GREGG L DUESTER

Summary

Affiliation: The Burnham Institute
Country: USA

Publications

  1. pmc Nolz1 promotes striatal neurogenesis through the regulation of retinoic acid signaling
    Noelia Urbán
    Department of Cell Biology, Immunology and Neuroscience, Faculty of Medicine, IDIBAPS, Universitat de Barcelona, C Casanova 143, 08036 Barcelona, Spain
    Neural Dev 5:21. 2010
  2. pmc Keeping an eye on retinoic acid signaling during eye development
    Gregg Duester
    Development and Aging Program, Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Chem Biol Interact 178:178-81. 2009
  3. pmc Retinoic acid synthesis and signaling during early organogenesis
    Gregg Duester
    Burnham Institute for Medical Research, Development and Aging Program, La Jolla, CA 92037, USA
    Cell 134:921-31. 2008
  4. pmc Retinoic acid regulation of the somitogenesis clock
    Gregg Duester
    Developmental Biology Program, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    Birth Defects Res C Embryo Today 81:84-92. 2007
  5. ncbi Families of retinoid dehydrogenases regulating vitamin A function: production of visual pigment and retinoic acid
    G Duester
    Burnham Institute, La Jolla, CA 92037, USA
    Eur J Biochem 267:4315-24. 2000
  6. ncbi Cytosolic retinoid dehydrogenases govern ubiquitous metabolism of retinol to retinaldehyde followed by tissue-specific metabolism to retinoic acid
    Gregg Duester
    Onco Developmental Biology Program, Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Chem Biol Interact 143:201-10. 2003
  7. ncbi Genetic dissection of retinoid dehydrogenases
    G Duester
    Gene Regulation Program, Burnham Institute, 10901 North Torrey Pines Road, 92037, La Jolla, CA, USA
    Chem Biol Interact 130:469-80. 2001
  8. pmc Stimulation of retinoic acid production and growth by ubiquitously expressed alcohol dehydrogenase Adh3
    Andrei Molotkov
    Gene Regulation Program, Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:5337-42. 2002
  9. pmc Retinoic acid controls heart anteroposterior patterning by down-regulating Isl1 through the Fgf8 pathway
    Ioan Ovidiu Sirbu
    Burnham Institute for Medical Research, Development and Aging Program, La Jolla, California 92037, USA
    Dev Dyn 237:1627-35. 2008
  10. pmc Requirement of mesodermal retinoic acid generated by Raldh2 for posterior neural transformation
    Natalia Molotkova
    OncoDevelopmental Biology Program, Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Mech Dev 122:145-55. 2005

Research Grants

Collaborators

  • Pierre Chambon
  • D M Benbrook
  • WILLIAM BLANER
  • Andrei Molotkov
  • Felix A Mic
  • Natalia Molotkova
  • Ioan Ovidiu Sirbu
  • Xianling Zhao
  • Sandeep Kumar
  • Xiaohong Fan
  • Noelia Urbán
  • Mario H Foglio
  • Arnold E Cuenca
  • Louise Deltour
  • I Ovidiu Sirbu
  • Angel R de Lera
  • Miriam Esgleas
  • Jordi Alberch
  • Héctor R Méndez-Gómez
  • Thomas J Cunningham
  • Kenneth Campbell
  • Raquel Martín-Ibáñez
  • Ronald Waclaw
  • Cristina Herranz
  • Rosana Alvarez
  • Monica Pardo
  • Susana Alvarez
  • Ivan Crespo-Enríquez
  • Christina Chatzi
  • Thomas Brade
  • Salvador Martinez
  • Carlos Vicario-Abejón
  • Josep M Canals
  • Empar Crespo
  • Lionel Gresh
  • Jacqueline Barra
  • Norbert B Ghyselinck
  • Stuart A Lipton
  • Shin Ichi Manabe
  • Christine M Donmoyer
  • Xavier Parés
  • Robert J Haselbeck
  • Silvia Martras
  • Jaume Farrés

