D J Dlugos

Summary

Affiliation: The Children's Hospital of Philadelphia
Country: USA

Publications

  1. pmc Pretreatment EEG in childhood absence epilepsy: associations with attention and treatment outcome
    Dennis Dlugos
    Children s Hospital of Philadelphia, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA, USA
    Neurology 81:150-6. 2013
  2. ncbi request reprint Novel de novo mutation of a conserved SCN1A amino-acid residue (R1596)
    Dennis J Dlugos
    Department of Neurology, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Pediatr Neurol 37:303-5. 2007
  3. ncbi request reprint Subacute sclerosing panencephalitis in an American-born adult
    D J Dlugos
    Department of Neurology, University of Pennsylvania School of Medicine, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Clin Infect Dis 32:173-4. 2001
  4. ncbi request reprint A child with epilepsy: initial presentation and subsequent course
    Dennis J Dlugos
    Division of Neurology, Children s Hospital of Philadelphia, Department of Neurology and Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Epilepsia 47:54-7. 2006
  5. ncbi request reprint Recruitment rates and fear of phlebotomy in pediatric patients in a genetic study of epilepsy
    Dennis J Dlugos
    Division of Neurology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Epilepsy Behav 6:444-6. 2005
  6. ncbi request reprint The early identification of candidates for epilepsy surgery
    D J Dlugos
    Division of Neurology, The Children s Hospital of Philadelphia, 6th Floor, Wood Building, 34th Street and Civic Center Boulevard, Philadelphia, PA 19014, USA
    Arch Neurol 58:1543-6. 2001
  7. ncbi request reprint Response to first drug trial predicts outcome in childhood temporal lobe epilepsy
    D J Dlugos
    Pediatric Regional Epilepsy Program, Division of Neurology, Children s Hospital of Philadelphia, PA 19014, USA
    Neurology 57:2259-64. 2001
  8. pmc Nonconvulsive seizures are common in critically ill children
    N S Abend
    Division of Neurology, The Children s Hospital of Philadelphia, 34th Street and Civic Center Blvd, Philadelphia, PA 19104, USA
    Neurology 76:1071-7. 2011
  9. ncbi request reprint Dysplasia: a common finding in intractable pediatric temporal lobe epilepsy
    B E Porter
    Pediatric Regional Epilepsy Program, Children s Hospital of Philadelphia, and Department of Pediatrics and Neurology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Neurology 61:365-8. 2003
  10. doi request reprint Treatment of refractory status epilepticus: literature review and a proposed protocol
    Nicholas S Abend
    Division of Neurology, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Pediatr Neurol 38:377-90. 2008

