Kathryn A Eaton

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. ncbi The role of T cell subsets and cytokines in the pathogenesis of Helicobacter pylori gastritis in mice
    K A Eaton
    Department of Veterinary Biosciences, Ohio State University, Columbus, OH 43210, USA
    J Immunol 166:7456-61. 2001
  2. pmc In vivo complementation of ureB restores the ability of Helicobacter pylori to colonize
    Kathryn A Eaton
    Department of Veterinary Biosciences, Ohio State University, Columbus, Ohio 43210, USA
    Infect Immun 70:771-8. 2002
  3. ncbi Vaccination of gnotobiotic piglets against Helicobacter pylori
    K A Eaton
    Department of Veterinary Biosciences, Ohio State University, Columbus, USA
    J Infect Dis 178:1399-405. 1998
  4. pmc Murine splenocytes induce severe gastritis and delayed-type hypersensitivity and suppress bacterial colonization in Helicobacter pylori-infected SCID mice
    K A Eaton
    Department of Veterinary Biosciences, Ohio State University, Columbus, Ohio 43210, USA
    Infect Immun 67:4594-602. 1999
  5. pmc Cure of Helicobacter pylori infection and resolution of gastritis by adoptive transfer of splenocytes in mice
    K A Eaton
    Department of Veterinary Biosciences, Ohio State University, Columbus, Ohio 43210, USA
    Infect Immun 69:1025-31. 2001
  6. pmc Role of Helicobacter pylori cag region genes in colonization and gastritis in two animal models
    K A Eaton
    Department of Veterinary Biosciences, Ohio State University, Columbus, Ohio 43210, USA
    Infect Immun 69:2902-8. 2001
  7. ncbi Adoptive transfer of splenocytes in SCID mice implicates CD4+ T cells in apoptosis and epithelial proliferation associated with Helicobacter pylori-induced gastritis
    Richard A Peterson
    The Ohio State University, College of Veterinary Medicine, Department of Veterinary Biosciences, Columbus, Ohio 43210, USA
    Comp Med 53:498-509. 2003
  8. ncbi Comparison of gastritis and gastric epithelial proliferation in Helicobacter heilmannii-infected nude and BALB/c mice
    R A Peterson
    Department of Veterinary Biosciences, College of Veterinary Medicine, Ohio State University, Columbus 43210, USA
    Vet Pathol 38:173-83. 2001
  9. ncbi A reproducible scoring system for quantification of histologic lesions of inflammatory disease in mouse gastric epithelium
    Kathryn A Eaton
    Ohio State University, Columbus, USA
    Comp Med 57:57-65. 2007
  10. ncbi Cystoscopic appearance of proliferative urethritis in 2 dogs before and after treatment
    Roger A Hostutler
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Ohio State University, Columbus, OH 43210, USA
    J Vet Intern Med 18:113-6. 2004

