Elliott D Crouser

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. pmc An in silico modeling approach to understanding the dynamics of sarcoidosis
    Baltazar D Aguda
    Neuro Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
    PLoS ONE 6:e19544. 2011
  2. pmc Differential expression of microRNA and predicted targets in pulmonary sarcoidosis
    Elliott D Crouser
    Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, The Ohio State University Medical Center, Columbus, OH 43210, United States
    Biochem Biophys Res Commun 417:886-91. 2012
  3. pmc Monocyte activation by necrotic cells is promoted by mitochondrial proteins and formyl peptide receptors
    Elliott D Crouser
    Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Dorothy M Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH, USA
    Crit Care Med 37:2000-9. 2009
  4. pmc Gene expression profiling identifies MMP-12 and ADAMDEC1 as potential pathogenic mediators of pulmonary sarcoidosis
    Elliott D Crouser
    Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, The Dorothy M Davis Heart and Lung Research Institute, Columbus, Ohio 43210 1252, USA
    Am J Respir Crit Care Med 179:929-38. 2009
  5. ncbi request reprint Carbamoyl phosphate synthase-1: a marker of mitochondrial damage and depletion in the liver during sepsis
    Elliott D Crouser
    Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, The Ohio State University Medical Center, Columbus, 43210, USA
    Crit Care Med 34:2439-46. 2006
  6. ncbi request reprint A proteomic analysis of liver mitochondria during acute endotoxemia
    Elliott D Crouser
    Division of Pulmonary, Critical Care and Sleep Medicine, Dorothy M Davis Heart and Lung Research Institute, The Ohio State University, 473 West 12 Avenue, Columbus, OH 43210 1252, USA
    Intensive Care Med 32:1252-62. 2006
  7. ncbi request reprint Abnormal permeability of inner and outer mitochondrial membranes contributes independently to mitochondrial dysfunction in the liver during acute endotoxemia
    Elliott D Crouser
    Division of Pulmonary and Critical Care Medicine, The Ohio State University Medical Center, Columbus, OH, USA
    Crit Care Med 32:478-88. 2004
  8. ncbi request reprint Mitochondrial iPLA2 activity modulates the release of cytochrome c from mitochondria and influences the permeability transition
    Martha E Gadd
    Department of Molecular and Cellular Biochemistry, Ohio State University, 1645 Neil Avenue, Columbus, OH 43210, USA
    J Biol Chem 281:6931-9. 2006
  9. ncbi request reprint Cyclosporin A ameliorates mitochondrial ultrastructural injury in the ileum during acute endotoxemia
    Elliott D Crouser
    Division of Pulmonary and Critical Care Medicine, The Ohio State University Medical Center, 201F Davis Heart and Lung Research Institute, 473 West Twelfth Avenue, Columbus, OH 43210 1252, USA
    Crit Care Med 30:2722-8. 2002
  10. pmc Intestinal epithelium is more susceptible to cytopathic injury and altered permeability than the lung epithelium in the context of acute sepsis
    Mark W Julian
    Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, The Ohio State University Medical Center, Columbus, OH 43210 1252, USA
    Int J Exp Pathol 92:366-76. 2011

