Research Topics
| P DasSummaryAffiliation: The University of Texas Country: USA Publications
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Publications
Clinical benefit of palliative radiation therapy in advanced gastric cancerMichelle M Kim
Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Acta Oncol 47:421-7. 2008..Local progression of advanced gastric cancer often manifests as bleeding, dysphagia/obstruction, or pain. We evaluated the magnitude and durability of palliation with radiotherapy (RT)...
Intensity modulated radiation therapy (IMRT): differences in target volumes and improvement in clinically relevant doses to small bowel in rectal carcinomaHenry Mok
Department of Radiation Oncology, The University of Texas, M, d, Anderson Cancer Center, Houston, Texas, USA
Radiat Oncol 6:63. 2011..Therefore, we performed a comprehensive dosimetric evaluation of IMRT compared to 3-dimensional conformal radiation therapy (3DCRT) in standard, preoperative treatment for rectal cancer...
Concurrent capecitabine and upper abdominal radiation therapy is well toleratedPrajnan Das
Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, USA
Radiat Oncol 1:41. 2006..Therefore, capecitabine and concurrent radiotherapy to the upper abdomen appears to be well tolerated. Capecitabine may serve as an alternative to bolus or infusional 5-FU during chemoradiation for upper gastrointestinal malignancies...
ACR Appropriateness Criteria on Hodgkin's lymphoma: favorable prognosis stage I and IIPrajnan Das
The Universityof Texas MD Anderson Cancer Center, Department of Radiation Oncology, Houston, TX 77030, USA
J Am Coll Radiol 5:1054-66. 2008..Representative clinical cases are presented, with treatment recommendations from an expert panel of radiation oncologists and medical oncologists...
Long-term quality of life after radiotherapy for the treatment of anal cancerPrajnan Das
Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston1515 Holcombe Boulevard, Unit 97, Houston, TX 77030, USA
Cancer 116:822-9. 2010..Radiotherapy is the current standard of care for patients with localized squamous cell cancer of the anal canal. The goal of the current study was to evaluate long-term quality of life (QoL) in patients after this treatment...
Reirradiation to the abdomen for gastrointestinal malignanciesWaqar Haque
Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
Radiat Oncol 4:55. 2009..Our goal was to retrospectively determine rates of toxicity, freedom from local progression and overall survival in gastrointestinal cancer patients treated with reirradiation to the abdomen...
Predictors and patterns of recurrence after definitive chemoradiation for anal cancerPrajnan Das
Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Int J Radiat Oncol Biol Phys 68:794-800. 2007..To evaluate patterns of locoregional failure, and predictors of recurrence and survival in patients treated with chemoradiation for anal cancer...
Predictors of tumor response and downstaging in patients who receive preoperative chemoradiation for rectal cancerPrajnan Das
Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 109:1750-5. 2007..The objective of this study was to identify predictive factors for pathologic complete response and tumor downstaging after preoperative chemoradiation for rectal cancer...
Hyperfractionated accelerated radiotherapy for rectal cancer in patients with prior pelvic irradiationPrajnan Das
Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Int J Radiat Oncol Biol Phys 77:60-5. 2010..To retrospectively determine rates of toxicity, freedom from local progression, and survival in rectal cancer patients treated with reirradiation...
Current treatment for localized anal carcinomaPrajnan Das
Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Curr Opin Oncol 19:396-400. 2007..Chemoradiation represents the standard of care for most patients with localized squamous cell carcinoma of the anal canal. This article reviews randomized trials and recent studies on chemoradiation for anal cancer...
Preoperative chemoradiotherapy with capecitabine versus protracted infusion 5-fluorouracil for rectal cancer: a matched-pair analysisPrajnan Das
Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Int J Radiat Oncol Biol Phys 66:1378-83. 2006....
Multimodality approaches to localized gastric cancerPrajnan Das
Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas77030, USA
J Natl Compr Canc Netw 8:417-25. 2010..Other recent trials have evaluated the roles of preoperative chemoradiation and adjuvant chemotherapy. Multidisciplinary evaluation plays a crucial role in the management of these patients...
Clinical and pathologic predictors of locoregional recurrence, distant metastasis, and overall survival in patients treated with chemoradiation and mesorectal excision for rectal cancerPrajnan Das
Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Am J Clin Oncol 29:219-24. 2006..To identify predictive factors for locoregional recurrence (LR), distant metastasis (DM), and overall survival (OS) in patients treated with chemoradiation and surgery for rectal cancer...
Preoperative and adjuvant treatment of localized rectal cancerPrajnan Das
Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 97, Houston, TX 77030, USA
Curr Oncol Rep 8:167-73. 2006..The roles of newer agents, such as capecitabine, oxaliplatin, and bevacizumab, are also discussed, and other key issues in the treatment of localized rectal cancer are reviewed...
Combined modality therapy of localized gastric and esophageal cancersPrajnan Das
Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
J Natl Compr Canc Netw 4:375-82. 2006..This article reviews the role of staging, surgery, and adjuvant and preoperative therapies in the management of localized gastric and esophageal cancers...
Computed tomography screening for lung cancer in Hodgkin's lymphoma survivors: decision analysis and cost-effectiveness analysisP Das
Department of Radiation Oncology, U T M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 97, Houston, TX 77030, USA
Ann Oncol 17:785-93. 2006..We derived model parameters from published studies and the Surveillance, Epidemiology and End Results (SEER) Program, and assumed that stage-shift produces a survival benefit...
ACR Appropriateness Criteria® on Hodgkin's lymphoma-unfavorable clinical stage I and IIPrajnan Das
The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
J Am Coll Radiol 8:302-8. 2011..This article presents illustrative clinical cases, with treatment recommendations from an expert panel of radiation oncologists and medical oncologists...
