Phyllis Dennery

Summary

Affiliation: The Children's Hospital of Philadelphia
Country: USA

Publications

  1. ncbi request reprint Pharmacological interventions for the treatment of neonatal jaundice
    Phyllis A Dennery
    Department of Neonatal and Developmental Medicine, Stanford University, 750 Welch Road, Suite315, Palo Alto, CA 94304, USA
    Semin Neonatol 7:111-9. 2002
  2. doi request reprint Oxidative stress in development: nature or nurture?
    Phyllis A Dennery
    Department of Pediatrics, University of Pennsylvania School of Medicine, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Free Radic Biol Med 49:1147-51. 2010
  3. ncbi request reprint Oxygen administration in the care of neonates: a double-edged sword
    Phyllis A Dennery
    University of Pennsylvania School of Medicine, Children s Hospital of Philadelphia, Philadelphia, PA 19072, USA
    Chin Med J (Engl) 123:2938-42. 2010
  4. pmc Disrupted postnatal lung development in heme oxygenase-1 deficient mice
    Tiangang Zhuang
    Division of Neonatology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Respir Res 11:142. 2010
  5. ncbi request reprint Metalloporphyrins for the treatment of neonatal jaundice
    Phyllis A Dennery
    Department of Pediatrics, University of Pennsylvania School of Medicine, and Children s Hospital of Philadelphia, Division of Neonatology, Philadelphia, Pennsylvania 19104, USA
    Curr Opin Pediatr 17:167-9. 2005
  6. ncbi request reprint Training and retaining of underrepresented minority physician scientists - an African-American perspective: NICHD AAP workshop on research in neonatal and perinatal medicine
    P A Dennery
    Division of Neonatology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, USA
    J Perinatol 26:S46-8. 2006
  7. ncbi request reprint Role of redox in fetal development and neonatal diseases
    Phyllis A Dennery
    Department of Pediatrics, University of Pennsylvania, Division of Neonatology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Antioxid Redox Signal 6:147-53. 2004
  8. ncbi request reprint Effects of oxidative stress on embryonic development
    Phyllis A Dennery
    Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Birth Defects Res C Embryo Today 81:155-62. 2007
  9. ncbi request reprint Introduction to serial review on the role of oxidative stress in diabetes mellitus
    Phyllis A Dennery
    Division of Neonatology, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Free Radic Biol Med 40:1-2. 2006
  10. ncbi request reprint Introduction to serial review on heme oxygenase in human disease
    Phyllis A Dennery
    Department of Pediatrics, University of Pennsylvania School of Medicine, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Free Radic Biol Med 37:1095-6. 2004

