Affiliation: The Rockefeller University
- Immature dendritic cells selectively replicate macrophagetropic (M-tropic) human immunodeficiency virus type 1, while mature cells efficiently transmit both M- and T-tropic virus to T cellsA Granelli-Piperno
Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, New York 10021, USA
J Virol 72:2733-7. 1998..Therefore, the developmental stage of DCs can influence the interaction of these cells with HIV-1 and influence the extent to which M-tropic and T-tropic virus can replicate...
- Virus replication begins in dendritic cells during the transmission of HIV-1 from mature dendritic cells to T cellsA Granelli-Piperno
Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York 10021 6399, USA
Curr Biol 9:21-9. 1999..The initial site for HIV-1 replication remains unknown and it is unclear whether replication can take place in DCs or whether the virus must first be transmitted from DCs to T cells...
- Dendritic cells, infected with vesicular stomatitis virus-pseudotyped HIV-1, present viral antigens to CD4+ and CD8+ T cells from HIV-1-infected individualsA Granelli-Piperno
Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY 10021 Mount Sinai Medical School, New York, NY 10029, USA
J Immunol 165:6620-6. 2000..Therefore, nonreplicating vaccines can be targeted to immature DCs, which upon further maturation induce combined and robust CD4(+) and CD8(+) immunity...