DARRYL D D'LIMA

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. ncbi request reprint In vivo knee moments and shear after total knee arthroplasty
    DARRYL D D'LIMA
    Shiley Center for Orthopaedic Research and Education, Scripps Clinic, 11025 N Torrey Pines Road, Suite 140, La Jolla, CA 92037, USA Department of Bioengineering, University of California, San Diego, CA, USA
    J Biomech 40:S11-7. 2007
  2. ncbi request reprint The effect of the orientation of the acetabular and femoral components on the range of motion of the hip at different head-neck ratios
    D D D'Lima
    Division of Orthopaedic Surgery, Scripps Clinic, La Jolla, California 92037, USA
    J Bone Joint Surg Am 82:315-21. 2000
  3. pmc An in vivo evaluation of bone response to three implant surfaces using a rabbit intramedullary rod model
    Juan C Hermida
    Orthopaedic Research Laboratories, Shiley Center for Orthopaedic Research and Education at Scripps Clinic, 11025 North Torrey Pines Road, Suite 140, La Jolla, CA, 92037, USA
    J Orthop Surg Res 5:57. 2010
  4. pmc The Mark Coventry Award: in vivo knee forces during recreation and exercise after knee arthroplasty
    DARRYL D D'LIMA
    Shiley Center for Orthopaedic Research and Education at Scripps Clinic, La Jolla, CA 92037, USA
    Clin Orthop Relat Res 466:2605-11. 2008
  5. doi request reprint In vivo contact stresses during activities of daily living after knee arthroplasty
    DARRYL D D'LIMA
    Shiley Center for Orthopaedic Research and Education at Scripps Clinic, 11025 North Torrey Pines Road, Suite 140, La Jolla, California 92037, USA
    J Orthop Res 26:1549-55. 2008
  6. pmc The 2011 ABJS Nicolas Andry Award: 'Lab'-in-a-knee: in vivo knee forces, kinematics, and contact analysis
    DARRYL D D'LIMA
    Shiley Center for Orthopaedic Research and Education at Scripps Clinic, 11025 North Torrey Pines Road, Suite 200, La Jolla, CA 92037, USA
    Clin Orthop Relat Res 469:2953-70. 2011
  7. ncbi request reprint An ABJS Best Paper: Dynamic intraoperative ligament balancing for total knee arthroplasty
    DARRYL D D'LIMA
    Orthopaedic Research Laboratories, Shiley Center for Orthopaedic Research and Education at Scripps Clinic, 11025 North Torrey Pines Road, La Jolla, CA 92037, USA
    Clin Orthop Relat Res 463:208-12. 2007
  8. ncbi request reprint The Chitranjan Ranawat Award: in vivo knee forces after total knee arthroplasty
    DARRYL D D'LIMA
    Orthopaedic Research Laboratories, Shiley Center for Orthopaedic Research and Education at Scripps Clinic, La Jolla, CA 92037, USA
    Clin Orthop Relat Res 440:45-9. 2005
  9. ncbi request reprint Impact of patellofemoral design on patellofemoral forces and polyethylene stresses
    DARRYL D D'LIMA
    Scripps Clinic Center for Orthopaedic Research and Education, La Jolla, CA 92037, USA
    J Bone Joint Surg Am 85:85-93. 2003
  10. ncbi request reprint Polyethylene wear and acetabular component orientation
    Shantanu Patil
    Orthopaedic Research Laboratories, Scripps Clinic Center for Orthopaedic Research and Education, La Jolla, CA 92037, USA
    J Bone Joint Surg Am 85:56-63. 2003

Research Grants

  1. A Novel Load Sensing Tibial Prosthesis Design
    DARRYL D LIMA; Fiscal Year: 2006

Collaborators

Detail Information

Publications67

  1. ncbi request reprint In vivo knee moments and shear after total knee arthroplasty
    DARRYL D D'LIMA
    Shiley Center for Orthopaedic Research and Education, Scripps Clinic, 11025 N Torrey Pines Road, Suite 140, La Jolla, CA 92037, USA Department of Bioengineering, University of California, San Diego, CA, USA
    J Biomech 40:S11-7. 2007
    ..These findings indicate that the soft tissues around the knee absorbed most of the external shear forces. Our results highlight the importance of direct measurements of knee forces...
