Research Topics
| Marcia DawsonSummaryAffiliation: The Burnham Institute Country: USA Publications
Research Grants
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Detail Information
Publications
Novel cis-trans interactions are involved in post-transcriptional regulation of cyclin-dependent kinase inhibitor p21WAF1/CIP1 mRNALiyue Zhang
Karmanos Cancer Institute, Department of Internal Medicine, Wayne State University and John D, Dingell VA Medical Center, Room B4325, 4646 John R, Detroit, MI 48201, USA
J Mol Signal 5:12. 2010..We previously found that cell growth suppressing retinoid CD437 enhanced expression of p21WAF1/CIP1 and DNA damage inducible GADD45 proteins in part by elevating their mRNA stability...- An adamantyl-substituted retinoid-derived molecule that inhibits cancer cell growth and angiogenesis by inducing apoptosis and binds to small heterodimer partner nuclear receptor: effects of modifying its carboxylate group on apoptosis, proliferation, andMarcia I Dawson
Cancer Center, Burnham Institute for Medical Research, La Jolla, California 92037, USA
J Med Chem 50:2622-39. 2007..3-Cl-AHPC at 1.0 microM induced human microvascular endothelial cell apoptosis but did not inhibit cell migration or tube formation... 
Antagonist analogue of 6-[3'-(1-adamantyl)-4'-hydroxyphenyl]-2-naphthalenecarboxylic acid (AHPN) family of apoptosis inducers that effectively blocks AHPN-induced apoptosis but not cell-cycle arrestMarcia I Dawson
The Burnham Institute, Cancer Center, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
J Med Chem 47:3518-36. 2004..As a result, the position of RARgamma helix H12 in forming the coactivator-binding site was impacted in a manner consistent with the experimental effect of each analogue on RARgamma transcriptional activation...- Synthetic retinoids and their nuclear receptorsM I Dawson
Cancer Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Curr Med Chem Anticancer Agents 4:199-230. 2004..Emphasis is placed on the retinoid X receptors and their ligands... 
Adamantyl-substituted retinoid-derived molecules that interact with the orphan nuclear receptor small heterodimer partner: effects of replacing the 1-adamantyl or hydroxyl group on inhibition of cancer cell growth, induction of cancer cell apoptosis, and Marcia I Dawson
Cancer Center and Inflammatory and Infectious Disease Center, Burnham Institute for Medical Research, La Jolla, California 92037, USA
J Med Chem 51:5650-62. 2008..Inhibitory activity against Src homology 2 domain-containing protein tyrosine phosphatase 2 (Shp-2) was also assessed. The most active Shp-2 inhibitor was found to be the 3'-(3,3-dimethylbutynyl) analogue of 3-Cl-AHPC...- Derivation of a retinoid X receptor scaffold from peroxisome proliferator-activated receptor gamma ligand 1-Di(1H-indol-3-yl)methyl-4-trifluoromethylbenzeneMarcia I Dawson
Cancer Center, Burnham Institute for Medical Research, 10901 North Torrey Pines Rd, La Jolla, CA 92037, USA
ChemMedChem 4:1106-19. 2009.... - The peptidomimetic, 1-adamantyl-substituted, and flex-het classes of retinoid-derived molecules: structure-activity relationships and retinoid receptor-independent anticancer activitiesMarcia I Dawson
Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Mini Rev Med Chem 10:455-91. 2010..Structure-activity relationships and potential for clinical translation as anticancer therapeutics are presented... - Determinants of retinoid X receptor transcriptional antagonismClaudio N Cavasotto
Cancer Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
J Med Chem 47:4360-72. 2004..The antagonist also blocked activation of RAR subtypes alpha and beta by 9-cis-RA but not that of RARgamma... - Nicotine modulates the effects of retinoids on growth inhibition and RAR beta expression in lung cancer cellsGuo-quan Chen
The Burnham Institute, Cancer Center, La Jolla, CA 92037, USA
Int J Cancer 99:171-8. 2002.... - Regulation of retinoic acid receptor beta expression by peroxisome proliferator-activated receptor gamma ligands in cancer cellsSharon Y James
Cancer Center, The Burnham Institute, La Jolla, California 92037, USA
