Research Topics
Species | DARRYL D D'LIMASummaryAffiliation: The Scripps Research Institute Country: USA Publications
Research Grants
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Detail Information
Publications
The effect of the orientation of the acetabular and femoral components on the range of motion of the hip at different head-neck ratiosD D D'Lima
Division of Orthopaedic Surgery, Scripps Clinic, La Jolla, California 92037, USA
J Bone Joint Surg Am 82:315-21. 2000..In this study, a computer model was used to determine the effects of the positions of the acetabular and femoral components and of varying head-neck ratios on impingement and range of motion...- In vivo knee moments and shear after total knee arthroplastyDARRYL D D'LIMA
Shiley Center for Orthopaedic Research and Education, Scripps Clinic, 11025 N Torrey Pines Road, Suite 140, La Jolla, CA 92037, USA Department of Bioengineering, University of California, San Diego, CA, USA
J Biomech 40:S11-7. 2007..These findings indicate that the soft tissues around the knee absorbed most of the external shear forces. Our results highlight the importance of direct measurements of knee forces... - An ABJS Best Paper: Dynamic intraoperative ligament balancing for total knee arthroplastyDARRYL D D'LIMA
Orthopaedic Research Laboratories, Shiley Center for Orthopaedic Research and Education at Scripps Clinic, 11025 North Torrey Pines Road, La Jolla, CA 92037, USA
Clin Orthop Relat Res 463:208-12. 2007..Surgical navigation systems have reduced the variability in component alignment. An instrumented tibial trial can be a valuable adjunct to directly measure soft tissue balance... 
An in vivo evaluation of bone response to three implant surfaces using a rabbit intramedullary rod modelJuan C Hermida
Orthopaedic Research Laboratories, Shiley Center for Orthopaedic Research and Education at Scripps Clinic, 11025 North Torrey Pines Road, Suite 140, La Jolla, CA, 92037, USA
J Orthop Surg Res 5:57. 2010..The results of this in vivo lapine study suggest that the presence of an hydroxyapatite coating enhances osseointegration despite similarities in average surface roughness...- The 2011 ABJS Nicolas Andry Award: 'Lab'-in-a-knee: in vivo knee forces, kinematics, and contact analysisDARRYL D D'LIMA
Shiley Center for Orthopaedic Research and Education at Scripps Clinic, 11025 North Torrey Pines Road, Suite 200, La Jolla, CA 92037, USA
Clin Orthop Relat Res 469:2953-70. 2011..Although this approach is useful for quantitative measurements and experimental studies, the extrapolation of results to clinical conditions may not always be valid... - The Chitranjan Ranawat Award: in vivo knee forces after total knee arthroplastyDARRYL D D'LIMA
Orthopaedic Research Laboratories, Shiley Center for Orthopaedic Research and Education at Scripps Clinic, La Jolla, CA 92037, USA
Clin Orthop Relat Res 440:45-9. 2005..This should lead to refined surgical techniques and to enhanced prosthetic designs that will improve patient function, patient quality of life, and longevity of total knee arthroplasty implants... 
In vivo contact stresses during activities of daily living after knee arthroplastyDARRYL D D'LIMA
Shiley Center for Orthopaedic Research and Education at Scripps Clinic, 11025 North Torrey Pines Road, Suite 140, La Jolla, California 92037, USA
J Orthop Res 26:1549-55. 2008..Our results support the use of "high flexion" designs that improve contact conditions and preserve contact area at high flexion angles...- Impact of patellofemoral design on patellofemoral forces and polyethylene stressesDARRYL D D'LIMA
Scripps Clinic Center for Orthopaedic Research and Education, La Jolla, CA 92037, USA
J Bone Joint Surg Am 85:85-93. 2003..The presence of a functioning posterior cruciate ligament and the design parameters of a total knee arthroplasty, such as trochlear groove alignment and cam-post configuration, can have a major effect on patellar biomechanics... - The Mark Coventry Award: in vivo knee forces during recreation and exercise after knee arthroplastyDARRYL D D'LIMA
Shiley Center for Orthopaedic Research and Education at Scripps Clinic, La Jolla, CA 92037, USA
Clin Orthop Relat Res 466:2605-11. 2008.... - Effects of perfusion and dynamic loading on human neocartilage formation in alginate hydrogelsShawn P Grogan
Shiley Center for Orthopaedic Research and Education at Scripps Clinic, La Jolla, CA 92037, USA
Tissue Eng Part A 18:1784-92. 2012..Optimal conditions, which permit appropriate anabolic and catabolic processes for accumulation of ECM and tissue remodeling for neocartilage development, specifically for humans, are needed... - Effect of tibial component varus on wear in total knee arthroplastyAjay Srivastava
Orthopaedic Research Laboratories, Shiley Center for Orthopaedic Research and Education at Scripps Clinic, La Jolla, CA 92037, USA
