Research Topics
| George P DastonSummaryAffiliation: The Procter and Gamble Company Country: USA Publications
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Detail Information
Publications
Gene expression profile induced by 17alpha-ethynyl estradiol, bisphenol A, and genistein in the developing female reproductive system of the ratJorge M Naciff
The Procter and Gamble Company, Miami Valley Laboratories, P O Box 538707, No 805, Cincinnati, OH 45253 8707, USA
Toxicol Sci 68:184-99. 2002....- The genomic response of a human uterine endometrial adenocarcinoma cell line to 17alpha-ethynyl estradiolJorge M Naciff
Miami Valley Innovation Center, The Procter and Gamble Company, Cincinnati, Ohio 45253, USA
Toxicol Sci 107:40-55. 2009.... - Developmental toxicity evaluation of butylparaben in Sprague-Dawley ratsGeorge P Daston
Miami Valley Laboratories, The Procter and Gamble Company, Cincinnati, OH, USA
Birth Defects Res B Dev Reprod Toxicol 71:296-302. 2004..Based on the results of this study, the maternal NOAEL for butylparaben was 100 mg/kg/day. Butylparaben does not have the potential to cause developmental toxicity in the Sprague-Dawley rat at oral dosages up to 1000 mg/kg/day... - Gene expression changes related to growth and differentiation in the fetal and juvenile reproductive system of the female rat: evaluation of microarray resultsGeorge P Daston
Miami Valley Laboratories, The Procter and Gamble Company, P O Box 538707, Cincinnati, OH 45253, USA
Reprod Toxicol 19:381-94. 2005.... - Gene expression, dose-response, and phenotypic anchoring: applications for toxicogenomics in risk assessmentGeorge P Daston
Central Product Safety, Procter and Gamble, Cincinnati, Ohio 45253, USA
Toxicol Sci 105:233-4. 2008 - Predicting developmental toxicity through toxicogenomicsGeorge P Daston
Miami Valley Innovation Center, The Procter and Gamble Company, Cincinnati, Ohio 45253, USA
Birth Defects Res C Embryo Today 90:110-7. 2010..Although gene expression in response to estrogens is tissue, life stage, and sex specific, it is feasible to identify transcript profiles that are diagnostic of this mode of action... - A different approach to validating screening assays for developmental toxicityGeorge P Daston
Procter and Gamble, Cincinnati, Ohio, USA
Birth Defects Res B Dev Reprod Toxicol 89:526-30. 2010..e. dose) and timing of exposure, which makes it difficult to develop lists of compounds neatly assigned as developmental toxicants or not... - Skeletal malformations and variations in developmental toxicity studies: interpretation issues for human risk assessmentGeorge P Daston
Miami Valley Innovation Center, Procter and Gamble, Cincinnati, Ohio 45253, USA
Birth Defects Res B Dev Reprod Toxicol 80:421-4. 2007 - Genomics and developmental risk assessmentGeorge P Daston
Miami Valley Innovation Center, Procter and Gamble, PO Box 538707, Cincinnati, Ohio 45253, USA
Birth Defects Res A Clin Mol Teratol 79:1-7. 2007 - Laboratory models and their role in assessing teratogenesisGeorge P Daston
Miami Valley Innovation Center, The Procter and Gamble Company, Cincinnati, OH 45253, USA
Am J Med Genet C Semin Med Genet 157:183-7. 2011..These models have served as the principal basis for regulatory decisions about acceptable exposure levels and restrictions on use of certain drugs during pregnancy... - Uterine temporal response to acute exposure to 17alpha-ethinyl estradiol in the immature ratJorge M Naciff
The Procter and Gamble Company, Miami Valley Innovation Center, Cincinnati, OH 45253, USA
Toxicol Sci 97:467-90. 2007..The compendium of genes here presented represents a comprehensive compilation of estrogen-responsive genes involved in the uterotrophic response... - Gene expression changes induced in the testis by transplacental exposure to high and low doses of 17{alpha}-ethynyl estradiol, genistein, or bisphenol AJorge M Naciff
Miami Valley Innovation Center, The Procter and Gamble Company, Cincinnati, Ohio 45253, USA
Toxicol Sci 86:396-416. 2005..These results indicate that gene expression data are diagnostic of mode of action and, if they are evaluated in the context of traditional toxicological end-points, can be used to elucidate dose-response characteristics... - Evaluation of the gene expression changes induced by 17-alpha-ethynyl estradiol in the immature uterus/ovaries of the rat using high density oligonucleotide arraysJorge M Naciff
Miami Valley Innovation Center, The Procter and Gamble Company, Cincinnati, Ohio 45253 8707, USA