Research Grants

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Pharmacological interventions for the treatment of neonatal jaundice
    Phyllis A Dennery
    Department of Neonatal and Developmental Medicine, Stanford University, 750 Welch Road, Suite315, Palo Alto, CA 94304, USA
    Semin Neonatol 7:111-9. 2002
    ..The safety and efficacy of these therapies will need to be confirmed prior to widespread use...
  2. doi request reprint Oxidative stress in development: nature or nurture?
    Phyllis A Dennery
    Department of Pediatrics, University of Pennsylvania School of Medicine, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Free Radic Biol Med 49:1147-51. 2010
    ..This article reviews the role of redox in fetal development and will focus on how developmental programming is influenced by the fetal and placental redox state as well as discuss potential therapeutic interventions...
  3. ncbi request reprint Oxygen administration in the care of neonates: a double-edged sword
    Phyllis A Dennery
    University of Pennsylvania School of Medicine, Children s Hospital of Philadelphia, Philadelphia, PA 19072, USA
    Chin Med J (Engl) 123:2938-42. 2010
    ..To evaluate the use of oxygen in neonates in the past, present and future...
  4. pmc Disrupted postnatal lung development in heme oxygenase-1 deficient mice
    Tiangang Zhuang
    Division of Neonatology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Respir Res 11:142. 2010
    ..We hypothesized that HO-1 is required for mouse postnatal lung alveolar development and that vascular expression of HO-1 is essential and protective during postnatal alveolar development...
  5. ncbi request reprint Metalloporphyrins for the treatment of neonatal jaundice
    Phyllis A Dennery
    Department of Pediatrics, University of Pennsylvania School of Medicine, and Children s Hospital of Philadelphia, Division of Neonatology, Philadelphia, Pennsylvania 19104, USA
    Curr Opin Pediatr 17:167-9. 2005
    ..To evaluate the safety and efficacy of metalloporphyrins for the treatment of neonatal hyperbilirubinemia...
  6. ncbi request reprint Training and retaining of underrepresented minority physician scientists - an African-American perspective: NICHD AAP workshop on research in neonatal and perinatal medicine
    P A Dennery
    Division of Neonatology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, USA
    J Perinatol 26:S46-8. 2006
  7. ncbi request reprint Role of redox in fetal development and neonatal diseases
    Phyllis A Dennery
    Department of Pediatrics, University of Pennsylvania, Division of Neonatology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Antioxid Redox Signal 6:147-53. 2004
    ..Nonetheless, sufficient evidence suggests a role for redox throughout embryonic, fetal, and postnatal development. This evidence will be explored here...
  8. ncbi request reprint Effects of oxidative stress on embryonic development
    Phyllis A Dennery
    Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Birth Defects Res C Embryo Today 81:155-62. 2007
    ..A better understanding of ROS-mediated reactions and their impact on embryonic development is important to ensure optimal outcomes...
  9. ncbi request reprint Introduction to serial review on the role of oxidative stress in diabetes mellitus
    Phyllis A Dennery
    Division of Neonatology, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Free Radic Biol Med 40:1-2. 2006
  10. ncbi request reprint Introduction to serial review on heme oxygenase in human disease
    Phyllis A Dennery
    Department of Pediatrics, University of Pennsylvania School of Medicine, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Free Radic Biol Med 37:1095-6. 2004
  11. ncbi request reprint Catalytic inactive heme oxygenase-1 protein regulates its own expression in oxidative stress
    Qing S Lin
    Children s Hospital of Philadelphia, University of Pennsylvania, 34th and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Free Radic Biol Med 44:847-55. 2008
    ..We speculate that this mechanism may be useful for maintaining HO-1 expression when substrate is limited and may also serve to up-regulate other genes to promote cytoprotection and to modulate cell proliferation...
  12. pmc Silencing hyperoxia-induced C/EBPα in neonatal mice improves lung architecture via enhanced proliferation of alveolar epithelial cells
    Guang Yang
    Division of Neonatology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Am J Physiol Lung Cell Mol Physiol 301:L187-96. 2011
    ..These data suggest that C/EBPα is an important regulator of postnatal alveolar epithelial cell proliferation and differentiation during injury and repair...
  13. ncbi request reprint Apigenin decreases hemin-mediated heme oxygenase-1 induction
    Aida Abate
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA
    Free Radic Biol Med 39:711-8. 2005
    ..These results suggest that hemin-induced HO-1 expression can be attenuated by flavonoids, such as APG...
  14. pmc Bach1 modulates heme oxygenase-1 expression in the neonatal mouse lung
    Sacha Kassovska-Bratinova
    Division of Neonatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Pediatr Res 65:145-9. 2009
    ..These data suggest that elevated levels of Bach1 may help to limit HO-1 induction in the newborn at baseline and in response to oxidative stress...
  15. ncbi request reprint Heme oxygenase-1 protein localizes to the nucleus and activates transcription factors important in oxidative stress
    Qing Lin
    Children s Hospital of Philadelphia and Department of Pediatrics, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Biol Chem 282:20621-33. 2007
    ..We speculate that nuclear localization of HO-1 protein may serve to up-regulate genes that promote cytoprotection against oxidative stress...
  16. ncbi request reprint Inhaled NO and markers of oxidant injury in infants with respiratory failure
    Krisa P Van Meurs
    Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    J Perinatol 25:463-9. 2005
    ..Inhaled nitric oxide (iNO) is an effective adjunct in the treatment of infants with respiratory failure. Although there are clear benefits to this therapy, potential toxicity could result from reactive nitrosylated species...
