Marcia Dawson

Summary

Affiliation: The Burnham Institute
Country: USA

Publications

  1. pmc Novel cis-trans interactions are involved in post-transcriptional regulation of cyclin-dependent kinase inhibitor p21WAF1/CIP1 mRNA
    Liyue Zhang
    Karmanos Cancer Institute, Department of Internal Medicine, Wayne State University and John D, Dingell VA Medical Center, Room B4325, 4646 John R, Detroit, MI 48201, USA
    J Mol Signal 5:12. 2010
  2. pmc An adamantyl-substituted retinoid-derived molecule that inhibits cancer cell growth and angiogenesis by inducing apoptosis and binds to small heterodimer partner nuclear receptor: effects of modifying its carboxylate group on apoptosis, proliferation, and
    Marcia I Dawson
    Cancer Center, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Med Chem 50:2622-39. 2007
  3. ncbi request reprint Antagonist analogue of 6-[3'-(1-adamantyl)-4'-hydroxyphenyl]-2-naphthalenecarboxylic acid (AHPN) family of apoptosis inducers that effectively blocks AHPN-induced apoptosis but not cell-cycle arrest
    Marcia I Dawson
    The Burnham Institute, Cancer Center, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Med Chem 47:3518-36. 2004
  4. ncbi request reprint Synthetic retinoids and their nuclear receptors
    M I Dawson
    Cancer Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Med Chem Anticancer Agents 4:199-230. 2004
  5. doi request reprint Adamantyl-substituted retinoid-derived molecules that interact with the orphan nuclear receptor small heterodimer partner: effects of replacing the 1-adamantyl or hydroxyl group on inhibition of cancer cell growth, induction of cancer cell apoptosis, and
    Marcia I Dawson
    Cancer Center and Inflammatory and Infectious Disease Center, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Med Chem 51:5650-62. 2008
  6. pmc Derivation of a retinoid X receptor scaffold from peroxisome proliferator-activated receptor gamma ligand 1-Di(1H-indol-3-yl)methyl-4-trifluoromethylbenzene
    Marcia I Dawson
    Cancer Center, Burnham Institute for Medical Research, 10901 North Torrey Pines Rd, La Jolla, CA 92037, USA
    ChemMedChem 4:1106-19. 2009
  7. ncbi request reprint The peptidomimetic, 1-adamantyl-substituted, and flex-het classes of retinoid-derived molecules: structure-activity relationships and retinoid receptor-independent anticancer activities
    Marcia I Dawson
    Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Mini Rev Med Chem 10:455-91. 2010
  8. ncbi request reprint Determinants of retinoid X receptor transcriptional antagonism
    Claudio N Cavasotto
    Cancer Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    J Med Chem 47:4360-72. 2004
  9. ncbi request reprint Nicotine modulates the effects of retinoids on growth inhibition and RAR beta expression in lung cancer cells
    Guo quan Chen
    The Burnham Institute, Cancer Center, La Jolla, CA 92037, USA
    Int J Cancer 99:171-8. 2002
  10. ncbi request reprint Regulation of retinoic acid receptor beta expression by peroxisome proliferator-activated receptor gamma ligands in cancer cells
    Sharon Y James
    Cancer Center, The Burnham Institute, La Jolla, California 92037, USA
    Cancer Res 63:3531-8. 2003