Cancer Res 63:3531-8. 2003.... - Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3Bingzhen Lin
The Burnham Institute, Cancer Center, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Cell 116:527-40. 2004.... - Studies of cannabinoid-1 receptor antagonists for the treatment of obesity: hologram QSAR model for biarylpyrazolyl oxadiazole ligandsMao Ye
Burnham Institute for Medical Research, La Jolla, CA 92037, USA
Bioorg Med Chem Lett 19:3310-5. 2009..Both the HQSAR model and analysis from the contribution map should be useful for the further design of novel structurally related CB(1) antagonists... - 3D-QSAR and QSSR studies of 3,8-diazabicyclo[4.2.0]octane derivatives as neuronal nicotinic acetylcholine receptors by comparative molecular field analysis (CoMFA)Mao Ye
Burnham Institute for Medical Research, La Jolla, CA 92037, USA
Bioorg Med Chem Lett 19:127-31. 2009..924, 0.935 and 0.875 for conventional r(2). Analyses indicated that both the steric and electrostatic factors should be considered in the rational design of more active and selective nAChR agonists... - Retinoid X receptor regulates Nur77/TR3-dependent apoptosis [corrected] by modulating its nuclear export and mitochondrial targetingXihua Cao
The Burnham Institute, Cancer Center, 10901 N Torrey Pines Rd, La Jolla, CA 92037, USA
Mol Cell Biol 24:9705-25. 2004..Together, our results reveal a novel nongenotropic function of RXRalpha and its involvement in the regulation of the Nur77-dependent apoptotic pathway [corrected].. - Quantum dot-doped silica nanoparticles as probes for targeting of T-lymphocytesMassimo Bottini
Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Int J Nanomedicine 2:227-33. 2007..Thus, quantum dot-doped silica nanoparticles decorated with neutravidin represent a potentially excellent scaffold for constructing specific intracellular nanoprobes and transporters... - Discovery and design of retinoic acid receptor and retinoid X receptor class- and subtype-selective synthetic analogs of all-trans-retinoic acid and 9-cis-retinoic acidMarcia I Dawson
Department of Medicinal Chemistry, Molecular Medicine Research Institute, Mountain View, La Jolla, CA 94043, USA
Curr Med Chem 9:623-37. 2002.... - Full-length single-walled carbon nanotubes decorated with streptavidin-conjugated quantum dots as multivalent intracellular fluorescent nanoprobesMassimo Bottini
Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
Biomacromolecules 7:2259-63. 2006.... - Cell-type specific and cytoplasmic targeting of PEGylated carbon nanotube-based nanoassembliesMatthew H Cato
Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
J Nanosci Nanotechnol 8:2259-69. 2008..The present manuscript is the first report about the cytoplasmic delivery of carbon nanotubes in a specific cell type in intact animals and paves the way for their use as in vivo intracellular delivery systems... - Synthesis and characterization of supramolecular nanostructures of carbon nanotubes and ruthenium-complex LuminophoresMassimo Bottini
Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
J Nanosci Nanotechnol 6:1381-6. 2006..These structures were evaluated as potential electron-acceptor complexes for use in the fabrication of photovoltaic devices, and for their properties as fluorescent nanocomposites for use in biosensors or nanoelectronics... - Isolation and characterization of fluorescent nanoparticles from pristine and oxidized electric arc-produced single-walled carbon nanotubesMassimo Bottini
Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
J Phys Chem B 110:831-6. 2006.... - Mitogenic effect of orphan receptor TR3 and its regulation by MEKK1 in lung cancer cellsSiva Kumar Kolluri
Cancer Center, The Burnham Institute, La Jolla, California 92037, USA
Mol Cell Biol 23:8651-67. 2003..Together, our results demonstrate that TR3 is capable of inducing both proliferation and apoptosis in the same cells depending on the stimuli and its cellular localization... - Adamantyl-substituted retinoid-related molecules bind small heterodimer partner and modulate the Sin3A repressorLulu Farhana
John D Dingell Veterans Affairs Medical Center, 4646 John R Street, Detroit, MI 48201, USA