Detail Information

Publications29

  1. pmc Nolz1 promotes striatal neurogenesis through the regulation of retinoic acid signaling
    Noelia Urbán
    Department of Cell Biology, Immunology and Neuroscience, Faculty of Medicine, IDIBAPS, Universitat de Barcelona, C Casanova 143, 08036 Barcelona, Spain
    Neural Dev 5:21. 2010
    ..Nolz1 is a zinc finger transcription factor whose expression is enriched in the lateral ganglionic eminence (LGE), although its function is still unknown...
  2. pmc Keeping an eye on retinoic acid signaling during eye development
    Gregg Duester
    Development and Aging Program, Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Chem Biol Interact 178:178-81. 2009
    ..These findings will help guide future studies designed to identify retinoic acid target genes during eye organogenesis...
  3. pmc Retinoic acid synthesis and signaling during early organogenesis
    Gregg Duester
    Burnham Institute for Medical Research, Development and Aging Program, La Jolla, CA 92037, USA
    Cell 134:921-31. 2008
    ..Recent studies suggest that retinoic acid may act primarily in a paracrine manner and provide insight into the cell-cell signaling networks that control differentiation of pluripotent cells...
  4. pmc Retinoic acid regulation of the somitogenesis clock
    Gregg Duester
    Developmental Biology Program, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    Birth Defects Res C Embryo Today 81:84-92. 2007
    ..These findings suggest that human vertebral birth defects such as scoliosis, an abnormal left-right bending of the vertebral column, may be caused by a defect in RA signaling during somitogenesis...
  5. ncbi Families of retinoid dehydrogenases regulating vitamin A function: production of visual pigment and retinoic acid
    G Duester
    Burnham Institute, La Jolla, CA 92037, USA
    Eur J Biochem 267:4315-24. 2000
    ..For several SDRs (RoDH1, RoDH4, CRAD1, and CRAD2) androgens rather than retinoids are the predominant substrates suggesting a function in androgen metabolism as well as retinoid metabolism...
  6. ncbi Cytosolic retinoid dehydrogenases govern ubiquitous metabolism of retinol to retinaldehyde followed by tissue-specific metabolism to retinoic acid
    Gregg Duester
    Onco Developmental Biology Program, Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Chem Biol Interact 143:201-10. 2003
    ..An important concept to emerge is that selective expression of enzymes catalyzing the second step is what limits the tissues that can completely metabolize retinol to RA to initiate retinoid signaling...
  7. ncbi Genetic dissection of retinoid dehydrogenases
    G Duester
    Gene Regulation Program, Burnham Institute, 10901 North Torrey Pines Road, 92037, La Jolla, CA, USA
    Chem Biol Interact 130:469-80. 2001
    ..Overall, these studies provide genetic evidence that Adh1, Adh4, Raldh1, and Raldh2 encode retinoid dehydrogenases involved in retinoic acid synthesis in vivo...
  8. pmc Stimulation of retinoic acid production and growth by ubiquitously expressed alcohol dehydrogenase Adh3
    Andrei Molotkov
    Gene Regulation Program, Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:5337-42. 2002
    ..ADH3 was also shown to have in vitro retinol oxidation activity. Unlike the second step, the first step of RA synthesis is not tissue-restricted because it is catalyzed by ADH3, a ubiquitous enzyme having an ancient origin...
  9. pmc Retinoic acid controls heart anteroposterior patterning by down-regulating Isl1 through the Fgf8 pathway
    Ioan Ovidiu Sirbu
    Burnham Institute for Medical Research, Development and Aging Program, La Jolla, California 92037, USA
    Dev Dyn 237:1627-35. 2008
    ..We provide evidence that retinoic acid acts specifically in the posterior-medial region of the cardiac field to establish the heart posterior boundary potentially by reducing Fgf8 expression which restricts the Isl1 domain...
  10. pmc Requirement of mesodermal retinoic acid generated by Raldh2 for posterior neural transformation