Research Grants

  1. Rexinoid Synergy in Prostate Cancer Apoptosis
    Marcia Dawson; Fiscal Year: 2009

Collaborators

Detail Information

Publications30

  1. pmc Novel cis-trans interactions are involved in post-transcriptional regulation of cyclin-dependent kinase inhibitor p21WAF1/CIP1 mRNA
    Liyue Zhang
    Karmanos Cancer Institute, Department of Internal Medicine, Wayne State University and John D, Dingell VA Medical Center, Room B4325, 4646 John R, Detroit, MI 48201, USA
    J Mol Signal 5:12. 2010
    ..We previously found that cell growth suppressing retinoid CD437 enhanced expression of p21WAF1/CIP1 and DNA damage inducible GADD45 proteins in part by elevating their mRNA stability...
  2. pmc An adamantyl-substituted retinoid-derived molecule that inhibits cancer cell growth and angiogenesis by inducing apoptosis and binds to small heterodimer partner nuclear receptor: effects of modifying its carboxylate group on apoptosis, proliferation, and
    Marcia I Dawson
    Cancer Center, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Med Chem 50:2622-39. 2007
    ..3-Cl-AHPC at 1.0 microM induced human microvascular endothelial cell apoptosis but did not inhibit cell migration or tube formation...
  3. ncbi request reprint Antagonist analogue of 6-[3'-(1-adamantyl)-4'-hydroxyphenyl]-2-naphthalenecarboxylic acid (AHPN) family of apoptosis inducers that effectively blocks AHPN-induced apoptosis but not cell-cycle arrest
    Marcia I Dawson
    The Burnham Institute, Cancer Center, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Med Chem 47:3518-36. 2004
    ..As a result, the position of RARgamma helix H12 in forming the coactivator-binding site was impacted in a manner consistent with the experimental effect of each analogue on RARgamma transcriptional activation...
  4. ncbi request reprint Synthetic retinoids and their nuclear receptors
    M I Dawson
    Cancer Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Med Chem Anticancer Agents 4:199-230. 2004
    ..Emphasis is placed on the retinoid X receptors and their ligands...
  5. doi request reprint Adamantyl-substituted retinoid-derived molecules that interact with the orphan nuclear receptor small heterodimer partner: effects of replacing the 1-adamantyl or hydroxyl group on inhibition of cancer cell growth, induction of cancer cell apoptosis, and
    Marcia I Dawson
    Cancer Center and Inflammatory and Infectious Disease Center, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Med Chem 51:5650-62. 2008
    ..Inhibitory activity against Src homology 2 domain-containing protein tyrosine phosphatase 2 (Shp-2) was also assessed. The most active Shp-2 inhibitor was found to be the 3'-(3,3-dimethylbutynyl) analogue of 3-Cl-AHPC...
  6. pmc Derivation of a retinoid X receptor scaffold from peroxisome proliferator-activated receptor gamma ligand 1-Di(1H-indol-3-yl)methyl-4-trifluoromethylbenzene
    Marcia I Dawson
    Cancer Center, Burnham Institute for Medical Research, 10901 North Torrey Pines Rd, La Jolla, CA 92037, USA
    ChemMedChem 4:1106-19. 2009
    ....
  7. ncbi request reprint The peptidomimetic, 1-adamantyl-substituted, and flex-het classes of retinoid-derived molecules: structure-activity relationships and retinoid receptor-independent anticancer activities
    Marcia I Dawson
    Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Mini Rev Med Chem 10:455-91. 2010
    ..Structure-activity relationships and potential for clinical translation as anticancer therapeutics are presented...
  8. ncbi request reprint Determinants of retinoid X receptor transcriptional antagonism
    Claudio N Cavasotto
    Cancer Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    J Med Chem 47:4360-72. 2004
    ..The antagonist also blocked activation of RAR subtypes alpha and beta by 9-cis-RA but not that of RARgamma...
  9. ncbi request reprint Nicotine modulates the effects of retinoids on growth inhibition and RAR beta expression in lung cancer cells
    Guo quan Chen
    The Burnham Institute, Cancer Center, La Jolla, CA 92037, USA
    Int J Cancer 99:171-8. 2002
    ....
  10. ncbi request reprint Regulation of retinoic acid receptor beta expression by peroxisome proliferator-activated receptor gamma ligands in cancer cells
    Sharon Y James
    Cancer Center, The Burnham Institute, La Jolla, California 92037, USA
    Cancer Res 63:3531-8. 2003
    ....
  11. ncbi request reprint Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3