Knee 19:560-3. 2012..However, component malalignment can occur even when overall limb mechanical axis is within the normal anatomic range. We studied the effect of component malalignment in the presence of acceptable knee alignment in knee arthroplasty... - Predicting the effect of tray malalignment on risk for bone damage and implant subsidence after total knee arthroplastyJowene Wong
Shiley Center for Orthopaedic Research and Education at Scripps Clinic, 11025 North Torrey Pines Road, Suite 140, La Jolla, California 92037, USA
J Orthop Res 29:347-53. 2011..Our results indicate that failure after tray malalignment is likely due to fatigue damage to the proximal tibia rather than shear across the implant-bone interface or failure of the cement mantle... - Aging-related differences in chondrocyte viscoelastic propertiesNikolai Steklov
Shiley Center for Orthopaedic Research and Education at Scripps Clinic, North Torrey Pines Road, La Jolla, CA 92037, USA
Mol Cell Biomech 6:113-9. 2009..A similar mechanism may be responsible for our finding of increased stiffness in aging chondrocytes. With advancing age, changes in the biomechanical properties of the cell could alter molecular and biochemical responses... - Can normal knee kinematics be restored with unicompartmental knee replacement?Shantanu Patil
Orthopaedic Research Laboratories, Scripps Clinic Center for Orthopaedic Research and Education, 11025 North Torrey Pines Road, Suite 140, La Jolla, CA 92037, USA
J Bone Joint Surg Am 87:332-8. 2005..To test this hypothesis, knee kinematics and quadriceps tension were recorded before and after replacement with a unicompartmental design and then with a tricompartmental design... - In situ tissue engineering using magnetically guided three-dimensional cell patterningShawn P Grogan
Shiley Center for Orthopaedic Research and Education, Scripps Clinic, La Jolla, CA 92037, USA
Tissue Eng Part C Methods 18:496-506. 2012..Taken together, this approach can be adapted for studying basic biological processes in vitro, for general tissue engineering approaches, and for producing organized repair tissues directly in situ... - Accuracy of CT-based measurements of glenoid version for total shoulder arthroplastyHeinz R Hoenecke
Shiley Center for Orthopaedic Research and Education at Scripps Clinic, La Jolla, CA 92037, USA
J Shoulder Elbow Surg 19:166-71. 2010..While a method for measurement of glenoid version using axial computed tomography (CT) has been reported and has been widely accepted, its accuracy and reproducibility has not been established... - Vimentin contributes to changes in chondrocyte stiffness in osteoarthritisDominik R Haudenschild
Shiley Center for Orthopaedic Research and Education at Scripps Clinic, 11025 North Torrey Pines Road, La Jolla, California 92037, USA
J Orthop Res 29:20-5. 2011..This 3D experimental system revealed contributions of vimentin to chondrocyte stiffness previously not apparent, and correlated changes in vimentin-based chondrocyte stiffness with osteoarthritis... - A quantitative three-dimensional templating method for shoulder arthroplasty: biomechanical validation in cadaversHeinz R Hoenecke
Department of Orthopaedic Surgery and Sports Medicine, Scripps Clinic, La Jolla, CA 92037, USA
J Shoulder Elbow Surg 21:1377-83. 2012..The purpose of this study was to develop a 3-dimensional templating technique for the humeral stem and to validate this templating in cadaveric specimens... - Effect of total knee arthroplasty implant position on flexion angle before implant-bone impingementHideki Mizu-uchi
Shiley Center for Orthopaedic Research and Education at Scripps Clinic, La Jolla, CA 92037, USA
J Arthroplasty 26:721-7. 2011..The rate of change in flexion angle was 0.4°/mm to 1.5°/mm with respect to implant position and 1.5°/mm increase in the posterior condylar offset... - Anterior cruciate ligament changes in the human knee joint in aging and osteoarthritisAkihiko Hasegawa
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
Arthritis Rheum 64:696-704. 2012.... - Knee joint forces: prediction, measurement, and significanceDARRYL D D'LIMA
Shiley Center for Orthopaedic Research and Education at Scripps Clinic, Scripps Health, 11025 North Torrey Pines Road, Suite 200, La Jolla, CA 92037, USA
Proc Inst Mech Eng H 226:95-102. 2012..Current gaps in our knowledge are identified and directions for future research in this area are outlined... - The effect of oxidative aging on the wear performance of highly crosslinked polyethylene knee inserts under conditions of severe malalignmentJuan C Hermida
Shiley Center for Orthopedic Research and Education at Scripps Clinic, 11025 North Torrey Pines Road, Suite 140, La Jolla, California 92037, USA
J Orthop Res 26:1585-90. 2008..74 +/- 0.3 and 4.72 +/- 0.7, respectively). These results support the low levels of free radicals and preservation of mechanical properties reported in second-generation crosslinked ultrahigh molecular weight polyethylene... - Optimizing glenoid component position using three-dimensional computed tomography reconstructionHeinz R Hoenecke