  2. ncbi request reprint The effect of the orientation of the acetabular and femoral components on the range of motion of the hip at different head-neck ratios
    D D D'Lima
    Division of Orthopaedic Surgery, Scripps Clinic, La Jolla, California 92037, USA
    J Bone Joint Surg Am 82:315-21. 2000
    ..In this study, a computer model was used to determine the effects of the positions of the acetabular and femoral components and of varying head-neck ratios on impingement and range of motion...
  3. pmc An in vivo evaluation of bone response to three implant surfaces using a rabbit intramedullary rod model
    Juan C Hermida
    Orthopaedic Research Laboratories, Shiley Center for Orthopaedic Research and Education at Scripps Clinic, 11025 North Torrey Pines Road, Suite 140, La Jolla, CA, 92037, USA
    J Orthop Surg Res 5:57. 2010
    ..The results of this in vivo lapine study suggest that the presence of an hydroxyapatite coating enhances osseointegration despite similarities in average surface roughness...
  4. pmc The Mark Coventry Award: in vivo knee forces during recreation and exercise after knee arthroplasty
    DARRYL D D'LIMA
    Shiley Center for Orthopaedic Research and Education at Scripps Clinic, La Jolla, CA 92037, USA
    Clin Orthop Relat Res 466:2605-11. 2008
    ....
  5. doi request reprint In vivo contact stresses during activities of daily living after knee arthroplasty
    DARRYL D D'LIMA
    Shiley Center for Orthopaedic Research and Education at Scripps Clinic, 11025 North Torrey Pines Road, Suite 140, La Jolla, California 92037, USA
    J Orthop Res 26:1549-55. 2008
    ..Our results support the use of "high flexion" designs that improve contact conditions and preserve contact area at high flexion angles...
  6. pmc The 2011 ABJS Nicolas Andry Award: 'Lab'-in-a-knee: in vivo knee forces, kinematics, and contact analysis
    DARRYL D D'LIMA
    Shiley Center for Orthopaedic Research and Education at Scripps Clinic, 11025 North Torrey Pines Road, Suite 200, La Jolla, CA 92037, USA
    Clin Orthop Relat Res 469:2953-70. 2011
    ..Although this approach is useful for quantitative measurements and experimental studies, the extrapolation of results to clinical conditions may not always be valid...
  7. ncbi request reprint An ABJS Best Paper: Dynamic intraoperative ligament balancing for total knee arthroplasty
    DARRYL D D'LIMA
    Orthopaedic Research Laboratories, Shiley Center for Orthopaedic Research and Education at Scripps Clinic, 11025 North Torrey Pines Road, La Jolla, CA 92037, USA
    Clin Orthop Relat Res 463:208-12. 2007
    ..Surgical navigation systems have reduced the variability in component alignment. An instrumented tibial trial can be a valuable adjunct to directly measure soft tissue balance...
  8. ncbi request reprint The Chitranjan Ranawat Award: in vivo knee forces after total knee arthroplasty
    DARRYL D D'LIMA
    Orthopaedic Research Laboratories, Shiley Center for Orthopaedic Research and Education at Scripps Clinic, La Jolla, CA 92037, USA
    Clin Orthop Relat Res 440:45-9. 2005
    ..This should lead to refined surgical techniques and to enhanced prosthetic designs that will improve patient function, patient quality of life, and longevity of total knee arthroplasty implants...
  9. ncbi request reprint Impact of patellofemoral design on patellofemoral forces and polyethylene stresses
    DARRYL D D'LIMA
    Scripps Clinic Center for Orthopaedic Research and Education, La Jolla, CA 92037, USA
    J Bone Joint Surg Am 85:85-93. 2003
    ..The presence of a functioning posterior cruciate ligament and the design parameters of a total knee arthroplasty, such as trochlear groove alignment and cam-post configuration, can have a major effect on patellar biomechanics...