Research Grants

Collaborators

Detail Information

Publications30

  1. pmc An in silico modeling approach to understanding the dynamics of sarcoidosis
    Baltazar D Aguda
    Neuro Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
    PLoS ONE 6:e19544. 2011
    ..We sought to develop a computational model to enhance our understanding of the pathological mechanisms of and predict potential treatments of sarcoidosis...
  2. pmc Differential expression of microRNA and predicted targets in pulmonary sarcoidosis
    Elliott D Crouser
    Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, The Ohio State University Medical Center, Columbus, OH 43210, United States
    Biochem Biophys Res Commun 417:886-91. 2012
    ..We sought to determine whether sarcoidosis tissues harbor a distinct pattern of miRNA expression and then considered their potential molecular targets...
  3. pmc Monocyte activation by necrotic cells is promoted by mitochondrial proteins and formyl peptide receptors
    Elliott D Crouser
    Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Dorothy M Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH, USA
    Crit Care Med 37:2000-9. 2009
    ..Thus, we hypothesized that the mitochondrial fraction of the cell, particularly N-formyl peptides, contributes significantly to the activation of monocytes by necrotic cells...
  4. pmc Gene expression profiling identifies MMP-12 and ADAMDEC1 as potential pathogenic mediators of pulmonary sarcoidosis
    Elliott D Crouser
    Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, The Dorothy M Davis Heart and Lung Research Institute, Columbus, Ohio 43210 1252, USA
    Am J Respir Crit Care Med 179:929-38. 2009
    ..Little is known about the genetic regulation of granulomatous inflammation in sarcoidosis...
  5. ncbi request reprint Carbamoyl phosphate synthase-1: a marker of mitochondrial damage and depletion in the liver during sepsis
    Elliott D Crouser
    Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, The Ohio State University Medical Center, Columbus, 43210, USA
    Crit Care Med 34:2439-46. 2006
    ..Thus, we hypothesized that the circulatory release of CPS-1 would correlate with mitochondrial damage or impaired mitochondrial function in the liver in a clinically relevant model of sepsis...
  6. ncbi request reprint A proteomic analysis of liver mitochondria during acute endotoxemia
    Elliott D Crouser
    Division of Pulmonary, Critical Care and Sleep Medicine, Dorothy M Davis Heart and Lung Research Institute, The Ohio State University, 473 West 12 Avenue, Columbus, OH 43210 1252, USA
    Intensive Care Med 32:1252-62. 2006
    ..We analyzed liver mitochondrial protein expression patterns (i.e., proteomics) during acute endotoxemia to discover novel insights into mitochondrial responses to acute systemic inflammation...
  7. ncbi request reprint Abnormal permeability of inner and outer mitochondrial membranes contributes independently to mitochondrial dysfunction in the liver during acute endotoxemia
    Elliott D Crouser
    Division of Pulmonary and Critical Care Medicine, The Ohio State University Medical Center, Columbus, OH, USA
    Crit Care Med 32:478-88. 2004
    ..This study was designed to determine the role played by the mitochondrial permeability transition in the pathogenesis of mitochondrial damage and dysfunction in a representative systemic organ during the acute phase of endotoxemia...
  8. ncbi request reprint Mitochondrial iPLA2 activity modulates the release of cytochrome c from mitochondria and influences the permeability transition
    Martha E Gadd
    Department of Molecular and Cellular Biochemistry, Ohio State University, 1645 Neil Avenue, Columbus, OH 43210, USA
    J Biol Chem 281:6931-9. 2006
    ..Through its effects on the permeability transition and release of intermembrane space proteins, the mitochondrial Ca(2+)-independent phospholipase A(2) may be an important factor governing cell death caused by necrosis or apoptosis...
  9. ncbi request reprint Cyclosporin A ameliorates mitochondrial ultrastructural injury in the ileum during acute endotoxemia
    Elliott D Crouser
    Division of Pulmonary and Critical Care Medicine, The Ohio State University Medical Center, 201F Davis Heart and Lung Research Institute, 473 West Twelfth Avenue, Columbus, OH 43210 1252, USA
    Crit Care Med 30:2722-8. 2002
    ..This study was designed to determine the role, if any, of the mitochondrial permeability transition in the pathogenesis of mitochondrial injury in a representative systemic organ during the acute phase of endotoxemia...