Detail Information

Publications28

  1. pmc Pretreatment EEG in childhood absence epilepsy: associations with attention and treatment outcome
    Dennis Dlugos
    Children s Hospital of Philadelphia, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA, USA
    Neurology 81:150-6. 2013
    ..In children with newly diagnosed childhood absence epilepsy (CAE), determine pretreatment EEG features and their associations with baseline neuropsychological function and short-term treatment outcome...
  2. ncbi request reprint Novel de novo mutation of a conserved SCN1A amino-acid residue (R1596)
    Dennis J Dlugos
    Department of Neurology, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Pediatr Neurol 37:303-5. 2007
    ..In this case, the wild type of residue (R1596) is well-conserved across evolution from bacteria to humans, providing support for the hypothesis that this mutation causes epilepsy...
  3. ncbi request reprint Subacute sclerosing panencephalitis in an American-born adult
    D J Dlugos
    Department of Neurology, University of Pennsylvania School of Medicine, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Clin Infect Dis 32:173-4. 2001
    ..We discuss the possibility that the patient contracted subclinical measles during the 1989-1991 measles epidemic in the United States...
  4. ncbi request reprint A child with epilepsy: initial presentation and subsequent course
    Dennis J Dlugos
    Division of Neurology, Children s Hospital of Philadelphia, Department of Neurology and Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Epilepsia 47:54-7. 2006
    ..The case demonstrates the poorly understood entities of age-related changes in seizure suspectibility, seizure types, and drug responsiveness...
  5. ncbi request reprint Recruitment rates and fear of phlebotomy in pediatric patients in a genetic study of epilepsy
    Dennis J Dlugos
    Division of Neurology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Epilepsy Behav 6:444-6. 2005
    ..Further analysis of the factors influencing decisions to decline study enrollment is warranted. These data will help in the design of future genetic studies and may increase future participation rates...
  6. ncbi request reprint The early identification of candidates for epilepsy surgery
    D J Dlugos
    Division of Neurology, The Children s Hospital of Philadelphia, 6th Floor, Wood Building, 34th Street and Civic Center Boulevard, Philadelphia, PA 19014, USA
    Arch Neurol 58:1543-6. 2001
    ....
  7. ncbi request reprint Response to first drug trial predicts outcome in childhood temporal lobe epilepsy
    D J Dlugos
    Pediatric Regional Epilepsy Program, Division of Neurology, Children s Hospital of Philadelphia, PA 19014, USA
    Neurology 57:2259-64. 2001
    ..To construct a clinical prediction model for the early identification of children destined to develop refractory temporal lobe epilepsy (TLE) 2 years after epilepsy onset...
  8. pmc Nonconvulsive seizures are common in critically ill children
    N S Abend
    Division of Neurology, The Children s Hospital of Philadelphia, 34th Street and Civic Center Blvd, Philadelphia, PA 19104, USA
    Neurology 76:1071-7. 2011
    ..We aimed to prospectively determine the incidence and risk factors of nonconvulsive seizures in critically ill children using predetermined EEG monitoring indications and EEG interpretation terminology...
  9. ncbi request reprint Dysplasia: a common finding in intractable pediatric temporal lobe epilepsy
    B E Porter
    Pediatric Regional Epilepsy Program, Children s Hospital of Philadelphia, and Department of Pediatrics and Neurology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Neurology 61:365-8. 2003
    ..Pre-existing cortical dysplasia (CD) may also predispose to refractory TLE, independent of other risk factors for epilepsy...
  10. doi request reprint Treatment of refractory status epilepticus: literature review and a proposed protocol
    Nicholas S Abend
    Division of Neurology, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Pediatr Neurol 38:377-90. 2008
    ..Additional management strategies that could be employed in tertiary-care settings, such as coma induction guided by continuous electroencephalogram monitoring and surgical options, are also discussed...
  11. doi request reprint Anticonvulsant medications in the pediatric emergency room and intensive care unit
    Nicholas S Abend
    Division of Neurology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Pediatr Emerg Care 24:705-18; quiz 719-21. 2008
    ..Treatment issues specific to complex medical patients, including patients with brain tumors, renal dysfunction, hepatic dysfunction, transplant, congenital heart disease, and anticoagulation, are also discussed...
  12. pmc Intravenous levetiracetam in critically ill children with status epilepticus or acute repetitive seizures
    Nicholas S Abend
    Division of Neurology, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Pediatr Crit Care Med 10:505-10. 2009
    ..We aim to investigate the safety, an appropriate dosing, and efficacy of IV LEV in critically ill children...
  13. pmc Use of EEG monitoring and management of non-convulsive seizures in critically ill patients: a survey of neurologists
    Nicholas S Abend
    Division of Neurology, The Children s Hospital of Philadelphia, 34th Street and Civic Center Blvd, Philadelphia, PA 19104, USA
    Neurocrit Care 12:382-9. 2010
    ..The indications for cEEG, as well as when and how to treat NCS, remain unclear. We aimed to describe the current practice of cEEG in critically ill patients to define areas of uncertainty that could aid in designing future research...
  14. doi request reprint Medical treatment of pediatric status epilepticus