  10. ncbi request reprint Polyethylene wear and acetabular component orientation
    Shantanu Patil
    Orthopaedic Research Laboratories, Scripps Clinic Center for Orthopaedic Research and Education, La Jolla, CA 92037, USA
    J Bone Joint Surg Am 85:56-63. 2003
    ..A series of studies was designed to test the hypothesis that acetabular component orientation can affect the magnitude and direction of polyethylene wear...
  11. ncbi request reprint Comparison of the wear rates of twenty-eight and thirty-two-millimeter femoral heads on cross-linked polyethylene acetabular cups in a wear simulator
    Juan C Hermida
    Scripps Clinic, 11025 North Torrey Pines Road, Suite 140, La Jolla, CA 92037, USA
    J Bone Joint Surg Am 85:2325-31. 2003
    ..e., polyethylene that is cross-linked to a higher degree than that obtained by radiation sterilization alone). The aim of this study was to test the effect of increased cross-linking and of increased head size on polyethylene wear rates...
  12. ncbi request reprint e-Knee: the electronic knee prosthesis
    Mary E Hardwick
    Shiley Center for Orthopaedic Research and Education at Scripps Clinic, La Jolla, CA, USA
    Orthop Nurs 25:326-9. 2006
    ..Direct measurement of knee forces can lead to a better understanding of the stresses seen following total knee arthroplasty. Information generated by the e-Knee will aid in the improvement of implant design and patient care...
  13. ncbi request reprint Effect of tibial component varus on wear in total knee arthroplasty
    Ajay Srivastava
    Orthopaedic Research Laboratories, Shiley Center for Orthopaedic Research and Education at Scripps Clinic, La Jolla, CA 92037, USA
    Knee 19:560-3. 2012
    ..However, component malalignment can occur even when overall limb mechanical axis is within the normal anatomic range. We studied the effect of component malalignment in the presence of acceptable knee alignment in knee arthroplasty...
  14. doi request reprint The importance of bony impingement in restricting flexion after total knee arthroplasty: computer simulation model with clinical correlation
    Hideki Mizu-uchi
    Shiley Center for Orthopaedic Research and Education at Scripps Clinic Scripps Health, La Jolla, California, USA
    J Arthroplasty 27:1710-6. 2012
    ....
  15. pmc Effects of perfusion and dynamic loading on human neocartilage formation in alginate hydrogels
    Shawn P Grogan
    Shiley Center for Orthopaedic Research and Education at Scripps Clinic, La Jolla, CA 92037, USA
    Tissue Eng Part A 18:1784-92. 2012
    ..Optimal conditions, which permit appropriate anabolic and catabolic processes for accumulation of ECM and tissue remodeling for neocartilage development, specifically for humans, are needed...
  16. ncbi request reprint An implantable telemetry device to measure intra-articular tibial forces
    DARRYL D D'LIMA
    Orthopaedic Research Laboratories, Scripps Clinic Center for Orthopaedic Research and Education, CA 92037, USA
    J Biomech 38:299-304. 2005
    ..Reasonable accuracy was obtained in measuring loads applied through a polyethylene insert. The implant was also able to detect unicondylar loading with liftoff...
  17. ncbi request reprint Patellofemoral forces after total knee arthroplasty: effect of extensor moment arm
    Christopher Browne
    Orthopaedic Research Laboratories, Scripps Clinic Center for Orthopaedic Research and Education, 11025 N Torrey Pines Road, Suite 140, La Jolla, CA 92037, USA
    Knee 12:81-8. 2005
    ..Reduction in patellofemoral forces could reduce patellar complications such as anterior knee pain, component wear, and loosening...
  18. ncbi request reprint Aging-related differences in chondrocyte viscoelastic properties
    Nikolai Steklov
    Shiley Center for Orthopaedic Research and Education at Scripps Clinic, North Torrey Pines Road, La Jolla, CA 92037, USA
    Mol Cell Biomech 6:113-9. 2009
    ..A similar mechanism may be responsible for our finding of increased stiffness in aging chondrocytes. With advancing age, changes in the biomechanical properties of the cell could alter molecular and biochemical responses...