  10. pmc Intestinal epithelium is more susceptible to cytopathic injury and altered permeability than the lung epithelium in the context of acute sepsis
    Mark W Julian
    Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, The Ohio State University Medical Center, Columbus, OH 43210 1252, USA
    Int J Exp Pathol 92:366-76. 2011
    ..Early alterations in mitochondrial function portend subsequent epithelial barrier dysfunction...
  11. pmc Mitochondrial transcription factor A, an endogenous danger signal, promotes TNFα release via RAGE- and TLR9-responsive plasmacytoid dendritic cells
    Mark W Julian
    Dorothy M Davis Heart and Lung Research Institute, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Wexner Medical Center, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 8:e72354. 2013
    ..We hypothesized that TFAM, bound to mtDNA (or equivalent CpG-enriched DNA), amplifies TNFα release from TLR9-expressing plasmacytoid dendritic cells (pDCs) by engaging RAGE...
  12. pmc At-risk but viable myocardium in a large animal model of non ST-segment elevation acute coronary syndrome: cardiovascular magnetic resonance with ex vivo validation
    Henry Chang
    Dorothy M, Davis Heart and Lung Research Institute, The Ohio State University, 473 W 12th Ave, Suite 200, Columbus, OH 43210, USA
    J Cardiovasc Magn Reson 15:94. 2013
    ..We hypothesized that a novel model of NSTE-ACS produces acute myocardial injury, measured by increased T2 cardiovascular magnetic resonance (CMR), without significant necrosis by late gadolinium enhancement (LGE)...
  13. pmc Formyl peptide receptor ligands promote wound closure in lung epithelial cells
    Guohong Shao
    Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, The Dorothy M Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH 43210 1252, USA
    Am J Respir Cell Mol Biol 44:264-9. 2011
    ..Considered together, these data confirm that human lung epithelial cells express functional FPRs, which are capable of responding to endogenous mitochondrial danger signals, to promote wound closure...
  14. pmc Mitochondrial transcription factor A serves as a danger signal by augmenting plasmacytoid dendritic cell responses to DNA
    Mark W Julian
    Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Dorothy M Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA
    J Immunol 189:433-43. 2012
    ....
  15. pmc Calcineurin regulates myocardial function during acute endotoxemia
    Mandar S Joshi
    Center for Cardiovascular Medicine, Columbus Children s Research Institute, Ohio State University Medical Center, Columbus, OH 43210 1252, USA
    Am J Respir Crit Care Med 173:999-1007. 2006
    ....
  16. ncbi request reprint Quantitation of cytochrome c release from rat liver mitochondria
    Elliott D Crouser
    Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
    Anal Biochem 317:67-75. 2003
    ..Swelling and the release of adenylate kinase activity have been determined simultaneously to show how the data can be applied to evaluate the role of outer membrane disruption in mechanisms that release cytochrome c...
  17. ncbi request reprint Nicotine treatment improves Toll-like receptor 2 and Toll-like receptor 9 responsiveness in active pulmonary sarcoidosis
    Mark W Julian
    Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Wexner Medical Center at The Ohio State University, Columbus, OH 43210, USA
    Chest 143:461-70. 2013
    ..We sought to determine whether nicotine treatment was well tolerated while effectively normalizing immune responses in patients with active pulmonary sarcoidosis...
  18. ncbi request reprint The CD4+ lymphopenic sarcoidosis phenotype is highly responsive to anti-tumor necrosis factor-{alpha} therapy
    Elliott D Crouser
    201 Davis Heart and Lung Research Institute, The Ohio State University Medical Center, 473 W 12th Ave, Columbus, OH 43210, USA
    Chest 137:1432-5. 2010
    ..No change in the distribution of T-cell subsets was noted. The presence of CD4(+) lymphopenia identifies a distinct sarcoidosis phenotype that is particularly responsive to anti-TNFalpha therapy...
  19. pmc Zinc deficiency increases organ damage and mortality in a murine model of polymicrobial sepsis
    Daren L Knoell
    Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Dorothy M Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH, USA
    Crit Care Med 37:1380-8. 2009
    ..e., cecal ligation and puncture (CLP){rsqb; resulting in increased mortality and that acute nutritional repletion of zinc would be beneficial...
