Titia de Lange

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. ncbi DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion
    Giulia B Celli
    Laboratory for Cell Biology and Genetic, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Nat Cell Biol 7:712-8. 2005
  2. ncbi Shelterin: the protein complex that shapes and safeguards human telomeres
    Titia de Lange
    The Rockefeller University, New York, New York 10021, USA
    Genes Dev 19:2100-10. 2005
  3. ncbi TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres
    Jeffrey Zheng Sheng Ye
    Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, New York 10021, USA
    J Biol Chem 279:47264-71. 2004
  4. ncbi Tel2 regulates the stability of PI3K-related protein kinases
    Hiroyuki Takai
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Cell 131:1248-59. 2007
  5. pmc Apollo contributes to G overhang maintenance and protects leading-end telomeres
    Peng Wu
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Mol Cell 39:606-17. 2010
  6. pmc Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signal
    Agnel Sfeir
    The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Science 327:1657-61. 2010
  7. pmc Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint
    Joshua Silverman
    Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, New York 10021, USA
    Genes Dev 18:2108-19. 2004
  8. pmc Telomere protection by TPP1/POT1 requires tethering to TIN2
    Kaori K Takai
    Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, NY 10065, USA
    Mol Cell 44:647-59. 2011
  9. ncbi Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1
    Eros Lazzerini Denchi
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nature 448:1068-71. 2007
  10. ncbi Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres
    Dirk Hockemeyer
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Cell 126:63-77. 2006

Collaborators

Detail Information

Publications66

  1. ncbi DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion
    Giulia B Celli
    Laboratory for Cell Biology and Genetic, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Nat Cell Biol 7:712-8. 2005
    ..Thus, activation of the ATM kinase pathway at chromosome ends does not require overhang degradation or other overt DNA processing...
  2. ncbi Shelterin: the protein complex that shapes and safeguards human telomeres
    Titia de Lange
    The Rockefeller University, New York, New York 10021, USA
    Genes Dev 19:2100-10. 2005
    ..Six shelterin subunits: TRF1, TRF2, TIN2, Rap1, TPP1, and POT1...
  3. ncbi TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres
    Jeffrey Zheng Sheng Ye
    Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, New York 10021, USA
    J Biol Chem 279:47264-71. 2004
    ..The TIN2-mediated cooperative binding of TRF1 and TRF2 to telomeres has important implications for the mechanism of telomere length regulation and protection...
  4. ncbi Tel2 regulates the stability of PI3K-related protein kinases
    Hiroyuki Takai
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Cell 131:1248-59. 2007
    ..These data identify Tel2 as a highly conserved regulator of PIKK stability...
  5. pmc Apollo contributes to G overhang maintenance and protects leading-end telomeres
    Peng Wu
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Mol Cell 39:606-17. 2010
    ..These data establish that the telomeric overhang is required for the protection of telomeres from the DNA damage response...
  6. pmc Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signal
    Agnel Sfeir
    The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Science 327:1657-61. 2010
    ..The data reveal that HDR at telomeres can take place in the absence of DNA damage foci and underscore the functional compartmentalization within shelterin...
  7. pmc Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint
    Joshua Silverman
    Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, New York 10021, USA
    Genes Dev 18:2108-19. 2004
    ..These data reveal that human Rif1 contributes to the ATM-mediated protection against DNA damage and point to a remarkable difference in the primary function of this protein in yeast and mammals...
  8. pmc Telomere protection by TPP1/POT1 requires tethering to TIN2
    Kaori K Takai
    Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, NY 10065, USA
    Mol Cell 44:647-59. 2011
    ..Thus, while TIN2 has a minor contribution to the repression of ATM by TRF2, its major role is to stabilize TPP1/POT1a on the ss telomeric DNA, thereby allowing effective exclusion of RPA and repression of ATR signaling...
  9. ncbi Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1
    Eros Lazzerini Denchi
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nature 448:1068-71. 2007
    ..The results reveal how mammalian telomeres use multiple mechanisms to avoid DNA damage surveillance and provide an explanation for the induction of replicative senescence and genome instability by shortened telomeres...
  10. ncbi Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres
    Dirk Hockemeyer
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Cell 126:63-77. 2006
    ..We conclude that mouse telomeres require two distinct POT1 proteins whereas human telomeres have one. Such divergence is unprecedented in mammalian chromosome biology and has implications for modeling human telomere biology in mice...