    Natalia Molotkova
    OncoDevelopmental Biology Program, Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Mech Dev 122:145-55. 2005
    ..An important concept to emerge from our studies is that the somitic mesodermal RA signal acts in the neuroectoderm but not mesoderm to generate a spinal cord fate...
  11. pmc Role of retinoic acid during forebrain development begins late when Raldh3 generates retinoic acid in the ventral subventricular zone
    Natalia Molotkova
    Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Dev Biol 303:601-10. 2007
    ..Our results suggest that the role of RA during forebrain development begins late when Raldh3 expression initiates in the ventral subventricular zone...
  12. pmc Retinoic acid guides eye morphogenetic movements via paracrine signaling but is unnecessary for retinal dorsoventral patterning
    Andrei Molotkov
    Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Development 133:1901-10. 2006
    ..At all stages, RA target tissues are distinct from locations of RA synthesis, indicating that RALDHs function cell-nonautonomously to generate paracrine RA signals that guide morphogenetic movements in neighboring cells...
  13. pmc Distinct retinoid metabolic functions for alcohol dehydrogenase genes Adh1 and Adh4 in protection against vitamin A toxicity or deficiency revealed in double null mutant mice
    Andrei Molotkov
    Gene Regulation Program, Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 277:13804-11. 2002
    ....
  14. pmc Novel retinoic acid generating activities in the neural tube and heart identified by conditional rescue of Raldh2 null mutant mice
    Felix A Mic
    Gene Regulation Program, Burnham Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    Development 129:2271-82. 2002
    ....
  15. ncbi Genetic evidence that retinaldehyde dehydrogenase Raldh1 (Aldh1a1) functions downstream of alcohol dehydrogenase Adh1 in metabolism of retinol to retinoic acid
    Andrei Molotkov
    OncoDevelopmental Biology Program, Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 278:36085-90. 2003
    ..These observations demonstrate that Raldh1 functions downstream of Adh1 in the oxidative metabolism of excess retinol and that toxicity correlates primarily with accumulating retinol rather than retinaldehyde...
  16. pmc Retinoic acid signaling in perioptic mesenchyme represses Wnt signaling via induction of Pitx2 and Dkk2
    Sandeep Kumar
    Burnham Institute for Medical Research, Development and Aging Program, La Jolla, California 92037, USA
    Dev Biol 340:67-74. 2010
    ..Our findings demonstrate excessive activation of Wnt signaling in the perioptic mesenchyme of RA deficient mice which may be responsible for abnormal development leading to defective optic cup, cornea, and eyelid morphogenesis...
  17. ncbi Retinoic acid synthesis controlled by Raldh2 is required early for limb bud initiation and then later as a proximodistal signal during apical ectodermal ridge formation
    Felix A Mic
    OncoDevelopmental Biology Program, Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 279:26698-706. 2004
    ..During ZPA formation, RA acts early to activate expression of dHand, but it is not required later for Shh activation...
  18. pmc Retinoic acid controls expression of tissue remodeling genes Hmgn1 and Fgf18 at the digit-interdigit junction
    Xianling Zhao
    Burnham Institute for Medical Research, Development and Aging Program, La Jolla, California, USA
    Dev Dyn 239:665-71. 2010
    ..Regulation of Hmgn1 and Fgf18 at the digit-interdigit junction suggests RA controls tissue remodeling as well as apoptosis...
  19. pmc Retinoic-acid signalling in node ectoderm and posterior neural plate directs left-right patterning of somitic mesoderm
    Ioan Ovidiu Sirbu
    OncoDevelopmental Biology Program, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Nat Cell Biol 8:271-7. 2006
    ....
