Wendy Demark-Wahnefried

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. pmc Lifestyle intervention development study to improve physical function in older adults with cancer: outcomes from Project LEAD
    Wendy Demark-Wahnefried
    School of Nursing, Department of Surgery, Older Americans Independence Center, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Oncol 24:3465-73. 2006
  2. ncbi request reprint Main outcomes of the FRESH START trial: a sequentially tailored, diet and exercise mailed print intervention among breast and prostate cancer survivors
    Wendy Demark-Wahnefried
    Duke School of Nursing, Duke Comprehensive Cancer Center, and Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Oncol 25:2709-18. 2007
  3. pmc Flaxseed supplementation (not dietary fat restriction) reduces prostate cancer proliferation rates in men presurgery
    Wendy Demark-Wahnefried
    Division of Cancer Prevention and Population Sciences, The University of Texas M D Anderson Cancer Center, P O Box 301439, Unit 1330, Houston, TX 77230 1439, USA
    Cancer Epidemiol Biomarkers Prev 17:3577-87. 2008
  4. pmc Folic acid supplementation before and during pregnancy in the Newborn Epigenetics STudy (NEST)
    Cathrine Hoyo
    Department of Community and Family Medicine and Program of Cancer Detection, Prevention and Control, Duke University, PO Box 104006, Durham, NC 27710, USA
    BMC Public Health 11:46. 2011
  5. pmc Promoting healthy lifestyles in older cancer survivors to improve health and preserve function
    Wendy Demark-Wahnefried
    University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    J Am Geriatr Soc 57:S262-4. 2009
  6. doi request reprint Results of a diet/exercise feasibility trial to prevent adverse body composition change in breast cancer patients on adjuvant chemotherapy
    Wendy Demark-Wahnefried
    Department of Behavioral Sciences, University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    Clin Breast Cancer 8:70-9. 2008
  7. pmc Overcoming challenges in designing and implementing a phase II randomized controlled trial using a presurgical model to test a dietary intervention in prostate cancer
    Wendy Demark-Wahnefried
    Division of Cancer Prevention and Control Department of Behavioral Science, MD Anderson Cancer Center, Houston, TX, USA
    Clin Trials 5:262-72. 2008
  8. pmc Dietary interventions in prostate cancer
    Wendy Demark-Wahnefried
    Division of Cancer Prevention and Population Sciences, MD Anderson Cancer Center, University of Texas, 1155 Pressler Street, CPB 3 3245, Houston, TX 77030, USA
    Curr Urol Rep 9:217-25. 2008
  9. pmc Long-term physical activity outcomes of home-based lifestyle interventions among breast and prostate cancer survivors
    Allison J Ottenbacher
    University of Texas Memorial Hermann, Center for Healthcare Quality and Safety, Houston, TX, USA
    Support Care Cancer 20:2483-9. 2012
  10. pmc Extant health behaviors and uptake of standardized vs tailored health messages among cancer survivors enrolled in the FRESH START trial: a comparison of fighting-spirits vs fatalists
    Anna V Wilkinson
    Division of Epidemiology, Human Genetics and Environmental Science, University of Texas School of Public Health, Austin Regional Campus, Austin, TX, USA
    Psychooncology 21:108-13. 2012

Research Grants

  1. PROMOTING HEALTH IN PROSTATE & BREAST CANCER
    Wendy Demark Wahnefried; Fiscal Year: 2005
  2. Prostate Cancer: Impact of Fat & Flaxseed Modified Diet
    Wendy Demark Wahnefried; Fiscal Year: 2005
  3. PROMOTING HEALTH IN PROSTATE & BREAST CANCER
    Wendy Demark Wahnefried; Fiscal Year: 2004
  4. RENEW Research-out to Enhance Wellness Older Survivors
    Wendy Demark Wahnefried; Fiscal Year: 2007

