Ronald L Davis

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. pmc Genetic association of cyclic AMP signaling genes with bipolar disorder
    M L McDonald
    Department of Molecular and Human Genetics, Center for Statistical Genetics, Baylor College of Medicine, Houston, TX, USA
    Transl Psychiatry 2:e169. 2012
  2. doi request reprint Rac in the act of forgetting
    Ronald L Davis
    Department of Neuroscience, The Scripps Research Institute Florida, Jupiter, 33458, USA
    Cell 140:456-8. 2010
  3. pmc Traces of Drosophila memory
    Ronald L Davis
    Department of Neuroscience, The Scripps Research Institute Florida, Jupiter, FL 33410, USA
    Neuron 70:8-19. 2011
  4. pmc Drosophila alpha/beta mushroom body neurons form a branch-specific, long-term cellular memory trace after spaced olfactory conditioning
    Dinghui Yu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Neuron 52:845-55. 2006
  5. pmc A distinct set of Drosophila brain neurons required for neurofibromatosis type 1-dependent learning and memory
    Monica E Buchanan
    Department of Molecular and Human Genetics and Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    J Neurosci 30:10135-43. 2010
  6. ncbi request reprint Drosophila DPM neurons form a delayed and branch-specific memory trace after olfactory classical conditioning
    Dinghui Yu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cell 123:945-57. 2005
  7. pmc Dopamine is required for learning and forgetting in Drosophila
    Jacob A Berry
    Department of Neuroscience, The Scripps Research Institute Florida, Jupiter, FL 33410, USA
    Neuron 74:530-42. 2012
  8. doi request reprint Gilgamesh is required for rutabaga-independent olfactory learning in Drosophila
    Ying Tan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 67:810-20. 2010
  9. pmc Distinct traces for appetitive versus aversive olfactory memories in DPM neurons of Drosophila
    Isaac Cervantes-Sandoval
    Department of Neuroscience, The Scripps Research Institute Florida, Jupiter, FL 33410, USA
    Curr Biol 22:1247-52. 2012
  10. pmc The GABAergic anterior paired lateral neuron suppresses and is suppressed by olfactory learning
    Xu Liu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Nat Neurosci 12:53-9. 2009

Research Grants

  1. MOLECULAR BIOLOGY OF DROSOPHILA LEARNING AND MEMORY
    Ronald L Davis; Fiscal Year: 2010
  2. Olfactory memory trace formation in Drosophila
    Ronald L Davis; Fiscal Year: 2010
  3. INTEGRIN FUNCTION IN MEMORY
    Ronald L Davis; Fiscal Year: 2010
  4. Cyclic AMP Signaling and Bipolar Disorder
    Ronald L Davis; Fiscal Year: 2009
  5. MOLECULAR BIOLOGY OF DROSOPHILA LEARNING AND MEMORY
    Ronald L Davis; Fiscal Year: 2011

