Donato A Di Monte

Summary

Affiliation: The Parkinson's Institute
Country: USA

Publications

  1. ncbi request reprint The environment and Parkinson's disease: is the nigrostriatal system preferentially targeted by neurotoxins?
    Donato A Di Monte
    Parkinson s Institute, Sunnyvale, CA 94089, USA
    Lancet Neurol 2:531-8. 2003
  2. ncbi request reprint Environmental factors in Parkinson's disease
    Donato A Di Monte
    The Parkinson s Institute, Sunnyvale, CA 94089 1605, USA
    Neurotoxicology 23:487-502. 2002
  3. pmc Microglial activation as a priming event leading to paraquat-induced dopaminergic cell degeneration
    Maya G Purisai
    The Parkinson s Institute, 1170 Morse Avenue, Sunnyvale, CA 94089, USA
    Neurobiol Dis 25:392-400. 2007
  4. ncbi request reprint Nicotine partially protects against paraquat-induced nigrostriatal damage in mice; link to alpha6beta2* nAChRs
    Mirium Khwaja
    The Parkinson s Institute, Sunnyvale, CA 94089, USA
    J Neurochem 100:180-90. 2007
  5. ncbi request reprint Alpha-synuclein expression in the substantia nigra of MPTP-lesioned non-human primates
    Maya G Purisai
    The Parkinson s Institute, 1170 Morse Avenue, Sunnyvale, California 94089, USA
    Neurobiol Dis 20:898-906. 2005
  6. ncbi request reprint Chronic oral nicotine treatment protects against striatal degeneration in MPTP-treated primates
    Maryka Quik
    The Parkinson s Institute, Sunnyvale, California, USA
    J Neurochem 98:1866-75. 2006
  7. ncbi request reprint Comparison of the neurotoxic effects of proteasomal inhibitors in primary mesencephalic cultures
    Stephen H Reaney
    The Parkinson s Institute, 1170 Morse Avenue, Sunnyvale, CA 94089, USA
    Exp Neurol 202:434-40. 2006
  8. pmc Lysosomal degradation of alpha-synuclein in vivo
    Sally K Mak
    The Parkinson s Institute, Sunnyvale, California 94085, USA
    J Biol Chem 285:13621-9. 2010
  9. pmc Paraquat exposure reduces nicotinic receptor-evoked dopamine release in monkey striatum
    Kathryn T O'Leary
    The Parkinson s Institute, 675 Almanor Ave, Sunnyvale, CA 94085 2934, USA
    J Pharmacol Exp Ther 327:124-9. 2008
  10. ncbi request reprint Cerebrospinal fluid 3,4-dihydroxyphenylacetic acid level after tolcapone administration as an indicator of nigrostriatal degeneration
    Christine Thiffault
    The Parkinson s Institute, 1170 Morse Avenue, Sunnyvale, CA 94089, USA
    Exp Neurol 183:173-9. 2003

Collaborators

Detail Information

Publications43

  1. ncbi request reprint The environment and Parkinson's disease: is the nigrostriatal system preferentially targeted by neurotoxins?
    Donato A Di Monte
    Parkinson s Institute, Sunnyvale, CA 94089, USA
    Lancet Neurol 2:531-8. 2003
    ..Similarities between clinical and experimental findings, such as the role of pesticide exposure as a potential environmental risk factor, highlight the importance of a multidisciplinary approach to the aetiology of PD...
  2. ncbi request reprint Environmental factors in Parkinson's disease
    Donato A Di Monte
    The Parkinson s Institute, Sunnyvale, CA 94089 1605, USA
    Neurotoxicology 23:487-502. 2002
    ..g. the protein alpha-synuclein); (iii) the tissue response to an initial toxic insult; and, last but not least, (iv) the effects of environmental factors on the background of genetic predisposition and aging...