  19. doi request reprint Predicting the effect of tray malalignment on risk for bone damage and implant subsidence after total knee arthroplasty
    Jowene Wong
    Shiley Center for Orthopaedic Research and Education at Scripps Clinic, 11025 North Torrey Pines Road, Suite 140, La Jolla, California 92037, USA
    J Orthop Res 29:347-53. 2011
    ..Our results indicate that failure after tray malalignment is likely due to fatigue damage to the proximal tibia rather than shear across the implant-bone interface or failure of the cement mantle...
  20. pmc Histopathological changes in the human posterior cruciate ligament during aging and osteoarthritis: correlations with anterior cruciate ligament and cartilage changes
    Yadin D Levy
    Correspondence to Professor Martin K Lotz, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Ann Rheum Dis 72:271-7. 2013
    ..To determine the histological patterns of posterior cruciate ligament (PCL) degeneration during aging and in relation to changes in articular cartilage and anterior cruciate ligament (ACL) across the entire adult age spectrum...
  21. pmc In situ tissue engineering using magnetically guided three-dimensional cell patterning
    Shawn P Grogan
    Shiley Center for Orthopaedic Research and Education, Scripps Clinic, La Jolla, CA 92037, USA
    Tissue Eng Part C Methods 18:496-506. 2012
    ..Taken together, this approach can be adapted for studying basic biological processes in vitro, for general tissue engineering approaches, and for producing organized repair tissues directly in situ...
  22. ncbi request reprint Can normal knee kinematics be restored with unicompartmental knee replacement?
    Shantanu Patil
    Orthopaedic Research Laboratories, Scripps Clinic Center for Orthopaedic Research and Education, 11025 North Torrey Pines Road, Suite 140, La Jolla, CA 92037, USA
    J Bone Joint Surg Am 87:332-8. 2005
    ..To test this hypothesis, knee kinematics and quadriceps tension were recorded before and after replacement with a unicompartmental design and then with a tricompartmental design...
  23. pmc Vimentin contributes to changes in chondrocyte stiffness in osteoarthritis
    Dominik R Haudenschild
    Shiley Center for Orthopaedic Research and Education at Scripps Clinic, 11025 North Torrey Pines Road, La Jolla, California 92037, USA
    J Orthop Res 29:20-5. 2011
    ..This 3D experimental system revealed contributions of vimentin to chondrocyte stiffness previously not apparent, and correlated changes in vimentin-based chondrocyte stiffness with osteoarthritis...
  24. doi request reprint Accuracy of CT-based measurements of glenoid version for total shoulder arthroplasty
    Heinz R Hoenecke
    Shiley Center for Orthopaedic Research and Education at Scripps Clinic, La Jolla, CA 92037, USA
    J Shoulder Elbow Surg 19:166-71. 2010
    ..While a method for measurement of glenoid version using axial computed tomography (CT) has been reported and has been widely accepted, its accuracy and reproducibility has not been established...
  25. ncbi request reprint Tibial forces measured in vivo after total knee arthroplasty
    DARRYL D D'LIMA
    Orthopaedic Research Laboratories, Shiley Center for Orthopaedic Research and Education at Scripps Clinic, California, USA
    J Arthroplasty 21:255-62. 2006
    ..Technical design improvements will enhance function, quality of life, and longevity of total knee arthroplasty...
  26. ncbi request reprint Polyethylene cross-linking by two different methods reduces acetabular liner wear in a hip joint wear simulator
    DARRYL D D'LIMA
    Joint Mechanics Laboratory, Scripps Clinic Center for Orthopaedic Research and Education, 11025 N Torrey Pines Road, Ste 140, La Jolla, CA 92037, USA
    J Orthop Res 21:761-6. 2003
    ..The differences in wear rates between the two highly cross-linked polyethylene designs (9.5 EB or 10 Gamma) are probably too small to be clinically significant...
  27. ncbi request reprint Hydroxyapatite-coated femoral stem survivorship at 10 years
    Gregory Y Lee
    Shiley Center for Orthopedic Research and Education at Scripps Clinic, Department of Orthopedic Surgery, La Jolla, California 92037, USA
    J Arthroplasty 20:57-62. 2005
    ..24 mm/y. Lysis was noted in 23% of the cups. No patient developed femoral lysis distally. This hydroxyapatite-coated stem continues to perform well and appears to protect against the migration of wear debris along the femoral stem...