Division of Orthopaedic Surgery at Scripps Clinic, La Jolla, CA 92037, USA
J Shoulder Elbow Surg 17:637-41. 2008..These results emphasize the need for accurate preoperative templating and for developing alignment guides or surgical navigation tools for shoulder arthroplasty and may be used to improve implant fixation designs... - Direct human cartilage repair using three-dimensional bioprinting technologyXiaofeng Cui
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, USA
Tissue Eng Part A 18:1304-12. 2012..These observations were consistent with gene expression results. This study indicates the importance of direct cartilage repair and promising anatomic cartilage engineering using 3D bioprinting technology... - Bony impingement limits design-related increases in hip range of motionAdam Bunn
Shiley Center for Orthopaedic Research and Education at Scripps Clinic, 11025 North Torrey Pines Road, Suite 200, La Jolla, CA 92037, USA
Clin Orthop Relat Res 470:418-27. 2012..Factors affecting risk for impingement and dislocation can be related to the patient, implant design, or surgeon. While these have been studied independently, the impact of each factor relative to the others is not known... - Effect of osteochondral graft insertion forces on chondrocyte viabilityShantanu Patil
Shiley Center for Orthopaedic Research and Education at Scripps Clinic, La Jolla, CA 92037, USA
Am J Sports Med 36:1726-32. 2008..Because chondrocytes are responsible for articular cartilage matrix synthesis and maintenance, reduced chondrocyte viability could compromise graft survival, healing, and clinical outcome... - Zone-specific gene expression patterns in articular cartilageShawn P Grogan
The Scripps Research Institute and Shiley Center for Orthopaedic Research and Education, Scripps Clinic, La Jolla, California, USA
Arthritis Rheum 65:418-28. 2013..To identify novel genes and pathways specific to the superficial zone (SZ), middle zone (MZ), and deep zone (DZ) of normal articular cartilage... - Ultrashort echo time MR imaging of osteochondral junction of the knee at 3 T: identification of anatomic structures contributing to signal intensityWon C Bae
Departments of Radiology and Bioengineering and Department of Radiology, Rady Children s Hospital, University of California San Diego, 200 W Arbor Dr, San Diego, CA 92103, USA
Radiology 254:837-45. 2010..UTE sequences may provide a way of evaluating abnormalities at or near the osteochondral junction. (c) RSNA, 2010... - Histopathological changes in the human posterior cruciate ligament during aging and osteoarthritis: correlations with anterior cruciate ligament and cartilage changesYadin D Levy
Correspondence to Professor Martin K Lotz, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Ann Rheum Dis 72:271-7. 2013..To determine the histological patterns of posterior cruciate ligament (PCL) degeneration during aging and in relation to changes in articular cartilage and anterior cruciate ligament (ACL) across the entire adult age spectrum... - Mesenchymal progenitor cell markers in human articular cartilage: normal distribution and changes in osteoarthritisShawn P Grogan
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
Arthritis Res Ther 11:R85. 2009.... - Glenoid morphology rather than version predicts humeral subluxation: a different perspective on the glenoid in total shoulder arthroplastyHeinz R Hoenecke
Department of Orthopaedic Surgery and Sports Medicine, Scripps Clinic, La Jolla, CA, USA
J Shoulder Elbow Surg 21:1136-41. 2012..We therefore analyzed the relative contribution of glenoid morphology and version to humeral head position... - Thermal inkjet printing in tissue engineering and regenerative medicineXiaofeng Cui
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
Recent Pat Drug Deliv Formul 6:149-55. 2012..This review article introduces some important patents related to bioprinting of living systems and the applications of bioprinting in tissue engineering field... - Rho kinase-dependent CCL20 induced by dynamic compression of human chondrocytesDominik R Haudenschild
Scripps Research Institute, and Scripps Clinic, La Jolla, California 92037, USA
Arthritis Rheum 58:2735-42. 2008..Reorganization of the actin cytoskeleton results from Rho GTPase activation. The purpose of this study was to examine the roles of both actin and Rho in mechanotransduction in chondrocytes... - A biomechanical evaluation of three surgical techniques for subscapularis repairGregory R Van den Berghe
Shiley Center for Orthopaedic Research and Education at Scripps Clinic, La Jolla, CA, USA
J Shoulder Elbow Surg 17:156-61. 2008..The bone-to-bone repair exhibited the best combination of repair strength and restoration of subscapularis length... - Thin-filament length correlates with fiber type in human skeletal muscleDavid S Gokhin
Dept of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
