Marcus Davey

Summary

Affiliation: The Children's Hospital of Philadelphia
Country: USA

Publications

  1. ncbi request reprint Prenatal glucocorticoids improve lung morphology and partially restores surfactant mRNA expression in lambs with diaphragmatic hernia undergoing fetal tracheal occlusion
    Marcus G Davey
    The Children s Institute for Surgical Science and the Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Pediatr Pulmonol 41:1188-96. 2006
  2. doi request reprint Jaagsiekte sheep retrovirus pseudotyped lentiviral vector-mediated gene transfer to fetal ovine lung
    M G Davey
    The Children s Center for Fetal Research, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Gene Ther 19:201-9. 2012
  3. pmc Surfactant levels in congenital diaphragmatic hernia
    Marcus Davey
    Department of Surgery, The University of Pennsylvania, Pennsylvania, USA
    PLoS Med 4:e243. 2007
  4. ncbi request reprint Prenatal glucocorticoids and exogenous surfactant therapy improve respiratory function in lambs with severe diaphragmatic hernia following fetal tracheal occlusion
    Marcus G Davey
    The Children s Institute for Surgical Science and the Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, PA 19104, USA
    Pediatr Res 60:131-5. 2006
  5. ncbi request reprint Respiratory function in lambs after in utero treatment of lung hypoplasia by tracheal obstruction
    M G Davey
    Fetal and Neonatal Research Unit, Department of Physiology, Monash University, Clayton, Victoria 3168, Australia
    J Appl Physiol 87:2296-304. 1999
  6. ncbi request reprint Surfactant protein expression is increased in the ipsilateral but not contralateral lungs of fetal sheep with left-sided diaphragmatic hernia
    Marcus G Davey
    Children s Institute for Surgical Science and Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, Abramson 1112 D, 3615 Civic Center Blvd, Philadelphia, PA 19104, USA
    Pediatr Pulmonol 39:359-67. 2005
  7. ncbi request reprint Computer-assisted stereology: point fraction of lung parenchyma and alveolar surface density in fetal and newborn sheep
    M G Davey
    The Children s Institute for Surgical Science and the Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Scanning 25:37-44. 2003
  8. ncbi request reprint Temporary tracheal occlusion in fetal sheep with lung hypoplasia does not improve postnatal lung function
    Marcus G Davey
    Children s Institute for Surgical Science and Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4399, USA
    J Appl Physiol 94:1054-62. 2003
  9. ncbi request reprint Pulmonary epithelial liquid absorption, expressed in relation to alveolar surface area, is reduced in fetal lambs following in utero tracheal occlusion
    M G Davey
    Children s Institute for Surgical Science and Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Pediatr Pulmonol 34:278-86. 2002
  10. ncbi request reprint Stimulation of lung growth in fetuses with lung hypoplasia leads to altered postnatal lung structure in sheep
    M G Davey
    Fetal and Neonatal Research Unit, Department of Physiology, Monash University, Clayton, Victoria, Australia
    Pediatr Pulmonol 32:267-76. 2001

