George P Daston

Summary

Affiliation: The Procter and Gamble Company
Country: USA

Publications

  1. ncbi request reprint Gene expression profile induced by 17alpha-ethynyl estradiol, bisphenol A, and genistein in the developing female reproductive system of the rat
    Jorge M Naciff
    The Procter and Gamble Company, Miami Valley Laboratories, P O Box 538707, No 805, Cincinnati, OH 45253 8707, USA
    Toxicol Sci 68:184-99. 2002
  2. doi request reprint The genomic response of a human uterine endometrial adenocarcinoma cell line to 17alpha-ethynyl estradiol
    Jorge M Naciff
    Miami Valley Innovation Center, The Procter and Gamble Company, Cincinnati, Ohio 45253, USA
    Toxicol Sci 107:40-55. 2009
  3. ncbi request reprint Developmental toxicity evaluation of butylparaben in Sprague-Dawley rats
    George P Daston
    Miami Valley Laboratories, The Procter and Gamble Company, Cincinnati, OH, USA
    Birth Defects Res B Dev Reprod Toxicol 71:296-302. 2004
  4. ncbi request reprint Skeletal malformations and variations in developmental toxicity studies: interpretation issues for human risk assessment
    George P Daston
    Miami Valley Innovation Center, Procter and Gamble, Cincinnati, Ohio 45253, USA
    Birth Defects Res B Dev Reprod Toxicol 80:421-4. 2007
  5. doi request reprint Gene expression, dose-response, and phenotypic anchoring: applications for toxicogenomics in risk assessment
    George P Daston
    Central Product Safety, Procter and Gamble, Cincinnati, Ohio 45253, USA
    Toxicol Sci 105:233-4. 2008
  6. ncbi request reprint Gene expression changes related to growth and differentiation in the fetal and juvenile reproductive system of the female rat: evaluation of microarray results
    George P Daston
    Miami Valley Laboratories, The Procter and Gamble Company, P O Box 538707, Cincinnati, OH 45253, USA
    Reprod Toxicol 19:381-94. 2005
  7. doi request reprint Predicting developmental toxicity through toxicogenomics
    George P Daston
    Miami Valley Innovation Center, The Procter and Gamble Company, Cincinnati, Ohio 45253, USA
    Birth Defects Res C Embryo Today 90:110-7. 2010
  8. doi request reprint A different approach to validating screening assays for developmental toxicity
    George P Daston
    Procter and Gamble, Cincinnati, Ohio, USA
    Birth Defects Res B Dev Reprod Toxicol 89:526-30. 2010
  9. doi request reprint Laboratory models and their role in assessing teratogenesis
    George P Daston
    Miami Valley Innovation Center, The Procter and Gamble Company, Cincinnati, OH 45253, USA
    Am J Med Genet C Semin Med Genet 157:183-7. 2011
  10. ncbi request reprint Genomics and developmental risk assessment
    George P Daston
    Miami Valley Innovation Center, Procter and Gamble, PO Box 538707, Cincinnati, Ohio 45253, USA
    Birth Defects Res A Clin Mol Teratol 79:1-7. 2007