  3. pmc Microglial activation as a priming event leading to paraquat-induced dopaminergic cell degeneration
    Maya G Purisai
    The Parkinson s Institute, 1170 Morse Avenue, Sunnyvale, CA 94089, USA
    Neurobiol Dis 25:392-400. 2007
    ..Data indicate that microglial activation and consequent induction of NADPH oxidase may act as risk factors for Parkinson's disease by increasing the vulnerability of dopaminergic cells to toxic injury...
  4. ncbi request reprint Nicotine partially protects against paraquat-induced nigrostriatal damage in mice; link to alpha6beta2* nAChRs
    Mirium Khwaja
    The Parkinson s Institute, Sunnyvale, CA 94089, USA
    J Neurochem 100:180-90. 2007
    ..Moreover, these data support epidemiological findings that environmental influences can elicit opposing effects on nigrostriatal dopaminergic integrity...
  5. ncbi request reprint Alpha-synuclein expression in the substantia nigra of MPTP-lesioned non-human primates
    Maya G Purisai
    The Parkinson s Institute, 1170 Morse Avenue, Sunnyvale, California 94089, USA
    Neurobiol Dis 20:898-906. 2005
    ..They support a direct relationship between neuronal injury and enhanced alpha-synuclein expression, and suggest that protein elevation within cell bodies may be a late feature of neurons that have endured a toxic stress...
  6. ncbi request reprint Chronic oral nicotine treatment protects against striatal degeneration in MPTP-treated primates
    Maryka Quik
    The Parkinson s Institute, Sunnyvale, California, USA
    J Neurochem 98:1866-75. 2006
    ..These data further support the possibility that nicotine contributes to the lower incidence of Parkinson's disease in smokers...
  7. ncbi request reprint Comparison of the neurotoxic effects of proteasomal inhibitors in primary mesencephalic cultures
    Stephen H Reaney
    The Parkinson s Institute, 1170 Morse Avenue, Sunnyvale, CA 94089, USA
    Exp Neurol 202:434-40. 2006
    ....
  8. pmc Lysosomal degradation of alpha-synuclein in vivo
    Sally K Mak
    The Parkinson s Institute, Sunnyvale, California 94085, USA
    J Biol Chem 285:13621-9. 2010
    ..It is conceivable that these neuronal mechanisms of protein clearance play an important role in neurodegenerative processes characterized by abnormal alpha-synuclein buildup...
  9. pmc Paraquat exposure reduces nicotinic receptor-evoked dopamine release in monkey striatum
    Kathryn T O'Leary
    The Parkinson s Institute, 675 Almanor Ave, Sunnyvale, CA 94085 2934, USA
    J Pharmacol Exp Ther 327:124-9. 2008
    ..The finding that paraquat treatment has a negative impact on striatal nAChR-mediated dopaminergic activity in monkeys but not mice indicates the need for determining the effects of pesticides in higher species...
  10. ncbi request reprint Cerebrospinal fluid 3,4-dihydroxyphenylacetic acid level after tolcapone administration as an indicator of nigrostriatal degeneration
    Christine Thiffault
    The Parkinson s Institute, 1170 Morse Avenue, Sunnyvale, CA 94089, USA
    Exp Neurol 183:173-9. 2003
    ..Thus, tolcapone administration enhances the detection of DOPAC in the CSF and, by doing so, improves the reliability of CSF DOPAC as a marker of nigrostriatal degeneration...
  11. doi request reprint Decreased alpha-synuclein expression in the aging mouse substantia nigra
    Sally K Mak
    The Parkinson s Institute, 675 Almanor Avenue, Sunnyvale, CA 94085, USA
    Exp Neurol 220:359-65. 2009
    ....
  12. ncbi request reprint Role of oxidative stress in paraquat-induced dopaminergic cell degeneration
    Alison L McCormack
    The Parkinson s Institute, Sunnyvale, CA 94089, USA
    J Neurochem 93:1030-7. 2005
    ..Thus, paraquat exposure yields a model that emphasizes the susceptibility of dopaminergic neurons to oxidative damage...