Am J Physiol Cell Physiol 302:C555-65. 2012..Together, these data challenge the widely held assumption that human thin-filament lengths are constant. Our results also have broad relevance to musculoskeletal modeling, surgical reattachment of muscles, and orthopedic rehabilitation... - Molecular basis of the effects of shear stress on vascular endothelial cellsYi-Shuan J Li
Department of Bioengineering, University of California, San Diego, La Jolla, 92093-0412, USA
J Biomech 38:1949-71. 2005..The knowledge gained on mechano-transduction, with verifications under in vivo conditions, will advance our understanding of the physiological and pathological processes in vascular remodeling and adaptation in health and disease... - Anisotropic rheology and directional mechanotransduction in vascular endothelial cellsJuan C Del Alamo
Department of Mechanical and Aerospace Engineering, University of California at San Diego, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 105:15411-6. 2008..The resulting directional anisotropy and spatial inhomogeneity of cytoplasmic rheology may play an important role in mechanotransduction in adherent cells by providing a means to sense the direction of mechanical stimuli... - Induction of apoptosis in vascular smooth muscle cells by mechanical stretchMohammad Sotoudeh
Department of Bioengineering and Whitaker Institute of Biomedical Engineering, Advanced Tissue Sciences, La Jolla, California 92093, USA
Am J Physiol Heart Circ Physiol 282:H1709-16. 2002..These results support the hypothesis that circumferential overload under hypertensive conditions induces a clustering of death receptors that cause vascular smooth muscle cell apoptosis... - Molecular and mechanical bases of focal lipid accumulation in arterial wallShu Chien
Department of Bioengineering and Medicine, The Whitaker Institute for Biomedical Engineering, University of California, San Diego, 9500 Gilman Drive, Mail Code 0427, SERF Room 221, La Jolla, CA 92093 0427, USA
Prog Biophys Mol Biol 83:131-51. 2003.... - Effects of disturbed flow on endothelial cellsShu Chien
Department of Bioengineering, University of California, San Diego, PFBH room 134, 9500 Gilman Drive, La Jolla, CA 92093 0412, USA
Ann Biomed Eng 36:554-62. 2008..Understanding of the EC responses to different flow patters helps to elucidate the mechanism of the region-specific localization of atherosclerosis in the arterial system... - Mechanotransduction and endothelial cell homeostasis: the wisdom of the cellShu Chien
Dept of Bioengineering, PFBH, Rm 134, Univ of California, San Diego, La Jolla, CA 92093 0412, USA
Am J Physiol Heart Circ Physiol 292:H1209-24. 2007.... - Effects of flow patterns on the localization and expression of VE-cadherin at vascular endothelial cell junctions: in vivo and in vitro investigationsHui Miao
Department of Bioengineering, The Whitaker Institute of Biomedical Engineering, University of California, San Diego, La Jolla, CA 92093-0412, USA
J Vasc Res 42:77-89. 2005.... - Molecular basis of mechanical modulation of endothelial cell migrationShu Chien
Department of Bioengineering and Whitaker Institute of Biomedical Engineering, University of California, San Diego, La Jolla, CA, USA
Front Biosci 10:1985-2000. 2005..Investigations of EC migration under shearing can provide valuable knowledge on vascular remodeling process under physiological and pathological conditions... - Visualizing the mechanical activation of SrcYingxiao Wang
Department of Bioengineering and The Whitaker Institute of Biomedical Engineering, La Jolla, California 92093, USA
Nature 434:1040-5. 2005..We find that the transmission of mechanically induced Src activation is a dynamic process that directs signals via the cytoskeleton to spatial destinations... - Chronotropic response of cultured neonatal rat ventricular myocytes to short-term fluid shearIlka Lorenzen-Schmidt
Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0613, USA
Cell Biochem Biophys 46:113-22. 2006..The results suggest that the beta-adrenergic signaling pathway and integrin activation, which are known to interact, may play an important role in the response mechanism... - Cooperative effects of Rho and mechanical stretch on stress fiber organizationRoland Kaunas
Department of Bioengineering, The Whitaker Institute of Biomedical Engineering, University of California at San Diego, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 102:15895-900. 2005..Our results demonstrate that the stretch-induced stress fiber orientation is a function of the interplay between Rho pathway activity and the magnitude of stretching... - Biochemistry and biomechanics of cell motilitySong Li
Department of Bioengineering and Center for Tissue Engineering, University of California, Berkeley, CA 94720, USA
Annu Rev Biomed Eng 7:105-50. 2005....
Research Grants
- A Novel Load Sensing Tibial Prosthesis DesignDARRYL D LIMA; Fiscal Year: 2006..Additional uses are intraoperative measurement of forces to determine soft tissue balancing, evaluation of the effects of rehabilitation, external bracing, and athletic activities, and activities of daily living. ..