    Bingzhen Lin
    The Burnham Institute, Cancer Center, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 116:527-40. 2004
    ....
  12. doi request reprint Studies of cannabinoid-1 receptor antagonists for the treatment of obesity: hologram QSAR model for biarylpyrazolyl oxadiazole ligands
    Mao Ye
    Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Bioorg Med Chem Lett 19:3310-5. 2009
    ..Both the HQSAR model and analysis from the contribution map should be useful for the further design of novel structurally related CB(1) antagonists...
  13. doi request reprint 3D-QSAR and QSSR studies of 3,8-diazabicyclo[4.2.0]octane derivatives as neuronal nicotinic acetylcholine receptors by comparative molecular field analysis (CoMFA)
    Mao Ye
    Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Bioorg Med Chem Lett 19:127-31. 2009
    ..924, 0.935 and 0.875 for conventional r(2). Analyses indicated that both the steric and electrostatic factors should be considered in the rational design of more active and selective nAChR agonists...
  14. pmc Retinoid X receptor regulates Nur77/TR3-dependent apoptosis [corrected] by modulating its nuclear export and mitochondrial targeting
    Xihua Cao
    The Burnham Institute, Cancer Center, 10901 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Mol Cell Biol 24:9705-25. 2004
    ..Together, our results reveal a novel nongenotropic function of RXRalpha and its involvement in the regulation of the Nur77-dependent apoptotic pathway [corrected]..
  15. pmc Quantum dot-doped silica nanoparticles as probes for targeting of T-lymphocytes
    Massimo Bottini
    Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Int J Nanomedicine 2:227-33. 2007
    ..Thus, quantum dot-doped silica nanoparticles decorated with neutravidin represent a potentially excellent scaffold for constructing specific intracellular nanoprobes and transporters...
  16. ncbi request reprint Discovery and design of retinoic acid receptor and retinoid X receptor class- and subtype-selective synthetic analogs of all-trans-retinoic acid and 9-cis-retinoic acid
    Marcia I Dawson
    Department of Medicinal Chemistry, Molecular Medicine Research Institute, Mountain View, La Jolla, CA 94043, USA
    Curr Med Chem 9:623-37. 2002
    ....
  17. ncbi request reprint Full-length single-walled carbon nanotubes decorated with streptavidin-conjugated quantum dots as multivalent intracellular fluorescent nanoprobes
    Massimo Bottini
    Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Biomacromolecules 7:2259-63. 2006
    ....
  18. ncbi request reprint Cell-type specific and cytoplasmic targeting of PEGylated carbon nanotube-based nanoassemblies
    Matthew H Cato
    Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Nanosci Nanotechnol 8:2259-69. 2008
    ..The present manuscript is the first report about the cytoplasmic delivery of carbon nanotubes in a specific cell type in intact animals and paves the way for their use as in vivo intracellular delivery systems...
  19. ncbi request reprint Synthesis and characterization of supramolecular nanostructures of carbon nanotubes and ruthenium-complex Luminophores
    Massimo Bottini
    Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Nanosci Nanotechnol 6:1381-6. 2006
    ..These structures were evaluated as potential electron-acceptor complexes for use in the fabrication of photovoltaic devices, and for their properties as fluorescent nanocomposites for use in biosensors or nanoelectronics...
  20. ncbi request reprint Isolation and characterization of fluorescent nanoparticles from pristine and oxidized electric arc-produced single-walled carbon nanotubes
    Massimo Bottini
    Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    J Phys Chem B 110:831-6. 2006
    ....
  21. pmc Mitogenic effect of orphan receptor TR3 and its regulation by MEKK1 in lung cancer cells
    Siva Kumar Kolluri
    Cancer Center, The Burnham Institute, La Jolla, California 92037, USA
    Mol Cell Biol 23:8651-67. 2003
    ..Together, our results demonstrate that TR3 is capable of inducing both proliferation and apoptosis in the same cells depending on the stimuli and its cellular localization...
  22. pmc Adamantyl-substituted retinoid-related molecules bind small heterodimer partner and modulate the Sin3A repressor
    Lulu Farhana
    John D Dingell Veterans Affairs Medical Center, 4646 John R Street, Detroit, MI 48201, USA
