Marilyn Diaz

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. pmc Evolution and the molecular basis of somatic hypermutation of antigen receptor genes
    M Diaz
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Philos Trans R Soc Lond B Biol Sci 356:67-72. 2001
  2. ncbi Decreased frequency of somatic hypermutation and impaired affinity maturation but intact germinal center formation in mice expressing antisense RNA to DNA polymerase zeta
    M Diaz
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 167:327-35. 2001
  3. ncbi Somatic immunoglobulin hypermutation
    Marilyn Diaz
    Department of Immunology, Imm16, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Opin Immunol 14:235-40. 2002
  4. ncbi Structural analysis, selection, and ontogeny of the shark new antigen receptor (IgNAR): identification of a new locus preferentially expressed in early development
    Marilyn Diaz
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Immunogenetics 54:501-12. 2002
  5. ncbi Decreased frequency and highly aberrant spectrum of ultraviolet-induced mutations in the hprt gene of mouse fibroblasts expressing antisense RNA to DNA polymerase zeta
    Marilyn Diaz
    Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA
    Mol Cancer Res 1:836-47. 2003
  6. pmc Known components of the immunoglobulin A:T mutational machinery are intact in Burkitt lymphoma cell lines with G:C bias
    Zheng Xiao
    Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, D3 01, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    Mol Immunol 44:2659-66. 2007
  7. ncbi An update on the role of translesion synthesis DNA polymerases in Ig hypermutation
    Marilyn Diaz
    Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA
    Trends Immunol 26:215-20. 2005
  8. ncbi Unprecedented multiplicity of Ig transmembrane and secretory mRNA forms in the cartilaginous fish
    Lynn L Rumfelt
    Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL 33101, USA
    J Immunol 173:1129-39. 2004
  9. ncbi Activation-induced cytosine deaminase (AID) is actively exported out of the nucleus but retained by the induction of DNA breaks
    Sukhdev S Brar
    Laboratory of Molecular Genetics, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709 2233, USA
    J Biol Chem 279:26395-401. 2004
  10. ncbi Cutting edge: DGYW/WRCH is a better predictor of mutability at G:C bases in Ig hypermutation than the widely accepted RGYW/WRCY motif and probably reflects a two-step activation-induced cytidine deaminase-triggered process
    Igor B Rogozin
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    J Immunol 172:3382-4. 2004

Collaborators

Detail Information

Publications12

  1. pmc Evolution and the molecular basis of somatic hypermutation of antigen receptor genes
    M Diaz
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Philos Trans R Soc Lond B Biol Sci 356:67-72. 2001
    ..Finally, targeting of the variable genes is probably obtained via transcription-related elements, and it is the targeting phase of somatic hypermutation that is the most likely to reveal molecules unique to adaptive immunity...
  2. ncbi Decreased frequency of somatic hypermutation and impaired affinity maturation but intact germinal center formation in mice expressing antisense RNA to DNA polymerase zeta
    M Diaz
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 167:327-35. 2001
    ..These data implicate DNA polymerase zeta, a nonreplicative polymerase, in the process of affinity maturation, possibly through a role in somatic hypermutation, clonal selection, or both...
  3. ncbi Somatic immunoglobulin hypermutation
    Marilyn Diaz
    Department of Immunology, Imm16, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Opin Immunol 14:235-40. 2002
    ..The nature of the targeting mechanism and the trans-factors effecting such breaks and their repair remain to be determined...
  4. ncbi Structural analysis, selection, and ontogeny of the shark new antigen receptor (IgNAR): identification of a new locus preferentially expressed in early development
    Marilyn Diaz
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Immunogenetics 54:501-12. 2002
    ....
  5. ncbi Decreased frequency and highly aberrant spectrum of ultraviolet-induced mutations in the hprt gene of mouse fibroblasts expressing antisense RNA to DNA polymerase zeta
    Marilyn Diaz
    Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA
    Mol Cancer Res 1:836-47. 2003
    ..The antisense Rev3 mice should be a useful model to study mutagenic lesion bypass by pol zeta in mammalian cells and to investigate the role this polymerase plays in carcinogenesis...
  6. pmc Known components of the immunoglobulin A:T mutational machinery are intact in Burkitt lymphoma cell lines with G:C bias
    Zheng Xiao
    Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, D3 01, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    Mol Immunol 44:2659-66. 2007
    ..Either scenario suggests that cytosine deamination by AID is not enough to trigger A:T mutation, and that additional unidentified factors are required for full spectrum hypermutation in vivo...
  7. ncbi An update on the role of translesion synthesis DNA polymerases in Ig hypermutation
    Marilyn Diaz
    Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA
    Trends Immunol 26:215-20. 2005
    ....
  8. ncbi Unprecedented multiplicity of Ig transmembrane and secretory mRNA forms in the cartilaginous fish
    Lynn L Rumfelt
    Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL 33101, USA
    J Immunol 173:1129-39. 2004
    ..Furthermore, these Tm cDNAs are prototypical and the truncated variants may translate as more stable protein at the cell surface...
  9. ncbi Activation-induced cytosine deaminase (AID) is actively exported out of the nucleus but retained by the induction of DNA breaks
    Sukhdev S Brar
    Laboratory of Molecular Genetics, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709 2233, USA
    J Biol Chem 279:26395-401. 2004
    ..Finally, we found that agents that induce DNA breaks caused retention of AID in the nucleus, suggesting that DNA breaks or the repair patches initiated as a result are a substrate for AID binding...
  10. ncbi Cutting edge: DGYW/WRCH is a better predictor of mutability at G:C bases in Ig hypermutation than the widely accepted RGYW/WRCY motif and probably reflects a two-step activation-induced cytidine deaminase-triggered process
    Igor B Rogozin
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    J Immunol 172:3382-4. 2004
    ..We also found evidence that a DNA repair enzyme may play a role in modifying the sequence of hypermutation hotspots...
  11. ncbi A novel cytidine deaminase AIDs in the delivery of error-prone polymerases to immunoglobulin genes
    Marilyn Diaz
    Laboratory of Molecular Genetics, NIEHS, Research Triangle Park, NC, USA
    DNA Repair (Amst) 2:623-7. 2003
    ..The authors review the implications of this work and argue that deamination of deoxy-cytidine to deoxy-uracil seems to initiate several pathways in which error-prone polymerases are postulated to create mutations...
  12. pmc Abrogation of lupus nephritis in activation-induced deaminase-deficient MRL/lpr mice
    Chuancang Jiang
    Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Immunol 178:7422-31. 2007
    ..This novel mouse model containing high levels of autoreactive, unmutated IgM Abs will help delineate the contribution of autoreactive IgM to autoimmunity...