Collaborators

Detail Information

Publications46

  1. pmc Lifestyle intervention development study to improve physical function in older adults with cancer: outcomes from Project LEAD
    Wendy Demark-Wahnefried
    School of Nursing, Department of Surgery, Older Americans Independence Center, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Oncol 24:3465-73. 2006
    ..Declines in physical functioning (PF) among elderly cancer patients threaten quality of life and the ability to maintain independence. Adherence to healthy lifestyle behaviors may prevent functional decline...
  2. ncbi request reprint Main outcomes of the FRESH START trial: a sequentially tailored, diet and exercise mailed print intervention among breast and prostate cancer survivors
    Wendy Demark-Wahnefried
    Duke School of Nursing, Duke Comprehensive Cancer Center, and Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Oncol 25:2709-18. 2007
    ..The FRESH START trial tested the efficacy of sequentially tailored versus standardized mailed materials on improving cancer survivors' diet and exercise behaviors...
  3. pmc Flaxseed supplementation (not dietary fat restriction) reduces prostate cancer proliferation rates in men presurgery
    Wendy Demark-Wahnefried
    Division of Cancer Prevention and Population Sciences, The University of Texas M D Anderson Cancer Center, P O Box 301439, Unit 1330, Houston, TX 77230 1439, USA
    Cancer Epidemiol Biomarkers Prev 17:3577-87. 2008
    ..Dietary factors are postulated to influence the development and progression of prostate cancer. Low-fat diets and flaxseed supplementation may offer potentially protective strategies...
  4. pmc Folic acid supplementation before and during pregnancy in the Newborn Epigenetics STudy (NEST)
    Cathrine Hoyo
    Department of Community and Family Medicine and Program of Cancer Detection, Prevention and Control, Duke University, PO Box 104006, Durham, NC 27710, USA
    BMC Public Health 11:46. 2011
    ..The primary objective is to estimate the proportion of women taking folic acid (FA) doses exceeding the TUL before and during pregnancy, and to identify correlates of high FA use...
  5. pmc Promoting healthy lifestyles in older cancer survivors to improve health and preserve function
    Wendy Demark-Wahnefried
    University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    J Am Geriatr Soc 57:S262-4. 2009
    ..Larger trials, such as Reach-out to ENhancE Wellness in Older Survivors, have recently produced compelling data...
  6. doi request reprint Results of a diet/exercise feasibility trial to prevent adverse body composition change in breast cancer patients on adjuvant chemotherapy
    Wendy Demark-Wahnefried
    Department of Behavioral Sciences, University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    Clin Breast Cancer 8:70-9. 2008
    ..Exercise interventions can prevent these changes, but time and travel pose barriers to participation. The Survivor Training for Enhancing Total Health (STRENGTH) trial assessed the feasibility and impact of 2 home-based interventions...
  7. pmc Overcoming challenges in designing and implementing a phase II randomized controlled trial using a presurgical model to test a dietary intervention in prostate cancer
    Wendy Demark-Wahnefried
    Division of Cancer Prevention and Control Department of Behavioral Science, MD Anderson Cancer Center, Houston, TX, USA
    Clin Trials 5:262-72. 2008
    ..Despite the many strengths of presurgical models, there are practical issues and challenges that arise when using this approach...
  8. pmc Dietary interventions in prostate cancer
    Wendy Demark-Wahnefried
    Division of Cancer Prevention and Population Sciences, MD Anderson Cancer Center, University of Texas, 1155 Pressler Street, CPB 3 3245, Houston, TX 77030, USA
    Curr Urol Rep 9:217-25. 2008
    ....
  9. pmc Long-term physical activity outcomes of home-based lifestyle interventions among breast and prostate cancer survivors
    Allison J Ottenbacher
    University of Texas Memorial Hermann, Center for Healthcare Quality and Safety, Houston, TX, USA
    Support Care Cancer 20:2483-9. 2012
    ..The goal of this study was to evaluate whether or not increased levels of moderate to vigorous physical activity (MVPA) were maintained by cancer survivors 1 year after receipt of two home-based interventions...
  10. pmc Extant health behaviors and uptake of standardized vs tailored health messages among cancer survivors enrolled in the FRESH START trial: a comparison of fighting-spirits vs fatalists
    Anna V Wilkinson
    Division of Epidemiology, Human Genetics and Environmental Science, University of Texas School of Public Health, Austin Regional Campus, Austin, TX, USA
    Psychooncology 21:108-13. 2012
    ....
  11. pmc Exercise among breast and prostate cancer survivors--what are their barriers?
    Allison J Ottenbacher
    University of Texas School of Public Health, Houston, TX, USA
    J Cancer Surviv 5:413-9. 2011