  11. pmc Removal of shelterin reveals the telomere end-protection problem
    Agnel Sfeir
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Science 336:593-7. 2012
    ....
  12. pmc Cell cycle control of telomere protection and NHEJ revealed by a ts mutation in the DNA-binding domain of TRF2
    Akimitsu Konishi
    Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, New York 10065, USA
    Genes Dev 22:1221-30. 2008
    ..In contrast, the processing of dysfunctional telomeres by NHEJ occurred primarily in G1, being repressed in S/G2 in a cyclin-dependent kinase (CDK)-dependent manner...
  13. pmc The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response
    Jan Karlseder
    Laboratory for Cell Biology and Genetics, Rockefeller University, New York, USA
    PLoS Biol 2:E240. 2004
    ....
  14. pmc POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex
    Jeffrey Zheng Sheng Ye
    Laboratory for Cell Biology and Genetics and Laboratory for Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, New York, New York 10021, USA
    Genes Dev 18:1649-54. 2004
    ..Reduction of PIP1 or POT1 levels with shRNAs led to telomere elongation, indicating that PIP1 contributes to telomere length control through recruitment of POT1...
  15. pmc Cell cycle-dependent role of MRN at dysfunctional telomeres: ATM signaling-dependent induction of nonhomologous end joining (NHEJ) in G1 and resection-mediated inhibition of NHEJ in G2
    Nadya Dimitrova
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10065 6399, USA
    Mol Cell Biol 29:5552-63. 2009
    ..Thus, the role of MRN at dysfunctional telomeres is multifaceted, involving both repression of NHEJ in G(2) through end resection and induction of NHEJ in G(1) through ATM-dependent signaling...
  16. pmc No overt nucleosome eviction at deprotected telomeres
    Peng Wu
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Mol Cell Biol 28:5724-35. 2008
    ..We conclude that ATM signaling, ATR signaling, NHEJ, and HR at deprotected telomeres can take place in the absence of overt nucleosome eviction...
  17. pmc Functional dissection of human and mouse POT1 proteins
    Wilhelm Palm
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10065 6399, USA
    Mol Cell Biol 29:471-82. 2009
    ..Thus, human POT1 combines the features of POT1a and POT1b...
  18. ncbi Telomere protection by mammalian Pot1 requires interaction with Tpp1
    Dirk Hockemeyer
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
    Nat Struct Mol Biol 14:754-61. 2007
    ....
  19. pmc Telomere protection by TPP1 is mediated by POT1a and POT1b
    Tatsuya Kibe
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10065 6399, USA
    Mol Cell Biol 30:1059-66. 2010
    ..No additional telomere dysfunction phenotypes were observed, establishing that the main role of TPP1 is to allow POT1a and POT1b to protect chromosome ends...
  20. pmc 53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility
    Nadya Dimitrova
    The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
    Nature 456:524-8. 2008
    ....
  21. ncbi Ku70 stimulates fusion of dysfunctional telomeres yet protects chromosome ends from homologous recombination
    Giulia B Celli
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Nat Cell Biol 8:885-90. 2006
    ..Therefore, Ku- and TRF2-mediated repression of homologous recombination is an important aspect of telomere protection...
  22. ncbi The role of the poly(ADP-ribose) polymerase tankyrase1 in telomere length control by the TRF1 component of the shelterin complex
    Jill R Donigian
    Laboratory of Cell Biology and Genetics, The Rockefeller University, New York, New York 10021, USA
    J Biol Chem 282:22662-7. 2007
    ..We propose that the tankyrase1-controlled telomere extension is a human-specific elaboration that allows additional control over telomere length in telomerase positive cells...
  23. pmc Rap1 affects the length and heterogeneity of human telomeres
    Bibo Li
    The Rockefeller University, New York, New York 10021, USA
    Mol Biol Cell 14:5060-8. 2003
    ..Surprisingly, hRap1 alleles lacking the BRCT domain diminished the heterogeneity of human telomeres, indicating that hRap1 also plays a role in the regulation of telomere length distribution...
