Research Topics
| GREGG L DUESTERSummaryAffiliation: The Burnham Institute Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Nolz1 promotes striatal neurogenesis through the regulation of retinoic acid signalingNoelia Urbán
Department of Cell Biology, Immunology and Neuroscience, Faculty of Medicine, IDIBAPS, Universitat de Barcelona, C Casanova 143, 08036 Barcelona, Spain
Neural Dev 5:21. 2010..Nolz1 is a zinc finger transcription factor whose expression is enriched in the lateral ganglionic eminence (LGE), although its function is still unknown...- Keeping an eye on retinoic acid signaling during eye developmentGregg Duester
Development and Aging Program, Burnham Institute for Medical Research, La Jolla, CA 92037, USA
Chem Biol Interact 178:178-81. 2009..These findings will help guide future studies designed to identify retinoic acid target genes during eye organogenesis... - Retinoic acid synthesis and signaling during early organogenesisGregg Duester
Burnham Institute for Medical Research, Development and Aging Program, La Jolla, CA 92037, USA
Cell 134:921-31. 2008..Recent studies suggest that retinoic acid may act primarily in a paracrine manner and provide insight into the cell-cell signaling networks that control differentiation of pluripotent cells... - Retinoic acid regulation of the somitogenesis clockGregg Duester
Developmental Biology Program, Burnham Institute for Medical Research, La Jolla, California 92037, USA
Birth Defects Res C Embryo Today 81:84-92. 2007..These findings suggest that human vertebral birth defects such as scoliosis, an abnormal left-right bending of the vertebral column, may be caused by a defect in RA signaling during somitogenesis... 
Families of retinoid dehydrogenases regulating vitamin A function: production of visual pigment and retinoic acidG Duester
Burnham Institute, La Jolla, CA 92037, USA
Eur J Biochem 267:4315-24. 2000..For several SDRs (RoDH1, RoDH4, CRAD1, and CRAD2) androgens rather than retinoids are the predominant substrates suggesting a function in androgen metabolism as well as retinoid metabolism...- Cytosolic retinoid dehydrogenases govern ubiquitous metabolism of retinol to retinaldehyde followed by tissue-specific metabolism to retinoic acidGregg Duester
Onco Developmental Biology Program, Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Chem Biol Interact 143:201-10. 2003..An important concept to emerge is that selective expression of enzymes catalyzing the second step is what limits the tissues that can completely metabolize retinol to RA to initiate retinoid signaling... - Genetic dissection of retinoid dehydrogenasesG Duester
Gene Regulation Program, Burnham Institute, 10901 North Torrey Pines Road, 92037, La Jolla, CA, USA
Chem Biol Interact 130:469-80. 2001..Overall, these studies provide genetic evidence that Adh1, Adh4, Raldh1, and Raldh2 encode retinoid dehydrogenases involved in retinoic acid synthesis in vivo... - Stimulation of retinoic acid production and growth by ubiquitously expressed alcohol dehydrogenase Adh3Andrei Molotkov
Gene Regulation Program, Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 99:5337-42. 2002..ADH3 was also shown to have in vitro retinol oxidation activity. Unlike the second step, the first step of RA synthesis is not tissue-restricted because it is catalyzed by ADH3, a ubiquitous enzyme having an ancient origin... - Retinoic acid controls heart anteroposterior patterning by down-regulating Isl1 through the Fgf8 pathwayIoan Ovidiu Sirbu
Burnham Institute for Medical Research, Development and Aging Program, La Jolla, California 92037, USA
Dev Dyn 237:1627-35. 2008..We provide evidence that retinoic acid acts specifically in the posterior-medial region of the cardiac field to establish the heart posterior boundary potentially by reducing Fgf8 expression which restricts the Isl1 domain... - Requirement of mesodermal retinoic acid generated by Raldh2 for posterior neural transformationNatalia Molotkova
OncoDevelopmental Biology Program, Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Mech Dev 122:145-55. 2005..An important concept to emerge from our studies is that the somitic mesodermal RA signal acts in the neuroectoderm but not mesoderm to generate a spinal cord fate... - Role of retinoic acid during forebrain development begins late when Raldh3 generates retinoic acid in the ventral subventricular zoneNatalia Molotkova
Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Dev Biol 303:601-10. 2007..Our results suggest that the role of RA during forebrain development begins late when Raldh3 expression initiates in the ventral subventricular zone... - Retinoic acid guides eye morphogenetic movements via paracrine signaling but is unnecessary for retinal dorsoventral patterningAndrei Molotkov
Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Development 133:1901-10. 2006..At all stages, RA target tissues are distinct from locations of RA synthesis, indicating that RALDHs function cell-nonautonomously to generate paracrine RA signals that guide morphogenetic movements in neighboring cells... - Distinct retinoid metabolic functions for alcohol dehydrogenase genes Adh1 and Adh4 in protection against vitamin A toxicity or deficiency revealed in double null mutant miceAndrei Molotkov
Gene Regulation Program, Burnham Institute, La Jolla, California 92037, USA
J Biol Chem 277:13804-11. 2002.... - Novel retinoic acid generating activities in the neural tube and heart identified by conditional rescue of Raldh2 null mutant miceFelix A Mic
Gene Regulation Program, Burnham Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
Development 129:2271-82. 2002.... - Genetic evidence that retinaldehyde dehydrogenase Raldh1 (Aldh1a1) functions downstream of alcohol dehydrogenase Adh1 in metabolism of retinol to retinoic acidAndrei Molotkov
OncoDevelopmental Biology Program, Burnham Institute, La Jolla, California 92037, USA
J Biol Chem 278:36085-90. 2003..These observations demonstrate that Raldh1 functions downstream of Adh1 in the oxidative metabolism of excess retinol and that toxicity correlates primarily with accumulating retinol rather than retinaldehyde... - Retinoic acid signaling in perioptic mesenchyme represses Wnt signaling via induction of Pitx2 and Dkk2Sandeep Kumar
Burnham Institute for Medical Research, Development and Aging Program, La Jolla, California 92037, USA
Dev Biol 340:67-74. 2010..Our findings demonstrate excessive activation of Wnt signaling in the perioptic mesenchyme of RA deficient mice which may be responsible for abnormal development leading to defective optic cup, cornea, and eyelid morphogenesis... - Retinoic acid synthesis controlled by Raldh2 is required early for limb bud initiation and then later as a proximodistal signal during apical ectodermal ridge formationFelix A Mic
OncoDevelopmental Biology Program, Burnham Institute, La Jolla, California 92037, USA
J Biol Chem 279:26698-706. 2004..During ZPA formation, RA acts early to activate expression of dHand, but it is not required later for Shh activation... - Retinoic acid controls expression of tissue remodeling genes Hmgn1 and Fgf18 at the digit-interdigit junctionXianling Zhao
Burnham Institute for Medical Research, Development and Aging Program, La Jolla, California, USA
Dev Dyn 239:665-71. 2010..Regulation of Hmgn1 and Fgf18 at the digit-interdigit junction suggests RA controls tissue remodeling as well as apoptosis... - Retinoic-acid signalling in node ectoderm and posterior neural plate directs left-right patterning of somitic mesodermIoan Ovidiu Sirbu
OncoDevelopmental Biology Program, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Nat Cell Biol 8:271-7. 2006.... - Retinol/ethanol drug interaction during acute alcohol intoxication in mice involves inhibition of retinol metabolism to retinoic acid by alcohol dehydrogenaseAndrei Molotkov
Gene Regulation Program, Burnham Institute, La Jolla, California 92037, USA
J Biol Chem 277:22553-7. 2002..These findings demonstrate that the reduced RA levels observed during acute retinol/ethanol drug interaction are due primarily to a decrease in ADH-catalyzed RA synthesis and secondarily to an increase in RA degradation... - Shifting boundaries of retinoic acid activity control hindbrain segmental gene expressionIoan Ovidiu Sirbu
OncoDevelopmental Biology Program, Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Development 132:2611-22. 2005..These two pulses of RA activity function to establish expression of Hoxb1 and vHnf1 on opposite sides of the r4/r5 boundary... - Retinoic acid promotes limb induction through effects on body axis extension but is unnecessary for limb patterningXianling Zhao
