G Duester

Summary

Affiliation: The Burnham Institute
Country: USA

Publications

  1. ncbi Recommended nomenclature for the vertebrate alcohol dehydrogenase gene family
    G Duester
    Gene Regulation Program, Burnham Institute, La Jolla, CA 92037, USA
    Biochem Pharmacol 58:389-95. 1999
  2. ncbi Involvement of alcohol dehydrogenase, short-chain dehydrogenase/reductase, aldehyde dehydrogenase, and cytochrome P450 in the control of retinoid signaling by activation of retinoic acid synthesis
    G Duester
    Burnham Institute, La Jolla, California 92037, USA
    Biochemistry 35:12221-7. 1996
  3. ncbi Genetic dissection of retinoid dehydrogenases
    G Duester
    Gene Regulation Program, Burnham Institute, 10901 North Torrey Pines Road, 92037, La Jolla, CA, USA
    Chem Biol Interact 130:469-80. 2001
  4. ncbi Class IV alcohol/retinol dehydrogenase localization in epidermal basal layer: potential site of retinoic acid synthesis during skin development
    R J Haselbeck
    Burnham Institute, La Jolla, California 92037, USA
    Dev Dyn 208:447-53. 1997
  5. ncbi ADH4-lacZ transgenic mouse reveals alcohol dehydrogenase localization in embryonic midbrain/hindbrain, otic vesicles, and mesencephalic, trigeminal, facial, and olfactory neural crest
    R J Haselbeck
    Gene Regulation Program, Burnham Institute, La Jolla, California 92037, USA
    Alcohol Clin Exp Res 22:1607-13. 1998
  6. ncbi RALDH3, a retinaldehyde dehydrogenase that generates retinoic acid, is expressed in the ventral retina, otic vesicle and olfactory pit during mouse development
    F A Mic
    Gene Regulation Program, Burnham Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    Mech Dev 97:227-30. 2000
  7. ncbi Families of retinoid dehydrogenases regulating vitamin A function: production of visual pigment and retinoic acid
    G Duester
    Burnham Institute, La Jolla, CA 92037, USA
    Eur J Biochem 267:4315-24. 2000
  8. ncbi Promoters for the human alcohol dehydrogenase genes ADH1, ADH2, and ADH3: interaction of CCAAT/enhancer-binding protein with elements flanking the ADH2 TATA box
    M J Stewart
    Department of Biochemistry, Colorado State University, Fort Collins 80523
    Gene 90:271-9. 1990
  9. pmc Temporal expression of the human alcohol dehydrogenase gene family during liver development correlates with differential promoter activation by hepatocyte nuclear factor 1, CCAAT/enhancer-binding protein alpha, liver activator protein, and D-element-bindi
    C van Ooij
    Department of Biochemistry, Colorado State University, Fort Collins 80523
    Mol Cell Biol 12:3023-31. 1992
  10. ncbi ADH1 and ADH4 alcohol/retinol dehydrogenases in the developing adrenal blastema provide evidence for embryonic retinoid endocrine function
    R J Haselbeck
    Gene Regulation Program, Burnham Institute, La Jolla, California 92037, USA
    Dev Dyn 213:114-20. 1998

Collaborators

  • J O Hoog
  • H Jornvall
  • X Pares
  • L Deltour
  • R J Haselbeck
  • H L Ang
  • M H Foglio
  • M Zgombic-Knight
  • D E Dolney
  • F A Mic
  • I Hoffmann
  • M R Felder
  • G Szalai
  • A E Cuenca
  • X Fan
  • A Molotkov
  • M L Shean
  • T F Hayamizu
  • M A Wagner
  • C van Ooij
  • L A Winter
  • M J Stewart
  • R C Snyder
  • B W Paeper
  • J D Ceci
  • M Smith
  • J A Gustafsson
  • S Okret
  • G W Hatfield
  • L Poellinger
  • Y Dong
  • M P O'Malley
  • M S McBride
  • R Lawther

