T E Dufresne
Affiliation: The Procter and Gamble Company
- Risedronate preserves bone architecture in early postmenopausal women in 1 year as measured by three-dimensional microcomputed tomographyT E Dufresne
Procter and Gamble Pharmaceuticals, Cincinnati, OH 45040, USA
Calcif Tissue Int 73:423-32. 2003..Although there is no direct link in this study between fracture and preservation of architecture, it is reasonable to infer that the preservation of bone architecture may play a role in risedronate's anti-fracture efficacy...
- Long-term risedronate treatment normalizes mineralization and continues to preserve trabecular architecture: sequential triple biopsy studies with micro-computed tomographyB Borah
Procter and Gamble Pharmaceuticals, Inc Health Care Research Center, 8700 Mason Montgomery Road, Mason, OH 45040, USA
Bone 39:345-52. 2006..Overall, risedronate provided sustained benefits on mineralization and architecture, two key determinants of bone strength, over 5 years lending support for its long-term efficacy in fracture risk reduction...
- Three-dimensional microimaging (MRmicroI and microCT), finite element modeling, and rapid prototyping provide unique insights into bone architecture in osteoporosisB Borah
Procter and Gamble Pharmaceuticals, Health Care Research Center, Mason, OH 45040 9462, USA
Anat Rec 265:101-10. 2001..The integration of these techniques provide us with an unique ability to investigate the role of bone architecture in osteoporotic fractures and to support the development of new therapies...
- Quantitative imaging of proteoglycan in cartilage using a gadolinium probe and microCTM D Cockman
Procter and Gamble Pharmaceuticals, 8700 Mason Montgomery Road, Mason, OH 45040, USA
Osteoarthritis Cartilage 14:210-4. 2006..This work was designed to demonstrate that exposure of cartilage to charged gadolinium compounds modifies the intensity to allow an improved visualization of cartilage morphology and the determination of proteoglycan content...