Collaborators

Detail Information

Publications41

  1. ncbi request reprint Gene expression profile induced by 17alpha-ethynyl estradiol, bisphenol A, and genistein in the developing female reproductive system of the rat
    Jorge M Naciff
    The Procter and Gamble Company, Miami Valley Laboratories, P O Box 538707, No 805, Cincinnati, OH 45253 8707, USA
    Toxicol Sci 68:184-99. 2002
    ....
  2. doi request reprint The genomic response of a human uterine endometrial adenocarcinoma cell line to 17alpha-ethynyl estradiol
    Jorge M Naciff
    Miami Valley Innovation Center, The Procter and Gamble Company, Cincinnati, Ohio 45253, USA
    Toxicol Sci 107:40-55. 2009
    ....
  3. ncbi request reprint Developmental toxicity evaluation of butylparaben in Sprague-Dawley rats
    George P Daston
    Miami Valley Laboratories, The Procter and Gamble Company, Cincinnati, OH, USA
    Birth Defects Res B Dev Reprod Toxicol 71:296-302. 2004
    ..Based on the results of this study, the maternal NOAEL for butylparaben was 100 mg/kg/day. Butylparaben does not have the potential to cause developmental toxicity in the Sprague-Dawley rat at oral dosages up to 1000 mg/kg/day...
  4. ncbi request reprint Skeletal malformations and variations in developmental toxicity studies: interpretation issues for human risk assessment
    George P Daston
    Miami Valley Innovation Center, Procter and Gamble, Cincinnati, Ohio 45253, USA
    Birth Defects Res B Dev Reprod Toxicol 80:421-4. 2007
  5. doi request reprint Gene expression, dose-response, and phenotypic anchoring: applications for toxicogenomics in risk assessment
    George P Daston
    Central Product Safety, Procter and Gamble, Cincinnati, Ohio 45253, USA
    Toxicol Sci 105:233-4. 2008
  6. ncbi request reprint Gene expression changes related to growth and differentiation in the fetal and juvenile reproductive system of the female rat: evaluation of microarray results
    George P Daston
    Miami Valley Laboratories, The Procter and Gamble Company, P O Box 538707, Cincinnati, OH 45253, USA
    Reprod Toxicol 19:381-94. 2005
    ....
  7. doi request reprint Predicting developmental toxicity through toxicogenomics
    George P Daston
    Miami Valley Innovation Center, The Procter and Gamble Company, Cincinnati, Ohio 45253, USA
    Birth Defects Res C Embryo Today 90:110-7. 2010
    ..Although gene expression in response to estrogens is tissue, life stage, and sex specific, it is feasible to identify transcript profiles that are diagnostic of this mode of action...
  8. doi request reprint A different approach to validating screening assays for developmental toxicity
    George P Daston
    Procter and Gamble, Cincinnati, Ohio, USA
    Birth Defects Res B Dev Reprod Toxicol 89:526-30. 2010
    ..e. dose) and timing of exposure, which makes it difficult to develop lists of compounds neatly assigned as developmental toxicants or not...
  9. doi request reprint Laboratory models and their role in assessing teratogenesis
    George P Daston
    Miami Valley Innovation Center, The Procter and Gamble Company, Cincinnati, OH 45253, USA
    Am J Med Genet C Semin Med Genet 157:183-7. 2011
    ..These models have served as the principal basis for regulatory decisions about acceptable exposure levels and restrictions on use of certain drugs during pregnancy...
  10. ncbi request reprint Genomics and developmental risk assessment
    George P Daston
    Miami Valley Innovation Center, Procter and Gamble, PO Box 538707, Cincinnati, Ohio 45253, USA
    Birth Defects Res A Clin Mol Teratol 79:1-7. 2007
  11. ncbi request reprint Uterine temporal response to acute exposure to 17alpha-ethinyl estradiol in the immature rat
    Jorge M Naciff
    The Procter and Gamble Company, Miami Valley Innovation Center, Cincinnati, OH 45253, USA
    Toxicol Sci 97:467-90. 2007
    ..The compendium of genes here presented represents a comprehensive compilation of estrogen-responsive genes involved in the uterotrophic response...
  12. ncbi request reprint Gene expression changes induced in the testis by transplacental exposure to high and low doses of 17{alpha}-ethynyl estradiol, genistein, or bisphenol A
    Jorge M Naciff
    Miami Valley Innovation Center, The Procter and Gamble Company, Cincinnati, Ohio 45253, USA
    Toxicol Sci 86:396-416. 2005
    ..These results indicate that gene expression data are diagnostic of mode of action and, if they are evaluated in the context of traditional toxicological end-points, can be used to elucidate dose-response characteristics...
  13. ncbi request reprint Evaluation of the gene expression changes induced by 17-alpha-ethynyl estradiol in the immature uterus/ovaries of the rat using high density oligonucleotide arrays
    Jorge M Naciff
    Miami Valley Innovation Center, The Procter and Gamble Company, Cincinnati, Ohio 45253 8707, USA
    Birth Defects Res B Dev Reprod Toxicol 74:164-84. 2005
    ..In order to better determine whether common sets of gene expression changes can be predictive of estrogenic activity, we have replicated the previous experiment using the more comprehensive microarray...
