Enrico Danzer

Summary

Affiliation: The Children's Hospital of Philadelphia
Country: USA

Publications

  1. ncbi request reprint Prenatal glucocorticoids improve lung morphology and partially restores surfactant mRNA expression in lambs with diaphragmatic hernia undergoing fetal tracheal occlusion
    Marcus G Davey
    The Children s Institute for Surgical Science and the Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Pediatr Pulmonol 41:1188-96. 2006
  2. doi request reprint Assessment of early pulmonary function abnormalities in giant omphalocele survivors
    Enrico Danzer
    Department of Surgery, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Pediatr Surg 47:1811-20. 2012
  3. doi request reprint Abnormal brain development and maturation on magnetic resonance imaging in survivors of severe congenital diaphragmatic hernia
    Enrico Danzer
    The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4318, USA
    J Pediatr Surg 47:453-61. 2012
  4. doi request reprint Fetal surgery for myelomeningocele: progress and perspectives
    Enrico Danzer
    Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia and University of Pennsylvania, School of Medicine, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Dev Med Child Neurol 54:8-14. 2012
  5. doi request reprint Neurodevelopmental and neurofunctional outcomes in children with congenital diaphragmatic hernia
    Enrico Danzer
    The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, PA 1910, USA
    Early Hum Dev 87:625-32. 2011
  6. doi request reprint Early neurodevelopmental outcome of infants with high-risk fetal lung lesions
    Enrico Danzer
    The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Fetal Diagn Ther 31:210-5. 2012
  7. doi request reprint Fetal MRI-calculated total lung volumes in the prediction of short-term outcome in giant omphalocele: preliminary findings
    Enrico Danzer
    The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Fetal Diagn Ther 31:248-53. 2012
  8. doi request reprint Fetal tracheal occlusion for severe congenital diaphragmatic hernia in humans: a morphometric study of lung parenchyma and muscularization of pulmonary arterioles
    Enrico Danzer
    The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, USA
    J Pediatr Surg 43:1767-75. 2008
  9. doi request reprint Use of magnetic resonance imaging in prenatal prognosis of the fetus with isolated left congenital diaphragmatic hernia
    Teresa Victoria
    Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, Philadelphia, PA, 19103, USA
    Prenat Diagn 32:715-23. 2012
  10. doi request reprint Intradural inclusion cysts following in utero closure of myelomeningocele: clinical implications and follow-up findings
    Enrico Danzer
    The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Neurosurg Pediatr 2:406-13. 2008

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Prenatal glucocorticoids improve lung morphology and partially restores surfactant mRNA expression in lambs with diaphragmatic hernia undergoing fetal tracheal occlusion
    Marcus G Davey
    The Children s Institute for Surgical Science and the Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Pediatr Pulmonol 41:1188-96. 2006
    ..We hypothesize that a GC-induced reduction in lung liquid volume during TO contributes, in part, to the observed increase in AE2 cell density and SPmRNA expression...
  2. doi request reprint Assessment of early pulmonary function abnormalities in giant omphalocele survivors
    Enrico Danzer
    Department of Surgery, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Pediatr Surg 47:1811-20. 2012
    ....
  3. doi request reprint Abnormal brain development and maturation on magnetic resonance imaging in survivors of severe congenital diaphragmatic hernia
    Enrico Danzer
    The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4318, USA
    J Pediatr Surg 47:453-61. 2012
    ..The aim of the study was to evaluate the incidence of abnormal brain maturation in survivors of severe congenital diaphragmatic hernia (CDH)...
  4. doi request reprint Fetal surgery for myelomeningocele: progress and perspectives
    Enrico Danzer
    Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia and University of Pennsylvania, School of Medicine, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Dev Med Child Neurol 54:8-14. 2012
    ..Consequently, additional research is necessary to further elucidate the pathophysiology of MMC, to define the ideal timing and technique of fetal closure, and to evaluate the long-term implications of prenatal intervention...
  5. doi request reprint Neurodevelopmental and neurofunctional outcomes in children with congenital diaphragmatic hernia
    Enrico Danzer
    The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, PA 1910, USA
    Early Hum Dev 87:625-32. 2011
    ....
