JENNIFER DARNELL

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. pmc FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism
    Jennifer C Darnell
    Laboratory of Molecular Neuro Oncology, The Rockefeller University, New York, NY 10065, USA
    Cell 146:247-61. 2011
  2. pmc Kissing complex RNAs mediate interaction between the Fragile-X mental retardation protein KH2 domain and brain polyribosomes
    Jennifer C Darnell
    Howard Hughes Medical Institute and Laboratory of Molecular Neuro Oncology, The Rockefeller University, New York, New York, USA
    Genes Dev 19:903-18. 2005
  3. pmc Discrimination of common and unique RNA-binding activities among Fragile X mental retardation protein paralogs
    Jennifer C Darnell
    Laboratory of Molecular Neuro Oncology, The Rockefeller University, New York, NY 10065, USA
    Hum Mol Genet 18:3164-77. 2009
  4. pmc Defects in translational regulation contributing to human cognitive and behavioral disease
    J C Darnell
    Department of Molecular Neuro Oncology, The Rockefeller University, 1230 York Ave, New York, NY 10065, USA
    Curr Opin Genet Dev 21:465-73. 2011
  5. ncbi Fragile X mental retardation protein is associated with translating polyribosomes in neuronal cells
    Giovanni Stefani
    Howard Hughes Medical Institute and Laboratory of Molecular Neuro Oncology, The Rockefeller University, New York, New York 10021, USA
    J Neurosci 24:7272-6. 2004
  6. ncbi The fragile X mental retardation protein, FMRP, recognizes G-quartets
    Jennifer C Darnell
    The Rockefeller University, Laboratory of Molecular Neuro Oncology New York, New York 10021, USA
    Ment Retard Dev Disabil Res Rev 10:49-52. 2004
  7. pmc A mouse model of the human Fragile X syndrome I304N mutation
    Julie B Zang
    Laboratory of Molecular Neuro Oncology, The Rockefeller University, New York, New York, USA
    PLoS Genet 5:e1000758. 2009
  8. pmc HITS-CLIP yields genome-wide insights into brain alternative RNA processing
    Donny D Licatalosi
    Laboratory of Molecular Neuro Oncology and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nature 456:464-9. 2008

Research Grants

  1. Identification and Validation of FMRP Target RNAs
    Jennifer C Darnell; Fiscal Year: 2010
  2. IDENTIFICATION OF FMRP TARGET RNAS
    JENNIFER DARNELL; Fiscal Year: 2004
  3. Identification and Validation of FMRP Target RNAs
    JENNIFER DARNELL; Fiscal Year: 2009

Collaborators

Detail Information

Publications8

  1. pmc FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism
    Jennifer C Darnell
    Laboratory of Molecular Neuro Oncology, The Rockefeller University, New York, NY 10065, USA
    Cell 146:247-61. 2011
    ..In addition, they provide insight into the molecular basis of the cognitive and allied defects in FXS and ASD and suggest multiple targets for clinical intervention...
  2. pmc Kissing complex RNAs mediate interaction between the Fragile-X mental retardation protein KH2 domain and brain polyribosomes
    Jennifer C Darnell
    Howard Hughes Medical Institute and Laboratory of Molecular Neuro Oncology, The Rockefeller University, New York, New York, USA
    Genes Dev 19:903-18. 2005
    ....
  3. pmc Discrimination of common and unique RNA-binding activities among Fragile X mental retardation protein paralogs
    Jennifer C Darnell
    Laboratory of Molecular Neuro Oncology, The Rockefeller University, New York, NY 10065, USA
    Hum Mol Genet 18:3164-77. 2009
    ..In contrast, FMRP is unique in its ability to recognize G-quadruplexes, suggesting the FMRP RGG domain may play a non-redundant role in the pathophysiology of the disease...
  4. pmc Defects in translational regulation contributing to human cognitive and behavioral disease
    J C Darnell
    Department of Molecular Neuro Oncology, The Rockefeller University, 1230 York Ave, New York, NY 10065, USA
    Curr Opin Genet Dev 21:465-73. 2011
    ..New approaches to the unbiased in vivo identification of maps of binding sites for these proteins on mRNA is expected to greatly increase our understanding of this crucial level of regulation in neuronal development and function...
  5. ncbi Fragile X mental retardation protein is associated with translating polyribosomes in neuronal cells
    Giovanni Stefani
    Howard Hughes Medical Institute and Laboratory of Molecular Neuro Oncology, The Rockefeller University, New York, New York 10021, USA
    J Neurosci 24:7272-6. 2004
    ..These data indicate that FMRP associates with functional polyribosomes in neurons...
  6. ncbi The fragile X mental retardation protein, FMRP, recognizes G-quartets
    Jennifer C Darnell
    The Rockefeller University, Laboratory of Molecular Neuro Oncology New York, New York 10021, USA
    Ment Retard Dev Disabil Res Rev 10:49-52. 2004
    ..Defects in the metabolism of this set of RNAs, presumably in the translation of their protein products, is likely to underlie the behavioral and cognitive changes seen in the disease...
  7. pmc A mouse model of the human Fragile X syndrome I304N mutation
    Julie B Zang
    Laboratory of Molecular Neuro Oncology, The Rockefeller University, New York, New York, USA
    PLoS Genet 5:e1000758. 2009
    ..These data suggest that loss of FMRP function, particularly in KH2-mediated RNA binding and in synaptic plasticity, play critical roles in pathogenesis of the Fragile X Syndrome and establish a new model for studying the disorder...
  8. pmc HITS-CLIP yields genome-wide insights into brain alternative RNA processing
    Donny D Licatalosi
    Laboratory of Molecular Neuro Oncology and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nature 456:464-9. 2008
    ..HITS-CLIP, therefore, provides a robust, unbiased means to identify functional protein-RNA interactions in vivo...

Research Grants11

  1. Identification and Validation of FMRP Target RNAs
    Jennifer C Darnell; Fiscal Year: 2010
    ....
  2. IDENTIFICATION OF FMRP TARGET RNAS
    JENNIFER DARNELL; Fiscal Year: 2004
    ..Moreover, comparison of the metabolism of candidate RNAs in mutant with wild-type mice will allow the investigators to conclude that FMRP acts on specific RNA targets in neurons. ..
  3. Identification and Validation of FMRP Target RNAs
    JENNIFER DARNELL; Fiscal Year: 2009
    ....