Development and Aging Program, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Curr Biol 19:1050-7. 2009.... - Excessive vitamin A toxicity in mice genetically deficient in either alcohol dehydrogenase Adh1 or Adh3Andrei Molotkov
Gene Regulation Program, Burnham Institute, La Jolla, CA 92037, USA
Eur J Biochem 269:2607-12. 2002..ADH3 plays a secondary role. Our results also show that retinoic acid is not the toxic moiety during vitamin A excess, as Adh1 mutants have less retinoic acid production while experiencing increased toxicity... - Retinoic acid generated by Raldh2 in mesoderm is required for mouse dorsal endodermal pancreas developmentAndrei Molotkov
OncoDevelopmental Biology Program, Burnham Institute, La Jolla, CA 92037, USA
Dev Dyn 232:950-7. 2005..Our findings demonstrate a specific role for RA in mouse embryos as a mesodermally synthesized signal needed for dorsal endodermal expression of Pdx1 during development of the dorsal pancreatic lineage... - Opposing actions of cellular retinol-binding protein and alcohol dehydrogenase control the balance between retinol storage and degradationAndrei Molotkov
OncoDevelopmental Biology Program, Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Biochem J 383:295-302. 2004.... - Patterning of forelimb bud myogenic precursor cells requires retinoic acid signaling initiated by Raldh2Felix A Mic
OncoDevelopmental Biology Program, Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Dev Biol 264:191-201. 2003.... - Targeted disruption of Aldh1a1 (Raldh1) provides evidence for a complex mechanism of retinoic acid synthesis in the developing retinaXiaohong Fan
OncoDevelopmental Biology Program Center for Neuroscience and Aging, Burnham Institute, La Jolla, California 92037, USA
Mol Cell Biol 23:4637-48. 2003..Our findings suggest that RA signaling may be necessary only during early stages of retina development and that if RA synthesis is needed in dorsal retina, it is catalyzed by multiple enzymes, including Raldh1... - Retinoid activation of retinoic acid receptor but not retinoid X receptor is sufficient to rescue lethal defect in retinoic acid synthesisFelix A Mic
OncoDevelopmental Biology Program, Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 100:7135-40. 2003..Because 9-cis-RA is undetectable and unnecessary for Raldh2-/- rescue, and others have shown that 4-oxo-RA is unnecessary for mouse development, all-trans-RA emerges as the only ligand clearly necessary for retinoid receptor signaling... - Raldh2 expression in optic vesicle generates a retinoic acid signal needed for invagination of retina during optic cup formationFelix A Mic
OncoDevelopmental Biology Program, Burnham Institute, La Jolla, California 92037, USA
Dev Dyn 231:270-7. 2004..Our findings suggest that RA functions as one of the signals needed for invagination of the retina to generate an optic cup...
Research Grants
- Retinoid Dehydrogenases Involved in Eye DevelopmentGregg Duester; Fiscal Year: 2005..abstract_text> ..
- Generation of Retinoid Signals during DevelopmentGregg Duester; Fiscal Year: 2005..Also, we will identify the novel RA-generating enzymes expressed in the neural tube and heart and begin genetic studies on them. ..
- Retinoid Dehydrogenases Involved in Eye DevelopmentGregg Duester; Fiscal Year: 2007....
- Retinoid Dehydrogenases Involved in Eye DevelopmentGregg Duester; Fiscal Year: 2009....
- Generation of Retinoid Signals during DevelopmentGREGG L DUESTER; Fiscal Year: 2010..3) The role RA signaling plays in forelimb budding will be investigated including the timing, target tissue, RA source tissue, and target genes. ..
- Retinoid Dehydrogenases Involved in Eye DevelopmentGREGG L DUESTER; Fiscal Year: 2010....
- GENETIC DISSECTION OF ALCOHOL/RETINOL METABOLIC PATHWAYSGregg Duester; Fiscal Year: 2002..3) Prepare and ALDH-I knockout mouse plus mice mutated for one or more ADHs and ALDH-I, then analyze their phenotype as above. ..
- Generation of Retinoid Signals during DevelopmentGregg Duester; Fiscal Year: 2009..3) The role RA signaling plays in forelimb budding will be investigated including the timing, target tissue, RA source tissue, and target genes. ..