  6. doi request reprint Early neurodevelopmental outcome of infants with high-risk fetal lung lesions
    Enrico Danzer
    The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Fetal Diagn Ther 31:210-5. 2012
    ....
  7. doi request reprint Fetal MRI-calculated total lung volumes in the prediction of short-term outcome in giant omphalocele: preliminary findings
    Enrico Danzer
    The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Fetal Diagn Ther 31:248-53. 2012
    ..To determine the value of fetal MRI-calculated total lung volumes (TLV) in the prediction of short-term outcome in patients with giant omphalocele (GO)...
  8. doi request reprint Fetal tracheal occlusion for severe congenital diaphragmatic hernia in humans: a morphometric study of lung parenchyma and muscularization of pulmonary arterioles
    Enrico Danzer
    The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, USA
    J Pediatr Surg 43:1767-75. 2008
    ..The aim of this study is to examine structure of lung parenchyma (Pp) and muscularization of pulmonary arterioles (PAs) in human fetuses that underwent tracheal occlusion (TO) therapy for severe congenital diaphragmatic hernia (CDH)...
  9. doi request reprint Use of magnetic resonance imaging in prenatal prognosis of the fetus with isolated left congenital diaphragmatic hernia
    Teresa Victoria
    Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, Philadelphia, PA, 19103, USA
    Prenat Diagn 32:715-23. 2012
    ....
  10. doi request reprint Intradural inclusion cysts following in utero closure of myelomeningocele: clinical implications and follow-up findings
    Enrico Danzer
    The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Neurosurg Pediatr 2:406-13. 2008
    ..The goal in this study was to evaluate the incidence and clinical implications of the development of cutaneously derived intradural inclusion cysts (ICs) following fetal myelomeningocele (fMMC) closure...
  11. pmc A randomized trial of prenatal versus postnatal repair of myelomeningocele
    N Scott Adzick
    Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    N Engl J Med 364:993-1004. 2011
    ..Prenatal repair of myelomeningocele, the most common form of spina bifida, may result in better neurologic function than repair deferred until after delivery. We compared outcomes of in utero repair with standard postnatal repair...
  12. doi request reprint Fetal myelomeningocele surgery: preschool functional status using the Functional Independence Measure for children (WeeFIM)
    Enrico Danzer
    The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, The University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Childs Nerv Syst 27:1083-8. 2011
    ..To study preschool functional status in children following fetal myelomeningocele (fMMC) surgery...
  13. doi request reprint Prospective, interdisciplinary follow-up of children with prenatally diagnosed giant omphalocele: short-term neurodevelopmental outcome
    Enrico Danzer
    The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Pediatr Surg 45:718-23. 2010
    ..The objective of this study is to determine the short-term neurodevelopmental outcome in infants with giant omphalocele (GO)...
  14. ncbi request reprint Pulmonary arteriole muscularization in lambs with diaphragmatic hernia after combined tracheal occlusion/glucocorticoid therapy
    Marcus Davey
    Center of Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Am J Obstet Gynecol 197:381.e1-7. 2007
    ....
  15. doi request reprint Amniotic fluid levels of glial fibrillary acidic protein in fetal rats with retinoic acid induced myelomeningocele: a potential marker for spinal cord injury
    Enrico Danzer
    Children s Center for Fetal Research, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Am J Obstet Gynecol 204:178.e1-11. 2011
    ....
  16. doi request reprint Preschool neurological assessment in congenital diaphragmatic hernia survivors: outcome and perinatal factors associated with neurodevelopmental impairment
    Enrico Danzer
    The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Early Hum Dev 89:393-400. 2013
    ..To evaluate the preschool neurodevelopmental outcome in CDH survivors between 2 and 5 years of age and to identify perinatal and postnatal factors that may be predictive of persistent neurological deficits...
  17. doi request reprint In utero meconium passage in fetuses and newborns with myelomeningocele
    Enrico Danzer
    The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, and the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4318, USA
    J Neurosurg Pediatr 3:141-6. 2009
    ..The authors retrospectively investigated whether midgestational fetal myelomeningocele (fMMC) repair alters intrauterine meconium exposure...
  18. doi request reprint Lower extremity neuromotor function and short-term ambulatory potential following in utero myelomeningocele surgery
    Enrico Danzer
    Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Fetal Diagn Ther 25:47-53. 2009
    ..To evaluate lower extremity neuromotor function (LENF) and short-term ambulatory potential following fetal myelomeningocele (fMMC) closure...