    Cancer Res 67:318-25. 2007
    ..These results suggest that AHPN/3-Cl-AHPC and their analogues are SHP ligands and their induction of apoptosis is mediated by their binding to the SHP receptor...
  23. ncbi request reprint Induction of apoptosis of human B-CLL and ALL cells by a novel retinoid and its nonretinoidal analog
    Yuxiang Zhang
    Department of Medicine, Karmanos Cancer Institute, Wayne State University, and the John D Dingell VA Medical Center, Detroit, MI 48201, USA
    Blood 100:2917-25. 2002
    ..These results suggest that CD437 and MM002 analogs may have a potential role in the treatment of B-CLL and ALL...
  24. ncbi request reprint Induction of apoptosis in retinoid-refractory acute myelogenous leukemia by a novel AHPN analog
    Yuxiang Zhang
    John D Dingell VA Medical Center, and Department of Medicine, Wayne State University, Detroit, MI 48201, USA
    Blood 102:3743-52. 2003
    ..3-log kill in the leukemic blasts. While 3-Cl-AHPC does not activate retinoic nuclear receptors, it is a potent inducer of apoptosis in AML cells and may represent a novel therapy in the treatment of this disease...
  25. ncbi request reprint Apoptosis signaling by the novel compound 3-Cl-AHPC involves increased EGFR proteolysis and accompanying decreased phosphatidylinositol 3-kinase and AKT kinase activities
    Lulu Farhana
    John D Dingell VA Medical Center, Karmanos Cancer Institute, Department of Internal Medicine, Wayne State University, Detroit, MI 48201, USA
    Oncogene 23:1874-84. 2004
    ..Inhibition of AKT activity by this compound results in the inability of AKT to phosphorylate and inactivate the proapoptotic forkhead transcription factor...
  26. ncbi request reprint Apoptosis induction by a novel retinoid-related molecule requires nuclear factor-kappaB activation
    Lulu Farhana
    John D Dingell Veterans Affairs Medical Center, Detroit, Michigan 48201, USA
    Cancer Res 65:4909-17. 2005
    ..Thus, 3-Cl-AHPC, which is under preclinical development, has pleotrophic effects on malignant cells resulting in their apoptosis...
  27. pmc Retinoic acid (RA) regulates 17beta-hydroxysteroid dehydrogenase type 2 expression in endometrium: interaction of RA receptors with specificity protein (SP) 1/SP3 for estradiol metabolism
    You Hong Cheng
    Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Northwestern University, 303 E Superior Street, Chicago, IL 60611, USA
    J Clin Endocrinol Metab 93:1915-23. 2008
    ..Retinoic acid (RA) induces HSD17B2 expression, but the underlying mechanism is not known...
  28. ncbi request reprint Identification and characterization of a cell cycle and apoptosis regulatory protein-1 as a novel mediator of apoptosis signaling by retinoid CD437
    Arun K Rishi
    Veterans Affairs Medical Center, Department of Internal Medicine and Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA
    J Biol Chem 278:33422-35. 2003
    ..Identification of CARP-1 as a key mediator of signaling by CD437 or adriamycin allows for delineation of pathways that, in turn, may prove beneficial for design and targeting of novel antitumor agents...
  29. ncbi request reprint Investigation of ligand interactions with human RXRalpha by hydrogen/deuterium exchange and mass spectrometry
    Xuguang Yan
    Department of Chemistry, Oregon State University, Corvallis, Oregon 94331, USA
    J Am Soc Mass Spectrom 17:1510-7. 2006
    ..Methoprenic acid did not significantly protect hRXRalpha against amide hydrogen exchange. An efficient method is described for comparing the effects of different agonists on the protein structure of the agonist-RXRalpha complex...
  30. pmc Mass-spectrometric analysis of agonist-induced retinoic acid receptor gamma conformational change
    Valerie J Peterson
    Laboratory of Molecular Pharmacology, Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR 97331, U S A
    Biochem J 362:173-81. 2002
    ..This technique should be generally applicable to other members of the nuclear receptor superfamily that undergo an induced structural alteration upon agonist or antagonist binding, DNA binding and/or protein-protein interaction...

Research Grants5

  1. Rexinoid Synergy in Prostate Cancer Apoptosis
    Marcia Dawson; Fiscal Year: 2009
    ..We anticipate that our results will provide a more effective and less systemically toxic means of enhancing the efficacy of chemotherapeutic agents currently used to treat prostate cancer. ..