    ..The purpose of this paper is to identify and compare exercise barriers among cancer survivors, both cross-sectionally and longitudinally as they undergo home-based behavioral interventions...
  12. pmc Effect of low-fat diets on plasma levels of NF-κB-regulated inflammatory cytokines and angiogenic factors in men with prostate cancer
    John V Heymach
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
    Cancer Prev Res (Phila) 4:1590-8. 2011
    ..These results suggest that a LF diet without flaxseed may reduce levels of specific inflammatory CAFs and suggests that the NF-κB pathway may be a mediator of these changes...
  13. ncbi request reprint Lifestyle interventions to reduce cancer risk and improve outcomes
    Wendy Demark-Wahnefried
    Department of Behavioral Science, University of Texas M D Anderson Cancer Center, Houston, Texas 77230, USA
    Am Fam Physician 77:1573-8. 2008
    ....
  14. pmc Associations between leisure-time physical activity and health-related quality of life among adolescent and adult survivors of childhood cancers
    Raheem J Paxton
    Department of Health Disparities Research, The University of Texas M D Anderson Cancer Center, Houston, TX 77230 1439, USA
    Psychooncology 19:997-1003. 2010
    ..We thus explored the relationship between physical activity (PA) and HRQOL among survivors of childhood cancer...
  15. pmc Cancer-specific concerns and physical activity among recently diagnosed breast and prostate cancer survivors
    Allison Ottenbacher
    Texas Prevention Institute University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Integr Cancer Ther 12:206-12. 2013
    ..Cancer treatment -related side effects may have a negative impact on quality of life among cancer survivors and may limit participation in physical activity (PA)...
  16. pmc Promoting a healthy lifestyle among cancer survivors
    Wendy Demark-Wahnefried
    Department of Behavioral Science, The University of Texas MD Anderson Cancer Center, 1155 Herman P Pressler, CPPB3 3245, Houston, TX 77030, USA
    Hematol Oncol Clin North Am 22:319-42, viii. 2008
    ....
  17. ncbi request reprint Agreement between a brief mailed screener and an in-depth telephone survey: observations from the Fresh Start study
    Denise Clutter Snyder
    Department of Surgery, Center for the Study of Aging and Human Development, Duke University Medical Center, Box 3003, Durham, NC 27710, USA
    J Am Diet Assoc 104:1593-6. 2004
    ..Decisions to use brief screening instruments should be based on available resources and tolerance for misclassification...
  18. doi request reprint Differences in baseline characteristics and outcomes at 1- and 2-year follow-up of cancer survivors accrued via self-referral versus cancer registry in the FRESH START Diet and exercise trial
    Denise Clutter Snyder
    School of Nursing, Duke University Medical Center, Box 3322, Room 1057, 311 Trent Drive, Durham, NC 27710
    Cancer Epidemiol Biomarkers Prev 17:1288-94. 2008
    ..05). Several differences exist between self-referred and registry-ascertained participants, including motivation to respond to standardized educational materials, which appears significantly greater in self-referred populations...
  19. ncbi request reprint Can lifestyle modification increase survival in women diagnosed with breast cancer?
    Cheryl L Rock
    Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA 92093 0901, USA
    J Nutr 132:3504S-3507S. 2002
    ..The results of these studies will contribute to understanding the roles of diet and physical activity in the progression of breast cancer...
  20. ncbi request reprint Effect of flaxseed supplementation on prostatic carcinoma in transgenic mice
    Xu Lin
    Division of Urologic Surgery, Department of Surgery, and Center for Aging and Human Development, Duke University Medical Center, Durham, North Carolina 27710, USA
    Urology 60:919-24. 2002
    ..To investigate the effects of flaxseed supplementation on prostatic neoplasia in the transgenic adenocarcinoma mouse prostate (TRAMP) model...
  21. ncbi request reprint The Diet Quality Index-Revised: a tool to promote and evaluate dietary change among older cancer survivors enrolled in a home-based intervention trial
    Denise Clutter Snyder
    School of Nursing, Duke University, Box 3322 Duke University Medical Center, Durham, NC 27710, USA
    J Am Diet Assoc 107:1519-29. 2007
    ..To utilize the Diet Quality Index-Revised (DQI-R) as a framework for delivering and evaluating an intervention to improve overall diet quality among older cancer survivors...
  22. ncbi request reprint Design of FRESH START: a randomized trial of exercise and diet among cancer survivors
    Wendy Demark-Wahnefried
    Duke University Medical Center DUMC, Durham, NC 27710, USA
    Med Sci Sports Exerc 35:415-24. 2003
    ....
  23. pmc Dietary intervention in the management of prostate cancer
    Wendy Demark-Wahnefried
    School of Nursing and Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Curr Opin Urol 17:168-74. 2007