Collaborators

Detail Information

Publications49

  1. pmc Genetic association of cyclic AMP signaling genes with bipolar disorder
    M L McDonald
    Department of Molecular and Human Genetics, Center for Statistical Genetics, Baylor College of Medicine, Houston, TX, USA
    Transl Psychiatry 2:e169. 2012
    ..This report is among the first to use multiple rare variant analysis methods following common tagSNPs associations with BPD...
  2. doi request reprint Rac in the act of forgetting
    Ronald L Davis
    Department of Neuroscience, The Scripps Research Institute Florida, Jupiter, 33458, USA
    Cell 140:456-8. 2010
    ..In this issue, Shuai et al. (2010) find that the small G protein Rac may function as a switch for remembering versus forgetting...
  3. pmc Traces of Drosophila memory
    Ronald L Davis
    Department of Neuroscience, The Scripps Research Institute Florida, Jupiter, FL 33410, USA
    Neuron 70:8-19. 2011
    ....
  4. pmc Drosophila alpha/beta mushroom body neurons form a branch-specific, long-term cellular memory trace after spaced olfactory conditioning
    Dinghui Yu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Neuron 52:845-55. 2006
    ....
  5. pmc A distinct set of Drosophila brain neurons required for neurofibromatosis type 1-dependent learning and memory
    Monica E Buchanan
    Department of Molecular and Human Genetics and Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    J Neurosci 30:10135-43. 2010
    ....
  6. ncbi request reprint Drosophila DPM neurons form a delayed and branch-specific memory trace after olfactory classical conditioning
    Dinghui Yu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cell 123:945-57. 2005
    ..DPM neurons are therefore "odor generalists" and form a delayed, branch-specific, and amnesiac-dependent memory trace that may guide behavior after acquisition...
  7. pmc Dopamine is required for learning and forgetting in Drosophila
    Jacob A Berry
    Department of Neuroscience, The Scripps Research Institute Florida, Jupiter, FL 33410, USA
    Neuron 74:530-42. 2012
    ..We propose a dual role for dopamine: memory acquisition through dDA1 signaling and forgetting through DAMB signaling in the mushroom body neurons...
  8. doi request reprint Gilgamesh is required for rutabaga-independent olfactory learning in Drosophila
    Ying Tan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 67:810-20. 2010
    ..Therefore, gish participates in a rutabaga-independent pathway for memory formation and accounts for some of the residual learning that occurs in rutabaga mutants...
  9. pmc Distinct traces for appetitive versus aversive olfactory memories in DPM neurons of Drosophila
    Isaac Cervantes-Sandoval
    Department of Neuroscience, The Scripps Research Institute Florida, Jupiter, FL 33410, USA
    Curr Biol 22:1247-52. 2012
    ..These results indicate that the persistence and breadth of the DPM neuron memory trace influences the duration of behavioral memory...
  10. pmc The GABAergic anterior paired lateral neuron suppresses and is suppressed by olfactory learning
    Xu Liu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Nat Neurosci 12:53-9. 2009
    ..These results demonstrate a mutual suppression between the GABAergic APL neuron and olfactory learning, and emphasize the functional neuroplasticity of the GABAergic system as a result of learning...
  11. pmc Roles for Drosophila mushroom body neurons in olfactory learning and memory
    David Benjamin G Akalal
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Learn Mem 13:659-68. 2006
    ....
  12. pmc Beta 1-integrins are required for hippocampal AMPA receptor-dependent synaptic transmission, synaptic plasticity, and working memory
    Chi Shing Chan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 26:223-32. 2006
    ..These observations suggest a new function of beta1-integrins as regulators of synaptic glutamate receptor function and working memory...
  13. pmc Alpha3-integrins are required for hippocampal long-term potentiation and working memory
    Chi Shing Chan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Learn Mem 14:606-15. 2007
    ..The impairment in LTP and working memory is similar to that observed in beta1-integrin conditional knockout mice, suggesting that alpha3-integrin is the functional binding partner for beta1 for these processes in the forebrain...
  14. pmc GABAA receptor RDL inhibits Drosophila olfactory associative learning
    Xu Liu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 56:1090-102. 2007
    ..Together, these data suggest that RDL negatively modulates olfactory associative learning, possibly by gating the input of olfactory information into the MBs...
  15. ncbi request reprint Spatiotemporal rescue of memory dysfunction in Drosophila
    Sean E McGuire
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Science 302:1765-8. 2003
    ..The TARGET system offers general utility in simultaneously addressing issues of when and where gene products are required...
  16. pmc Aging impairs intermediate-term behavioral memory by disrupting the dorsal paired medial neuron memory trace
    Ayako Tonoki
    Department of Neuroscience, The Scripps Research Institute Florida, Jupiter, FL 33458, USA
    Proc Natl Acad Sci U S A 109:6319-24. 2012
    ....
  17. ncbi request reprint The dachshund gene is required for the proper guidance and branching of mushroom body axons in Drosophila melanogaster
    Sharyl R Martini
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurobiol 64:133-44. 2005
    ..In addition, mushroom body axons exhibit excessive branching in dachshund mutant clones. Thus, dachshund is required in mushroom body neurons for proper axon guidance and branching...
  18. ncbi request reprint Drosophila homer is required in a small set of neurons including the ellipsoid body for normal ethanol sensitivity and tolerance
    Nancy L Urizar
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 27:4541-51. 2007
    ..Thus, some of the molecular- and systems-level requirements for these two behavioral responses to ethanol are identical...