Cancer Res 67:318-25. 2007..These results suggest that AHPN/3-Cl-AHPC and their analogues are SHP ligands and their induction of apoptosis is mediated by their binding to the SHP receptor... - Induction of apoptosis of human B-CLL and ALL cells by a novel retinoid and its nonretinoidal analogYuxiang Zhang
Department of Medicine, Karmanos Cancer Institute, Wayne State University, and the John D Dingell VA Medical Center, Detroit, MI 48201, USA
Blood 100:2917-25. 2002..These results suggest that CD437 and MM002 analogs may have a potential role in the treatment of B-CLL and ALL... - Induction of apoptosis in retinoid-refractory acute myelogenous leukemia by a novel AHPN analogYuxiang Zhang
John D Dingell VA Medical Center, and Department of Medicine, Wayne State University, Detroit, MI 48201, USA
Blood 102:3743-52. 2003..3-log kill in the leukemic blasts. While 3-Cl-AHPC does not activate retinoic nuclear receptors, it is a potent inducer of apoptosis in AML cells and may represent a novel therapy in the treatment of this disease... - Apoptosis signaling by the novel compound 3-Cl-AHPC involves increased EGFR proteolysis and accompanying decreased phosphatidylinositol 3-kinase and AKT kinase activitiesLulu Farhana
John D Dingell VA Medical Center, Karmanos Cancer Institute, Department of Internal Medicine, Wayne State University, Detroit, MI 48201, USA
Oncogene 23:1874-84. 2004..Inhibition of AKT activity by this compound results in the inability of AKT to phosphorylate and inactivate the proapoptotic forkhead transcription factor... - Apoptosis induction by a novel retinoid-related molecule requires nuclear factor-kappaB activationLulu Farhana
John D Dingell Veterans Affairs Medical Center, Detroit, Michigan 48201, USA
Cancer Res 65:4909-17. 2005..Thus, 3-Cl-AHPC, which is under preclinical development, has pleotrophic effects on malignant cells resulting in their apoptosis... - Retinoic acid (RA) regulates 17beta-hydroxysteroid dehydrogenase type 2 expression in endometrium: interaction of RA receptors with specificity protein (SP) 1/SP3 for estradiol metabolismYou Hong Cheng
Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Northwestern University, 303 E Superior Street, Chicago, IL 60611, USA
J Clin Endocrinol Metab 93:1915-23. 2008..Retinoic acid (RA) induces HSD17B2 expression, but the underlying mechanism is not known... - Identification and characterization of a cell cycle and apoptosis regulatory protein-1 as a novel mediator of apoptosis signaling by retinoid CD437Arun K Rishi
Veterans Affairs Medical Center, Department of Internal Medicine and Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA
J Biol Chem 278:33422-35. 2003..Identification of CARP-1 as a key mediator of signaling by CD437 or adriamycin allows for delineation of pathways that, in turn, may prove beneficial for design and targeting of novel antitumor agents... - Investigation of ligand interactions with human RXRalpha by hydrogen/deuterium exchange and mass spectrometryXuguang Yan
Department of Chemistry, Oregon State University, Corvallis, Oregon 94331, USA
J Am Soc Mass Spectrom 17:1510-7. 2006..Methoprenic acid did not significantly protect hRXRalpha against amide hydrogen exchange. An efficient method is described for comparing the effects of different agonists on the protein structure of the agonist-RXRalpha complex... - Mass-spectrometric analysis of agonist-induced retinoic acid receptor gamma conformational changeValerie J Peterson
Laboratory of Molecular Pharmacology, Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR 97331, U.S.A
Biochem J 362:173-81. 2002..This technique should be generally applicable to other members of the nuclear receptor superfamily that undergo an induced structural alteration upon agonist or antagonist binding, DNA binding and/or protein-protein interaction...
Research Grants
- Rexinoid Synergy in Prostate Cancer ApoptosisMarcia Dawson; Fiscal Year: 2009..We anticipate that our results will provide a more effective and less systemically toxic means of enhancing the efficacy of chemotherapeutic agents currently used to treat prostate cancer. ..