  13. ncbi request reprint Environmental risk factors and Parkinson's disease: selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquat
    Alison L McCormack
    The Parkinson s Institute, Sunnyvale, California 94089, USA
    Neurobiol Dis 10:119-27. 2002
    ....
  14. pmc The selective kappa-opioid receptor agonist U50,488 reduces L-dopa-induced dyskinesias but worsens parkinsonism in MPTP-treated primates
    Heather Cox
    The Parkinson s Institute, 1170 Morse Avenue, Sunnyvale, CA 94089, USA
    Exp Neurol 205:101-7. 2007
    ..These data suggest that kappa-opioid agonists such as U50,488 may not be clinically useful antidyskinetic agents because they also reverse the anti-parkinsonian effect of l-dopa...
  15. ncbi request reprint Lack of nigrostriatal pathology in a rat model of proteasome inhibition
    Amy B Manning-Bog
    Department of Basic Research, The Parkinson s Institute, Sunnyvale, CA, USA
    Ann Neurol 60:256-60. 2006
    ....
  16. ncbi request reprint Alpha-synuclein overexpression protects against paraquat-induced neurodegeneration
    Amy B Manning-Bog
    The Parkinson s Institute, Sunnyvale, California 94089 1605, USA
    J Neurosci 23:3095-9. 2003
    ....
  17. ncbi request reprint Toxicity of redox cycling pesticides in primary mesencephalic cultures
    Dafna Bonneh-Barkay
    The Parkinson s Institute, Sunnyvale, CA 94089, USA
    Antioxid Redox Signal 7:649-53. 2005
    ....
  18. ncbi request reprint Effects of L-dopa and other amino acids against paraquat-induced nigrostriatal degeneration
    Alison L McCormack
    The Parkinson s Institute, Sunnyvale, California 94089, USA
    J Neurochem 85:82-6. 2003
    ..g. amino acids) or therapeutic agents (e.g. l-dopa) may modify the effects of toxicants targeting the nigrostriatal system...
  19. doi request reprint Evidence of oxidative stress in young and aged DJ-1-deficient mice
    Arjun V Raman
    The Parkinson s Institute, Department of Basic Research, Sunnyvale, CA, USA
    FEBS Lett 587:1562-70. 2013
    ..These changes were concomitant with increased striatal dopamine levels and uptake. Thus, increased oxidants and diminished protein quality control may contribute to nigral oxidative damage with aging in the model...
  20. pmc Pathologic modifications of alpha-synuclein in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated squirrel monkeys
    Alison L McCormack
    The Parkinson s Institute, Sunnyvale, California 94085, USA
    J Neuropathol Exp Neurol 67:793-802. 2008
    ..The findings are also consistent with a pattern of evolution of alpha-synuclein pathology that may begin with the accumulation and aggregation of the protein within damaged axons...
  21. ncbi request reprint The Webcam system: a simple, automated, computer-based video system for quantitative measurement of movement in nonhuman primates
    Daniel M Togasaki
    The Parkinson s Institute, 1170 Morse Avenue, Sunnyvale, CA 94089, USA
    J Neurosci Methods 145:159-66. 2005
    ..These results indicate that the Webcam system is reliable under both untreated and experimental conditions and is an excellent method for quantifying motor activity in animals...
  22. ncbi request reprint Dyskinesias in normal squirrel monkeys induced by nomifensine and levodopa
    Daniel M Togasaki
    The Parkinson s Institute, 1170 Morse Avenue, Sunnyvale, CA 94089, USA
    Neuropharmacology 48:398-405. 2005
    ..Thus, this study suggests that diminished buffering capacity for dopamine could play a role in the development of dyskinesias, and that an endogenous mechanism might exist that ameliorates dyskinesias...
