Research Topics
| Robert DarnellSummaryAffiliation: The Rockefeller University Country: USA Publications
Research Grants
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Detail Information
Publications
HITS-CLIP: panoramic views of protein-RNA regulation in living cellsRobert B Darnell
Laboratory of Neuro Oncology, The Rockefeller University, Howard Hughes Medical Institute, New York, NY 10065, USA
Wiley Interdiscip Rev RNA 1:266-86. 2010..Examples of the successes, limitations, and future of the technique will be discussed...
Neuronal signaling through alternative splicing: some exons CaRREK J O'Donovan
Laboratory of Molecular Neuro Oncology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
Sci STKE 2001:pe2. 2001..O'Donovan and Darnell discuss a mechanism by which neurons can alter channel splicing in response to neuronal activity through a signal generated by calcium and calcium/calmodulin-dependent kinase activity...- Paraneoplastic syndromes affecting the nervous systemRobert B Darnell
Howard Hughes Medical Institute and Laboratory of Molecular Neuro Oncology, The Rockefeller University, New York, NY 10021, USA
Semin Oncol 33:270-98. 2006..We review the currently known PND and their pathogenesis... - CLIP identifies Nova-regulated RNA networks in the brainJernej Ule
Howard Hughes Medical Institute, Rockefeller University, New York, NY 10021, USA
Science 302:1212-5. 2003..Thus, CLIP reveals that Nova coordinately regulates a biologically coherent set of RNAs encoding multiple components of the inhibitory synapse, an observation that may relate to the cause of abnormal motor inhibition in POMA... - An RNA map predicting Nova-dependent splicing regulationJernej Ule
Howard Hughes Medical Institute, New York, New York 10021, USA
Nature 444:580-6. 2006.... - RNA logic in time and spaceRobert B Darnell
Howard Hughes Medical Institute, Laboratory of Molecular Neuro Oncology, The Rockefeller University, New York, NY 10021, USA
Cell 110:545-50. 2002..The talks covered mechanisms of translational regulation, particularly in terms of temporal and spatial regulation, over a wide range of biological systems... - Nova autoregulation reveals dual functions in neuronal splicingB Kate Dredge
Laboratory of Molecular Neuro Oncology, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
EMBO J 24:1608-20. 2005..These studies demonstrate that in addition to its previously described role as a splicing activator, Nova autoregulates its own expression by acting as a splicing repressor... - Nova regulates GABA(A) receptor gamma2 alternative splicing via a distal downstream UCAU-rich intronic splicing enhancerB Kate Dredge
Laboratory of Molecular Neuro Oncology, Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10021, USA
Mol Cell Biol 23:4687-700. 2003.... - Kissing complex RNAs mediate interaction between the Fragile-X mental retardation protein KH2 domain and brain polyribosomesJennifer C Darnell
Howard Hughes Medical Institute and Laboratory of Molecular Neuro Oncology, The Rockefeller University, New York, New York, USA
Genes Dev 19:903-18. 2005.... - Alternative splicing microarrays reveal functional expression of neuron-specific regulators in Hodgkin lymphoma cellsAngela Relógio
European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
J Biol Chem 280:4779-84. 2005..This microarray design can help assess the role of alternative splicing in a variety of biological and medical problems and potentially serve as a diagnostic tool... - Determination and augmentation of RNA sequence specificity of the Nova K-homology domainsKiran Musunuru
Laboratory of Molecular Neuro-Oncology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
Nucleic Acids Res 32:4852-61. 2004..These data yield important insights into KH domain function and suggest a strategy by which to engineer KH domains with novel sequence preferences... - Paraneoplastic neurologic disorders: windows into neuronal function and tumor immunityRobert B Darnell
Department of Molecular Neuro-Oncology, Howard Hughes Medical Institute, Rockefeller University, Box 226, 1230 York Avenue, New York, NY 10021-6399, USA
Arch Neurol 61:30-2. 2004 - Fragile X mental retardation protein is associated with translating polyribosomes in neuronal cellsGiovanni Stefani
Howard Hughes Medical Institute and Laboratory of Molecular Neuro Oncology, The Rockefeller University, New York, New York 10021, USA
J Neurosci 24:7272-6. 2004..These data indicate that FMRP associates with functional polyribosomes in neurons... - The fragile X mental retardation protein, FMRP, recognizes G-quartetsJennifer C Darnell
The Rockefeller University, Laboratory of Molecular Neuro Oncology New York, New York 10021, USA
Ment Retard Dev Disabil Res Rev 10:49-52. 2004..Defects in the metabolism of this set of RNAs, presumably in the translation of their protein products, is likely to underlie the behavioral and cognitive changes seen in the disease... - Functional and mechanistic insights from genome-wide studies of splicing regulation in the brainJernej Ule
MRC Laboratory of Molecular Biology, Cambridge, England
