuron-restrictive silencer factor
    C Koenigsberger
    Department of Neurobiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 97:2291-6. 2000
    ..Combinatorial arrangements of these promoters with enhancer and repressor regions may allow modulation of REST expression in particular contexts...
  40. pmc Internal initiation of translation of five dendritically localized neuronal mRNAs
    J K Pinkstaff
    Department of Neurobiology, Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 98:2770-5. 2001
    ..Although translation mediated by this IRES occurred throughout the cell, it was relatively more efficient in dendrites. These data suggest that IRESes may increase translation efficiency at postsynaptic sites after synaptic activation...
  41. pmc Biochemical and functional analysis of a 9-nt RNA sequence that affects translation efficiency in eukaryotic cells
    Stephen A Chappell
    Department of Neurobiology, The Scripps Research Institute, and The Skaggs Institute for Chemical Biology, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 101:9590-4. 2004
    ..The results suggest that the Gtx 9-nt sequence affects translation efficiency by a mechanism that involves base pairing to 18S rRNA...
  42. ncbi request reprint Chlorotoxin-mediated disinhibition of noradrenergic locus coeruleus neurons using a conditional transgenic approach
    J Michael Salbaum
    The Neurosciences Institute, 10640 John J Hopkins Drive, San Diego, CA 92121, USA
    Brain Res 1016:20-32. 2004
    ..This method represents a powerful new tool to assess the long-term effects of LC activation and is potentially applicable to other neuronal systems...
  43. pmc The fragile X mental retardation protein and group I metabotropic glutamate receptors regulate levels of mRNA granules in brain
    Armaz Aschrafi
    Department of Neurobiology, The Scripps Research Institute, and The Skaggs Institute for Chemical Biology, 10550 North Torrey Pines Road, SBR 14, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 102:2180-5. 2005
    ..Together, these data suggest that although large, polysome-containing granules can form in the absence of FMRP, their use in response to mGluR-induced translation is exaggerated...
  44. pmc Ribosomal shunting mediated by a translational enhancer element that base pairs to 18S rRNA
    Stephen A Chappell
    Department of Neurobiology, The Scripps Research Institute, and The Skaggs Institute for Chemical Biology, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 103:9488-93. 2006
    ..The data obtained by this model system provide direct evidence that ribosomal shunting can be mediated by mRNA-rRNA base pairing, a finding that may have general implications for mechanisms of ribosome movement...
  45. pmc BDNF induces translocation of initiation factor 4E to mRNA granules: evidence for a role of synaptic microfilaments and integrins
    Fiona M Smart
    Department of Neurobiology, The Scripps Research Institute, and The Skaggs Institute for Chemical Biology, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:14403-8. 2003
    ..Integrins, which are known to be essential for stabilizing certain forms of synaptic plasticity, may be critical regulators of local translation events at synapses...
  46. ncbi request reprint Distinguishing causal interactions in neural populations
    Anil K Seth
    Neural Comput 19:910-33. 2007
    ....
  47. ncbi request reprint Interview with Gerald M. Edelman: part II
    Gerald M Edelman
    Bioessays 26:326-35. 2004
  48. ncbi request reprint The covalent structure of an entire gamma G immunoglobulin molecule. 1969
    Gerald M Edelman
    J Immunol 173:5335-42. 2004