  23. ncbi request reprint Aging of the nigrostriatal system in the squirrel monkey
    Alison L McCormack
    The Parkinson s Institute, Sunnyvale, California 94089, USA
    J Comp Neurol 471:387-95. 2004
    ..NM content appears to be an important marker of these age-related effects...
  24. ncbi request reprint Enhanced alpha-synuclein expression in human neurodegenerative diseases: pathogenetic and therapeutic implications
    Alison L McCormack
    The Parkinson s Institute, Sunnyvale, California 94085, USA
    Curr Protein Pept Sci 10:476-82. 2009
    ..g. macroautophagy) involved in alpha-synuclein clearance, and (iii) the development of anti-aggregation agents counteracting the formation of toxic oligomeric or fibrillar forms of the protein...
  25. ncbi request reprint Redox cycling of the herbicide paraquat in microglial cultures
    Dafna Bonneh-Barkay
    The Parkinson s Institute, 1170 Morse Avenue, Sunnyvale, CA 94089 1605, USA
    Brain Res Mol Brain Res 134:52-6. 2005
    ..Microglial NOS and NADPH oxidase could promote the generation of ROS via the redox cycling of paraquat-like toxicants...
  26. ncbi request reprint Effect of the D3 dopamine receptor partial agonist BP897 [N-[4-(4-(2-methoxyphenyl)piperazinyl)butyl]-2-naphthamide] on L-3,4-dihydroxyphenylalanine-induced dyskinesias and parkinsonism in squirrel monkeys
    Albert Hsu
    The Parkinson s Institute, 1170 Morse Ave, Sunnyvale, CA 94089, USA
    J Pharmacol Exp Ther 311:770-7. 2004
    ..These results suggest that BP897 may be less effective than originally anticipated for treating LIDs in Parkinson's disease...
  27. ncbi request reprint The herbicide paraquat causes up-regulation and aggregation of alpha-synuclein in mice: paraquat and alpha-synuclein
    Amy B Manning-Bog
    Parkinson s Institute, Sunnyvale, California 94089, USA
    J Biol Chem 277:1641-4. 2002
    ....
  28. ncbi request reprint Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice
    Eric K Richfield
    Department of Pathology and Lab Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Exp Neurol 175:35-48. 2002
    ..Expression of hm2alpha-SYN adversely affects the integrity of dopaminergic terminals and leads to age-related declines in motor coordination and dopaminergic markers...
  29. ncbi request reprint Mechanistic approaches to Parkinson's disease pathogenesis
    Ranjita Betarbet
    Center for Neurodegenerative Disease and Department of Neurology, Emory University, Atlanta, GA 30322, USA
    Brain Pathol 12:499-510. 2002
    ..A better understanding of the mechanisms underlying PD should reveal novel therapeutic targets...
  30. ncbi request reprint Age-related irreversible progressive nigrostriatal dopaminergic neurotoxicity in the paraquat and maneb model of the Parkinson's disease phenotype
    Mona Thiruchelvam
    Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Eur J Neurosci 18:589-600. 2003
    ..Collectively, these data demonstrate enhanced sensitivity of the ageing nigrostriatal dopamine pathway to these pesticides, particularly paraquat + maneb, resulting in irreversible and progressive neurotoxicity...
  31. pmc MAO-B elevation in mouse brain astrocytes results in Parkinson's pathology
    Jyothi K Mallajosyula
    Buck Institute for Age Research, Novato, California, USA
    PLoS ONE 3:e1616. 2008
    ..Our inducible astrocytic MAO-B transgenic provides a novel model for exploring pathways involved in initiation and progression of several key features associated with PD pathology and for therapeutic drug testing...
  32. ncbi request reprint Paraquat neurotoxicity is mediated by a Bak-dependent mechanism
    Qingyan Fei
    Division of Biomedical Sciences, University of California, Riverside, California 92521, USA
    J Biol Chem 283:3357-64. 2008
    ..Finally, we tested the sensitivity of Bak-deficient mice and found them to be resistant to PQ treatments that depleted tyrosine hydroxylase immuno-positive neurons in the substantia nigra pars compacta of wild-type mice...