Collaborators

Detail Information

Publications26

  1. ncbi The role of T cell subsets and cytokines in the pathogenesis of Helicobacter pylori gastritis in mice
    K A Eaton
    Department of Veterinary Biosciences, Ohio State University, Columbus, OH 43210, USA
    J Immunol 166:7456-61. 2001
    ..The results support the assertion that H. pylori is mediated by a Th1-biased cellular immune response...
  2. pmc In vivo complementation of ureB restores the ability of Helicobacter pylori to colonize
    Kathryn A Eaton
    Department of Veterinary Biosciences, Ohio State University, Columbus, Ohio 43210, USA
    Infect Immun 70:771-8. 2002
    ..Finally, our results suggest that total urease activity and colonization density do not contribute to gastritis due to H. pylori...
  3. ncbi Vaccination of gnotobiotic piglets against Helicobacter pylori
    K A Eaton
    Department of Veterinary Biosciences, Ohio State University, Columbus, USA
    J Infect Dis 178:1399-405. 1998
    ..pylori, and parenteral vaccination does not cure infected piglets. Vaccination does not ameliorate gastritis due to H. pylori in piglets but does induce neutrophilic gastric inflammation in some infected piglets...
  4. pmc Murine splenocytes induce severe gastritis and delayed-type hypersensitivity and suppress bacterial colonization in Helicobacter pylori-infected SCID mice
    K A Eaton
    Department of Veterinary Biosciences, Ohio State University, Columbus, Ohio 43210, USA
    Infect Immun 67:4594-602. 1999
    ..The greater severity of gastritis in recipient SCID mice than in donor C57BL/6 mice suggests that gastritis is due to specific T-cell subsets and/or the absence of regulatory cell subsets in the transferred splenocytes...
  5. pmc Cure of Helicobacter pylori infection and resolution of gastritis by adoptive transfer of splenocytes in mice
    K A Eaton
    Department of Veterinary Biosciences, Ohio State University, Columbus, Ohio 43210, USA
    Infect Immun 69:1025-31. 2001
    ..pylori infection and allowing resolution of gastritis. Thus, immune mechanisms of cure exist, and effective and safe vaccination protocols may be feasible...
  6. pmc Role of Helicobacter pylori cag region genes in colonization and gastritis in two animal models
    K A Eaton
    Department of Veterinary Biosciences, Ohio State University, Columbus, Ohio 43210, USA
    Infect Immun 69:2902-8. 2001
    ....
  7. ncbi Adoptive transfer of splenocytes in SCID mice implicates CD4+ T cells in apoptosis and epithelial proliferation associated with Helicobacter pylori-induced gastritis
    Richard A Peterson
    The Ohio State University, College of Veterinary Medicine, Department of Veterinary Biosciences, Columbus, Ohio 43210, USA
    Comp Med 53:498-509. 2003
    ..Influx of CD4 cells and gastritis are correlated with epithelial proliferation and apoptosis, and suggest that CD4-dependent H. pylori gastritis leads to epithelial damage with attendant proliferative and metaplastic responses...
  8. ncbi Comparison of gastritis and gastric epithelial proliferation in Helicobacter heilmannii-infected nude and BALB/c mice
    R A Peterson
    Department of Veterinary Biosciences, College of Veterinary Medicine, Ohio State University, Columbus 43210, USA
    Vet Pathol 38:173-83. 2001
    ..Additionally, CD4 immunocompetence is an integral aspect of the mucosal hypertrophy/nodular hyperplasia in experimental H. heilmannii-associated disease of mice...
  9. ncbi A reproducible scoring system for quantification of histologic lesions of inflammatory disease in mouse gastric epithelium
    Kathryn A Eaton
    Ohio State University, Columbus, USA
    Comp Med 57:57-65. 2007
    ..We propose that this system may be useful in standardizing the morphologic evaluation of rodent models of H. pylori and that a similar system could be devised for evaluation of other animal models of enteric disease...
  10. ncbi Cystoscopic appearance of proliferative urethritis in 2 dogs before and after treatment
    Roger A Hostutler
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Ohio State University, Columbus, OH 43210, USA
    J Vet Intern Med 18:113-6. 2004
  11. pmc Antimicrobial therapies for Helicobacter pylori infection in gnotobiotic piglets
    S Krakowka
    Department of Veterinary Biosciences, College of Veterinary Medicine, Ohio State University, Columbus 43210, USA
    Antimicrob Agents Chemother 42:1549-54. 1998
    ..These data establish the H. pylori-infected gnotobiotic piglet as a useful model for the identification of novel antimicrobials for the treatment of this disease and for drug assessment during preclinical evaluations...
  12. pmc Role of vacuolating cytotoxin in gastritis due to Helicobacter pylori in gnotobiotic piglets
    K A Eaton
    Department of Veterinary Biosciences, Ohio State University, Columbus 43210, USA
    Infect Immun 65:3462-4. 1997
    ....
  13. ncbi Helicobacter pylori-specific immunoglobulin synthesis in gnotobiotic piglets: evidence for the induction of mucosal immunity in the stomach
    Steven Krakowka
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210, USA
    Vet Immunol Immunopathol 88:173-82. 2002
    ..These data support the contention that the Ig response to H. pylori is initiated within the gastric compartment and matures over time to a generalized IgA-dominated mucosal and IgG-dominated nonmucosal humoral immune response...
  14. pmc The Entner-Doudoroff pathway has little effect on Helicobacter pylori colonization of mice
