ANDREW G DILLIN

Summary

Affiliation: The Salk Institute
Country: USA

Publications

  1. pmc Protein homeostasis and aging in neurodegeneration
    Peter M Douglas
    Howard Hughes Medical Institute, Glenn Center for Aging Research, Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    J Cell Biol 190:719-29. 2010
  2. pmc Temporal requirements of insulin/IGF-1 signaling for proteotoxicity protection
    Ehud Cohen
    Howard Hughes Medical Institute, Glenn Center for Aging Research, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Aging Cell 9:126-34. 2010
  3. pmc The specifics of small interfering RNA specificity
    Andrew Dillin
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:6289-91. 2003
  4. pmc Ageing and protein aggregation-mediated disorders: from invertebrates to mammals
    Andrew Dillin
    Howard Hughes Medical Institute, Glenn Center for Ageing Research, Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Philos Trans R Soc Lond B Biol Sci 366:94-8. 2011
  5. ncbi request reprint Medicine. The yin-yang of sirtuins
    Andrew Dillin
    Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 317:461-2. 2007
  6. ncbi request reprint SMK-1, an essential regulator of DAF-16-mediated longevity
    Suzanne Wolff
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 124:1039-53. 2006
  7. ncbi request reprint The trifecta of aging in Caenorhabditis elegans
    Suzanne Wolff
    The Salk Institute for Biological Studies, Molecular and Cell Biology Laboratory, 10010 N Torrey Pines Road, La Jolla, CA 92037, USA
    Exp Gerontol 41:894-903. 2006
  8. ncbi request reprint PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans
    Siler H Panowski
    The Salk Institute for Biological Studies, Molecular and Cell Biology Laboratory, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 447:550-5. 2007
  9. doi request reprint Signals of youth: endocrine regulation of aging in Caenorhabditis elegans
    Siler H Panowski
    Howard Hughes Medical Institute, Glenn Center for Aging Research, Salk Institute for Biological Studies, Molecular and Cell Biology Laboratory, La Jolla, CA 92037, USA
    Trends Endocrinol Metab 20:259-64. 2009
  10. ncbi request reprint Opposing activities protect against age-onset proteotoxicity
    Ehud Cohen
    Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 313:1604-10. 2006

Collaborators

  • Ehud Cohen
  • TONY R HUNTER
  • William Mair
  • Martin Holzenberger
  • REUBEN JAMES SHAW
  • RICHARD MORIMOTO
  • Zheng Liu
  • Eliezer Masliah
  • Suzanne Wolff
  • Siler H Panowski
  • Jenni Durieux
  • Marcela Raices
  • Meng Qiu Dong
  • Hugo Aguilaniu
  • John D Venable
  • Peter M Douglas
  • Andrea C Carrano
  • Jan Bieschke
  • Jeffery W Kelly
  • Thomas J Baiga
  • William E Balch
  • Jan Karlseder
  • John R Yates
  • John A T Young
  • Amber Murray
  • Haibing Guo
  • Sarah A Compton
  • Candy I Haggblom
  • Yalan Xing
  • Michael B Austin
  • Ramiro E Verdun
  • James J La Clair
  • Jack D Griffith
  • Joseph P Noel
  • GEORGE A O'DOHERTY
  • Jeffrey R Johnson
  • Nora Au
  • Sung Kyu Park
  • Tao Xu
  • Daniel Cociorva
  • Gustavo A Maciel
  • Denise Burch
  • Hui Ma
  • Hugo Maruyama
  • James Wohlschlegel

