Lynn DustinSummaryAffiliation: The Rockefeller University Country: USA Publications
Research Grants
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Detail Information
Publications
Primary, post-primary and non-specific immunoglobulin M responses in HCV infectionLynn B Dustin
Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA
Antivir Ther 17:1449-52. 2012..More study is required to identify the antigens that drive the development of MC...
Flying under the radar: the immunobiology of hepatitis CLynn B Dustin
The Rockefeller University, Center for the Study of Hepatitis C, New York, NY 10021, USA
Annu Rev Immunol 25:71-99. 2007..Persistent high levels of viral antigens may contribute to immune exhaustion. Finally, the virus may benefit from the efficient enlistment of memory T and B cells in the pursuit of a moving target...
Hepatitis C virus-induced cryoglobulinemiaEdgar D Charles
Center for the Study of Hepatitis C, The Rockefeller University, New York, New York 10065, USA
Kidney Int 76:818-24. 2009..It is unclear how B cells become dysregulated during the course of chronic HCV infection, and continued patient-centered research is necessary to elucidate the pathogenesis of HCV-related B-cell dysregulation...- Plasma chemokine levels correlate with the outcome of antiviral therapy in patients with hepatitis CDavid Butera
Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University, Box 64, 1230 York Ave, New York, NY 10021, USA
Blood 106:1175-82. 2005..This observation has implications for understanding the pathogenesis of HCV infection... - Clonal expansion of immunoglobulin M+CD27+ B cells in HCV-associated mixed cryoglobulinemiaEdgar D Charles
Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, Rockefeller University, New York, NY 10021, USA
Blood 111:1344-56. 2008..This study was registered at www.clinicaltrials.gov as NCT00219999... - Cell culture-produced hepatitis C virus does not infect peripheral blood mononuclear cellsSvetlana Marukian
Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA
Hepatology 48:1843-50. 2008..Supernatants from HCV RNA-transfected macrophages inhibited HCV replication in Huh-7.5 cells. Conclusion: We conclude that multiple blocks prevent blood cells from supporting HCV infection... - Reexamining the role of the humoral immune response in control of hepatitis C virus infectionLynn B Dustin
Center for the Study of Hepatitis C, The Rockefeller University, New York, NY, USA
Hepatology 40:756-8. 2004 - Accumulation of B lymphocytes with a naive, resting phenotype in a subset of hepatitis C patientsJianhua Ni
Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10021, USA
J Immunol 170:3429-39. 2003..Instead, factors other than antigenic stimulation may promote the accumulation of peripheral blood B cells with a naive phenotype in a subset of HCV patients... - Quasispecies heterogeneity within the E1/E2 region as a pretreatment variable during pegylated interferon therapy of chronic hepatitis C virus infectionThomas J Chambers
Department of Molecular Microbiology and Immunology, St Louis University School of Medicine, St Louis University Health Sciences Center, St Louis, Missouri, USA
J Virol 79:3071-83. 2005..One interpretation of these data is that early viral responses are governed to some extent by viral factors, whereas sustained responses may be more influenced by host factors, in addition to effects of viral complexity and diversity... - Interferon (IFN)-gamma-inducible protein-10: association with histological results, viral kinetics, and outcome during treatment with pegylated IFN-alpha 2a and ribavirin for chronic hepatitis C virus infectionAna I Romero
Department of Virology, , , Sweden
J Infect Dis 194:895-903. 2006..CONCLUSION: Baseline IP-10 levels are predictive of the response to HCV treatment...
Research Grants
- Immune complexes: origins and effects in HCV infectionLynn Dustin; Fiscal Year: 2006..By characterizing the roles of immune complexes in cell entry, these studies may also lead to a better understanding of HCV pathogenesis and improved design of therapeutic and preventive vaccines. ..
- Immune complexes: origins and effects in HCV infectionLynn Dustin; Fiscal Year: 2007..By characterizing the roles of immune complexes in cell entry, these studies may also lead to a better understanding of HCV pathogenesis and improved design of therapeutic and preventive vaccines. ..
- Immune complexes: origins and effects in HCV infectionLynn B Dustin; Fiscal Year: 2010..HCV infection leads to cirrhosis, liver failure, and hepatocellular carcinoma, and fl- n a 9(D 0-0 -0v L-0 /1 c-0 N-0 f/1 -=- O-6 0-'.' m<W ... m. O> (1) (n. ND( a- .3. 'G 0-6 (_o 0 mCD ... ..