  28. pmc Zone-specific gene expression patterns in articular cartilage
    Shawn P Grogan
    The Scripps Research Institute and Shiley Center for Orthopaedic Research and Education, Scripps Clinic, La Jolla, California, USA
    Arthritis Rheum 65:418-28. 2013
    ..To identify novel genes and pathways specific to the superficial zone (SZ), middle zone (MZ), and deep zone (DZ) of normal articular cartilage...
  29. doi request reprint A quantitative three-dimensional templating method for shoulder arthroplasty: biomechanical validation in cadavers
    Heinz R Hoenecke
    Department of Orthopaedic Surgery and Sports Medicine, Scripps Clinic, La Jolla, CA 92037, USA
    J Shoulder Elbow Surg 21:1377-83. 2012
    ..The purpose of this study was to develop a 3-dimensional templating technique for the humeral stem and to validate this templating in cadaveric specimens...
  30. doi request reprint Effect of total knee arthroplasty implant position on flexion angle before implant-bone impingement
    Hideki Mizu-uchi
    Shiley Center for Orthopaedic Research and Education at Scripps Clinic, La Jolla, CA 92037, USA
    J Arthroplasty 26:721-7. 2011
    ..The rate of change in flexion angle was 0.4°/mm to 1.5°/mm with respect to implant position and 1.5°/mm increase in the posterior condylar offset...
  31. doi request reprint Anti-gravity treadmills are effective in reducing knee forces
    Shantanu Patil
    Shiley Center for Orthopaedic Research and Education at Scripps Clinic, 11025 North Torrey Pines Road, Suite 200, La Jolla, CA 92037, USA
    J Orthop Res 31:672-9. 2013
    ..The strong correlation between tibiofemoral force and walking speed and treadmill reaction forces allows for more precisely achieving the target knee forces desired during early rehabilitation...
  32. doi request reprint The effect of oxidative aging on the wear performance of highly crosslinked polyethylene knee inserts under conditions of severe malalignment
    Juan C Hermida
    Shiley Center for Orthopedic Research and Education at Scripps Clinic, 11025 North Torrey Pines Road, Suite 140, La Jolla, California 92037, USA
    J Orthop Res 26:1585-90. 2008
    ..74 +/- 0.3 and 4.72 +/- 0.7, respectively). These results support the low levels of free radicals and preservation of mechanical properties reported in second-generation crosslinked ultrahigh molecular weight polyethylene...
  33. ncbi request reprint Outcome of an acetabular design with hydroxyapatite coating on a rough substrate
    Juan C Hermida
    Shiley Center for Orthopaedic Research and Education, Scripps Clinic, La Jolla, CA 92037, USA
    Clin Orthop Relat Res 441:298-304. 2005
    ..Level of Evidence: Therapeutic study, Level IV (case series). See the Guidelines for Authors for a complete description of levels of evidence...
  34. doi request reprint Wear of polyethylene against oxidized zirconium femoral components effect of aggressive kinematic conditions and malalignment in total knee arthroplasty
    Kace A Ezzet
    Division of Orthopaedic Surgery, Scripps Clinic, La Jolla, California, USA
    J Arthroplasty 27:116-21. 2012
    ..An oxidized zirconium femoral component can significantly reduce PE wear under simulated conditions of athletically active patients with modestly malaligned total knee arthroplasty prostheses...
  35. pmc Anterior cruciate ligament changes in the human knee joint in aging and osteoarthritis
    Akihiko Hasegawa
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Arthritis Rheum 64:696-704. 2012
    ....
  36. pmc Knee joint forces: prediction, measurement, and significance
    DARRYL D D'LIMA
    Shiley Center for Orthopaedic Research and Education at Scripps Clinic, Scripps Health, 11025 North Torrey Pines Road, Suite 200, La Jolla, CA 92037, USA
    Proc Inst Mech Eng H 226:95-102. 2012
    ..Current gaps in our knowledge are identified and directions for future research in this area are outlined...