  24. pmc MDC1 accelerates nonhomologous end-joining of dysfunctional telomeres
    Nadya Dimitrova
    Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, New York 10021, USA
    Genes Dev 20:3238-43. 2006
    ..We propose that the binding of MDC1 to gamma-H2AX directly affects NHEJ in a manner that is independent of the ATM-dependent cell cycle arrest pathway...
  25. ncbi Regulation of telomerase by telomeric proteins
    Agata Smogorzewska
    The Rockefeller University, New York, New York 10021, USA
    Annu Rev Biochem 73:177-208. 2004
    ..Here we discuss the details of telomerase and its regulation by the telomere...
  26. pmc How telomeres solve the end-protection problem
    Titia de Lange
    Laboratory of Cell Biology and Genetics, Rockefeller University, New York, NY 10021, USA
    Science 326:948-52. 2009
    ..Telomeres appear to be tailored to these variations, explaining their variable structure and composition...
  27. pmc Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication
    Agnel Sfeir
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Cell 138:90-103. 2009
    ..These results identify a second telomere replication problem that is solved by the shelterin component TRF1...
  28. pmc Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway
    Courtney A Lovejoy
    Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, New York, United States of America
    PLoS Genet 8:e1002772. 2012
    ..These attributes will facilitate the diagnosis and treatment of ALT positive human cancers...
  29. ncbi Apollo, an Artemis-related nuclease, interacts with TRF2 and protects human telomeres in S phase
    Megan Van Overbeek
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Curr Biol 16:1295-302. 2006
    ..We propose that the Artemis-like nuclease Apollo is a shelterin accessory factor required for the protection of telomeres during or after their replication...
  30. ncbi POT1 as a terminal transducer of TRF1 telomere length control
    Diego Loayza
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nature 423:1013-8. 2003
    ....
  31. pmc In vivo stoichiometry of shelterin components
    Kaori K Takai
    Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, New York 10065 6399, USA
    J Biol Chem 285:1457-67. 2010
    ..Finally, we report that a 10-fold reduction in TRF2 affects the regulation of telomere length but not the protection of telomeres in tumor cell lines...
  32. pmc A Shld1-controlled POT1a provides support for repression of ATR signaling at telomeres through RPA exclusion
    Yi Gong
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Mol Cell 40:377-87. 2010
    ..In G1, the accumulation of RPA at dysfunctional telomeres was strikingly less, and POT1a was sufficient to repress ATR signaling. These results support an RPA exclusion model for the repression of ATR signaling at telomeres...
  33. ncbi TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex
    Jeffrey Zheng Sheng Ye
    The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nat Genet 36:618-23. 2004
    ..These data identify TIN2 as a PARP modulator in the TRF1 complex and can explain how TIN2 contributes to the regulation of telomere length...
  34. ncbi Homologous recombination generates T-loop-sized deletions at human telomeres
    Richard C Wang
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Cell 119:355-68. 2004
    ..These findings show that t-loop deletion by HR influences the integrity and dynamics of mammalian telomeres...
  35. pmc Role of 53BP1 oligomerization in regulating double-strand break repair
    Francisca Lottersberger
    Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 110:2146-51. 2013
    ..Second, 53BP1-dependent repression of CtIP at double-strand breaks (DSBs) is unlikely to be sufficient for the generation of radial chromosomes in PARP1 inhibitor-treated Brca1-deficient cells...
  36. pmc Mammalian Rif1 contributes to replication stress survival and homology-directed repair
    Sara B C Buonomo
    Laboratory of Cell Biology and Genetics, The Rockefeller University, New York, NY 10065, USA
    J Cell Biol 187:385-98. 2009
    ..Collectively, these findings reveal a function for Rif1 in the repair of stalled forks by facilitating HDR...
  37. pmc Engineered telomere degradation models dyskeratosis congenita
    Dirk Hockemeyer
    Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, New York 10065, USA
    Genes Dev 22:1773-85. 2008
    ..These results provide experimental support for the notion that DC is caused by telomere dysfunction, and demonstrate that key aspects of a human telomere-based disease can be modeled in the mouse...
  38. ncbi ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes
    Xu Dong Zhu
    The Rockefeller University, New York, NY 10021, USA
    Mol Cell 12:1489-98. 2003
    ....