  19. pmc A late-phase, long-term memory trace forms in the γ neurons of Drosophila mushroom bodies after olfactory classical conditioning
    David Benjamin G Akalal
    Department of Molecular and Cellular Biology and Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 30:16699-708. 2010
    ..These results demonstrate that behavioral long-term olfactory memory is encoded as modifications of calcium influx into distinct MB neurons during overlapping but different windows of time after training...
  20. pmc The GABAA receptor RDL suppresses the conditioned stimulus pathway for olfactory learning
    Xu Liu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 29:1573-9. 2009
    ..The combined data suggest that RDL suppresses olfactory learning via CS pathway involvement...
  21. pmc Exploratory activity in Drosophila requires the kurtz nonvisual arrestin
    Lingzhi Liu
    Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204, USA
    Genetics 175:1197-212. 2007
    ..Therefore, the exploratory phase of open field activity requires kurtz in the nervous system, but is independent of dopamine's stimulation of activity...
  22. ncbi request reprint Spatiotemporal gene expression targeting with the TARGET and gene-switch systems in Drosophila
    Sean E McGuire
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Sci STKE 2004:pl6. 2004
    ..In this protocol, we provide guidelines for the use of these two novel systems, which should have general utility in studying Drosophila biology and in using the fly as a model for human disease...
  23. pmc A Drosophila nonvisual arrestin is required for the maintenance of olfactory sensitivity
    Hong Ge
    Department of Biology and Biochemistry, University of Houston, 4800 Calhoun Road, Houston, TX 77204, USA
    Chem Senses 31:49-62. 2006
    ..The reduced receptor potentials in krz(1) antenna indicate that nonvisual arrestins are required for the early odor-induced signaling events within the ORNs...
  24. pmc Olfactory learning in Drosophila
    Germain U Busto
    Department of Neuroscience, The Scripps Research Institute Florida, Jupiter, Florida, USA
    Physiology (Bethesda) 25:338-46. 2010
    ..The results from these and other experiments also indicate that cross talk between mushroom bodies and several other brain regions is critical for memory formation...
  25. pmc Wnt signaling is required for long-term memory formation
    Ying Tan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Cell Rep 4:1082-9. 2013
    ..Thus, inhibiting three key components of the Wnt signaling pathway in adult mushroom bodies impairs LTM, indicating that this pathway mechanistically underlies this specific form of memory. ..
  26. pmc Dynamics of learning-related cAMP signaling and stimulus integration in the Drosophila olfactory pathway
    Seth M Tomchik
    Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 64:510-21. 2009
    ..These data suggest that rutabaga functions as a coincidence detector in an intact neuronal circuit, with dopamine and octopamine bidirectionally influencing the generation of cAMP...
  27. ncbi request reprint Altered representation of the spatial code for odors after olfactory classical conditioning; memory trace formation by synaptic recruitment
    Dinghui Yu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030 USA
    Neuron 42:437-49. 2004
    ..The rapid recruitment by conditioning of new synapses into the representation of sensory information may be a general mechanism underlying many forms of short-term memory...
  28. pmc The long-term memory trace formed in the Drosophila α/β mushroom body neurons is abolished in long-term memory mutants
    David Benjamin G Akalal
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 31:5643-7. 2011
    ..These observations elevate the significance of this LTM trace given that 26 independent mutants all exhibit a defect in the trace, and further suggest that the calcium trace is a fundamental mechanism underlying Drosophila LTM...
  29. pmc System-like consolidation of olfactory memories in Drosophila
    Isaac Cervantes-Sandoval
    Department of Neuroscience, The Scripps Research Institute Florida, Jupiter, Florida 33410, USA
    J Neurosci 33:9846-54. 2013
    ....
  30. ncbi request reprint Gene expression systems in Drosophila: a synthesis of time and space
    Sean E McGuire
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Trends Genet 20:384-91. 2004
    ....
  31. ncbi request reprint Olfactory memory formation in Drosophila: from molecular to systems neuroscience
    Ronald L Davis
    Department of Molecular and Cellular Biology, Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    Annu Rev Neurosci 28:275-302. 2005
    ..Finally, the genes identified to participate in Drosophila olfactory learning have conserved roles in mammalian organisms, highlighting the value of Drosophila for gene discovery...
  32. ncbi request reprint Thirty years of olfactory learning and memory research in Drosophila melanogaster
    Sean E McGuire
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Prog Neurobiol 76:328-47. 2005
    ....
  33. pmc Olfactory memory traces in Drosophila
    Jacob Berry
    Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Prog Brain Res 169:293-304. 2008
    ..Therefore, it appears that aversive olfactory associations are encoded by multiple cellular memory traces that occur in different regions of the brain with different temporal domains...
  34. pmc Pharmacogenetic rescue in time and space of the rutabaga memory impairment by using Gene-Switch
    Zhengmei Mao
    Departments of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:198-203. 2004
    ..Such combined pharmacogenetic regulation of transgene expression now allows this time and space dissection to be made for other behavioral mutants...
  35. ncbi request reprint Insect olfactory memory in time and space
    Xu Liu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Curr Opin Neurobiol 16:679-85. 2006
    ....
