L de Lecea

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. ncbi request reprint Targeted disruption of RC3 reveals a calmodulin-based mechanism for regulating metaplasticity in the hippocampus
    Thomas Krucker
    Departments of Neuropharmacology and Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 22:5525-35. 2002
  2. ncbi request reprint Urotensin II modulates rapid eye movement sleep through activation of brainstem cholinergic neurons
    Salvador Huitron-Resendiz
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 25:5465-74. 2005
  3. ncbi request reprint Neural substrates of awakening probed with optogenetic control of hypocretin neurons
    Antoine R Adamantidis
    Department of Psychiatry and Behavioral Sciences, Stanford University, 701B Welch Road, Palo Alto, California 94304, USA
    Nature 450:420-4. 2007
  4. ncbi request reprint The hypocretins/orexins: novel hypothalamic neuropeptides involved in different physiological systems
    L de Lecea
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Cell Mol Life Sci 56:473-80. 1999
  5. ncbi request reprint The hypocretins and sleep
    Luis de Lecea
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    FEBS J 272:5675-88. 2005
  6. ncbi request reprint Cortistatin: a natural somatostatin analog
    L de Lecea
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Endocrinol Invest 28:10-4. 2005
  7. ncbi request reprint Hypocretins/orexins as integrators of physiological information: lessons from mutant animals
    Luis de Lecea
    Departments of Molecular Biology and Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropeptides 36:85-95. 2002
  8. ncbi request reprint A cortical neuropeptide with neuronal depressant and sleep-modulating properties
    L de Lecea
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nature 381:242-5. 1996
  9. ncbi request reprint Cortistatin and somatostatin mRNAs are differentially regulated in response to kainate
    M Calbet
    Department of Molecular Biology, MB 10, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA, USA
    Brain Res Mol Brain Res 72:55-64. 1999
  10. ncbi request reprint The hypocretins: excitatory neuromodulatory peptides for multiple homeostatic systems, including sleep and feeding
    J G Sutcliffe
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci Res 62:161-8. 2000

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Targeted disruption of RC3 reveals a calmodulin-based mechanism for regulating metaplasticity in the hippocampus
    Thomas Krucker
    Departments of Neuropharmacology and Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 22:5525-35. 2002
    ..We propose an mGluR-dependent CaM-based sliding threshold mechanism for metaplasticity that is governed by the phosphorylation states of RC3 and CaMKII...
  2. ncbi request reprint Urotensin II modulates rapid eye movement sleep through activation of brainstem cholinergic neurons
    Salvador Huitron-Resendiz
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 25:5465-74. 2005
    ..Collectively, these results suggest that UII plays a role in the regulation of REM sleep independently of its cerebrovascular actions by directly activating cholinergic brainstem neurons...
  3. ncbi request reprint Neural substrates of awakening probed with optogenetic control of hypocretin neurons
    Antoine R Adamantidis
    Department of Psychiatry and Behavioral Sciences, Stanford University, 701B Welch Road, Palo Alto, California 94304, USA
    Nature 450:420-4. 2007
    ..This study establishes a causal relationship between frequency-dependent activity of a genetically defined neural cell type and a specific mammalian behaviour central to clinical conditions and neurobehavioural physiology...
  4. ncbi request reprint The hypocretins/orexins: novel hypothalamic neuropeptides involved in different physiological systems
    L de Lecea
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Cell Mol Life Sci 56:473-80. 1999
    ..Here we review recent progress in identifying the role of the hypocretins/orexins in the control of energy balance and in other physiological systems...
  5. ncbi request reprint The hypocretins and sleep
    Luis de Lecea
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    FEBS J 272:5675-88. 2005
    ..Multiple lines of evidence suggest that the hypocretinergic system integrates homeostatic, metabolic and limbic information and provides a coherent output that results in stability of the states of vigilance...
  6. ncbi request reprint Cortistatin: a natural somatostatin analog
    L de Lecea
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Endocrinol Invest 28:10-4. 2005
    ..We also examine the evidence pointing towards a specific receptor for this novel neuropeptide member of the somatostatin gene family...
  7. ncbi request reprint Hypocretins/orexins as integrators of physiological information: lessons from mutant animals
    Luis de Lecea
    Departments of Molecular Biology and Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropeptides 36:85-95. 2002
    ..Here we review studies in humans and mutant animals that have provided clues about the functions of the hypocretinergic system, which appear to involve the coherent regulation of networks that dictate the states of arousal...
  8. ncbi request reprint A cortical neuropeptide with neuronal depressant and sleep-modulating properties
    L de Lecea
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nature 381:242-5. 1996
    ..This suggests a mechanism for cortical synchronization related to sleep...