  37. doi request reprint Optimizing glenoid component position using three-dimensional computed tomography reconstruction
    Heinz R Hoenecke
    Division of Orthopaedic Surgery at Scripps Clinic, La Jolla, CA 92037, USA
    J Shoulder Elbow Surg 17:637-41. 2008
    ..These results emphasize the need for accurate preoperative templating and for developing alignment guides or surgical navigation tools for shoulder arthroplasty and may be used to improve implant fixation designs...
  38. pmc Digital micromirror device projection printing system for meniscus tissue engineering
    Shawn P Grogan
    Shiley Center for Orthopaedic Research and Education at Scripps Clinic, 11025 North Torrey Pines Road, Suite 200, La Jolla, CA 92037, USA
    Acta Biomater 9:7218-26. 2013
    ..Prefabrication of GelMA scaffolds with architectures mimicking the meniscus collagen bundle organization shows promise for meniscal repair. Furthermore, the technique presented may be scaled up to repair larger defects...
  39. ncbi request reprint A multiaxial force-sensing implantable tibial prosthesis
    Bryan Kirking
    Orthopaedic Research Laboratories, Shiley Center for Orthopaedic Research and Education at Scripps Clinic, CA, USA
    J Biomech 39:1744-51. 2006
    ..Additional uses are intraoperative measurement of forces to determine soft-tissue balancing and to evaluate the effects of rehabilitation, external bracing, and athletic activities, and activities of daily living...
  40. pmc Direct human cartilage repair using three-dimensional bioprinting technology
    Xiaofeng Cui
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, USA
    Tissue Eng Part A 18:1304-12. 2012
    ..These observations were consistent with gene expression results. This study indicates the importance of direct cartilage repair and promising anatomic cartilage engineering using 3D bioprinting technology...
  41. pmc Bony impingement limits design-related increases in hip range of motion
    Adam Bunn
    Shiley Center for Orthopaedic Research and Education at Scripps Clinic, 11025 North Torrey Pines Road, Suite 200, La Jolla, CA 92037, USA
    Clin Orthop Relat Res 470:418-27. 2012
    ..Factors affecting risk for impingement and dislocation can be related to the patient, implant design, or surgeon. While these have been studied independently, the impact of each factor relative to the others is not known...
  42. ncbi request reprint Effect of osteochondral graft insertion forces on chondrocyte viability
    Shantanu Patil
    Shiley Center for Orthopaedic Research and Education at Scripps Clinic, La Jolla, CA 92037, USA
    Am J Sports Med 36:1726-32. 2008
    ..Because chondrocytes are responsible for articular cartilage matrix synthesis and maintenance, reduced chondrocyte viability could compromise graft survival, healing, and clinical outcome...
  43. pmc Influence of cartilage extracellular matrix molecules on cell phenotype and neocartilage formation
    Shawn P Grogan
    1 Shiley Center for Orthopaedic Research and Education, Scripps Clinic, La Jolla, California
    Tissue Eng Part A 20:264-74. 2014
    ..These data indicate that an appropriate exposure to cartilage-specific ECM proteins could be used to enhance cartilage formation and to even induce the formation of zone-specific phenotypes to improve cartilage regeneration. ..
  44. ncbi request reprint What's new in orthopaedic rehabilitation
    Michael J Botte
    Division of Orthopaedic Surgery, Scripps Clinic, La Jolla California 92037, USA
    J Bone Joint Surg Am 84:2312-20. 2002
  45. pmc Ultrashort echo time MR imaging of osteochondral junction of the knee at 3 T: identification of anatomic structures contributing to signal intensity
    Won C Bae
    Departments of Radiology and Bioengineering and Department of Radiology, Rady Children s Hospital, University of California San Diego, 200 W Arbor Dr, San Diego, CA 92103, USA
    Radiology 254:837-45. 2010
    ....
  46. doi request reprint Augmented wedge-shaped glenoid component for the correction of glenoid retroversion: a finite element analysis
    Juan C Hermida
    Shiley Center for Orthopaedic Research and Education at Scripps Clinic, La Jolla, CA, USA
    J Shoulder Elbow Surg 23:347-54. 2014
    ..Bone grafting to correct retroverted deformity does not consistently generate successful results...