Detail Information

Publications25

  1. pmc Protein homeostasis and aging in neurodegeneration
    Peter M Douglas
    Howard Hughes Medical Institute, Glenn Center for Aging Research, Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    J Cell Biol 190:719-29. 2010
    ..Thus, understanding the relationship between proteostasis and aging has provided important insights into neurodegeneration...
  2. pmc Temporal requirements of insulin/IGF-1 signaling for proteotoxicity protection
    Ehud Cohen
    Howard Hughes Medical Institute, Glenn Center for Aging Research, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Aging Cell 9:126-34. 2010
    ....
  3. pmc The specifics of small interfering RNA specificity
    Andrew Dillin
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:6289-91. 2003
  4. pmc Ageing and protein aggregation-mediated disorders: from invertebrates to mammals
    Andrew Dillin
    Howard Hughes Medical Institute, Glenn Center for Ageing Research, Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Philos Trans R Soc Lond B Biol Sci 366:94-8. 2011
    ..Here, we review these novel studies and discuss the potential of ageing alteration as a therapeutic approach for the treatment of late onset neurodegeneration...
  5. ncbi request reprint Medicine. The yin-yang of sirtuins
    Andrew Dillin
    Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 317:461-2. 2007
  6. ncbi request reprint SMK-1, an essential regulator of DAF-16-mediated longevity
    Suzanne Wolff
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 124:1039-53. 2006
    ..SMK-1 therefore plays a role in longevity by modulating DAF-16 transcriptional specificity without affecting other processes regulated by IIS...
  7. ncbi request reprint The trifecta of aging in Caenorhabditis elegans
    Suzanne Wolff
    The Salk Institute for Biological Studies, Molecular and Cell Biology Laboratory, 10010 N Torrey Pines Road, La Jolla, CA 92037, USA
    Exp Gerontol 41:894-903. 2006
    ..Examination of these findings will help us to understand how the molecular mechanisms of distinct pathways can unite in the regulation of longevity...
  8. ncbi request reprint PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans
    Siler H Panowski
    The Salk Institute for Biological Studies, Molecular and Cell Biology Laboratory, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 447:550-5. 2007
    ..elegans. The role of PHA-4 in lifespan determination is specific for dietary restriction, because it is not required for the increased longevity caused by other genetic pathways that regulate ageing...
  9. doi request reprint Signals of youth: endocrine regulation of aging in Caenorhabditis elegans
    Siler H Panowski
    Howard Hughes Medical Institute, Glenn Center for Aging Research, Salk Institute for Biological Studies, Molecular and Cell Biology Laboratory, La Jolla, CA 92037, USA
    Trends Endocrinol Metab 20:259-64. 2009
    ..elegans, the insulin/IGF-1 and germline signalling pathways, in which endocrine signalling is clearly important. We also incorporate recent data to create a model of how endocrine signalling in these pathways might occur...
  10. ncbi request reprint Opposing activities protect against age-onset proteotoxicity
    Ehud Cohen
    Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 313:1604-10. 2006
    ..Because the IIS pathway is central to the regulation of longevity and youthfulness in worms, flies, and mammals, these results suggest a mechanistic link between the aging process and aggregation-mediated proteotoxicity...
  11. pmc The insulin paradox: aging, proteotoxicity and neurodegeneration
    Ehud Cohen
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Rev Neurosci 9:759-67. 2008
    ..Here we review this apparent paradox and delineate the therapeutic potential of manipulating the insulin/IGF1 signalling pathway for the treatment of neurodegenerative diseases...
  12. ncbi request reprint Quantitative mass spectrometry identifies insulin signaling targets in C. elegans
    Meng Qiu Dong
    Scripps Research Institute, La Jolla, CA92037, USA
    Science 317:660-3. 2007
    ..In particular, we discovered a compensatory mechanism activated in response to reduced DAF-2 signaling, which involves the protein phosphatase calcineurin...
  13. doi request reprint Aging and survival: the genetics of life span extension by dietary restriction
    William Mair
    The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Annu Rev Biochem 77:727-54. 2008
    ..Here, we discuss how recent work in nonmammalian model organisms has revealed new insight into the genetics of DR and how the discovery of DR-specific transcription factors will advance our understanding of this phenomenon...
  14. pmc A conserved ubiquitination pathway determines longevity in response to diet restriction
    Andrea C Carrano
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nature 460:396-9. 2009
    ..Taken together, our results indicate that WWP-1 and UBC-18 function to ubiquitinate substrates that regulate diet-restriction-induced longevity...
  15. pmc Uncoupling of longevity and telomere length in C. elegans
    Marcela Raices
    The Salk Institute for Biological Studies, La Jolla, California, USA
    PLoS Genet 1:e30. 2005
    ..Collectively, our data indicate that telomere length and life span can be uncoupled in a post-mitotic setting, suggesting separate pathways for replication-dependent and -independent aging...
  16. ncbi request reprint Mitochondria and aging: dilution is the solution
    Jenni Durieux
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Metab 6:427-9. 2007
    ..Recently, Rea et al. (2007) have shown that mitochondrial electron transport chain RNAi phenotypes in the worm C. elegans are dose dependent, providing an alternative view of mitochondrial function in longevity and metabolic diseases...
  17. ncbi request reprint Metabolism, ubiquinone synthesis, and longevity
    Hugo Aguilaniu
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Genes Dev 19:2399-406. 2005
  18. pmc Optimizing dietary restriction for genetic epistasis analysis and gene discovery in C. elegans
    William Mair
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California, United States of America
    PLoS ONE 4:e4535. 2009
    ..1, highlighting the importance of first optimizing DR to identify universal regulators of DR mediated longevity...
  19. pmc Reduced IGF-1 signaling delays age-associated proteotoxicity in mice
    Ehud Cohen
    Howard Hughes Medical Institute, Glenn Center for Aging Research, Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 139:1157-69. 2009
    ....
  20. pmc A kinetic assessment of the C. elegans amyloid disaggregation activity enables uncoupling of disassembly and proteolysis
    Jan Bieschke
    Department of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Protein Sci 18:2231-41. 2009
    ..Future discovery of the molecular basis of the disaggregation and proteolysis activities offers the promise of delaying the age-onset proteotoxicity that leads to neurodegeneration in a spectrum of maladies...
  21. pmc MAPping innate immunity
    John A T Young
    Infectious Disease Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 101:12781-2. 2004
  22. ncbi request reprint Automated approach for quantitative analysis of complex peptide mixtures from tandem mass spectra
    John D Venable
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92014, USA
    Nat Methods 1:39-45. 2004
    ....
  23. pmc Metabolite induction of Caenorhabditis elegans dauer larvae arises via transport in the pharynx
    Thomas J Baiga
    Howard Hughes Medical Institute, Jack H Skirball Center for Chemical Biology and Proteomics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    ACS Chem Biol 3:294-304. 2008
    ..These studies provide cogent evidence supporting the roles of the glycosylated fatty acid daumone and related ascarosides and the ubiquitous plant flavone apigenin as chemical cues regulating C. elegans development...
  24. doi request reprint C. elegans telomeres contain G-strand and C-strand overhangs that are bound by distinct proteins
    Marcela Raices
    The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 132:745-57. 2008
    ..Our results suggest that C. elegans telomere homeostasis relies on a novel mechanism that involves 5' and 3' single-stranded termini...
  25. doi request reprint Adapting proteostasis for disease intervention
    William E Balch
    Department of Cell Biology and Institute for Childhood and Neglected Diseases, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 319:916-9. 2008
    ....