  14. ncbi request reprint Gene expression profile induced by 17 alpha-ethynyl estradiol in the prepubertal female reproductive system of the rat
    Jorge M Naciff
    Miami Valley Laboratories, The Procter and Gamble Company, Cincinnati, Ohio 45253, USA
    Toxicol Sci 72:314-30. 2003
    ..Moreover, those genes could be used as biomarkers to identify chemicals with estrogenic activity...
  15. pmc Design of a microsphere-based high-throughput gene expression assay to determine estrogenic potential
    Jorge M Naciff
    Miami Valley Innovation Center, Procter and Gamble Company, Cincinnati, OH 45253, USA
    Environ Health Perspect 113:1164-71. 2005
    ..5 microg starting cRNA. This assay offers increased throughput with decreased costs compared with existing microarray technologies, with the trade-off being in the total number of transcripts that can be analyzed...
  16. doi request reprint The genomic response of Ishikawa cells to bisphenol A exposure is dose- and time-dependent
    Jorge M Naciff
    Miami Valley Innovation Center, The Procter and Gamble Company, PO Box 538707 805, Cincinnati, OH 45253 8707, United States
    Toxicology 270:137-49. 2010
    ..These results indicate that Ishikawa cells are capable of generating a biologically relevant estrogenic response after exposure to chemicals with varied estrogenic activity, and offer an in vitro model to assess this mode of action...
  17. ncbi request reprint Toxicogenomic approach to endocrine disrupters: identification of a transcript profile characteristic of chemicals with estrogenic activity
    Jorge M Naciff
    Miami Valley Laboratories, The Procter and Gamble Company, Cincinnati, Ohio 45253, USA
    Toxicol Pathol 32:59-70. 2004
    ....
  18. pmc Impact of the phytoestrogen content of laboratory animal feed on the gene expression profile of the reproductive system in the immature female rat
    Jorge M Naciff
    Miami Valley Laboratories, The Procter and Gamble Company, Cincinnati, Ohio 45253 8707, USA
    Environ Health Perspect 112:1519-26. 2004
    ..Our results indicate that although diet composition has an impact on gene expression in uterus and ovaries, it does not contribute to the effects of an ER agonist...
  19. doi request reprint Effects of transplacental 17-α-ethynyl estradiol or bisphenol A on the developmental profile of steroidogenic acute regulatory protein in the rat testis
    Karla A Horstman
    Mason Business Center, The Procter and Gamble Company, Mason, OH, USA
    Birth Defects Res B Dev Reprod Toxicol 95:318-25. 2012
    ..High levels of estrogens decrease StAR expression in the fetal rat testis during late gestation...
  20. pmc Workgroup report: Implementing a national occupational reproductive research agenda--decade one and beyond
    Christina C Lawson
    National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226 1998, USA
    Environ Health Perspect 114:435-41. 2006
    ..We describe a broad domain of scholarship activities where a cohesive system of organized and aligned work activities integrates 10 years of team efforts and provides guidance for future research...
  21. ncbi request reprint Metabolic detoxification determines species differences in coumarin-induced hepatotoxicity
    Jeffrey D Vassallo
    Miami Valley Laboratories, The Procter and Gamble Company, 11810 East Miami River Road, Cincinnati, Ohio 45252, USA
    Toxicol Sci 80:249-57. 2004
    ..Collectively, these in vitro data implicate o-HPA detoxification through oxidation to o-HPAA as the major determinant of species differences in coumarin-induced hepatotoxicity...
  22. ncbi request reprint Liquid chromatographic determination of the glutathione conjugate and ring-opened metabolites formed from coumarin epoxidation
    Jeffrey D Vassallo
    Miami Valley Laboratories, The Procter and Gamble Company, Cincinnati, OH 45252, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 794:257-71. 2003
    ..Species differences in o-HPA detoxification were consistent with sensitivity to coumarin, thereby demonstrating that these methods have utility in addressing the fate of CE and its contribution to toxicity...
  23. ncbi request reprint Developmental toxicity evaluation of trimethylolpropane caprylate caprate in Sprague-Dawley rats
    Charles Azuka
    The Procter and Gamble Company, Cincinnati, OH 45253, USA
    Birth Defects Res B Dev Reprod Toxicol 71:374-9. 2004
    ..TMPCC did not cause any developmental toxicity in the Sprague-Dawley rat at dermal dosages up to 2,000 mg/kg/day...
  24. pmc An occupational reproductive research agenda for the third millennium
    Christina C Lawson
    National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio 45226, USA
    Environ Health Perspect 111:584-92. 2003
    ..The objective of this article is to recommend future directions in occupational reproductive health research. By bridging interdisciplinary gaps, the scientific community can work together to improve health and reduce adverse outcomes...