  19. doi request reprint Neurodevelopmental outcome of infants with congenital diaphragmatic hernia prospectively enrolled in an interdisciplinary follow-up program
    Enrico Danzer
    The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, USA
    J Pediatr Surg 45:1759-66. 2010
    ..The purpose of the study was to evaluate the neurodevelopmental outcome in infants with congenital diaphragmatic hernia (CDH)...
  20. ncbi request reprint Prenatal glucocorticoids and exogenous surfactant therapy improve respiratory function in lambs with severe diaphragmatic hernia following fetal tracheal occlusion
    Marcus G Davey
    The Children s Institute for Surgical Science and the Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, PA 19104, USA
    Pediatr Res 60:131-5. 2006
    ..GC or surfactant therapy alone significantly improved respiratory gas exchange, Cl, and ventilatory efficiency index. Total lung capacity was normalized only in DH/TO lambs that received both GC and S...
  21. doi request reprint Preschool neurobehavioral outcome following fetal myelomeningocele surgery
    Enrico Danzer
    Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104 4388, USA
    Fetal Diagn Ther 30:174-9. 2011
    ..It was the aim of this study to assess the prevalence of preschool neurobehavioral problems in children following fetal myelomeningocele (fMMC) surgery...
  22. ncbi request reprint Liver position and lung-to-head ratio for prediction of extracorporeal membrane oxygenation and survival in isolated left congenital diaphragmatic hernia
    Holly L Hedrick
    Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Am J Obstet Gynecol 197:422.e1-4. 2007
    ..The purpose of this study was to determine the ability of liver position and lung-to-head ratio to predict outcome in isolated left congenital diaphragmatic hernia...
  23. ncbi request reprint Morphologic analysis of the neuromuscular development of the anorectal unit in fetal rats with retinoic acid induced myelomeningocele
    Enrico Danzer
    The Children s Center for Fetal Research, Children s Hospital of Philadelphia, The University of Pennsylvania School of Medicine, Abramson Research Center, Room 1116B, 3615 Civic Center Boulevard, Philadelphia, PA 19104 4318, USA
    Neurosci Lett 430:157-62. 2008
    ....
  24. ncbi request reprint Gastroschisis in mice lacking aortic carboxypeptidase-like protein is associated with a defect in neuromuscular development of the eviscerated intestine
    Enrico Danzer
    The Center for Fetal Research, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Pediatr Res 68:23-8. 2010
    ..The defect observed in ACLP mice closely resembles GS. Absence of ICC, NCC, EN, and immature differentiation of SMC supports an associated defect in neuromuscular development that is restricted to the EI...
  25. doi request reprint Prenatal ultrasonographic gastrointestinal abnormalities in fetuses with gastroschisis do not correlate with postnatal outcomes
    Andrea T Badillo
    The Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Pediatr Surg 43:647-53. 2008
    ..The purpose of this study was to correlate prenatal identification of additional gastrointestinal sonographic abnormalities with postnatal clinical outcome...
  26. doi request reprint Preschool neurodevelopmental outcome of children following fetal myelomeningocele closure
    Enrico Danzer
    Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia and The University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Obstet Gynecol 202:450.e1-9. 2010
    ..We sought to investigate the preschool neurodevelopmental outcomes of children following fetal myelomeningocele (fMMC) surgery...
  27. ncbi request reprint Structural and functional characterization of bladder smooth muscle in fetal rats with retinoic acid-induced myelomeningocele
    Enrico Danzer
    The Center for Fetal Research, The Children s Hospital of Philadelphia, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4318, USA
    Am J Physiol Renal Physiol 292:F197-206. 2007
    ....
  28. pmc Fetal tendon wound size modulates wound gene expression and subsequent wound phenotype
    Benjamin J Herdrich
    The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Wound Repair Regen 18:543-9. 2010
    ..This model allows the process of regenerative healing to be examined without the confounding variable of gestational age...
  29. doi request reprint Fetal surgery for myelomeningocele: patient selection, perioperative management and outcomes
    Enrico Danzer
    Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104 4388, USA
    Fetal Diagn Ther 30:163-73. 2011
    ..Consequently, further research is warranted to further expand our understanding of the pathophysiology of MMC, to evaluate the long-term impact of in utero intervention and to refine the timing and technique of fetal MMC surgery...
