Jennifer C Darnell

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. pmc Cytoplasmic RNA-binding proteins and the control of complex brain function
    Jennifer C Darnell
    Department of Molecular Neuro Oncology, Rockefeller University, New York, New York 10065, USA
    Cold Spring Harb Perspect Biol 4:a012344. 2012
  2. pmc FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism
    Jennifer C Darnell
    Laboratory of Molecular Neuro Oncology, The Rockefeller University, New York, NY 10065, USA
    Cell 146:247-61. 2011
  3. pmc Discrimination of common and unique RNA-binding activities among Fragile X mental retardation protein paralogs
    Jennifer C Darnell
    Laboratory of Molecular Neuro Oncology, The Rockefeller University, New York, NY 10065, USA
    Hum Mol Genet 18:3164-77. 2009
  4. pmc Kissing complex RNAs mediate interaction between the Fragile-X mental retardation protein KH2 domain and brain polyribosomes
    Jennifer C Darnell
    Howard Hughes Medical Institute and Laboratory of Molecular Neuro Oncology, The Rockefeller University, New York, New York, USA
    Genes Dev 19:903-18. 2005
  5. pmc Protein-RNA and protein-protein recognition by dual KH1/2 domains of the neuronal splicing factor Nova-1
    Marianna Teplova
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Structure 19:930-44. 2011
  6. doi request reprint Mapping Argonaute and conventional RNA-binding protein interactions with RNA at single-nucleotide resolution using HITS-CLIP and CIMS analysis
    Michael J Moore
    1 Laboratory of Molecular Neuro Oncology, The Rockefeller University, New York, New York, USA 2
    Nat Protoc 9:263-93. 2014
  7. doi request reprint The translation of translational control by FMRP: therapeutic targets for FXS
    Jennifer C Darnell
    Laboratory of Molecular Neuro Oncology, The Rockefeller University, New York, New York, USA
    Nat Neurosci 16:1530-6. 2013
  8. pmc A mouse model of the human Fragile X syndrome I304N mutation
    Julie B Zang
    Laboratory of Molecular Neuro Oncology, The Rockefeller University, New York, New York, USA
    PLoS Genet 5:e1000758. 2009
  9. pmc Structure-function studies of FMRP RGG peptide recognition of an RNA duplex-quadruplex junction
    Anh Tuân Phan
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Nat Struct Mol Biol 18:796-804. 2011
  10. pmc HITS-CLIP yields genome-wide insights into brain alternative RNA processing
    Donny D Licatalosi
    Laboratory of Molecular Neuro Oncology and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nature 456:464-9. 2008

Collaborators

Detail Information

Publications11

  1. pmc Cytoplasmic RNA-binding proteins and the control of complex brain function
    Jennifer C Darnell
    Department of Molecular Neuro Oncology, Rockefeller University, New York, New York 10065, USA
    Cold Spring Harb Perspect Biol 4:a012344. 2012
    ....
  2. pmc FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism
    Jennifer C Darnell
    Laboratory of Molecular Neuro Oncology, The Rockefeller University, New York, NY 10065, USA
    Cell 146:247-61. 2011
    ..In addition, they provide insight into the molecular basis of the cognitive and allied defects in FXS and ASD and suggest multiple targets for clinical intervention...
  3. pmc Discrimination of common and unique RNA-binding activities among Fragile X mental retardation protein paralogs
    Jennifer C Darnell
    Laboratory of Molecular Neuro Oncology, The Rockefeller University, New York, NY 10065, USA
    Hum Mol Genet 18:3164-77. 2009
    ..In contrast, FMRP is unique in its ability to recognize G-quadruplexes, suggesting the FMRP RGG domain may play a non-redundant role in the pathophysiology of the disease...
  4. pmc Kissing complex RNAs mediate interaction between the Fragile-X mental retardation protein KH2 domain and brain polyribosomes
    Jennifer C Darnell
    Howard Hughes Medical Institute and Laboratory of Molecular Neuro Oncology, The Rockefeller University, New York, New York, USA
    Genes Dev 19:903-18. 2005
    ....
  5. pmc Protein-RNA and protein-protein recognition by dual KH1/2 domains of the neuronal splicing factor Nova-1
    Marianna Teplova
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Structure 19:930-44. 2011
    ....
  6. doi request reprint Mapping Argonaute and conventional RNA-binding protein interactions with RNA at single-nucleotide resolution using HITS-CLIP and CIMS analysis
    Michael J Moore
    1 Laboratory of Molecular Neuro Oncology, The Rockefeller University, New York, New York, USA 2
    Nat Protoc 9:263-93. 2014
    ..Once IP conditions are established, HITS-CLIP takes ∼8 d to prepare RNA for sequencing. Established pipelines for data analysis, including those for CIMS, take 3-4 d. ..
  7. doi request reprint The translation of translational control by FMRP: therapeutic targets for FXS
    Jennifer C Darnell
    Laboratory of Molecular Neuro Oncology, The Rockefeller University, New York, New York, USA
    Nat Neurosci 16:1530-6. 2013
    ....
  8. pmc A mouse model of the human Fragile X syndrome I304N mutation
    Julie B Zang
    Laboratory of Molecular Neuro Oncology, The Rockefeller University, New York, New York, USA
    PLoS Genet 5:e1000758. 2009
    ..These data suggest that loss of FMRP function, particularly in KH2-mediated RNA binding and in synaptic plasticity, play critical roles in pathogenesis of the Fragile X Syndrome and establish a new model for studying the disorder...
  9. pmc Structure-function studies of FMRP RGG peptide recognition of an RNA duplex-quadruplex junction
    Anh Tuân Phan
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Nat Struct Mol Biol 18:796-804. 2011
    ..These findings on FMRP RGG domain recognition by a combination of G-quadruplex and surrounding RNA sequences have implications for the recognition of other genomic G-rich RNAs...
  10. pmc HITS-CLIP yields genome-wide insights into brain alternative RNA processing
    Donny D Licatalosi
    Laboratory of Molecular Neuro Oncology and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nature 456:464-9. 2008
    ..HITS-CLIP, therefore, provides a robust, unbiased means to identify functional protein-RNA interactions in vivo...
  11. ncbi request reprint Fragile X mental retardation protein is associated with translating polyribosomes in neuronal cells
    Giovanni Stefani
    Howard Hughes Medical Institute and Laboratory of Molecular Neuro Oncology, The Rockefeller University, New York, New York 10021, USA
    J Neurosci 24:7272-6. 2004
    ..These data indicate that FMRP associates with functional polyribosomes in neurons...