  20. ncbi request reprint Endotoxin-induced mitochondrial damage correlates with impaired respiratory activity
    Elliott D Crouser
    Division of Pulmonary and Critical Care Medicine, Dorothy M Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH 43210 1252, USA
    Crit Care Med 30:276-84. 2002
    ....
  21. ncbi request reprint Considering an infectious etiology of sarcoidosis
    Michael E Ezzie
    Division of Pulmonary, Critical Care, and Sleep Medicine, The Ohio State University Medical Center, Columbus, OH 43210 1252, USA
    Clin Dermatol 25:259-66. 2007
    ..Moreover, recent advances in our understanding of the relationships between sarcoidosis phenotype and host genetic factors may further illuminate the mechanisms linking infection and sarcoidosis...
  22. doi request reprint Quantitative computerized two-point correlation analysis of lung CT scans correlates with pulmonary function in pulmonary sarcoidosis
    Barbaros Selnur Erdal
    Department of Electrical and Computer Engineering, The Ohio State University College of Engineering, Columbus, OH, USA
    Chest 142:1589-97. 2012
    ..We sought to create a computerized CT image analysis tool that would provide quantitative and clinically relevant information...
  23. ncbi request reprint Toxicity of Food Drug and Cosmetic Blue No. 1 dye in critically ill patients
    Maria R Lucarelli
    Division of Pulmonary and Critical Care Medicine, Department of Pharmacy, The Dorothy M Davis Heart and Lung Research Institute, The Ohio State University Medical Center, 473 West Twelfth Avenue, Columbus, OH 43210 1252, USA
    Chest 125:793-5. 2004
    ..Risk factors and mechanisms of FD&C Blue No. 1 toxicity are discussed, and alternate approaches to gastric aspiration detection in critically ill patients are considered...
  24. pmc Flavopiridol causes early mitochondrial damage in chronic lymphocytic leukemia cells with impaired oxygen consumption and mobilization of intracellular calcium
    Syed Rehan A Hussain
    Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
    Blood 111:3190-9. 2008
    ..These observations suggest that in CLL and 697 cells, flavopiridol mediates its cytotoxic effects via induction of the mitochondrial permeability transition and changes in intracellular calcium...
  25. ncbi request reprint Unexpectedly high prevalence of sarcoidosis in a representative U.S. Metropolitan population
    Barbaros S Erdal
    Department of Radiology, The Ohio State University College of Medicine, Columbus, OH, USA
    Respir Med 106:893-9. 2012
    ..S. estimates...
  26. ncbi request reprint Redefining the roles of apoptosis pathways during sepsis
    Elliott D Crouser
    Crit Care Med 33:670-2. 2005
  27. ncbi request reprint Respiratory failure during critical illness: are mitochondria to blame?
    Elliott D Crouser
    Am J Respir Crit Care Med 172:793-4. 2005
  28. ncbi request reprint Suppression of monocyte metabolism by septic plasma: revisiting the concept of "blood poisoning"
    Elliott D Crouser
    Crit Care Med 35:2856-7. 2007
  29. ncbi request reprint Therapeutic benefits of antioxidants during sepsis: is protection against oxidant-mediated tissue damage only half the story?
    Elliott D Crouser
    Crit Care Med 32:589-90. 2004
  30. ncbi request reprint Pore formation and uncoupling initiate a Ca2+-independent degradation of mitochondrial phospholipids
    Kimberly M Broekemeier
    Department of Chemistry, Ohio Northern University, Ada, Ohio 45018, USA
    Biochemistry 41:7771-80. 2002
    ..It is proposed that this enzyme, rather than the Ca(2+)-dependent type IIA phospholipase A(2), initiates the removal of poorly functioning mitochondria by processes involving autolysis...

Research Grants3

  1. MITOCHONDRIAL CYTOCHROME C RELEASE VIA MEMBRANE PORES
    Elliott Crouser; Fiscal Year: 2004
    ..These advisors are actively investigating the role mitochondria in the pathogenesis of disease. Thus, the prospects for successful collaborative initiatives, a critical determinant of future success, are excellent. ..
  2. Stromal Gene Expression During Pulmonary Sarcoidosis
    Elliott Crouser; Fiscal Year: 2005
    ..Statistical comparisons of gene expression patterns will then be performed. Novel insights relating gene profiles to disease manifestation, prognosis and pathogenesis are likely outcomes of these investigations. ..
  3. Induction of Inflammation by Mitochondrial Proteins
    Elliott Crouser; Fiscal Year: 2006
    ....