  9. ncbi request reprint Cortistatin and somatostatin mRNAs are differentially regulated in response to kainate
    M Calbet
    Department of Molecular Biology, MB 10, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA, USA
    Brain Res Mol Brain Res 72:55-64. 1999
    ..Our data demonstrate that CST and SST, which are often co-expressed in the same neurons, are regulated by different stimuli...
  10. ncbi request reprint The hypocretins: excitatory neuromodulatory peptides for multiple homeostatic systems, including sleep and feeding
    J G Sutcliffe
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci Res 62:161-8. 2000
    ..These peptides appear to be part of a complex circuit that integrates aspects of energy metabolism, cardiovascular function, hormone homeostasis, and sleep-wake behaviors...
  11. pmc The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity
    L de Lecea
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 95:322-7. 1998
    ..One of the Hcrt peptides was excitatory when applied to cultured, synaptically coupled hypothalamic neurons, but not hippocampal neurons. These observations suggest that the hypocretins function within the CNS as neurotransmitters...
  12. ncbi request reprint A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms
    T W Lovenberg
    Department of Molecular Biology, Scripps Research Institute, La Jolla, California 92037
    Neuron 11:449-58. 1993
    ..These findings suggest a physiological role in the regulation of circadian rhythms for one subtype of serotonin receptor, 5-HT7, and provide a pharmacological test to evaluate its role in other neuronal systems...
  13. ncbi request reprint Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin
    L de Lecea
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Genomics 42:499-506. 1997
    ..The human putative cortistatin peptide has an arginine for lysine substitution, compared to the rat and mouse products, and is N-terminally extended by 3 amino acids...
  14. ncbi request reprint Interaction of the hypocretins with neurotransmitters in the nucleus accumbens
    Gilles Martin
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Regul Pept 104:111-7. 2002
    ..Our results strongly suggest that the hypocretin peptides may be inhibitory peptides, probably via binding hcrt receptor 2...
  15. ncbi request reprint The role of the hypocretinergic system in the integration of networks that dictate the states of arousal
    Raphaelle Winsky-Sommerer
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Drug News Perspect 16:504-12. 2003
    ..The hypocretins are also an excellent target for the pharmacological treatment of the deregulated arousal state that characterizes depression or addictive behavior...
  16. ncbi request reprint Chromosomal mapping of mouse genes expressed selectively within the central nervous system
    P E Danielson
    Scripps Research Institute, Department of Molecular Biology, La Jolla, California 92037
    Genomics 19:454-61. 1994
    ....
  17. ncbi request reprint Interaction between the corticotropin-releasing factor system and hypocretins (orexins): a novel circuit mediating stress response
    Raphaelle Winsky-Sommerer
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 24:11439-48. 2004
    ..We propose that, after stressor stimuli, CRF stimulates the release of hypocretins and that this circuit contributes to activation and maintenance of arousal associated with the stress response...
  18. ncbi request reprint Cortistatin: a member of the somatostatin neuropeptide family with distinct physiological functions
    A D Spier
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, 92037, La Jolla, CA, USA
    Brain Res Brain Res Rev 33:228-41. 2000
    ..recent advances in our understanding of the neurobiology of cortistatin, examines the similarities and differences between cortistatin and somatostatin, and asks the question: does cortistatin bind to a cortistatin-specific receptor?..
  19. ncbi request reprint Stress and arousal: the corticotrophin-releasing factor/hypocretin circuitry
    Raphaelle Winsky-Sommerer
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA, USA
    Mol Neurobiol 32:285-94. 2005
    ....
  20. ncbi request reprint Transgenic mice with a reduced core body temperature have an increased life span
    Bruno Conti
    Harold L Dorris Neurological Research Center, Scripps Research Institute, La Jolla, CA 92037, USA
    Science 314:825-8. 2006
    ..Thus, modest, sustained reduction of core body temperature prolonged life span independent of altered diet or CR...
  21. ncbi request reprint Glutamatergic transmission in opiate and alcohol dependence
    George Robert Siggins
    Department of Neuropharmacology, Department of Molecular Biology, The Scripps Research Institute, 10550 Torrey Pines Road, La Jolla, California 92037, USA
    Ann N Y Acad Sci 1003:196-211. 2003
    ..These combined findings suggest that changes in glutamatergic transmission in NAcc and CeA may underlie the neuroadaptions that lead to opiate and ethanol dependence...