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Prenatal glucocorticoids improve lung morphology and partially restores surfactant mRNA expression in lambs with diaphragmatic hernia undergoing fetal tracheal occlusion
    Marcus G Davey
    The Children s Institute for Surgical Science and the Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Pediatr Pulmonol 41:1188-96. 2006
    ..We hypothesize that a GC-induced reduction in lung liquid volume during TO contributes, in part, to the observed increase in AE2 cell density and SPmRNA expression...
  2. doi request reprint Jaagsiekte sheep retrovirus pseudotyped lentiviral vector-mediated gene transfer to fetal ovine lung
    M G Davey
    The Children s Center for Fetal Research, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Gene Ther 19:201-9. 2012
    ....
  3. pmc Surfactant levels in congenital diaphragmatic hernia
    Marcus Davey
    Department of Surgery, The University of Pennsylvania, Pennsylvania, USA
    PLoS Med 4:e243. 2007
  4. ncbi request reprint Prenatal glucocorticoids and exogenous surfactant therapy improve respiratory function in lambs with severe diaphragmatic hernia following fetal tracheal occlusion
    Marcus G Davey
    The Children s Institute for Surgical Science and the Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, PA 19104, USA
    Pediatr Res 60:131-5. 2006
    ..GC or surfactant therapy alone significantly improved respiratory gas exchange, Cl, and ventilatory efficiency index. Total lung capacity was normalized only in DH/TO lambs that received both GC and S...
  5. ncbi request reprint Respiratory function in lambs after in utero treatment of lung hypoplasia by tracheal obstruction
    M G Davey
    Fetal and Neonatal Research Unit, Department of Physiology, Monash University, Clayton, Victoria 3168, Australia
    J Appl Physiol 87:2296-304. 1999
    ..We conclude that 10 days of TO in the presence of initial lung hypoplasia prevents death at birth and returns most aspects of pulmonary function to normal by 1-2 wk after birth...
  6. ncbi request reprint Surfactant protein expression is increased in the ipsilateral but not contralateral lungs of fetal sheep with left-sided diaphragmatic hernia
    Marcus G Davey
    Children s Institute for Surgical Science and Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, Abramson 1112 D, 3615 Civic Center Blvd, Philadelphia, PA 19104, USA
    Pediatr Pulmonol 39:359-67. 2005
    ..Furthermore, AE2 cell density is increased in DH, suggesting that the increase in SP mRNA and protein levels is due to increases AE2 cell number. Our data further support the premise that fetal lung hypoplasia favors an AE2 phenotype...
  7. ncbi request reprint Computer-assisted stereology: point fraction of lung parenchyma and alveolar surface density in fetal and newborn sheep
    M G Davey
    The Children s Institute for Surgical Science and the Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Scanning 25:37-44. 2003
    ....
  8. ncbi request reprint Temporary tracheal occlusion in fetal sheep with lung hypoplasia does not improve postnatal lung function
    Marcus G Davey
    Children s Institute for Surgical Science and Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4399, USA
    J Appl Physiol 94:1054-62. 2003
    ..Lung compliance remained low in DH/TO+R lambs, most likely as a consequence of the persistent increase in alveolar wall thickness in these animals...
  9. ncbi request reprint Pulmonary epithelial liquid absorption, expressed in relation to alveolar surface area, is reduced in fetal lambs following in utero tracheal occlusion
    M G Davey
    Children s Institute for Surgical Science and Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Pediatr Pulmonol 34:278-86. 2002
    ..We hypothesize that loss of alveolar epithelial type-II cells induced by increased levels of fetal lung expansion may impair alveolar liquid clearance in the perinatal period...
  10. ncbi request reprint Stimulation of lung growth in fetuses with lung hypoplasia leads to altered postnatal lung structure in sheep
    M G Davey
    Fetal and Neonatal Research Unit, Department of Physiology, Monash University, Clayton, Victoria, Australia
    Pediatr Pulmonol 32:267-76. 2001
    ..The presence of fewer, larger alveoli in postnatal TLH animals may predispose these animals to respiratory complications during later life...
  11. doi request reprint Cystic adenomatoid malformations are induced by localized FGF10 overexpression in fetal rat lung
    Silvia Gonzaga
    The Children s Center for Fetal Research, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4318, USA
    Am J Respir Cell Mol Biol 39:346-55. 2008
    ..These findings support a role for FGF10 in the induction of human CCAM and provide further mechanistic insight into the role of FGF10 in normal and abnormal lung development...
  12. ncbi request reprint Pulmonary arteriole muscularization in lambs with diaphragmatic hernia after combined tracheal occlusion/glucocorticoid therapy
    Marcus Davey
    Center of Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Am J Obstet Gynecol 197:381.e1-7. 2007
    ....
  13. ncbi request reprint Targeted gene transfer to fetal rat lung interstitium by ultrasound-guided intrapulmonary injection
    Tiago Henriques-Coelho
    The Center for Fetal Research, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Mol Ther 15:340-7. 2007
    ..This model system may facilitate in vivo studies of dynamic lung morphogenesis and could provide insight into the efficacy of prenatal gene transfer strategies for treatment of specific lung disorders...
  14. doi request reprint Main bronchus occlusion for treatment of congenital diaphragmatic hernia in fetal lambs
    Jean Marc Biard
    The Center for Fetal Diagnosis and Treatment at the Children s Hospital of Philadelphia, PA 19104 4399, USA
    J Pediatr Surg 43:620-6. 2008
    ....
  15. ncbi request reprint Correction of hindbrain herniation and anatomy of the vermis after in utero repair of myelomeningocele in sheep
    Sarah Bouchard
    Division of Pediatric General, Thoracic, and Fetal Surgery, The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Pediatr Surg 38:451-8; discussion 451-8. 2003
    ..This hypothesis was tested by assessing the impact of a spinal cord myelotomy on hindbrain anatomy in fetal sheep...
  16. ncbi request reprint Effects of intra-amniotic endotoxin on lung structure and function two months after term birth in sheep
    Timothy J M Moss
    School of Women s and Infants Health, The University of Western Australia, Perth, Western Australia
    J Soc Gynecol Investig 9:220-5. 2002
    ..Our aim was to determine the effects on lung structure and function after term birth in lambs exposed to intra-amniotic or intra-allantoic endotoxin...
  17. ncbi request reprint Tracheal occlusion in fetal rats alters expression of mesenchymal nuclear transcription factors without affecting surfactant protein expression
    Enrico Danzer
    The Children s Institute for Surgical Science, Children s Hospital of Philadelphia, The University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4318, USA
    J Pediatr Surg 41:774-80. 2006
    ..The objectives of this study were to evaluate the effects of short-term (3 days) TO on normal lung growth and protein expression of pulmonary MNTF involved in SP synthesis...