  47. doi request reprint Comparative biomechanical analysis of human and caprine knee articular cartilage
    Shantanu Patil
    Shiley Center for Orthopaedic Research and Education at Scripps Clinic, La Jolla, CA, United States
    Knee 21:119-25. 2014
    ..Differences between human and caprine knees have not been quantified and their significance is largely unknown...
  48. ncbi request reprint Detection of apoptosis in cartilage in situ and in isolated chondrocytes
    DARRYL D D'LIMA
    Orthopaedic Research Laboratories, Scripps Clinic Center for Orthopaedic Research and Education, La Jolla, CA, USA
    Methods Mol Med 100:275-90. 2004
    ..Labeled nucleotides are polymerized to these termini in a reaction catalyzed by TdT. The tissue can then be examined histologically for identification of TUNEL-positive cells in situ...
  49. pmc Mesenchymal progenitor cell markers in human articular cartilage: normal distribution and changes in osteoarthritis
    Shawn P Grogan
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    Arthritis Res Ther 11:R85. 2009
    ....
  50. ncbi request reprint Reverse total shoulder arthroplasty component center of rotation affects muscle function
    Heinz R Hoenecke
    Division of Orthopaedic Surgery, Scripps Clinic, La Jolla, CA, USA
    J Shoulder Elbow Surg 23:1128-35. 2014
    ..The objective of this study was to determine the effect of position of the glenosphere on deltoid efficiency and the range of glenohumeral adduction...
  51. doi request reprint Glenoid morphology rather than version predicts humeral subluxation: a different perspective on the glenoid in total shoulder arthroplasty
    Heinz R Hoenecke
    Department of Orthopaedic Surgery and Sports Medicine, Scripps Clinic, La Jolla, CA, USA
    J Shoulder Elbow Surg 21:1136-41. 2012
    ..We therefore analyzed the relative contribution of glenoid morphology and version to humeral head position...
  52. pmc Thermal inkjet printing in tissue engineering and regenerative medicine
    Xiaofeng Cui
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Recent Pat Drug Deliv Formul 6:149-55. 2012
    ..This review article introduces some important patents related to bioprinting of living systems and the applications of bioprinting in tissue engineering field...
  53. ncbi request reprint A biomechanical evaluation of three surgical techniques for subscapularis repair
    Gregory R Van den Berghe
    Shiley Center for Orthopaedic Research and Education at Scripps Clinic, La Jolla, CA, USA
    J Shoulder Elbow Surg 17:156-61. 2008
    ..The bone-to-bone repair exhibited the best combination of repair strength and restoration of subscapularis length...
  54. pmc Rho kinase-dependent CCL20 induced by dynamic compression of human chondrocytes
    Dominik R Haudenschild
    Scripps Research Institute, and Scripps Clinic, La Jolla, California 92037, USA
    Arthritis Rheum 58:2735-42. 2008
    ..Reorganization of the actin cytoskeleton results from Rho GTPase activation. The purpose of this study was to examine the roles of both actin and Rho in mechanotransduction in chondrocytes...
  55. pmc Thin-filament length correlates with fiber type in human skeletal muscle
    David S Gokhin
    Dept of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Am J Physiol Cell Physiol 302:C555-65. 2012
    ..Together, these data challenge the widely held assumption that human thin-filament lengths are constant. Our results also have broad relevance to musculoskeletal modeling, surgical reattachment of muscles, and orthopedic rehabilitation...
  56. pmc Anisotropic rheology and directional mechanotransduction in vascular endothelial cells
    Juan C Del Alamo
    Department of Mechanical and Aerospace Engineering, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 105:15411-6. 2008
    ..The resulting directional anisotropy and spatial inhomogeneity of cytoplasmic rheology may play an important role in mechanotransduction in adherent cells by providing a means to sense the direction of mechanical stimuli...
  57. ncbi request reprint Mechanotransduction and endothelial cell homeostasis: the wisdom of the cell
    Shu Chien
    Dept of Bioengineering, PFBH, Rm 134, Univ of California, San Diego, La Jolla, CA 92093 0412, USA
    Am J Physiol Heart Circ Physiol 292:H1209-24. 2007
    ....