  25. ncbi request reprint Roles for epoxidation and detoxification of coumarin in determining species differences in clara cell toxicity
    Jeffrey D Vassallo
    Miami Valley Laboratories, The Procter and Gamble Company, 11810 East Miami River Road, Cincinnati, OH 45252, USA
    Toxicol Sci 82:26-33. 2004
    ....
  26. ncbi request reprint Uncertainties for endocrine disrupters: our view on progress
    George P Daston
    Miami Valley Laboratories, The Procter and Gamble Company, P O Box 538707, Cincinnati, Ohio 45253, USA
    Toxicol Sci 74:245-52. 2003
    ....
  27. doi request reprint Identification and characterization of toxicity of contaminants in pet food leading to an outbreak of renal toxicity in cats and dogs
    Roy L M Dobson
    The Procter and Gamble Company, Cincinnati, Ohio 45253, USA
    Toxicol Sci 106:251-62. 2008
    ....
  28. doi request reprint CERHR bisphenol A: review and commentaries
    George P Daston
    Birth Defects Res B Dev Reprod Toxicol 83:151. 2008
  29. doi request reprint Lack of effect of butylparaben and methylparaben on the reproductive system in male rats
    Alan M Hoberman
    Charles River Preclinical Services, Horsham, PA 19044, USA
    Birth Defects Res B Dev Reprod Toxicol 83:123-33. 2008
    ..Our studies used two representative parabens, methyl- and butylparaben, to try to replicate these studies and thereby evaluate potential reproductive effects in male Wistar rats...
  30. ncbi request reprint MIAME guidelines
    Thomas B Knudsen
    Reprod Toxicol 19:263. 2005
  31. ncbi request reprint EPA risk assessment principles and practices. BOSC (board of scientific counselors) workshop, February 2-3, 2005, Washington, DC
    Rogene F Henderson
    Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA
    Environ Sci Pollut Res Int 12:388-90. 2005
  32. pmc Toxicogenomics in regulatory ecotoxicology
    Gerald T Ankley
    U S EPA
    Environ Sci Technol 40:4055-65. 2006
  33. ncbi request reprint Evaluation and interpretation of maternal toxicity in Segment II studies: issues, some answers, and data needs
    John M Rogers
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, MD 67, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Appl Pharmacol 207:367-74. 2005
    ....
  34. ncbi request reprint Zinc influences the in vitro development of peri-implantation mouse embryos
    Lynn A Hanna
    Department of Nutrition, University of California, Davis, California 95616, USA
    Birth Defects Res A Clin Mol Teratol 67:414-20. 2003
    ..We investigated the influence of zinc (Zn) deficiency on embryonic development at the time of embryo implantation...
  35. ncbi request reprint NTP-CERHR Expert Panel Report on the reproductive and developmental toxicity of 2-bromopropane
    Kim Boekelheide
    Brown University, Providence, RI, USA
    Reprod Toxicol 18:189-217. 2004
  36. ncbi request reprint Evaluation of physiologically based models of pregnancy and lactation for their application in children's health risk assessments
    Richard A Corley
    Battelle, Pacific Northwest Division, Richland, WA 99352, USA
    Crit Rev Toxicol 33:137-211. 2003
    ....
  37. pmc Alterations in protein kinase C activity and processing during zinc-deficiency-induced cell death
    Susan S Chou
    Department of Nutrition, University of California, One Shields Avenue, Davis, CA 95616 8669, USA
    Biochem J 383:63-71. 2004
    ..These results support the concept that intracellular zinc concentrations influence PKC activity and processing, and that zinc-deficiency-induced apoptosis occurs in part through PKC-dependent pathways...
  38. ncbi request reprint NTP-CERHR Expert Panel Report on the reproductive and developmental toxicity of styrene
    Ulrike Luderer
    University of California Irvine, Irvine, CA, USA
    Birth Defects Res B Dev Reprod Toxicol 77:110-93. 2006
  39. pmc Meeting report: hazard assessment for nanoparticles--report from an interdisciplinary workshop
    John M Balbus
    Environmental Defense, Washington, DC 20009, USA
    Environ Health Perspect 115:1654-9. 2007
    ..Finally, the group identified general policy and strategic opportunities to accelerate the development and implementation of testing protocols and ensure that the information generated is translated effectively for all stakeholders...
  40. pmc Endocrine disrupting chemicals research program of the U.S. Environmental Protection Agency: summary of a peer-review report
    Anna K Harding
    Department of Public Health, Oregon State University, Corvallis, Oregon 97331 6406, USA
    Environ Health Perspect 114:1276-82. 2006
    ....
  41. ncbi request reprint The embryolethality of lipopolysaccharide in CD-1 and metallothionein I-II null mice: lack of a role for induced zinc deficiency or metallothionein induction
    Tyra M Leazer
    Curriculum in Toxicology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Toxicol Sci 73:442-7. 2003
    ..In conclusion, while LPS can induce maternal hepatic MT and Zn redistribution in CD-1 mice, this does not appear to be a key mechanism leading to LPS embryotoxicity...