  17. ncbi request reprint Interaction between heme oxygenase-1 and -2 proteins
    Yi Hao Weng
    Department of Pediatrics, Stanford University, Stanford, California 94304, USA
    J Biol Chem 278:50999-1005. 2003
    ..We speculate that this HO-1.HO-2 protein interaction may promote non-enzymatic functions of HO...
  18. ncbi request reprint Heme oxygenase-1 modulates fetal growth in the rat
    Doron Kreiser
    Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94304, USA
    Lab Invest 82:687-92. 2002
    ..These observations demonstrate that HO-1 modulates fetal growth by its effects on placental growth factors...
  19. ncbi request reprint Effect of glutathione on lung activator protein-1 activation and heme oxygenase-1 induction in the immature rat
    Guang Yang
    Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94304, USA
    Pediatr Res 52:34-9. 2002
    ..Changes in lung GSSG/GSH ratio did not alter AP-1 binding but did increase HO-1 mRNA in neonates. These data suggest that the neonatal lung is relatively resistant to AP-1 activation and HO-1 induction by GSH perturbation...
  20. ncbi request reprint Treatment with a catalytic antioxidant corrects the neurobehavioral defect in ataxia-telangiectasia mice
    Susan E Browne
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY, USA
    Free Radic Biol Med 36:938-42. 2004
    ..We show that treatment with a catalytic antioxidant corrects the neurobehavioral deficit in these mice...
  21. ncbi request reprint Developmental expression of heme oxygenase in the rat lung
    Phyllis A Dennery
    Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94305, U S A
    Pediatr Res 53:42-7. 2003
    ..In response to hyperoxia, HO-1 mRNA was induced only in the adult lungs. A better understanding of the maturational regulation of lung HO will define a role for HO in newborns at risk for oxygen toxicity...
  22. ncbi request reprint Endothelial protection by pentaerithrityl trinitrate: bilirubin and carbon monoxide as possible mediators
    Stefanie Oberle
    Department of Pharmacology and Toxicology, School of Pharmacy, Martin Luther University, 06120 Halle Saale, Germany
    Exp Biol Med (Maywood) 228:529-34. 2003
    ..Increased HO-1 expression and ensuing formation of bilirubin and carbon monoxide may contribute to and explain the specific antioxidant and antiatherogenic actions of PETN...
  23. ncbi request reprint trans-Arachidonic acids induce a heme oxygenase-dependent vasorelaxation of cerebral microvasculature
    Amna Kooli
    Department of Paediatrics, Research Center of Hôpital Ste Justine, Montreal, Quebec, Canada
    Free Radic Biol Med 44:815-25. 2008
    ..Our findings provide new insights into the characterization of nitrative stress-derived TAA products, by showing they can act as acute mediators of nitrative stress on neurovascular tone...
  24. ncbi request reprint Gestational pattern of heme oxygenase expression in the rat
    Doron Kreiser
    Department of Pediatrics, Stanford University School of Medicine, 750 Welch Rd, 315, Palo Alto, CA 94304, U S A
    Pediatr Res 54:172-8. 2003
    ..We conclude that there is a clear uterine and placental gestational pattern of HO expression in the rat. This pattern is comparable to that of vascular endothelial growth factor and leptin...
  25. ncbi request reprint Neonatal blue-light phototherapy could increase the risk of dysplastic nevus development
    Phyllis A Dennery
    Pediatrics 120:247-8. 2007
  26. ncbi request reprint Effect of iron overload and dietary fat on indices of oxidative stress and hepatic fibrogenesis in rats
    Kyle E Brown
    Gastroenterology Section, John Cochran VAMC, St Louis, MO, USA
    Liver Int 23:232-42. 2003
    ..The aim of this study was to determine the effects of dietary fat of varying PUFA content on iron-induced oxidative stress and fibrosis...
  27. ncbi request reprint Heme oxygenase-1 induction may explain the antioxidant profile of aspirin
    Nina Grosser
    Department of Pharmacology and Toxicology, School of Pharmacy, Martin Luther University, Wolfgang Langenbeck Str 4, Halle Saale 06099, Germany
    Biochem Biophys Res Commun 308:956-60. 2003
    ..Induction of HO-1 expression and activity may be a novel mechanism by which aspirin prevents cellular injury under inflammatory conditions and in cardiovascular disease...
  28. ncbi request reprint Heme oxygenase-2 deficiency contributes to diabetes-mediated increase in superoxide anion and renal dysfunction
    Alvin I Goodman
    New York Medical College, Department of Pharmacology, Grassland Road, Valhalla, NY 10595, USA
    J Am Soc Nephrol 17:1073-81. 2006
    ..These observations indicate that HO activity is essential in preserving renal function and morphology in STZ-induced diabetic mice probably via mitigation of concomitant oxidative stress...
  29. ncbi request reprint Heme oxygenase-1 induction may explain the antioxidant profile of pentaerythrityl trinitrate
    Stefanie Oberle
    Department of Pharmacology and Toxicology, School of Pharmacy, Martin Luther University Halle Wittenberg, Wolfgang Langenbeck Strasse 4, Halle Saale 06099, Germany
    Biochem Biophys Res Commun 290:1539-44. 2002
    ..Increased HO-1 expression and ensuing formation of cytoprotective bilirubin may contribute to and explain the specific antioxidant and antiatherogenic actions of PETN...

Research Grants17

  1. Mechanisms that Regulate Neonatal Lung Heme Oxygenase in Hyperoxia
    Phyllis A Dennery; Fiscal Year: 2010
    ....
  2. Role of Heme Oxygenase in Neonatal Hyperoxic Injury
    Phyllis Dennery; Fiscal Year: 2007
    ..A better understanding of the mechanism by which HO mediates its actions may help dictate therapeutic strategies to enhance or suppress HO effects. ..
  3. Zinc Protoporphyrin and the Cell Cycle in Neonatal Mice
    Phyllis Dennery; Fiscal Year: 2007
    ..This may also lead to therapeutic strategies to modify ZnPP so as to prevent abnormal proliferation in cells. ..
  4. HEME OXYGENASE AND NEONATAL HYPEROXIC INJURY
    Phyllis Dennery; Fiscal Year: 2002
    ..A better understanding of the role of lung HO in the neonate will allow us to identify strategies to enhance this endogenous neonatal antioxidant defense. ..