Birth Defects Res B Dev Reprod Toxicol 74:164-84. 2005..In order to better determine whether common sets of gene expression changes can be predictive of estrogenic activity, we have replicated the previous experiment using the more comprehensive microarray... - Design of a microsphere-based high-throughput gene expression assay to determine estrogenic potentialJorge M Naciff
Miami Valley Innovation Center, Procter and Gamble Company, Cincinnati, OH 45253, USA
Environ Health Perspect 113:1164-71. 2005..5 microg starting cRNA. This assay offers increased throughput with decreased costs compared with existing microarray technologies, with the trade-off being in the total number of transcripts that can be analyzed... - Gene expression profile induced by 17 alpha-ethynyl estradiol in the prepubertal female reproductive system of the ratJorge M Naciff
Miami Valley Laboratories, The Procter and Gamble Company, Cincinnati, Ohio 45253, USA
Toxicol Sci 72:314-30. 2003..Moreover, those genes could be used as biomarkers to identify chemicals with estrogenic activity... - The genomic response of Ishikawa cells to bisphenol A exposure is dose- and time-dependentJorge M Naciff
Miami Valley Innovation Center, The Procter and Gamble Company, PO Box 538707 805, Cincinnati, OH 45253 8707, United States
Toxicology 270:137-49. 2010..These results indicate that Ishikawa cells are capable of generating a biologically relevant estrogenic response after exposure to chemicals with varied estrogenic activity, and offer an in vitro model to assess this mode of action... - Toxicogenomic approach to endocrine disrupters: identification of a transcript profile characteristic of chemicals with estrogenic activityJorge M Naciff
Miami Valley Laboratories, The Procter and Gamble Company, Cincinnati, Ohio 45253, USA
Toxicol Pathol 32:59-70. 2004.... - Impact of the phytoestrogen content of laboratory animal feed on the gene expression profile of the reproductive system in the immature female ratJorge M Naciff
Miami Valley Laboratories, The Procter and Gamble Company, Cincinnati, Ohio 45253 8707, USA
Environ Health Perspect 112:1519-26. 2004..Our results indicate that although diet composition has an impact on gene expression in uterus and ovaries, it does not contribute to the effects of an ER agonist... - Workgroup report: Implementing a national occupational reproductive research agenda--decade one and beyondChristina C Lawson
National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226 1998, USA
Environ Health Perspect 114:435-41. 2006..We describe a broad domain of scholarship activities where a cohesive system of organized and aligned work activities integrates 10 years of team efforts and provides guidance for future research... - Effects of Transplacental 17-?-Ethynyl Estradiol or Bisphenol A on the Developmental Profile of Steroidogenic Acute Regulatory Protein in the Rat TestisKarla A Horstman
Mason Business Center, The Procter and Gamble Company, Mason, Ohio
Birth Defects Res B Dev Reprod Toxicol 95:318-25. 2012..High levels of estrogens decrease StAR expression in the fetal rat testis during late gestation... - Metabolic detoxification determines species differences in coumarin-induced hepatotoxicityJeffrey D Vassallo
Miami Valley Laboratories, The Procter and Gamble Company, 11810 East Miami River Road, Cincinnati, Ohio 45252, USA
Toxicol Sci 80:249-57. 2004..Collectively, these in vitro data implicate o-HPA detoxification through oxidation to o-HPAA as the major determinant of species differences in coumarin-induced hepatotoxicity... - Liquid chromatographic determination of the glutathione conjugate and ring-opened metabolites formed from coumarin epoxidationJeffrey D Vassallo
Miami Valley Laboratories, The Procter and Gamble Company, Cincinnati, OH 45252, USA
J Chromatogr B Analyt Technol Biomed Life Sci 794:257-71. 2003..Species differences in o-HPA detoxification were consistent with sensitivity to coumarin, thereby demonstrating that these methods have utility in addressing the fate of CE and its contribution to toxicity... - Developmental toxicity evaluation of trimethylolpropane caprylate caprate in Sprague-Dawley ratsCharles Azuka
The Procter and Gamble Company, Cincinnati, OH 45253, USA
Birth Defects Res B Dev Reprod Toxicol 71:374-9. 2004..TMPCC did not cause any developmental toxicity in the Sprague-Dawley rat at dermal dosages up to 2,000 mg/kg/day... - An occupational reproductive research agenda for the third millenniumChristina C Lawson
National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio 45226, USA