  20. ncbi Retinol/ethanol drug interaction during acute alcohol intoxication in mice involves inhibition of retinol metabolism to retinoic acid by alcohol dehydrogenase
    Andrei Molotkov
    Gene Regulation Program, Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 277:22553-7. 2002
    ..These findings demonstrate that the reduced RA levels observed during acute retinol/ethanol drug interaction are due primarily to a decrease in ADH-catalyzed RA synthesis and secondarily to an increase in RA degradation...
  21. pmc Shifting boundaries of retinoic acid activity control hindbrain segmental gene expression
    Ioan Ovidiu Sirbu
    OncoDevelopmental Biology Program, Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Development 132:2611-22. 2005
    ..These two pulses of RA activity function to establish expression of Hoxb1 and vHnf1 on opposite sides of the r4/r5 boundary...
  22. pmc Retinoic acid promotes limb induction through effects on body axis extension but is unnecessary for limb patterning
    Xianling Zhao
    Development and Aging Program, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Biol 19:1050-7. 2009
    ....
  23. ncbi Excessive vitamin A toxicity in mice genetically deficient in either alcohol dehydrogenase Adh1 or Adh3
    Andrei Molotkov
    Gene Regulation Program, Burnham Institute, La Jolla, CA 92037, USA
    Eur J Biochem 269:2607-12. 2002
    ..ADH3 plays a secondary role. Our results also show that retinoic acid is not the toxic moiety during vitamin A excess, as Adh1 mutants have less retinoic acid production while experiencing increased toxicity...
  24. ncbi Retinoic acid generated by Raldh2 in mesoderm is required for mouse dorsal endodermal pancreas development
    Andrei Molotkov
    OncoDevelopmental Biology Program, Burnham Institute, La Jolla, CA 92037, USA
    Dev Dyn 232:950-7. 2005
    ..Our findings demonstrate a specific role for RA in mouse embryos as a mesodermally synthesized signal needed for dorsal endodermal expression of Pdx1 during development of the dorsal pancreatic lineage...
  25. pmc Opposing actions of cellular retinol-binding protein and alcohol dehydrogenase control the balance between retinol storage and degradation
    Andrei Molotkov
    OncoDevelopmental Biology Program, Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Biochem J 383:295-302. 2004
    ....
  26. ncbi Patterning of forelimb bud myogenic precursor cells requires retinoic acid signaling initiated by Raldh2
    Felix A Mic
    OncoDevelopmental Biology Program, Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Dev Biol 264:191-201. 2003
    ....
  27. pmc Targeted disruption of Aldh1a1 (Raldh1) provides evidence for a complex mechanism of retinoic acid synthesis in the developing retina
    Xiaohong Fan
    OncoDevelopmental Biology Program Center for Neuroscience and Aging, Burnham Institute, La Jolla, California 92037, USA
    Mol Cell Biol 23:4637-48. 2003
    ..Our findings suggest that RA signaling may be necessary only during early stages of retina development and that if RA synthesis is needed in dorsal retina, it is catalyzed by multiple enzymes, including Raldh1...
  28. pmc Retinoid activation of retinoic acid receptor but not retinoid X receptor is sufficient to rescue lethal defect in retinoic acid synthesis
    Felix A Mic
    OncoDevelopmental Biology Program, Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:7135-40. 2003
    ..Because 9-cis-RA is undetectable and unnecessary for Raldh2-/- rescue, and others have shown that 4-oxo-RA is unnecessary for mouse development, all-trans-RA emerges as the only ligand clearly necessary for retinoid receptor signaling...
  29. ncbi Raldh2 expression in optic vesicle generates a retinoic acid signal needed for invagination of retina during optic cup formation
    Felix A Mic
    OncoDevelopmental Biology Program, Burnham Institute, La Jolla, California 92037, USA
    Dev Dyn 231:270-7. 2004
    ..Our findings suggest that RA functions as one of the signals needed for invagination of the retina to generate an optic cup...