  33. ncbi request reprint Reduced vesicular storage of dopamine causes progressive nigrostriatal neurodegeneration
    W Michael Caudle
    Center for Neurodegenerative Disease, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci 27:8138-48. 2007
    ..In addition, the altered dopamine homeostasis resulting from reduced VMAT2 function may be conducive to pathogenic mechanisms induced by genetic or environmental factors thought to be involved in Parkinson's disease...
  34. ncbi request reprint L-DOPA does not cause neurotoxicity in VMAT2 heterozygote knockout mice
    Maria E Reveron
    Neurotoxicology 23:611-9. 2002
    ..These data indicate that in an animal model that displays increased susceptibility to dopaminergic injury, a subchronic administration of L-DOPA does not induce toxicity...
  35. ncbi request reprint Nigrostriatal dopaminergic neurodegeneration in the weaver mouse is mediated via neuroinflammation and alleviated by minocycline administration
    Jun Peng
    Buck Institute for Age Research, Novato, California 94945, USA
    J Neurosci 26:11644-51. 2006
    ..This has novel implications for the use of the weaver mouse as a model for Parkinson's disease, which has been associated with increased neuroinflammation...
  36. ncbi request reprint Increased murine neonatal iron intake results in Parkinson-like neurodegeneration with age
    Deepinder Kaur
    Buck Institute for Age Research, Novato, CA 94945, USA
    Neurobiol Aging 28:907-13. 2007
    ..This may have major implications for the impact of neonatal iron intake as a potential risk factor for later development of Parkinson's disease (PD)...
  37. ncbi request reprint Dopamine and L-dopa disaggregate amyloid fibrils: implications for Parkinson's and Alzheimer's disease
    Jie Li
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA
    FASEB J 18:962-4. 2004
    ..g., the relationship between fibril formation and neurodegeneration) of protein aggregation. It is also likely to help in the development of strategies for the prevention and treatment of protein deposition diseases...
  38. pmc Dieldrin exposure induces oxidative damage in the mouse nigrostriatal dopamine system
    Jaime M Hatcher
    Center for Neurodegenerative Disease, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
    Exp Neurol 204:619-30. 2007
    ..These effects represent the ability of low doses of dieldrin to increase the vulnerability of nigrostriatal dopamine neurons by inducing oxidative stress and suggest that pesticide exposure may act as a promoter of PD...
  39. ncbi request reprint Nuclear localization of alpha-synuclein and its interaction with histones
    John Goers
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA
    Biochemistry 42:8465-71. 2003
    ..e., injections of the herbicide paraquat). These observations indicate that translocation into the nucleus and binding with histones represent potential mechanisms underlying alpha-synuclein pathophysiology...
  40. ncbi request reprint Effect of 4-hydroxy-2-nonenal modification on alpha-synuclein aggregation
    Zhijie Qin
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA
    J Biol Chem 282:5862-70. 2007
    ..Our observations indicate that HNE modification of alpha-synuclein prevents fibrillation but may result in toxic oligomers, which could therefore contribute to the demise of neurons subjected to oxidative damage...
  41. ncbi request reprint Letter regarding: "Paraquat: the red herring of Parkinson's disease research"
    Deborah A Cory-Slechta
    Toxicol Sci 103:215-6; author reply 217-8. 2008
  42. ncbi request reprint The etiopathogenesis of Parkinson disease and suggestions for future research. Part I
    Irene Litvan
    University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    J Neuropathol Exp Neurol 66:251-7. 2007
  43. ncbi request reprint The etiopathogenesis of Parkinson disease and suggestions for future research. Part II
    Irene Litvan
    University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    J Neuropathol Exp Neurol 66:329-36. 2007
    ..Topics reviewed in Part II are genetics, animal models, and oxidative stress...