    Amy E Wanken
    Department of Veterinary Biosciences, Ohio State University, Columbus, Ohio 43210, USA
    Infect Immun 71:2920-3. 2003
    ..In spite of better colonization, however, wild-type strains did not displace the mutant in cocolonization experiments. Loss of 6PGD diminishes the fitness of H. pylori in vivo, but the pathway is nonessential for colonization...
  15. ncbi Polypoid cystitis in 17 dogs (1978-2001)
    Ivan Martinez
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Ohio State University, Columbus, OH 43210, USA
    J Vet Intern Med 17:499-509. 2003
    ..Surgery and removal of all polyps was the most efficacious treatment in dogs of this study. The question of whether or not polyps represent preneoplastic lesions remains unanswered and constitutes an area for future investigation...
  16. ncbi Transient proximal renal tubular acidosis and Fanconi syndrome in a dog
    Roger A Hostutler
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    J Am Vet Med Assoc 224:1611-4, 1605. 2004
    ..The dog's clinical condition appeared to have been transient in nature, a phenomenon that is rarely seen in human or veterinary medicine...
  17. ncbi Surgical management of diffuse polypoid cystitis using submucosal resection in a dog
    Tina M Wolfe
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, 601 Vernon L Tharp Street, Columbus, Ohio 43210, USA
    J Am Anim Hosp Assoc 46:281-4. 2010
    ..Resection of mucosa and submucosa of the urinary bladder in dogs with polypoid cystitis may be a useful surgical treatment and can be considered as an alternative to partial cystectomy or mucosal resection...
  18. pmc Prevalence and varieties of Helicobacter species in dogs from random sources and pet dogs: animal and public health implications
    K A Eaton
    Department of Veterinary Biosciences, Ohio State University, Columbus 43210, USA
    J Clin Microbiol 34:3165-70. 1996
    ..Nongastrospirillum helicobacters are rare in dogs and are not histologically detectable. Helicobacter pylori was not isolated from domestic dogs...
  19. pmc Helicobacter pylori-pulsed dendritic cells induce H. pylori-specific immunity in mice
    Min Zhang
    Department of Internal Medicine Gastroenterology Division, University of Michigan, Ann Arbor, Michigan 48109, USA
    Helicobacter 13:200-8. 2008
    ..The growing concern over the emergence of antibiotic-resistant Helicobacter pylori infection is propelling the development of an efficacious vaccine to control this highly adaptive organism...
  20. pmc Role of transcription factor T-bet expression by CD4+ cells in gastritis due to Helicobacter pylori in mice
    Kathryn A Eaton
    University of Michigan, Ann Arbor, Michigan 48109, USA
    Infect Immun 74:4673-84. 2006
    ..pylori-infected recipient SCID mice. This indicates that Th1-independent mechanisms can cause gastric inflammation and disease due to H. pylori...
  21. pmc Modulation of host immune responses by the cytolethal distending toxin of Helicobacter hepaticus
    Jason S Pratt
    Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan 48824, USA
    Infect Immun 74:4496-504. 2006
    ..hepaticus. These results suggest that CDT plays a key immunomodulatory role that allows persistence of H. hepaticus and that in IL-10-/- mice this alteration of the host immune response results in the development of colitis...
  22. ncbi Response to "eradication of Helicobacter pylori and resolution of gastritis in the gastric mucosa of IL-10-deficient mice"
    Kathryn A Eaton
    Helicobacter 11:135-6. 2006
  23. ncbi Helicobacter pylori-secreted factors inhibit dendritic cell IL-12 secretion: a mechanism of ineffective host defense
    John Y Kao
    Division of Gastroenterology, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109 0682, USA
    Am J Physiol Gastrointest Liver Physiol 291:G73-81. 2006
    ..lwoffi. Our findings suggest that dendritic cells participate in the host immune response against H. pylori and that their suppression by H. pylori may explain why infected hosts fail to prevent bacterial colonization...
  24. pmc Helicobacter acinonychis: genetic and rodent infection studies of a Helicobacter pylori-like gastric pathogen of cheetahs and other big cats
    Daiva Dailidiene
    Department of Molecular Microbiology, Washington University Medical School, St Louis, Missouri 63110, USA
    J Bacteriol 186:356-65. 2004
    ..pylori, its ability to infect mice, and its ability to coexist and recombine with certain H. pylori strains in vivo should be useful in studies of Helicobacter infection and virulence mechanisms and studies of genome evolution...
  25. ncbi Parietal cell hyperstimulation and autoimmune gastritis in cholera toxin transgenic mice
    Lymari Lopez-Diaz
    Department of Molecular and Integrative Physiology, University of Michigan, 7761 Medical Science II Building, Ann Arbor, MI 48109, USA
    Am J Physiol Gastrointest Liver Physiol 290:G970-9. 2006
    ..High Ctox in parietal cells can also induce progressive changes in the cellular architecture of the gastric glands, corresponding to the development of anti-parietal cell antibodies and autoimmune gastritis...
  26. ncbi Chronic gastritis in the hypochlorhydric gastrin-deficient mouse progresses to adenocarcinoma
    Yana Zavros
    Department of Gastroenterology, University of Michigan, Ann Arbor, MI 48109 0650, USA
    Oncogene 24:2354-66. 2005
    ..Moreover, neoplastic transformation of the antral gastric mucosa does not require gastrin...