Gastric and gastro-oesophageal cancer therapyPrajnan Das
Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Expert Opin Pharmacother 6:2805-12. 2005..This article reviews recent trials on localised and metastatic gastric and gastro-oesophageal cancers...
Clinical course of thoracic cancers in Hodgkin's disease survivorsP Das
Department of Radiation Oncology, U T M D Anderson Cancer Center, Houston, TX 77030, USA
Ann Oncol 16:793-7. 2005..Hodgkin's disease survivors have a high risk of subsequently developing thoracic cancers. Our goal was to evaluate the prognosis and treatment outcomes of thoracic cancers after Hodgkin's disease...
Staging, prognostic factors, and therapy of localized rectal cancerPrajnan Das
Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 97, Houston, TX 77030, USA
Curr Oncol Rep 11:167-74. 2009..This article reviews recent studies on staging, prognostic factors, and therapy of localized rectal cancer...
Lung malignancies after Hodgkin lymphoma: disease characteristics, detection methods and clinical outcomeJ D Schoenfeld
Harvard Radiation Oncology Program, Department of Radiation Oncology, Brigham and Women s Hospital, Boston, MA 02115, USA
Ann Oncol 23:1813-8. 2012..Hodgkin lymphoma (HL) survivors have an increased risk of secondary malignancies. We analyzed outcomes in patients with lung cancers following HL treatment...
Preoperative gemcitabine and cisplatin followed by gemcitabine-based chemoradiation for resectable adenocarcinoma of the pancreatic headGauri R Varadhachary
Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Box 426, Houston, TX 77030, USA
J Clin Oncol 26:3487-95. 2008..We conducted a phase II trial of preoperative gemcitabine and cisplatin chemotherapy in addition to chemoradiation (Gem-Cis-XRT) and pancreaticoduodenectomy (PD) for patients with stage I/II pancreatic adenocarcinoma...
Chemoradiation therapy for potentially resectable gastric cancer: clinical outcomes among patients who do not undergo planned surgeryMichelle M Kim
Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Int J Radiat Oncol Biol Phys 71:167-72. 2008....
Patterns of locoregional recurrence after surgery and radiotherapy or chemoradiation for rectal cancerTse Kuan Yu
Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Int J Radiat Oncol Biol Phys 71:1175-80. 2008..To identify patterns of locoregional recurrence in patients treated with surgery and preoperative or postoperative radiotherapy or chemoradiation for rectal cancer...
Incidence, natural history, and patterns of locoregional recurrence in gastric cancer patients treated with preoperative chemoradiotherapyValerie K Reed
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Int J Radiat Oncol Biol Phys 71:741-7. 2008..To retrospectively determine the incidence and patterns (in-field, marginal, or out-of-field) of locoregional gastric cancer recurrence in patients who received preoperative chemoradiotherapy and to determine the outcome in these patients...
Role of adjuvant chemoradiation therapy in adenocarcinomas of the ampulla of vaterSunil Krishnan
Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
Int J Radiat Oncol Biol Phys 70:735-43. 2008..We retrospectively compared treatment outcomes in patients treated with pancreaticoduodenectomy alone versus those who received additional adjuvant CRT...
Induction chemotherapy selects patients with locally advanced, unresectable pancreatic cancer for optimal benefit from consolidative chemoradiation therapySunil Krishnan
Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
Cancer 110:47-55. 2007....
Radiotherapy and Hodgkin's lymphomaPrajnan Das
J Clin Oncol 23:8914; author reply 8914-6. 2005
Prognostic factors in patients with unresectable locally advanced pancreatic adenocarcinoma treated with chemoradiationSunil Krishnan
Department of Radiation Oncology, The University of Texas, M D Anderson Cancer Center, Houston, Texas, USA
Cancer 107:2589-96. 2006..Prognostic factors are inadequately defined for disease-free survival and overall survival in patients with LAPC who are receiving chemoradiation, so more definitive prognostic factors would be very useful for designing clinical trials...
Phase II study of capecitabine (Xeloda) and concomitant boost radiotherapy in patients with locally advanced rectal cancerSunil Krishnan
Department of Radiation Oncology, The University of Texas, M.D. Anderson Cancer Center, Houston, TX, USA
Int J Radiat Oncol Biol Phys 66:762-71. 2006..The pathologic response rate is comparable to our previous experience using protracted venous infusion 5-FU for LARC...
The optimization of dose delivery for intraoperative high-dose-rate radiation therapy using curved HAM applicatorsA Sam Beddar
Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Radiother Oncol 78:207-12. 2006..To determine the effect of the curvature of Harrison-Anderson-Mick applicators on the dose distribution in high-dose-rate intraoperative radiation therapy (HDR-IORT)...
Conformal radiotherapy of the dominant liver metastasis: a viable strategy for treatment of unresectable chemotherapy refractory colorectal cancer liver metastasesSunil Krishnan
Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA
Am J Clin Oncol 29:562-7. 2006..CONCLUSIONS: Conformal RT to the dominant liver metastasis as palliative therapy for unresectable colorectal cancer liver metastases has an acceptable toxicity profile and may improve survival. This approach merits further exploration...
Using the magnitude of PSA bounce after MRI-guided prostate brachytherapy to distinguish recurrence, benign precipitating factors, and idiopathic bouncePrajnan Das
Joint Center for Radiation Therapy, Harvard Medical School, Boston, MA 02115, USA
Int J Radiat Oncol Biol Phys 54:698-702. 2002..To identify events that precipitated a prostate-specific antigen (PSA) bounce and characterize the magnitude, duration, and time to PSA bounce after MRI-guided prostate brachytherapy...