  22. ncbi request reprint The hypocretins: setting the arousal threshold
    J Gregor Sutcliffe
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nat Rev Neurosci 3:339-49. 2002
    ..The rapidity with which the hypocretin story has emerged is a testament to both the conceptual and the technical evolution of genomic science in the past two decades...
  23. ncbi request reprint Chronic morphine treatment alters N-methyl-D-aspartate receptors in freshly isolated neurons from nucleus accumbens
    Gilles Martin
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA, USA
    J Pharmacol Exp Ther 311:265-73. 2004
    ....
  24. ncbi request reprint Overexpression of the human beta-amyloid precursor protein downregulates cortistatin mRNA in PDAPP mice
    Raphaelle Winsky-Sommerer
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Brain Res 1023:157-62. 2004
    ..These deficits in cortistatin expression may play a role in the deficits in hippocampal-dependent spatial learning and sleep/wake states previously demonstrated in aged Tg mice...
  25. ncbi request reprint The corticotropin-releasing factor-hypocretin connection: implications in stress response and addiction
    C Paneda
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Drug News Perspect 18:250-5. 2005
    ..We propose that upon stressor stimuli, CRF stimulates the release of hypocretins, and this circuit contributes to activation and maintenance of arousal associated with the stress response and addiction...
  26. ncbi request reprint Transcripts encoding a neural membrane CD26 peptidase-like protein are stimulated by synaptic activity
    L de Lecea
    Department of Molecular Biology, Scripps Research Institute, La Jolla, CA 92037
    Brain Res Mol Brain Res 25:286-96. 1994
    ..Hybridization signals could be detected in dendritic processes of pyramidal neurons and in some glial cells upon either type of stimulation. These data suggest that BSPL may be involved in synaptic plasticity...
  27. ncbi request reprint Cortistatin promotes and negatively correlates with slow-wave sleep
    Patrice Bourgin
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Eur J Neurosci 26:729-38. 2007
    ..The capacity of CST-14 to increase SWA, together with preprocortistatin's inverse correlation with time spent in SWS, suggests a potential role in sleep homeostatic processes...
  28. pmc Neuropeptide S reinstates cocaine-seeking behavior and increases locomotor activity through corticotropin-releasing factor receptor 1 in mice
    Covadonga Paneda
    Department of Molecular and Integrative Neurosciences, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 29:4155-61. 2009
    ..Our results suggest that NPS receptors may be an important target for drug abuse research and treatment and that CRF(1) mediates the cocaine-seeking and locomotor stimulant effects of NPS, but not its effects on anxiety-like behavior...
  29. pmc Two members of a distinct subfamily of 5-hydroxytryptamine receptors differentially expressed in rat brain
    M G Erlander
    Department of Molecular Biology, Scripps Research Institute, La Jolla, CA 92037
    Proc Natl Acad Sci U S A 90:3452-6. 1993
    ..In contrast, mRNAs encoding REC17 were found throughout the rat central nervous system. We propose that REC17 and MR22, designated as 5-HT5 alpha and 5-HT5 beta, represent a distinct subfamily of 5-HT receptors...
  30. ncbi request reprint Cortistatin radioligand binding in wild-type and somatostatin receptor-deficient mouse brain
    Avron D Spier
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Regul Pept 124:179-86. 2005
    ..We conclude that the somatostatin receptor subtype-2 is responsible for somatostatin binding in cortical and amygdaloid regions and that cortistatin predominantly interacts with the same receptors as somatostatin...
  31. doi request reprint Addiction and arousal: the hypocretin connection
    Benjamin Boutrel
    Center for Psychiatric Neurosciences, Department of Psychiatry, University of Lausanne, Switzerland
    Physiol Behav 93:947-51. 2008
    ..Hence, the hypocretinergic system is a new drug target that may be used to prevent relapse of drug seeking...
  32. doi request reprint Neuropeptide interactions and REM sleep: a role for Urotensin II?
    Luis de Lecea
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 701 B Welch Road, Palo Alto, CA 94304, United States
    Peptides 29:845-51. 2008
    ..This review focuses on the implications of these findings for the neurobiology of REM sleep regulation and discusses the possible impact of UII and other neuropeptides on the balance of the alternation between sleep states...
  33. doi request reprint Effect of cortistatin on tau phosphorylation at Ser262 site
    Alicia Rubio
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Madrid, Spain
    J Neurosci Res 86:2462-75. 2008
    ..Our results suggest an important role for cortistatin in the regulation of tau phosphorylation that may be associated with the pathophysiology of Alzheimer's disease in regions such as the cerebral cortex...