  30. doi request reprint Open fetal surgery for myelomeningocele
    Michael W Bebbington
    Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Prenat Diagn 31:689-94. 2011
    ..This will mean that not every fetus with an MMC will be a candidate for in utero surgery. The balance of risk to benefit will continue to evolve as further technological advances are evaluated and more follow-up information is obtained...
  31. ncbi request reprint Fetal head biometry assessed by fetal magnetic resonance imaging following in utero myelomeningocele repair
    Enrico Danzer
    The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, The University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Fetal Diagn Ther 22:1-6. 2007
    ..To examine the impact of fetal myelomeningocele (MMC) repair on fetal head biometry and cerebrospinal fluid (CSF) spaces assessed by magnetic resonance imaging (MR) studies...
  32. ncbi request reprint Tracheal occlusion in fetal rats alters expression of mesenchymal nuclear transcription factors without affecting surfactant protein expression
    Enrico Danzer
    The Children s Institute for Surgical Science, Children s Hospital of Philadelphia, The University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4318, USA
    J Pediatr Surg 41:774-80. 2006
    ..The objectives of this study were to evaluate the effects of short-term (3 days) TO on normal lung growth and protein expression of pulmonary MNTF involved in SP synthesis...
  33. doi request reprint Use of ultrasound and MRI for evaluation of lung volumes in fetuses with isolated left congenital diaphragmatic hernia
    Teresa Victoria
    Department of Radiology, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19103, USA
    Semin Pediatr Surg 22:30-6. 2013
    ..These imaging indicators may be used to provide health professionals and the parents with the most accurate information about fetal prognosis...
  34. ncbi request reprint Diagnosis and characterization of fetal sacrococcygeal teratoma with prenatal MRI
    Enrico Danzer
    The Center for Fetal Diagnosis and Treatment, Department of Radiology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4399, USA
    AJR Am J Roentgenol 187:W350-6. 2006
    ..The purpose of this study was to determine whether prenatal MRI provides additional information about fetal sacrococcygeal teratoma compared with prenatal sonography...
  35. pmc Regenerative healing following foetal myocardial infarction
    Benjamin J Herdrich
    The University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Eur J Cardiothorac Surg 38:691-8. 2010
    ..Understanding the mechanisms involved in foetal myocardial regeneration may lead to applications to alter the adult response following myocardial infarction...
  36. pmc In utero lung gene transfer using adeno-associated viral and lentiviral vectors in mice
    Luc Joyeux
    1 Children s Center for Fetal Research, Children s Hospital of Philadelphia, Philadelphia, PA 19104
    Hum Gene Ther Methods 25:197-205. 2014
    ....
  37. ncbi request reprint Incidence and factors associated with sensorineural and conductive hearing loss among survivors of congenital diaphragmatic hernia
    Emily A Partridge
    The Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, Philadelphia, PA, USA
    J Pediatr Surg 49:890-4; discussion 894. 2014
    ..We sought to characterize the incidence and risk factors associated with SNHL and CHL in a large cohort of CDH patients who underwent standardized treatment and follow-up at a single institution...
  38. ncbi request reprint Surfactant protein expression is increased in the ipsilateral but not contralateral lungs of fetal sheep with left-sided diaphragmatic hernia
    Marcus G Davey
    Children s Institute for Surgical Science and Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, Abramson 1112 D, 3615 Civic Center Blvd, Philadelphia, PA 19104, USA
    Pediatr Pulmonol 39:359-67. 2005
    ..Furthermore, AE2 cell density is increased in DH, suggesting that the increase in SP mRNA and protein levels is due to increases AE2 cell number. Our data further support the premise that fetal lung hypoplasia favors an AE2 phenotype...
  39. doi request reprint Fetal surgery for neural tube defects
    Enrico Danzer
    The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia and the Perelman School of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Semin Fetal Neonatal Med 19:2-8. 2014
    ..The secondary objective is to briefly discuss our approach to fetal MMC. Finally, the ongoing clinical research and the recent developments of potential alternative fetal surgical techniques will be highlighted. ..