  58. ncbi request reprint Induction of apoptosis in vascular smooth muscle cells by mechanical stretch
    Mohammad Sotoudeh
    Department of Bioengineering and Whitaker Institute of Biomedical Engineering, Advanced Tissue Sciences, La Jolla, California 92093, USA
    Am J Physiol Heart Circ Physiol 282:H1709-16. 2002
    ..These results support the hypothesis that circumferential overload under hypertensive conditions induces a clustering of death receptors that cause vascular smooth muscle cell apoptosis...
  59. pmc Effects of disturbed flow on endothelial cells
    Shu Chien
    Department of Bioengineering, University of California, San Diego, PFBH room 134, 9500 Gilman Drive, La Jolla, CA 92093 0412, USA
    Ann Biomed Eng 36:554-62. 2008
    ..Understanding of the EC responses to different flow patters helps to elucidate the mechanism of the region-specific localization of atherosclerosis in the arterial system...
  60. ncbi request reprint Molecular and mechanical bases of focal lipid accumulation in arterial wall
    Shu Chien
    Department of Bioengineering and Medicine, The Whitaker Institute for Biomedical Engineering, University of California, San Diego, 9500 Gilman Drive, Mail Code 0427, SERF Room 221, La Jolla, CA 92093 0427, USA
    Prog Biophys Mol Biol 83:131-51. 2003
    ....
  61. ncbi request reprint Effects of flow patterns on the localization and expression of VE-cadherin at vascular endothelial cell junctions: in vivo and in vitro investigations
    Hui Miao
    Department of Bioengineering, The Whitaker Institute of Biomedical Engineering, University of California, San Diego, La Jolla, CA 92093 0412, USA
    J Vasc Res 42:77-89. 2005
    ....
  62. pmc Cooperative effects of Rho and mechanical stretch on stress fiber organization
    Roland Kaunas
    Department of Bioengineering, The Whitaker Institute of Biomedical Engineering, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 102:15895-900. 2005
    ..Our results demonstrate that the stretch-induced stress fiber orientation is a function of the interplay between Rho pathway activity and the magnitude of stretching...
  63. ncbi request reprint Molecular basis of mechanical modulation of endothelial cell migration
    Shu Chien
    Department of Bioengineering and Whitaker Institute of Biomedical Engineering, University of California, San Diego, La Jolla, CA, USA
    Front Biosci 10:1985-2000. 2005
    ..Investigations of EC migration under shearing can provide valuable knowledge on vascular remodeling process under physiological and pathological conditions...
  64. ncbi request reprint Visualizing the mechanical activation of Src
    Yingxiao Wang
    Department of Bioengineering and The Whitaker Institute of Biomedical Engineering, La Jolla, California 92093, USA
    Nature 434:1040-5. 2005
    ..We find that the transmission of mechanically induced Src activation is a dynamic process that directs signals via the cytoskeleton to spatial destinations...
  65. ncbi request reprint Biochemistry and biomechanics of cell motility
    Song Li
    Department of Bioengineering and Center for Tissue Engineering, University of California, Berkeley, CA 94720, USA
    Annu Rev Biomed Eng 7:105-50. 2005
    ....
  66. pmc Chronotropic response of cultured neonatal rat ventricular myocytes to short-term fluid shear
    Ilka Lorenzen-Schmidt
    Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0613, USA
    Cell Biochem Biophys 46:113-22. 2006
    ..The results suggest that the beta-adrenergic signaling pathway and integrin activation, which are known to interact, may play an important role in the response mechanism...
  67. ncbi request reprint Molecular basis of the effects of shear stress on vascular endothelial cells
    Yi Shuan J Li
    Department of Bioengineering, University of California, San Diego, La Jolla, 92093 0412, USA
    J Biomech 38:1949-71. 2005
    ..The knowledge gained on mechano-transduction, with verifications under in vivo conditions, will advance our understanding of the physiological and pathological processes in vascular remodeling and adaptation in health and disease...

Research Grants1

  1. A Novel Load Sensing Tibial Prosthesis Design
    DARRYL D LIMA; Fiscal Year: 2006
    ..Additional uses are intraoperative measurement of forces to determine soft tissue balancing, evaluation of the effects of rehabilitation, external bracing, and athletic activities, and activities of daily living. ..