Adv Exp Med Biol 623:148-60. 2007..These studies provide us with a platform for understanding the role of RNA binding proteins in tissue-specific splicing regulation and in disease... - A T-cell receptor associated with naturally occurring human tumor immunityBianca D Santomasso
Howard Hughes Medical Institute, Laboratory of Molecular Neuro Oncology, The Rockefeller University, New York, NY 10065, USA
Proc Natl Acad Sci U S A 104:19073-8. 2007..Cloned cdr2-specific TCR genes provide a clinically relevant means for immunologic targeting of human gynecologic cancers... - Evolution of Nova-dependent splicing regulation in the brainNejc Jelen
Laboratory of Molecular Neuro Oncology, The Rockefeller University, New York, New York, USA
PLoS Genet 3:1838-47. 2007.... - Memory, synaptic translation, and...prions?Robert B Darnell
Howard Hughes Medical Institute, Laboratory of Molecular Neuro Oncology, The Rockefeller University, New York, NY 10021, USA
Cell 115:767-8. 2003..2003a, 2003b [this issue of Cell])... - Dendritic-cell maturation alters intracellular signaling networks, enabling differential effects of IFN-alpha/beta on antigen cross-presentationRandy S Longman
Rockefeller University, New York, NY, USA
Blood 109:1113-22. 2007..These data provide evidence for a molecular switch in signaling pathways concomitant with DC maturation that offers a novel mechanism by which DCs modulate the integration of signals from the surrounding environment... - Splicing regulation in neurologic diseaseDonny D Licatalosi
Howard Hughes Medical Institute, Laboratory of Molecular Neuro-Oncology, The Rockefeller University, New York, New York 10021, USA
Neuron 52:93-101. 2006..This review considers the evidence that defects in regulation of splicing may underlie many types of human neurologic diseases... - Neuroimmunology of the paraneoplastic neurological degenerationsWendy K Roberts
Howard Hughes Medical Institute, The Rockefeller University, Box 226, 1230 York Avenue, New York, New York 10021, USA
Curr Opin Immunol 16:616-22. 2004..Pieces of the mystery of this tumor immune response and neuronal autoimmunity have been assembled, but much more needs to be learned... - RNA binding proteins and the regulation of neuronal synaptic plasticityJernej Ule
Howard Hughes Medical Institute and the Laboratory of Molecular Neuro-Oncology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
Curr Opin Neurobiol 16:102-10. 2006..Specificity in the regulation of synaptic plasticity might, in part, relate to the functional coherence of proteins encoded by the RNA targets of each RNA-binding protein... - CLIP: a method for identifying protein-RNA interaction sites in living cellsJernej Ule
Howard Hughes Medical Institute and the Laboratory of Molecular Neuro-Oncology, The Rockefeller University, New York, USA
Methods 37:376-86. 2005..Here, we present an improved protocol that performs RNA linker ligation before the SDS-PAGE step, and describe its application to the specific purification and amplification of RNA ligands of Nova in neurons... - Common molecular pathways mediate long-term potentiation of synaptic excitation and slow synaptic inhibitionCindy Shen Huang
Howard Hughes Medical Institute and Departments of Physiology and Biochemistry, University of California, San Francisco, CA 94143, USA
Cell 123:105-18. 2005.... - A new cause of limbic encephalopathyRobert B Darnell
The Rockefeller University, New York, USA
Brain 128:1745-6. 2005 - Sox21 is a repressor of neuronal differentiation and is antagonized by YB-1Hiroyuki Ohba
CREST JST and Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
Neurosci Lett 358:157-60. 2004..These results suggest that Sox21 is a repressor of neuronal differentiation in the developing nervous system... - Nova regulates brain-specific splicing to shape the synapseJernej Ule
Howard Hughes Medical Institute and Laboratory of Molecular Neuro Oncology, The Rockefeller University, New York, New York, USA
Nat Genet 37:844-52. 2005..Validating a large set of Nova RNA targets has led us to identify a multi-tiered network in which Nova regulates the exon content of RNAs encoding proteins that interact in the synapse...
Research Grants
- Tolerance versus tumor immunity in PNDRobert Darnell; Fiscal Year: 2005..These experiments offer the possibility of developing new cancer treatments and advancing the understanding of autoimmune disease of the nervous system. ..
- Structure/function studies of RBPs in neurologic diseaseRobert Darnell; Fiscal Year: 2005....
- NEUROLOGY AND THE MOLECULAR ROLE OF N-RBPS IN THE BRAINRobert Darnell; Fiscal Year: 2006..These studies will allow us to formulate a model comparing and contrasting the role that the Nova and FMRP RNA binding proteins in neurons and in neurologic disease. ..
- Prostate Cancer ImmunotherapyRobert Darnell; Fiscal Year: 2007..Our results should indicate whether this new approach to DC based, immunotherapy has a potential role in the treatment of prostatic cancer as well as other malignancies. ..
- NEUROLOGY AND THE MOLECULAR ROLE OF N-RBPS IN THE BRAINRobert Darnell; Fiscal Year: 2009..abstract_text> ..
- NEUROLOGY AND THE MOLECULAR ROLE OF N-RBPS IN THE BRAINRobert Darnell; Fiscal Year: 2001....
- NEUROLOGY AND THE MOLECULAR ROLE OF N-RBPS IN THE BRAINRobert B Darnell; Fiscal Year: 2010....