Research Topics
| Phyllis DennerySummaryAffiliation: The Children's Hospital of Philadelphia Country: USA Publications
Research Grants
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Detail Information
Publications
Pharmacological interventions for the treatment of neonatal jaundicePhyllis A Dennery
Department of Neonatal and Developmental Medicine, Stanford University, 750 Welch Road, Suite315, Palo Alto, CA 94304, USA
Semin Neonatol 7:111-9. 2002..The safety and efficacy of these therapies will need to be confirmed prior to widespread use...
Oxidative stress in development: nature or nurture?Phyllis A Dennery
Department of Pediatrics, University of Pennsylvania School of Medicine, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Free Radic Biol Med 49:1147-51. 2010..This article reviews the role of redox in fetal development and will focus on how developmental programming is influenced by the fetal and placental redox state as well as discuss potential therapeutic interventions...
Disrupted postnatal lung development in heme oxygenase-1 deficient miceTiangang Zhuang
Division of Neonatology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Respir Res 11:142. 2010..We hypothesized that HO-1 is required for mouse postnatal lung alveolar development and that vascular expression of HO-1 is essential and protective during postnatal alveolar development...- Metalloporphyrins for the treatment of neonatal jaundicePhyllis A Dennery
Department of Pediatrics, University of Pennsylvania School of Medicine, and Children s Hospital of Philadelphia, Division of Neonatology, Philadelphia, Pennsylvania 19104, USA
Curr Opin Pediatr 17:167-9. 2005..To evaluate the safety and efficacy of metalloporphyrins for the treatment of neonatal hyperbilirubinemia... - Training and retaining of underrepresented minority physician scientists - an African-American perspective: NICHD AAP workshop on research in neonatal and perinatal medicineP A Dennery
Division of Neonatology, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, USA
J Perinatol 26:S46-8. 2006 - Role of redox in fetal development and neonatal diseasesPhyllis A Dennery
Department of Pediatrics, University of Pennsylvania, Division of Neonatology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Antioxid Redox Signal 6:147-53. 2004..Nonetheless, sufficient evidence suggests a role for redox throughout embryonic, fetal, and postnatal development. This evidence will be explored here... - Effects of oxidative stress on embryonic developmentPhyllis A Dennery
Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Birth Defects Res C Embryo Today 81:155-62. 2007..A better understanding of ROS-mediated reactions and their impact on embryonic development is important to ensure optimal outcomes... - Introduction to serial review on the role of oxidative stress in diabetes mellitusPhyllis A Dennery
Division of Neonatology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Free Radic Biol Med 40:1-2. 2006 - Introduction to serial review on heme oxygenase in human diseasePhyllis A Dennery
Department of Pediatrics, University of Pennsylvania School of Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA
Free Radic Biol Med 37:1095-6. 2004 - Oxygen administration in the care of neonates: a double-edged swordPhyllis A Dennery
University of Pennsylvania School of Medicine, Children s Hospital of Philadelphia, Philadelphia, PA 19072, USA
Chin Med J (Engl) 123:2938-42. 2010..To evaluate the use of oxygen in neonates in the past, present and future... - Catalytic inactive heme oxygenase-1 protein regulates its own expression in oxidative stressQing S Lin
Children s Hospital of Philadelphia, University of Pennsylvania, 34th and Civic Center Boulevard, Philadelphia, PA 19104, USA
Free Radic Biol Med 44:847-55. 2008..We speculate that this mechanism may be useful for maintaining HO-1 expression when substrate is limited and may also serve to up-regulate other genes to promote cytoprotection and to modulate cell proliferation... - Silencing hyperoxia-induced C/EBPα in neonatal mice improves lung architecture via enhanced proliferation of alveolar epithelial cellsGuang Yang
Division of Neonatology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Am J Physiol Lung Cell Mol Physiol 301:L187-96. 2011..These data suggest that C/EBPα is an important regulator of postnatal alveolar epithelial cell proliferation and differentiation during injury and repair... - Apigenin decreases hemin-mediated heme oxygenase-1 inductionAida Abate
Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA
Free Radic Biol Med 39:711-8. 2005..These results suggest that hemin-induced HO-1 expression can be attenuated by flavonoids, such as APG... - Bach1 modulates heme oxygenase-1 expression in the neonatal mouse lungSacha Kassovska-Bratinova
Division of Neonatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Pediatr Res 65:145-9. 2009..These data suggest that elevated levels of Bach1 may help to limit HO-1 induction in the newborn at baseline and in response to oxidative stress... - Heme oxygenase-1 protein localizes to the nucleus and activates transcription factors important in oxidative stressQing Lin
Children s Hospital of Philadelphia and Department of Pediatrics, University of Pennsylvania, Philadelphia, PA 19104, USA
J Biol Chem 282:20621-33. 2007..We speculate that nuclear localization of HO-1 protein may serve to up-regulate genes that promote cytoprotection against oxidative stress... - Inhaled NO and markers of oxidant injury in infants with respiratory failureKrisa P Van Meurs
Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA 94304, USA