Research Grants25

  1. Retinoid Dehydrogenases Involved in Eye Development
    Gregg Duester; Fiscal Year: 2005
    ..abstract_text> ..
  2. Generation of Retinoid Signals during Development
    Gregg Duester; Fiscal Year: 2005
    ..Also, we will identify the novel RA-generating enzymes expressed in the neural tube and heart and begin genetic studies on them. ..
  3. Generation of Retinoid Signals during Development
    Gregg Duester; Fiscal Year: 2007
    ..3) The role RA signaling plays in forelimb budding will be investigated including the timing, target tissue, RA source tissue, and target genes. ..
  4. Retinoid Dehydrogenases Involved in Eye Development
    Gregg Duester; Fiscal Year: 2007
    ....
  5. Generation of Retinoid Signals during Development
    Gregg Duester; Fiscal Year: 2009
    ..3) The role RA signaling plays in forelimb budding will be investigated including the timing, target tissue, RA source tissue, and target genes. ..
  6. Retinoid Dehydrogenases Involved in Eye Development
    Gregg Duester; Fiscal Year: 2009
    ....
  7. Generation of Retinoid Signals during Development
    GREGG L DUESTER; Fiscal Year: 2010
    ..3) The role RA signaling plays in forelimb budding will be investigated including the timing, target tissue, RA source tissue, and target genes. ..
  8. Retinoid Dehydrogenases Involved in Eye Development
    GREGG L DUESTER; Fiscal Year: 2010
    ....
  9. Generation of Retinoid Signals during Development
    Gregg Duester; Fiscal Year: 2004
    ..Also, we will identify the novel RA-generating enzymes expressed in the neural tube and heart and begin genetic studies on them. ..
  10. Retinoid Dehydrogenases Involved in Eye Development
    Gregg Duester; Fiscal Year: 2004
    ..abstract_text> ..
  11. Retinoid Dehydrogenases Involved in Eye Development
    Gregg Duester; Fiscal Year: 2003
    ..abstract_text> ..
  12. GENETIC DISSECTION OF ALCOHOL/RETINOL METABOLIC PATHWAYS
    Gregg Duester; Fiscal Year: 1999
    ..3) Prepare and ALDH-I knockout mouse plus mice mutated for one or more ADHs and ALDH-I, then analyze their phenotype as above. ..
  13. GENETIC DISSECTION OF ALCOHOL/RETINOL METABOLIC PATHWAYS
    Gregg Duester; Fiscal Year: 2000
    ..3) Prepare and ALDH-I knockout mouse plus mice mutated for one or more ADHs and ALDH-I, then analyze their phenotype as above. ..
  14. GENETIC DISSECTION OF ALCOHOL/RETINOL METABOLIC PATHWAYS
    Gregg Duester; Fiscal Year: 2001
    ..3) Prepare and ALDH-I knockout mouse plus mice mutated for one or more ADHs and ALDH-I, then analyze their phenotype as above. ..
  15. Retinoid Dehydrogenases Involved in Eye Development
    Gregg Duester; Fiscal Year: 2002
    ..abstract_text> ..
  16. GENETIC DISSECTION OF ALCOHOL/RETINOL METABOLIC PATHWAYS
    Gregg Duester; Fiscal Year: 2002
    ..3) Prepare and ALDH-I knockout mouse plus mice mutated for one or more ADHs and ALDH-I, then analyze their phenotype as above. ..
  17. Generation of Retinoid Signals during Development
    Gregg Duester; Fiscal Year: 2002
    ..Also, we will identify the novel RA-generating enzymes expressed in the neural tube and heart and begin genetic studies on them. ..
  18. Generation of Retinoid Signals during Development
    Gregg Duester; Fiscal Year: 2003
    ..Also, we will identify the novel RA-generating enzymes expressed in the neural tube and heart and begin genetic studies on them. ..
  19. Generation of Retinoid Signals during Development
    Gregg Duester; Fiscal Year: 2009
    ..3) The role RA signaling plays in forelimb budding will be investigated including the timing, target tissue, RA source tissue, and target genes. ..