Research Grants14

  1. Specifying Insulin/IGF-1 Signaling in C. elegans
    Andrew Dillin; Fiscal Year: 2005
    ..The relevance of the interacting proteins will be determined by gene knockdown and overexpression. ..
  2. Tissue Specific Requirements of the ETC for Longevity
    Andrew Dillin; Fiscal Year: 2005
    ..Complementation of mev-1(kn1) mutant defects by tissue specific expression of wild type mev-1 will allow us to identify the tissues in which mev-1 is required to regulate longevity and stress resistance. ..
  3. Genetic Regulation of the Response to Dietary Restriction
    Andrew Dillin; Fiscal Year: 2009
    ..Our goal is to understand the molecular underpinnings of this pathway to allow manipulation of the DR response resulting in increased healthy lifespan without harmful effects on metabolism, development or reproduction. ..
  4. Specifying Insulin/IGF-1 Signaling in C. elegans
    Andrew Dillin; Fiscal Year: 2009
    ..The relevance of the interacting proteins will be determined by gene knockdown and overexpression. ..
  5. Tissue Specific Requirements of the ETC for Longevity
    Andrew Dillin; Fiscal Year: 2007
    ..Complementation of mev-1(kn1) mutant defects by tissue specific expression of wild type mev-1 will allow us to identify the tissues in which mev-1 is required to regulate longevity and stress resistance. ..
  6. Tissue Specific Requirements of the ETC for Longevity
    Andrew Dillin; Fiscal Year: 2004
    ..Complementation of mev-1(kn1) mutant defects by tissue specific expression of wild type mev-1 will allow us to identify the tissues in which mev-1 is required to regulate longevity and stress resistance. ..
  7. Specifying Insulin/IGF-1 Signaling in C. elegans
    Andrew Dillin; Fiscal Year: 2007
    ..The relevance of the interacting proteins will be determined by gene knockdown and overexpression. ..
  8. Tissue Specific Requirements of the ETC for Longevity
    Andrew Dillin; Fiscal Year: 2006
    ..Complementation of mev-1(kn1) mutant defects by tissue specific expression of wild type mev-1 will allow us to identify the tissues in which mev-1 is required to regulate longevity and stress resistance. ..
  9. Specifying Insulin/IGF-1 Signaling in C. elegans
    Andrew Dillin; Fiscal Year: 2006
    ..The relevance of the interacting proteins will be determined by gene knockdown and overexpression. ..
  10. Genetic Regulation of the Response to Dietary Restriction
    ANDREW G DILLIN; Fiscal Year: 2010
    ..Our goal is to understand the molecular underpinnings of this pathway to allow manipulation of the DR response resulting in increased healthy lifespan without harmful effects on metabolism, development or reproduction. ..