    ..This review integrates recent reports related to the dietary management of prostate cancer with the existing body of science in an effort to best inform practicing clinicians...
  24. ncbi request reprint Leading the Way in Exercise and Diet (Project LEAD): intervening to improve function among older breast and prostate cancer survivors
    Wendy Demark-Wahnefried
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Control Clin Trials 24:206-23. 2003
    ..In reporting our methods, we hope to give others "a leg up," so that they can hurdle with greater ease the barriers we experienced, and thus advance the field more rapidly...
  25. ncbi request reprint Carbohydrate restriction, prostate cancer growth, and the insulin-like growth factor axis
    Stephen J Freedland
    Department of Surgery, Durham VA Medical Center, Durham, North Carolina 27710, USA
    Prostate 68:11-9. 2008
    ..Recent evidence suggests carbohydrate intake may influence prostate cancer biology. We tested whether a no-carbohydrate ketogenic diet (NCKD) would delay prostate cancer growth relative to Western and low-fat diets in a xenograft model...
  26. pmc Cancer survival: time to get moving? Data accumulate suggesting a link between physical activity and cancer survival
    Wendy Demark-Wahnefried
    J Clin Oncol 24:3517-8. 2006
  27. ncbi request reprint Pilot study to explore effects of low-fat, flaxseed-supplemented diet on proliferation of benign prostatic epithelium and prostate-specific antigen
    Wendy Demark-Wahnefried
    Division of Urologic Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Urology 63:900-4. 2004
    ..Unknown, however, is the potential effect of such a diet on benign prostatic epithelium...
  28. pmc Nutrition and the cancer survivor: evidence to guide oncology nursing practice
    Mark Toles
    Duke University School of Nursing, Durham, NC, USA
    Semin Oncol Nurs 24:171-9. 2008
    ....
  29. ncbi request reprint Interest in healthy diet and physical activity interventions peripartum among female partners of active duty military
    Truls Ostbye
    Department of Community and Family Medicine, Duke University Medical Center Box 2914, Durham, NC 27710, USA
    Mil Med 168:320-5. 2003
    ..Interest was high for interventions that promote physical activity and facilitate social interaction. Based on these results, a postpartum exercise intervention is being designed for female partners of active duty soldiers...
  30. doi request reprint Childhood cancer survivors' perceived barriers to improving exercise and dietary behaviors
    Whitney D Arroyave
    School of Nursing, Duke University, Durham, NC, USA
    Oncol Nurs Forum 35:121-30. 2008
    ..To determine childhood cancer survivors' barriers to increasing exercise and consuming less fat and more fruits and vegetables, whole grains, and calcium-rich foods...
  31. ncbi request reprint Promoting health and physical function among cancer survivors: potential for prevention and questions that remain
    Wendy Demark-Wahnefried
    Duke University Medical Center, School of Nursing and Department of Surgery, Durham, NC 27710, USA
    J Clin Oncol 24:5125-31. 2006
    ....
  32. ncbi request reprint Nutrition-related issues for the breast cancer survivor
    Wendy Demark-Wahnefried
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Semin Oncol 30:789-98. 2003
    ..Furthermore, diets high in vegetables, fruit, whole grains, and low-fat dairy foods, and low in saturated fat, may help to lower overall disease risk in this population...
  33. ncbi request reprint No difference in response rate to a mailed survey among prostate cancer survivors using conditional versus unconditional incentives
    Brian R Evans
    Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cancer Epidemiol Biomarkers Prev 13:277-8. 2004
    ..Other means, however, appear necessary to achieve acceptable response rates among minority group cancer survivors...
  34. pmc Nutrition and survival after the diagnosis of breast cancer: a review of the evidence
    Cheryl L Rock
    Department of Family and Preventive Medicine, Cancer Prevention and Control Program, Dept 901, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0901, USA
    J Clin Oncol 20:3302-16. 2002
    ..To review and summarize evidence from clinical and epidemiologic studies that have examined the relationship between nutritional factors, survival, and recurrence after the diagnosis of breast cancer...
  35. ncbi request reprint Erythropoietin and erythropoietin receptor expression in human prostate cancer
    Murat O Arcasoy
    Department of Medicine, Duke University Medical Center, Durham, NC27710, USA
    Mod Pathol 18:421-30. 2005
    ..The coexpression of erythropoietin receptor and its ligand erythropoietin in human prostate cancer cells suggests the potential for growth regulation by erythropoietin-erythropoietin receptor in an autocrine or paracrine manner...
  36. ncbi request reprint IGF1 (CA)19 repeat and IGFBP3 -202 A/C genotypes and the risk of prostate cancer in Black and White men
    Joellen M Schildkraut