  34. ncbi request reprint Cortistatin as a therapeutic target in inflammation
    Alicia Rubio
    Universidad Autonoma de Madrid, Centro de Biologia Molecular, Madrid, Spain
    Expert Opin Ther Targets 11:1-9. 2007
    ..In this review, the authors address a new possible role for CST in the immune system and evaluate the possible therapeutic use of CST to treat disorders associated with inflammation...
  35. ncbi request reprint Addiction and arousal: alternative roles of hypothalamic peptides
    Luis de Lecea
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
    J Neurosci 26:10372-5. 2006
    ..This review summarizes a Mini-Symposium presented at the 2006 Annual Meeting of the Society for Neuroscience...
  36. ncbi request reprint Cortistatin: not just another somatostatin analog
    Luis de Lecea
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    Nat Clin Pract Endocrinol Metab 2:356-7. 2006
  37. ncbi request reprint Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects
    Yan Ling Xu
    Department of Pharmacology, University of California Irvine, Irvine, Irvine, California 92697, USA
    Neuron 43:487-97. 2004
    ..These results indicate that NPS could be a new modulator of arousal and anxiety. They also show that the LC region encompasses distinct nuclei expressing different arousal-promoting neurotransmitters...
  38. ncbi request reprint Injection of neuropeptide W into paraventricular nucleus of hypothalamus increases food intake
    Allen S Levine
    Department of Food Science and Nutrition, University of Minnesota, St Paul, MN 55108, USA
    Am J Physiol Regul Integr Comp Physiol 288:R1727-32. 2005
    ..3 to 3 nmol increased feeding for up to 24 h. In contrast, only the 3-nmol dose of NPW23 increased feeding after administration into the LH. Together, these data suggest a modulatory role for NPW in the control of food intake...
  39. ncbi request reprint Not asleep, not quite awake
    J Gregor Sutcliffe
    Nat Med 10:673-4. 2004
  40. ncbi request reprint Cortistatin overexpression in transgenic mice produces deficits in synaptic plasticity and learning
    Melanie K Tallent
    Department of Pharmacology and Physiology, Drexel University, University College of Medicine, Philadelphia, PA 19102, USA
    Mol Cell Neurosci 30:465-75. 2005
    ..Our findings implicate cortistatin in the modulation of synaptic plasticity and cognitive function. Thus, increases in hippocampal cortistatin expression during aging could have an impact on age-related cognitive deficits...
  41. ncbi request reprint Expression, synaptic localization, and developmental regulation of Ack1/Pyk1, a cytoplasmic tyrosine kinase highly expressed in the developing and adult brain
    Jesús Mariano Ureña
    Developmental Neurobiology and Regeneration Lab, Institute of Biomedical Research of Barcelona Parc Científic de Barcelona, University of Barcelona, Josep Samitier 1 5, E08028 Barcelona, Spain
    J Comp Neurol 490:119-32. 2005
    ..Altogether, our findings indicate that Ack1/Pyk1 tyrosine kinase may be involved both in adult synaptic function and plasticity and in brain development...
  42. ncbi request reprint Circuit-breakers: optical technologies for probing neural signals and systems
    Feng Zhang
    Department of Bioengineering, W083 Clark Center, 318 Campus Drive West, Stanford University, California, USA
    Nat Rev Neurosci 8:577-81. 2007
    ..These tools could lead to the development of precise neuromodulation technologies for animal models of disease and clinical neuropsychiatry...
  43. doi request reprint Somatostatin receptor subtype 4 couples to the M-current to regulate seizures
    Cuie Qiu
    Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19348, USA
    J Neurosci 28:3567-76. 2008
    ..SST(4) receptors could therefore be an important novel target for developing new antiepileptic and antiepileptogenic drugs...
  44. pmc Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior
    Benjamin Boutrel
    Center for Psychiatric Neuroscience and Service Universitaire de Psychiatrie de l Enfant et de l Adolescent, Centre Hospitalier Universitaire Vaudois Département de Psychiatrie, University of Lausanne, Prilly, Switzerland
    Proc Natl Acad Sci U S A 102:19168-73. 2005
    ..These findings reveal a previously unidentified role for hypocretins in driving drug seeking through activation of stress pathways in the brain...
  45. ncbi request reprint A collection of cDNAs enriched in upper cortical layers of the embryonic mouse brain
    Cristina Garcia-Frigola
    IRBB PCB and Department of Cell Biology, Faculty of Biology, University of Barcelona, 08071 Barcelona, Spain
    Brain Res Mol Brain Res 122:133-50. 2004
    ..We thus cloned a collection of subtracted cDNAs coding for protein products that may be involved in the development of the cerebral cortex...