  36. doi request reprint Mushroom-body memories: an obituary prematurely written?
    Ronald L Davis
    Department of Neuroscience, The Scripps Research Institute Florida, Jupiter, FL 33410, USA
    Curr Biol 22:R272-5. 2012
    ..Two new neurons in the fly brain are reported now as essential sites for LTM formation, while mushroom bodies are claimed to be unnecessary to this end...
  37. ncbi request reprint Integrin requirement for hippocampal synaptic plasticity and spatial memory
    Chi Shing Chan
    Department of Molecular and Cellular Biology, Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 23:7107-16. 2003
    ..These results demonstrate that several different integrins are involved in physiological plasticity and provide the first evidence of their requirement for behavioral plasticity in vertebrates...
  38. ncbi request reprint The role of cAMP response element-binding protein in Drosophila long-term memory
    Bastianella Perazzona
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 24:8823-8. 2004
    ..Overexpression of the dCREB2-b repressor transgene, in contrast, produced the anticipated block in LTM formation. We discuss the implications of these findings and propose an alternative model for the role of dCREB in Drosophila LTM...
  39. doi request reprint Cyclic AMP imaging sheds light on PDF signaling in circadian clock neurons
    Seth M Tomchik
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 58:161-3. 2008
    ..Thus, PDF apparently exerts more widespread effects on the circadian clock network than suggested by previous studies of PDF receptor expression...
  40. pmc Compensatory redistribution of neuroligins and N-cadherin following deletion of synaptic β1-integrin
    Steven Mortillo
    Department of Neuroscience, Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York, USA
    J Comp Neurol 520:2041-52. 2012
    ..Together, our findings demonstrate unequivocally that β1-integrin is an integral synaptic adhesion protein, and suggest that adhesive function at the synapse reflects a cooperative and dynamic network of multiple CAM families...
  41. pmc Eight different types of dopaminergic neurons innervate the Drosophila mushroom body neuropil: anatomical and physiological heterogeneity
    Zhengmei Mao
    Department of Molecular and Cellular Biology, Baylor College of Medicine Houston, TX, USA
    Front Neural Circuits 3:5. 2009
    ..Differences in functional response properties of these neurons suggest that they are involved in different behavioral processes...
  42. pmc Isolation of mRNA from specific tissues of Drosophila by mRNA tagging
    Zhiyong Yang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Nucleic Acids Res 33:e148. 2005
    ..Furthermore, at least 11 novel genes have been identified as enriched in photoreceptor cells. mRNA tagging is a powerful general method for profiling gene expression in specific tissues and for identifying tissue-specific genes...
  43. ncbi request reprint Olfactory learning
    Ronald L Davis
    Department of Molecular and Cellular Biology, Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 44:31-48. 2004
    ..Molecular genetic studies of olfactory learning in Drosophila have revealed numerous molecules that function within the third order olfactory neurons for normal olfactory learning...
  44. ncbi request reprint Remote control of fruit fly behavior
    Ronald L Davis
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Cell 121:6-7. 2005
    ..In this issue of Cell, Lima and Miesenböck (Lima and Miesenböck, 2005) dump the stimulating electrode in favor of a new remote control system to excite specific neurons--light activation of transgenically supplied ion channels...
  45. ncbi request reprint Detection of calcium transients in Drosophila mushroom body neurons with camgaroo reporters
    Dinghui Yu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 23:64-72. 2003
    ..Fluorescence was observed to increase in all three classes of mushroom body neurons, indicating that all types respond to cholinergic innervation...
  46. ncbi request reprint The scent of Drosophila sex
    Ronald L Davis
    Department of Molecular and Cellular Biology, Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX 77030 USA
    Neuron 54:14-6. 2007
  47. ncbi request reprint An adjustable-threshold algorithm for the identification of objects in three-dimensional images
    Artem L Ponomarev
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Bioinformatics 19:1431-5. 2003
    ..To test the algorithm on images of the Drosophila brain, and identify, count and determine the locations of neurons in the images...
  48. ncbi request reprint SRC-1 null mice exhibit moderate motor dysfunction and delayed development of cerebellar Purkinje cells
    Eijun Nishihara
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 23:213-22. 2003
    ..Disruption of SRC-1 specifically delays the PC development and maturation in early stages and results in moderate motor dysfunction in adulthood...
  49. ncbi request reprint Active forgetting of olfactory memories in Drosophila
    Jacob A Berry
    Department of Neuroscience, The Scripps Research Institute Florida, Jupiter, FL, USA
    Prog Brain Res 208:39-62. 2014
    ....

Research Grants5

  1. MOLECULAR BIOLOGY OF DROSOPHILA LEARNING AND MEMORY
    Ronald L Davis; Fiscal Year: 2010
    ....
  2. Olfactory memory trace formation in Drosophila
    Ronald L Davis; Fiscal Year: 2010
    ..This will aid in our understanding of the diseases that affect memory formation. ..
  3. INTEGRIN FUNCTION IN MEMORY
    Ronald L Davis; Fiscal Year: 2010
    ..Insights for the improvement of the diagnosis and treatment of diseases of working memory may be gathered from these studies. ..
  4. Cyclic AMP Signaling and Bipolar Disorder
    Ronald L Davis; Fiscal Year: 2009
    ..Public Health Relevance: Bipolar Disorder is a prevalent brain disorder. The studies proposed here will help to elucidate the genetic basis for the disease. ..
  5. MOLECULAR BIOLOGY OF DROSOPHILA LEARNING AND MEMORY
    Ronald L Davis; Fiscal Year: 2011
    ....