Detail Information

Publications28

  1. ncbi Recommended nomenclature for the vertebrate alcohol dehydrogenase gene family
    G Duester
    Gene Regulation Program, Burnham Institute, La Jolla, CA 92037, USA
    Biochem Pharmacol 58:389-95. 1999
    ..e. ADH1A, ADH1B, and ADH1C for human alpha, beta, and gamma class I ADHs, respectively. This nomenclature will accommodate newly discovered members of the vertebrate ADH family, and will facilitate functional and evolutionary studies...
  2. ncbi Involvement of alcohol dehydrogenase, short-chain dehydrogenase/reductase, aldehyde dehydrogenase, and cytochrome P450 in the control of retinoid signaling by activation of retinoic acid synthesis
    G Duester
    Burnham Institute, La Jolla, California 92037, USA
    Biochemistry 35:12221-7. 1996
    ..Further studies on these enzyme families will allow this layer of control in the retinoid signaling pathway to be understood...
  3. ncbi Genetic dissection of retinoid dehydrogenases
    G Duester
    Gene Regulation Program, Burnham Institute, 10901 North Torrey Pines Road, 92037, La Jolla, CA, USA
    Chem Biol Interact 130:469-80. 2001
    ..Overall, these studies provide genetic evidence that Adh1, Adh4, Raldh1, and Raldh2 encode retinoid dehydrogenases involved in retinoic acid synthesis in vivo...
  4. ncbi Class IV alcohol/retinol dehydrogenase localization in epidermal basal layer: potential site of retinoic acid synthesis during skin development
    R J Haselbeck
    Burnham Institute, La Jolla, California 92037, USA
    Dev Dyn 208:447-53. 1997
    ....
  5. ncbi ADH4-lacZ transgenic mouse reveals alcohol dehydrogenase localization in embryonic midbrain/hindbrain, otic vesicles, and mesencephalic, trigeminal, facial, and olfactory neural crest
    R J Haselbeck
    Gene Regulation Program, Burnham Institute, La Jolla, California 92037, USA
    Alcohol Clin Exp Res 22:1607-13. 1998
    ....
  6. ncbi RALDH3, a retinaldehyde dehydrogenase that generates retinoic acid, is expressed in the ventral retina, otic vesicle and olfactory pit during mouse development
    F A Mic
    Gene Regulation Program, Burnham Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    Mech Dev 97:227-30. 2000
    ..From E8.5 to E10.5 RALDH3 expression is distinct from that of RALDH1 or RALDH2, thus indicating a unique role in sensory organ development...
  7. ncbi Families of retinoid dehydrogenases regulating vitamin A function: production of visual pigment and retinoic acid
    G Duester
    Burnham Institute, La Jolla, CA 92037, USA
    Eur J Biochem 267:4315-24. 2000
    ..For several SDRs (RoDH1, RoDH4, CRAD1, and CRAD2) androgens rather than retinoids are the predominant substrates suggesting a function in androgen metabolism as well as retinoid metabolism...
  8. ncbi Promoters for the human alcohol dehydrogenase genes ADH1, ADH2, and ADH3: interaction of CCAAT/enhancer-binding protein with elements flanking the ADH2 TATA box
    M J Stewart
    Department of Biochemistry, Colorado State University, Fort Collins 80523
    Gene 90:271-9. 1990
    ..Alternatively, the C/EBP molecules may block access to the TATA box, and stimulate transcription of ADH2 by interacting with some component(s) other than TFIID...
  9. pmc Temporal expression of the human alcohol dehydrogenase gene family during liver development correlates with differential promoter activation by hepatocyte nuclear factor 1, CCAAT/enhancer-binding protein alpha, liver activator protein, and D-element-bindi
    C van Ooij
    Department of Biochemistry, Colorado State University, Fort Collins 80523
    Mol Cell Biol 12:3023-31. 1992
    ..These studies suggest that HNF-1 and C/EBP alpha help establish ADH gene family transcription in fetal liver and that LAP and DBP help maintain high-level ADH gene family transcription in postnatal liver...
  10. ncbi ADH1 and ADH4 alcohol/retinol dehydrogenases in the developing adrenal blastema provide evidence for embryonic retinoid endocrine function
    R J Haselbeck
    Gene Regulation Program, Burnham Institute, La Jolla, California 92037, USA
    Dev Dyn 213:114-20. 1998
    ....
  11. ncbi Alcohol dehydrogenases in Xenopus development: conserved expression of ADH1 and ADH4 in epithelial retinoid target tissues
    I Hoffmann
    Gene Regulation Program, Burnham Institute, La Jolla, California 92037, USA
    Dev Dyn 213:261-70. 1998
    ....
  12. ncbi Metabolic deficiencies in alcohol dehydrogenase Adh1, Adh3, and Adh4 null mutant mice. Overlapping roles of Adh1 and Adh4 in ethanol clearance and metabolism of retinol to retinoic acid
    L Deltour
    Gene Regulation Program, Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 274:16796-801. 1999
    ..Redundant roles for Adh1 and Adh4 in retinoic acid production may explain the apparent normal development of mutant mice...
  13. ncbi Impaired retinol utilization in Adh4 alcohol dehydrogenase mutant mice
    L Deltour
    Gene Regulation Program, Burnham Institute, La Jolla, California 92037, USA
    Dev Genet 25:1-10. 1999
    ..These findings demonstrate that another retinol dehydrogenase can compensate for a lack of Adh4 when vitamin A is sufficient, but that Adh4 helps optimize retinol utilization under conditions of both retinol deficiency and excess...
  14. ncbi Molecular docking studies on interaction of diverse retinol structures with human alcohol dehydrogenases predict a broad role in retinoid ligand synthesis
    M H Foglio
    Gene Regulation Program, Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Biochim Biophys Acta 1432:239-50. 1999