Environ Health Perspect 111:584-92. 2003..The objective of this article is to recommend future directions in occupational reproductive health research. By bridging interdisciplinary gaps, the scientific community can work together to improve health and reduce adverse outcomes... - Roles for epoxidation and detoxification of coumarin in determining species differences in clara cell toxicityJeffrey D Vassallo
Miami Valley Laboratories, The Procter and Gamble Company, 11810 East Miami River Road, Cincinnati, OH 45252, USA
Toxicol Sci 82:26-33. 2004.... - Uncertainties for endocrine disrupters: our view on progressGeorge P Daston
Miami Valley Laboratories, The Procter and Gamble Company, P.O. Box 538707, Cincinnati, Ohio 45253, USA
Toxicol Sci 74:245-52. 2003.... - Identification and characterization of toxicity of contaminants in pet food leading to an outbreak of renal toxicity in cats and dogsRoy L M Dobson
The Procter and Gamble Company, Cincinnati, Ohio 45253, USA
Toxicol Sci 106:251-62. 2008.... - CERHR bisphenol A: review and commentariesGeorge P Daston
Birth Defects Res B Dev Reprod Toxicol 83:151. 2008 - Lack of effect of butylparaben and methylparaben on the reproductive system in male ratsAlan M Hoberman
Charles River Preclinical Services, Horsham, PA 19044, USA
Birth Defects Res B Dev Reprod Toxicol 83:123-33. 2008..Our studies used two representative parabens, methyl- and butylparaben, to try to replicate these studies and thereby evaluate potential reproductive effects in male Wistar rats... - MIAME guidelinesThomas B Knudsen
Reprod Toxicol 19:263. 2005 - EPA risk assessment principles and practices. BOSC (board of scientific counselors) workshop, February 2-3, 2005, Washington, DCRogene F Henderson
Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA
Environ Sci Pollut Res Int 12:388-90. 2005 - Toxicogenomics in regulatory ecotoxicologyGerald T Ankley
U.S. EPA
Environ Sci Technol 40:4055-65. 2006 - Evaluation and interpretation of maternal toxicity in Segment II studies: issues, some answers, and data needsJohn M Rogers
National Health and Environmental Effects Research Laboratory, Office of Research and Development, MD 67, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Toxicol Appl Pharmacol 207:367-74. 2005.... - Zinc influences the in vitro development of peri-implantation mouse embryosLynn A Hanna
Department of Nutrition, University of California, Davis, California 95616, USA
Birth Defects Res A Clin Mol Teratol 67:414-20. 2003.... - NTP-CERHR Expert Panel Report on the reproductive and developmental toxicity of 2-bromopropaneKim Boekelheide
Brown University, Providence, RI, USA
Reprod Toxicol 18:189-217. 2004 - Evaluation of physiologically based models of pregnancy and lactation for their application in children's health risk assessmentsRichard A Corley
Battelle, Pacific Northwest Division, Richland, WA 99352, USA
Crit Rev Toxicol 33:137-211. 2003.... - Alterations in protein kinase C activity and processing during zinc-deficiency-induced cell deathSusan S Chou
Department of Nutrition, University of California, One Shields Avenue, Davis, CA 95616-8669, USA
Biochem J 383:63-71. 2004..These results support the concept that intracellular zinc concentrations influence PKC activity and processing, and that zinc-deficiency-induced apoptosis occurs in part through PKC-dependent pathways... - NTP-CERHR Expert Panel Report on the reproductive and developmental toxicity of styreneUlrike Luderer
University of California-Irvine, Irvine, CA, USA
Birth Defects Res B Dev Reprod Toxicol 77:110-93. 2006 - Meeting report: hazard assessment for nanoparticles--report from an interdisciplinary workshopJohn M Balbus
Environmental Defense, Washington, DC 20009, USA
Environ Health Perspect 115:1654-9. 2007..Finally, the group identified general policy and strategic opportunities to accelerate the development and implementation of testing protocols and ensure that the information generated is translated effectively for all stakeholders... - Endocrine disrupting chemicals research program of the U.S. Environmental Protection Agency: summary of a peer-review reportAnna K Harding
Department of Public Health, Oregon State University, Corvallis, Oregon 97331 6406, USA
Environ Health Perspect 114:1276-82. 2006.... - The embryolethality of lipopolysaccharide in CD-1 and metallothionein I-II null mice: lack of a role for induced zinc deficiency or metallothionein inductionTyra M Leazer
Curriculum in Toxicology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Toxicol Sci 73:442-7. 2003..In conclusion, while LPS can induce maternal hepatic MT and Zn redistribution in CD-1 mice, this does not appear to be a key mechanism leading to LPS embryotoxicity...