Lynn Dustin

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. pmc Primary, post-primary and non-specific immunoglobulin M responses in HCV infection
    Lynn B Dustin
    Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA
    Antivir Ther 17:1449-52. 2012
  2. ncbi request reprint Flying under the radar: the immunobiology of hepatitis C
    Lynn B Dustin
    The Rockefeller University, Center for the Study of Hepatitis C, New York, NY 10021, USA
    Annu Rev Immunol 25:71-99. 2007
  3. pmc Hepatitis C virus-induced cryoglobulinemia
    Edgar D Charles
    Center for the Study of Hepatitis C, The Rockefeller University, New York, New York 10065, USA
    Kidney Int 76:818-24. 2009
  4. pmc Plasma chemokine levels correlate with the outcome of antiviral therapy in patients with hepatitis C
    David Butera
    Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University, Box 64, 1230 York Ave, New York, NY 10021, USA
    Blood 106:1175-82. 2005
  5. pmc Clonal expansion of immunoglobulin M+CD27+ B cells in HCV-associated mixed cryoglobulinemia
    Edgar D Charles
    Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, Rockefeller University, New York, NY 10021, USA
    Blood 111:1344-56. 2008
  6. pmc Cell culture-produced hepatitis C virus does not infect peripheral blood mononuclear cells
    Svetlana Marukian
    Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA
    Hepatology 48:1843-50. 2008
  7. ncbi request reprint Reexamining the role of the humoral immune response in control of hepatitis C virus infection
    Lynn B Dustin
    Center for the Study of Hepatitis C, The Rockefeller University, New York, NY, USA
    Hepatology 40:756-8. 2004
  8. ncbi request reprint Accumulation of B lymphocytes with a naive, resting phenotype in a subset of hepatitis C patients
    Jianhua Ni
    Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10021, USA
    J Immunol 170:3429-39. 2003
  9. pmc Quasispecies heterogeneity within the E1/E2 region as a pretreatment variable during pegylated interferon therapy of chronic hepatitis C virus infection
    Thomas J Chambers
    Department of Molecular Microbiology and Immunology, St Louis University School of Medicine, St Louis University Health Sciences Center, St Louis, Missouri, USA
    J Virol 79:3071-83. 2005
  10. ncbi request reprint Interferon (IFN)-gamma-inducible protein-10: association with histological results, viral kinetics, and outcome during treatment with pegylated IFN-alpha 2a and ribavirin for chronic hepatitis C virus infection
    Ana I Romero
    Department of Virology, University of Goteborg, Goteborg, Sweden
    J Infect Dis 194:895-903. 2006

Collaborators

Detail Information

Publications10

  1. pmc Primary, post-primary and non-specific immunoglobulin M responses in HCV infection
    Lynn B Dustin
    Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA
    Antivir Ther 17:1449-52. 2012
    ..More study is required to identify the antigens that drive the development of MC...
  2. ncbi request reprint Flying under the radar: the immunobiology of hepatitis C
    Lynn B Dustin
    The Rockefeller University, Center for the Study of Hepatitis C, New York, NY 10021, USA
    Annu Rev Immunol 25:71-99. 2007
    ..Persistent high levels of viral antigens may contribute to immune exhaustion. Finally, the virus may benefit from the efficient enlistment of memory T and B cells in the pursuit of a moving target...
  3. pmc Hepatitis C virus-induced cryoglobulinemia
    Edgar D Charles
    Center for the Study of Hepatitis C, The Rockefeller University, New York, New York 10065, USA
    Kidney Int 76:818-24. 2009
    ..It is unclear how B cells become dysregulated during the course of chronic HCV infection, and continued patient-centered research is necessary to elucidate the pathogenesis of HCV-related B-cell dysregulation...
  4. pmc Plasma chemokine levels correlate with the outcome of antiviral therapy in patients with hepatitis C
    David Butera
    Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University, Box 64, 1230 York Ave, New York, NY 10021, USA
    Blood 106:1175-82. 2005
    ..This observation has implications for understanding the pathogenesis of HCV infection...
  5. pmc Clonal expansion of immunoglobulin M+CD27+ B cells in HCV-associated mixed cryoglobulinemia
    Edgar D Charles
    Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, Rockefeller University, New York, NY 10021, USA
    Blood 111:1344-56. 2008
    ..This study was registered at www.clinicaltrials.gov as NCT00219999...
  6. pmc Cell culture-produced hepatitis C virus does not infect peripheral blood mononuclear cells
    Svetlana Marukian
    Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA
    Hepatology 48:1843-50. 2008
    ..Supernatants from HCV RNA-transfected macrophages inhibited HCV replication in Huh-7.5 cells. Conclusion: We conclude that multiple blocks prevent blood cells from supporting HCV infection...
  7. ncbi request reprint Reexamining the role of the humoral immune response in control of hepatitis C virus infection
    Lynn B Dustin
    Center for the Study of Hepatitis C, The Rockefeller University, New York, NY, USA
    Hepatology 40:756-8. 2004
  8. ncbi request reprint Accumulation of B lymphocytes with a naive, resting phenotype in a subset of hepatitis C patients
    Jianhua Ni
    Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10021, USA
    J Immunol 170:3429-39. 2003
    ..Instead, factors other than antigenic stimulation may promote the accumulation of peripheral blood B cells with a naive phenotype in a subset of HCV patients...
  9. pmc Quasispecies heterogeneity within the E1/E2 region as a pretreatment variable during pegylated interferon therapy of chronic hepatitis C virus infection
    Thomas J Chambers
    Department of Molecular Microbiology and Immunology, St Louis University School of Medicine, St Louis University Health Sciences Center, St Louis, Missouri, USA
    J Virol 79:3071-83. 2005
    ..One interpretation of these data is that early viral responses are governed to some extent by viral factors, whereas sustained responses may be more influenced by host factors, in addition to effects of viral complexity and diversity...
  10. ncbi request reprint Interferon (IFN)-gamma-inducible protein-10: association with histological results, viral kinetics, and outcome during treatment with pegylated IFN-alpha 2a and ribavirin for chronic hepatitis C virus infection
    Ana I Romero
    Department of Virology, University of Goteborg, Goteborg, Sweden
    J Infect Dis 194:895-903. 2006
    ..We investigated associations between interferon (IFN)-gamma-inducible protein (IP)-10 and liver histological results, viral kinetic response, and treatment outcome in patients infected with hepatitis C virus (HCV) genotypes 1-4...

Research Grants7

  1. Immune complexes: origins and effects in HCV infection
    Lynn Dustin; Fiscal Year: 2006
    ..By characterizing the roles of immune complexes in cell entry, these studies may also lead to a better understanding of HCV pathogenesis and improved design of therapeutic and preventive vaccines. ..
  2. Immune complexes: origins and effects in HCV infection
    Lynn Dustin; Fiscal Year: 2007
    ..By characterizing the roles of immune complexes in cell entry, these studies may also lead to a better understanding of HCV pathogenesis and improved design of therapeutic and preventive vaccines. ..
  3. Immune complexes: origins and effects in HCV infection
    Lynn B Dustin; Fiscal Year: 2010
    ..HCV infection leads to cirrhosis, liver failure, and hepatocellular carcinoma, and fl- n a 9(D 0-0 -0v L-0 /1 c-0 N-0 f/1 -=- O-6 0-'.' m<W ... m. O> (1) (n. ND( a- .3. 'G 0-6 (_o 0 mCD ... ..