    Program of Cancer Prevention, Detection and Control Research, Department of Community and Family Medicine, Duke University Medical Center, Durham, NC, USA
    Cancer Epidemiol Biomarkers Prev 14:403-8. 2005
    ..Further research is needed to confirm these findings...
  37. ncbi request reprint Survivors of childhood cancer and their guardians
    Wendy Demark-Wahnefried
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA demar001mc duke edu
    Cancer 103:2171-80. 2005
    ..Although some data regarding health behaviors of this population exist, receptivity to health promotion is largely unknown...
  38. ncbi request reprint Response rates to a mailed survey targeting childhood cancer survivors: a comparison of conditional versus unconditional incentives
    Philip M Rosoff
    Division of Hematology Oncology, Department of Pediatrics, Duke University Medical Center, 222 Bell Building, Trent Drive, Durham, NC 27710, USA
    Cancer Epidemiol Biomarkers Prev 14:1330-2. 2005
    ..A study was undertaken among childhood cancer survivors and their parents to determine if response rate to a mailed survey differed with provision of immediate versus delayed incentives...
  39. ncbi request reprint Supplement use among men with prostate cancer
    Jeremy B Wiygul
    Division of Urology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Urology 66:161-6. 2005
    ..To characterize supplement use within a sample population of men diagnosed with prostate cancer...
  40. ncbi request reprint Nutrition and physical activity during and after cancer treatment: an American Cancer Society guide for informed choices
    Colleen Doyle
    American Cancer Society, Atlanta, GA, USA
    CA Cancer J Clin 56:323-53. 2006
    ....
  41. ncbi request reprint Diet, exercise, and complementary therapies after primary treatment for cancer
    Lee W Jones
    Department of Surgery, Duke University Medical Center, Durham, NC, USA
    Lancet Oncol 7:1017-26. 2006
    ..Overall, this review provides important information to oncology care providers who counsel their patients on preventive lifestyle practices to maximise health and longevity after a diagnosis of cancer...
  42. pmc Grade-specific prostate cancer associations of IGF1 (CA)19 repeats and IGFBP3-202A/C in blacks and whites
    Cathrine Hoyo
    Department of Community and Family Medicine, Hanes House Room 347, Trent Drive, Box 2914, Medical Center, Duke University Medical Center, Durham, NC 27710, USA
    J Natl Med Assoc 99:718-22. 2007
    ..If confirmed in larger studies, these findings support the hypothesis that the association between IGFBP3 C allele and prostate cancer is grade specific in both ethnic groups...
  43. pmc Move onward, press forward, and take a deep breath: can lifestyle interventions improve the quality of life of women with breast cancer, and how can we be sure?
    Wendy Demark-Wahnefried
    J Clin Oncol 25:4344-5. 2007
  44. ncbi request reprint Enterolactone induces apoptosis in human prostate carcinoma LNCaP cells via a mitochondrial-mediated, caspase-dependent pathway
    Li Hua Chen
    Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Mol Cancer Ther 6:2581-90. 2007
    ..Mechanistic studies suggested roles for Akt, GSK-3beta, MDM2, and p53 in enterolactone-dependent apoptosis. Our findings encourage further studies of enterolactone as a promising chemopreventive agent against prostate cancer...
  45. pmc Effects of a flaxseed-derived lignan supplement in type 2 diabetic patients: a randomized, double-blind, cross-over trial
    An Pan
    Key Laboratory of Systems Biology, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
    PLoS ONE 2:e1148. 2007
    ..The study aimed to investigate the effect of a flaxseed-derived lignan supplement on glycemic control, lipid profiles and insulin sensitivity in type 2 diabetic patients...
  46. ncbi request reprint Nutrition and physical activity during and after cancer treatment: an American Cancer Society guide for informed choices
    Jean K Brown
    University at Buffalo School of Nursing, The State University of New York, Buffalo, NY, USA
    CA Cancer J Clin 53:268-91. 2003
    ....

Research Grants14

  1. PROMOTING HEALTH IN PROSTATE & BREAST CANCER
    Wendy Demark Wahnefried; Fiscal Year: 2005
    ..If effective, this program could be modified, easily disseminated & used in a variety of health care settings, thus having broad public health impact. ..
  2. Prostate Cancer: Impact of Fat & Flaxseed Modified Diet
    Wendy Demark Wahnefried; Fiscal Year: 2005
    ..This research has the potential to expand the scope of complementary treatment offered for prostate cancer, and may provide a solid foundation for efforts aimed at prevention. ..
  3. PROMOTING HEALTH IN PROSTATE & BREAST CANCER
    Wendy Demark Wahnefried; Fiscal Year: 2004
    ..If effective, this program could be modified, easily disseminated & used in a variety of health care settings, thus having broad public health impact. ..
  4. RENEW Research-out to Enhance Wellness Older Survivors
    Wendy Demark Wahnefried; Fiscal Year: 2007
    ..abstract_text> ..