    ....
  15. ncbi Retinoic acid and alcohol/retinol dehydrogenase in the mouse adrenal gland: a potential endocrine source of retinoic acid during development
    R J Haselbeck
    The Burnham Institute, La Jolla, California 92037, USA
    Endocrinology 138:3035-41. 1997
    ....
  16. ncbi Gene structure and promoter for Adh3 encoding mouse class IV alcohol dehydrogenase (retinol dehydrogenase)
    M Zgombic-Knight
    Burnham Institute, La Jolla, California 92037, USA
    Genomics 41:105-9. 1997
    ....
  17. ncbi Initiation of retinoid signaling in primitive streak mouse embryos: spatiotemporal expression patterns of receptors and metabolic enzymes for ligand synthesis
    H L Ang
    Burnham Institute, La Jolla, CA 92037, USA
    Dev Dyn 208:536-43. 1997
    ..These results suggest that upregulation of ADH-IV and ALDH-I gene expression in primitive streak mesoderm may lead to retinoic acid synthesis and initiation of retinoid signaling during mouse embryogenesis...
  18. ncbi A hormone response element upstream from the human alcohol dehydrogenase gene ADH2 consists of three tandem glucocorticoid receptor binding sites
    L A Winter
    Department of Biochemistry, Colorado State University, Fort Collins 80523
    Gene 91:233-40. 1990
    ..Overall, these results indicate that the ADH2 gene possesses a functional GRE which can potentially regulate expression transcriptionally.(ABSTRACT TRUNCATED AT 250 WORDS)..
  19. ncbi Molecular analysis of the human class I alcohol dehydrogenase gene family and nucleotide sequence of the gene encoding the beta subunit
    G Duester
    J Biol Chem 261:2027-33. 1986
    ..The 5' flanking region possesses a TATA box promoter element as well as two tandem DNA sequences which display homology to previously examined glucocorticoid-responsive elements...
  20. ncbi Androgen induction of alcohol dehydrogenase in mouse kidney. Studies with a cDNA probe confirmed by nucleotide sequence analysis
    J D Ceci
    Gene 41:217-24. 1986
    ..No restriction fragment length polymorphisms were observed among the several inbred mouse strains examined...
  21. ncbi Cloning of the mouse class IV alcohol dehydrogenase (retinol dehydrogenase) cDNA and tissue-specific expression patterns of the murine ADH gene family
    M Zgombic-Knight
    Cancer Research Center, La Jolla Cancer Research Foundation, California 92037, USA
    J Biol Chem 270:10868-77. 1995
    ..The results presented here indicate that the mouse has a simpler ADH gene family than the human but has conserved class IV ADH previously shown to be a very active retinol dehydrogenase in humans...
  22. ncbi The role of alcohol dehydrogenase in retinoic acid homeostasis and fetal alcohol syndrome
    M L Shean
    Department of Biochemistry, Colorado State University, Fort Collins 80523, USA
    Alcohol Alcohol Suppl 2:51-6. 1993
    ..Thus, embryonic ADH can presumably be induced by retinoic acid, further strengthening the argument that ADH plays a role in embryonic retinoic acid synthesis and fetal alcohol syndrome...
  23. ncbi Genomic structure and expression of the ADH7 gene encoding human class IV alcohol dehydrogenase, the form most efficient for retinol metabolism in vitro
    M Zgombic-Knight
    Cancer Research Center, La Jolla Cancer Research Foundation, California 92037
    J Biol Chem 270:4305-11. 1995
    ..The class IV ADH promoter thus differs from the other ADH promoters, which contain either a TATA box (classes I and II) or GC-boxes (class III), suggesting a fundamentally different form of transcriptional regulation...
  24. ncbi Retinoic acid synthesis in mouse embryos during gastrulation and craniofacial development linked to class IV alcohol dehydrogenase gene expression
    H L Ang
    La Jolla Cancer Research Foundation, La Jolla, California 92037, USA
    J Biol Chem 271:9526-34. 1996
    ..In addition, the finding of endogenous RA and class IV ADH mRNA in the craniofacial region has implications for the mechanism of fetal alcohol syndrome...
  25. ncbi Characterization of the functional gene encoding mouse class III alcohol dehydrogenase (glutathione-dependent formaldehyde dehydrogenase) and an unexpressed processed pseudogene with an intact open reading frame
    M H Foglio
    La Jolla Cancer Foundation Research Foundation, CA 92037, USA
    Eur J Biochem 237:496-504. 1996
    ..Reporter gene expression following transfection into mouse F9 embryonal carcinoma cells indicated that only Adh-2 possesses promoter activity...
  26. ncbi Expression patterns of class I and class IV alcohol dehydrogenase genes in developing epithelia suggest a role for alcohol dehydrogenase in local retinoic acid synthesis
    H L Ang
    Burnham Institute, La Jolla, California 92037, USA
    Alcohol Clin Exp Res 20:1050-64. 1996
    ....
  27. ncbi Localization of class I and class IV alcohol dehydrogenases in mouse testis and epididymis: potential retinol dehydrogenases for endogenous retinoic acid synthesis
    L Deltour
    The Burnham Institute, La Jolla, California 92037, USA
    Biol Reprod 56:102-9. 1997
    ..These results support a role for ADHs during spermatogenesis, potentially as retinol dehydrogenases catalyzing local retinoic acid synthesis in the testis and epididymis...
  28. ncbi Molecular analysis of genetic differences among inbred mouse strains controlling tissue expression pattern of alcohol dehydrogenase 4
    D E Dolney
    Department of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA
    Gene 267:145-56. 2001
    ....