  39. pmc Hepatocytes with extensive telomere deprotection and fusion remain viable and regenerate liver mass through endoreduplication
    Eros Lazzerini Denchi
    Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, New York 10021, USA
    Genes Dev 20:2648-53. 2006
    ..We conclude that nondividing hepatocytes can maintain and regenerate liver function despite substantial loss of telomere integrity...
  40. ncbi DNA binding features of human POT1: a nonamer 5'-TAGGGTTAG-3' minimal binding site, sequence specificity, and internal binding to multimeric sites
    Diego Loayza
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1320 York Avenue, New York, NY 10021, USA
    J Biol Chem 279:13241-8. 2004
    ..These data indicate that POT1 has a strong sequence preference for the human telomeric repeat tract and predict that POT1 can bind both the 3' telomeric overhang and the displaced TTAGGG repeats at the base of the t-loop...
  41. pmc 53BP1 regulates DSB repair using Rif1 to control 5' end resection
    Michal Zimmermann
    Laboratory for Cell Biology and Genetics, Rockefeller University, New York, NY 10065, USA
    Science 339:700-4. 2013
    ..These data establish Rif1 as an important contributor to the control of DSB repair by 53BP1...
  42. pmc Telomere-driven tetraploidization occurs in human cells undergoing crisis and promotes transformation of mouse cells
    Teresa Davoli
    Laboratory for Genetics and Cell Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Cancer Cell 21:765-76. 2012
    ..These data establish that telomere-driven tetraploidization is induced by critically short telomeres and has the potential to promote tumorigenesis in early cancerous lesions...
  43. doi How shelterin protects mammalian telomeres
    Wilhelm Palm
    Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, NY 10021, USA
    Annu Rev Genet 42:301-34. 2008
    ..Recent experiments, discussed here, have revealed how shelterin represses the ATM and ATR kinase signaling pathways and hides chromosome ends from nonhomologous end joining and homology-directed repair...
  44. pmc Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes
    Hiroyuki Takai
    Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, New York 10065, USA
    Genes Dev 24:2019-30. 2010
    ..Taken together, our data suggest that the Tel2-Tti1-Tti2 complex is a PIKK-specific cochaperone for Hsp90...
  45. pmc Telomeric 3' overhangs derive from resection by Exo1 and Apollo and fill-in by POT1b-associated CST
    Peng Wu
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Cell 150:39-52. 2012
    ..3' overhang formation is thus a multistep, shelterin-controlled process, ensuring functional telomeric overhangs at chromosome ends...
  46. ncbi DNA damage foci at dysfunctional telomeres
    Hiroyuki Takai
    Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, NY 10021, USA
    Curr Biol 13:1549-56. 2003
    ..Furthermore, induction of TIFs through TRF2 inhibition provides an opportunity to study the DNA damage response within the context of well-defined, physically marked lesions...
  47. pmc Different telomere damage signaling pathways in human and mouse cells
    Agata Smogorzewska
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, NY 10021, USA
    EMBO J 21:4338-48. 2002
    ..These findings reveal a fundamental difference in telomere damage signaling in human and mouse cells that bears on the use of mouse models for the telomere tumor suppressor pathway...
  48. pmc POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end
    Dirk Hockemeyer
    Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, NY 10021, USA
    EMBO J 24:2667-78. 2005
    ....
  49. pmc A TIN2 dyskeratosis congenita mutation causes telomerase-independent telomere shortening in mice
    David Frescas
    Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, New York 10021, USA
    Genes Dev 28:153-66. 2014
    ....
  50. pmc TRF2-tethered TIN2 can mediate telomere protection by TPP1/POT1
    David Frescas
    Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, New York, USA
    Mol Cell Biol 34:1349-62. 2014
    ..We therefore conclude that shelterin can protect chromosome ends as a TRF2-tethered TIN2/TPP1/POT1 complex that lacks a physical connection to TRF1. ..
  51. pmc A TRF1-controlled common fragile site containing interstitial telomeric sequences
    Nazario Bosco
    Laboratory for Cell Biology and Genetics, The Rockefeller University, Box 159, 1230 York Avenue, New York, NY 10065, USA
    Chromosoma 121:465-74. 2012
    ..The data show that telomeric DNA is inherently fragile regardless of its genomic position and imply that CFS can be caused by a specific DNA sequence...