J Perinatol 25:463-9. 2005..CONCLUSIONS: In term infants with respiratory failure, prolonged iNO exposure is associated with a transient increase in markers of oxidative stress, but this finding does not appear to predict the development of CLD... - Interaction between heme oxygenase-1 and -2 proteinsYi Hao Weng
Department of Pediatrics, Stanford University, Stanford, California 94304, USA
J Biol Chem 278:50999-1005. 2003..We speculate that this HO-1.HO-2 protein interaction may promote non-enzymatic functions of HO... - Heme oxygenase-1 modulates fetal growth in the ratDoron Kreiser
Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94304, USA
Lab Invest 82:687-92. 2002..These observations demonstrate that HO-1 modulates fetal growth by its effects on placental growth factors... - Effect of glutathione on lung activator protein-1 activation and heme oxygenase-1 induction in the immature ratGuang Yang
Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94304, USA
Pediatr Res 52:34-9. 2002..Changes in lung GSSG/GSH ratio did not alter AP-1 binding but did increase HO-1 mRNA in neonates. These data suggest that the neonatal lung is relatively resistant to AP-1 activation and HO-1 induction by GSH perturbation... - Treatment with a catalytic antioxidant corrects the neurobehavioral defect in ataxia-telangiectasia miceSusan E Browne
Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY, USA
Free Radic Biol Med 36:938-42. 2004..We show that treatment with a catalytic antioxidant corrects the neurobehavioral deficit in these mice... - Developmental expression of heme oxygenase in the rat lungPhyllis A Dennery
Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94305, U S A
Pediatr Res 53:42-7. 2003..In response to hyperoxia, HO-1 mRNA was induced only in the adult lungs. A better understanding of the maturational regulation of lung HO will define a role for HO in newborns at risk for oxygen toxicity... - Endothelial protection by pentaerithrityl trinitrate: bilirubin and carbon monoxide as possible mediatorsStefanie Oberle
Department of Pharmacology and Toxicology, School of Pharmacy, Martin Luther University, 06120 Halle (Saale, Germany
Exp Biol Med (Maywood) 228:529-34. 2003..Increased HO-1 expression and ensuing formation of bilirubin and carbon monoxide may contribute to and explain the specific antioxidant and antiatherogenic actions of PETN... - trans-Arachidonic acids induce a heme oxygenase-dependent vasorelaxation of cerebral microvasculatureAmna Kooli
Department of Paediatrics, Research Center of Hôpital Ste Justine, Montreal, Quebec, Canada
Free Radic Biol Med 44:815-25. 2008..Our findings provide new insights into the characterization of nitrative stress-derived TAA products, by showing they can act as acute mediators of nitrative stress on neurovascular tone... - Gestational pattern of heme oxygenase expression in the ratDoron Kreiser
Department of Pediatrics, Stanford University School of Medicine, 750 Welch Rd, 315, Palo Alto, CA 94304, U S A
Pediatr Res 54:172-8. 2003..We conclude that there is a clear uterine and placental gestational pattern of HO expression in the rat. This pattern is comparable to that of vascular endothelial growth factor and leptin... - Neonatal blue-light phototherapy could increase the risk of dysplastic nevus developmentPhyllis A Dennery
Pediatrics 120:247-8. 2007 - Effect of iron overload and dietary fat on indices of oxidative stress and hepatic fibrogenesis in ratsKyle E Brown
Gastroenterology Section, John Cochran VAMC, St Louis, MO, USA
Liver Int 23:232-42. 2003..The aim of this study was to determine the effects of dietary fat of varying PUFA content on iron-induced oxidative stress and fibrosis... - Heme oxygenase-1 induction may explain the antioxidant profile of aspirinNina Grosser
Department of Pharmacology and Toxicology, School of Pharmacy, Martin Luther University, Wolfgang Langenbeck Str 4, Halle Saale 06099, Germany
Biochem Biophys Res Commun 308:956-60. 2003..Induction of HO-1 expression and activity may be a novel mechanism by which aspirin prevents cellular injury under inflammatory conditions and in cardiovascular disease... - Heme oxygenase-2 deficiency contributes to diabetes-mediated increase in superoxide anion and renal dysfunctionAlvin I Goodman
New York Medical College, Department of Pharmacology, Grassland Road, Valhalla, NY 10595, USA
J Am Soc Nephrol 17:1073-81. 2006..These observations indicate that HO activity is essential in preserving renal function and morphology in STZ-induced diabetic mice probably via mitigation of concomitant oxidative stress... - Heme oxygenase-1 induction may explain the antioxidant profile of pentaerythrityl trinitrateStefanie Oberle
Department of Pharmacology and Toxicology, School of Pharmacy, Martin Luther University Halle Wittenberg, Wolfgang Langenbeck Strasse 4, Halle Saale 06099, Germany
Biochem Biophys Res Commun 290:1539-44. 2002..Increased HO-1 expression and ensuing formation of cytoprotective bilirubin may contribute to and explain the specific antioxidant and antiatherogenic actions of PETN...
Research Grants
- Mechanisms that Regulate Neonatal Lung Heme Oxygenase in HyperoxiaPhyllis A Dennery; Fiscal Year: 2010....
- Role of Heme Oxygenase in Neonatal Hyperoxic InjuryPhyllis Dennery; Fiscal Year: 2007..A better understanding of the mechanism by which HO mediates its actions may help dictate therapeutic strategies to enhance or suppress HO effects. ..
- Zinc Protoporphyrin and the Cell Cycle in Neonatal MicePhyllis Dennery; Fiscal Year: 2007..This may also lead to therapeutic strategies to modify ZnPP so as to prevent abnormal proliferation in cells. ..
- HEME OXYGENASE AND NEONATAL HYPEROXIC INJURYPhyllis Dennery; Fiscal Year: 2002..A better understanding of the role of lung HO in the neonate will allow us to identify strategies to enhance this endogenous neonatal antioxidant defense. ..