    Nicholas S Abend
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Semin Pediatr Neurol 17:169-75. 2010
    ....
  15. pmc Levetiracetam for treatment of neonatal seizures
    Nicholas S Abend
    Division of Neurology, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    J Child Neurol 26:465-70. 2011
    ..Further study is warranted to determine optimal levetiracetam dosing in neonates and to compare efficacy with other antiseizure medications...
  16. ncbi request reprint Nonconvulsive status epilepticus in a pediatric intensive care unit
    Nicholas S Abend
    Division of Neurology, Children s Hospital of Philadelphia 19104, USA
    Pediatr Neurol 37:165-70. 2007
    ..These findings suggest that a high level of suspicion for nonconvulsive status epilepticus must be maintained, and long-term electroencephalogram monitoring may be indicated in a large number of patients...
  17. doi request reprint Intravenous levetiracetam terminates refractory focal status epilepticus
    Nicholas S Abend
    Division of Neurology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Neurocrit Care 10:83-6. 2009
    ....
  18. pmc Electroencephalographic monitoring during hypothermia after pediatric cardiac arrest
    N S Abend
    Division of Neurology, The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Neurology 72:1931-40. 2009
    ....
  19. ncbi request reprint Topiramate monotherapy in newly diagnosed epilepsy in children and adolescents
    Tracy A Glauser
    Division of Neurology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 2899, USA
    J Child Neurol 22:693-9. 2007
    ..As shown in this subset analysis, topiramate is effective and well tolerated as monotherapy in children and adolescents...
  20. ncbi request reprint Antiepileptic drug monotherapy: pediatric concerns
    Joseph E Sullivan
    Division of Neurology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Semin Pediatr Neurol 12:88-96. 2005
    ..Better comparative data emphasizing adverse event profiles, comorbidities and longer-term outcome are needed between the traditional and newer AEDs...
  21. ncbi request reprint Challenges in pediatric video-EEG monitoring
    Joseph E Sullivan
    The Children s Hospital of Philadelphia, Epilepsy Monitoring Unit, Section of Clinical Neurophysiology, Division of Neurology, Philadelphia, Pennsylvania 19104, USA
    Am J Electroneurodiagnostic Technol 47:127-39. 2007
    ..Only after careful consideration of these issues, can video-EEG monitoring be successful and provide safe, state of the art clinical care in an efficient manner...
  22. ncbi request reprint Challenges and opportunities in the application of pharmacogenetics to antiepileptic drug therapy
    Thomas N Ferraro
    University of Pennsylvania, Center for Neurobiology and Behavior, Room 2209, Translational Research Laboratories, and The Children s Hospital of Philadelphia, Department of Pediatrics, Philadelphia, PA 19104, USA
    Pharmacogenomics 7:89-103. 2006
    ..Further development of these critical factors will optimize chances for overcoming current challenges posed by AED pharmacogenetic research and ultimately allow the realization of improved, more rational therapeutic strategies...
  23. doi request reprint Magnetoencephalography for pediatric epilepsy: how we do it
    E S Schwartz
    Divisions of Neuroradiology, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    AJNR Am J Neuroradiol 29:832-7. 2008
    ..A collaborative effort between neuroradiology, neurology, neurosurgery, neuropsychology, technology, and physics ensures successful implementation of MEG within a pediatric epilepsy program...
  24. ncbi request reprint Defining the clinical role of pharmacogenetics in antiepileptic drug therapy
    D J Dlugos
    Divison of Neurology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 3403, USA
    Pharmacogenomics J 6:357-9. 2006
  25. doi request reprint Infantile spasms: a U.S. consensus report
    John M Pellock
    Division of Child Neurology, Department of Neurology, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298, USA
    Epilepsia 51:2175-89. 2010
    ..Differences of opinion among ISWG members occurred in areas where data were lacking; however, this article represents a consensus of the U.S. approach to the diagnostic evaluation and treatment of IS...
  26. ncbi request reprint Role of genetics in the diagnosis and treatment of epilepsy
    Thomas N Ferraro
    University of Pennsylvania, Department of Psychiatry, 125 S 31 Street, Room 2209 TRL, Philadelphia, PA 19104 3403, USA
    Expert Rev Neurother 6:1789-800. 2006
    ..Further elucidation of the relationship between gene mutations and channel function will add value to genetic testing in the future, as will better characterization of the association between gene mutations and clinical phenotypes...
  27. ncbi request reprint Comparison of novel computer detectors and human performance for spike detection in intracranial EEG
    Merritt W Brown
    Division of Child Neurology, Children s Hospital of Philadelphia, and Department of Neurology and Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    Clin Neurophysiol 118:1744-52. 2007
    ..Accurate automated spike detectors are necessary for understanding the role of spikes in epileptogenesis...
  28. ncbi request reprint Association between variation in the human KCNJ10 potassium ion channel gene and seizure susceptibility
    R J Buono
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, 415 Curie Boulevard, CRB 120, Philadelphia, PA 19104 6140, USA
    Epilepsy Res 58:175-83. 2004
    ..The purpose of this work was to translate these animal model data to a human genetic association study...