  52. ncbi DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2
    Agata Smogorzewska
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Curr Biol 12:1635-44. 2002
    ..However, the molecular nature of these fusions and the mechanism by which they occur have not been elucidated...
  53. ncbi Significant role for p16INK4a in p53-independent telomere-directed senescence
    Jacqueline J L Jacobs
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10021 USA
    Curr Biol 14:2302-8. 2004
    ..We conclude that p16(INK4a) contributes to the p53-independent response to telomere damage...
  54. doi The causes and consequences of polyploidy in normal development and cancer
    Teresa Davoli
    Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, NY 10065, USA
    Annu Rev Cell Dev Biol 27:585-610. 2011
    ..The origins of these polyploidization events and their consequences for tumor progression are explored in this review...
  55. pmc Taking apart Rap1: an adaptor protein with telomeric and non-telomeric functions
    Shaheen Kabir
    Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, NY, USA
    Cell Cycle 9:4061-7. 2010
    ..The protean nature of Rap1 is best understood by viewing it as an adaptor that can mediate a variety of protein-protein and protein-DNA interactions depending on the organism and the complex in which it is functioning...
  56. ncbi Lasker Laurels for telomerase
    Titia de Lange
    Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, NY 10021, USA
    Cell 126:1017-20. 2006
    ..This year the Lasker Foundation pays tribute to telomerase, a medically important enzyme required for chromosome stability and long-term cell proliferation...
  57. doi Human telomerase caught in the act
    Peng Wu
    The Rockefeller University, New York, NY 10065, USA
    Cell 138:432-4. 2009
    ..Contrary to this view, Zhao et al. (2009) now show that telomerase in human cancer cells extends most telomeres during every S phase and that complementary strand synthesis does not immediately follow telomerase action...
  58. ncbi Senescence induced by altered telomere state, not telomere loss
    Jan Karlseder
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 295:2446-9. 2002
    ..Thus, replicative senescence is induced by a change in the protected status of shortened telomeres rather than by a complete loss of telomeric DNA...
  59. pmc Super-resolution fluorescence imaging of telomeres reveals TRF2-dependent T-loop formation
    Ylli Doksani
    Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, NY 10065, USA
    Cell 155:345-56. 2013
    ..The TRF2-dependent remodeling of telomeres into t-loop structures, which sequester the ends of chromosomes, can explain why NHEJ and the ATM signaling pathway are repressed when TRF2 is present. ..
  60. pmc Targeted deletion reveals an essential function for the telomere length regulator Trf1
    Jan Karlseder
    Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, NY 10021, USA
    Mol Cell Biol 23:6533-41. 2003
    ..These data suggest that murine Trf1 has an essential function that is independent of telomere length regulation...
  61. pmc Persistent telomere damage induces bypass of mitosis and tetraploidy
    Teresa Davoli
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Cell 141:81-93. 2010
    ..These observations suggest a general mechanism for the induction of tetraploidization in the early stages of tumorigenesis when telomere dysfunction can result from excessive telomere shortening...
  62. ncbi Telomerase regulation at the telomere: a binary switch
    Diego Loayza
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Cell 117:279-80. 2004
    ..They show that short telomeres are elongated more frequently than long telomeres, arguing that telomeres switch between two states, one that allows telomere extension and one that does not...
  63. ncbi T-loops and the origin of telomeres
    Titia de Lange
    Laboratory for Cell Biology and Genetics, Box 159, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nat Rev Mol Cell Biol 5:323-9. 2004
  64. ncbi Protection of mammalian telomeres
    Titia de Lange
    Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, NY 10021, USA
    Oncogene 21:532-40. 2002
    ....
  65. doi A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins
    Yong Chen
    Department of Biological Chemistry, University of Michigan Medical School, 1150 West Medical Center Drive, Ann Arbor, MI 48109, USA
    Science 319:1092-6. 2008
    ..Conversely, the TRFH domain of TRF1, but not of TRF2, interacts with another shelterin-associated factor: PinX1...
  66. ncbi p16INK4a as a second effector of the telomere damage pathway
    Jacqueline J L Jacobs
    Deptartment of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Cell Cycle 4:1364-8. 2005
    ..Here we discuss the significance of p16INK4a as a second effector of the telomere damage response...