Research Topics
Genomes and Genes | FREDERICK CROSSSummaryAffiliation: The Rockefeller University Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Evolution of networks and sequences in eukaryotic cell cycle controlFrederick R Cross
The Rockefeller University, New York, NY 10065, USA
Philos Trans R Soc Lond B Biol Sci 366:3532-44. 2011....- Quantitative characterization of a mitotic cyclin threshold regulating exit from mitosisFrederick R Cross
The Rockefeller University, New York, NY 10021, USA
Mol Biol Cell 16:2129-38. 2005..The loss of robustness of the Clb2 overexpressing system is also predicted by the model. These results provide strong confirmation of the model's predictive ability... - Phosphorylation of the Sic1 inhibitor of B-type cyclins in Saccharomyces cerevisiae is not essential but contributes to cell cycle robustnessFrederick R Cross
The Rockefeller University, New York, New York 10021, USA
Genetics 176:1541-55. 2007.... - Genetic and biochemical evaluation of the importance of Cdc6 in regulating mitotic exitVincent Archambault
The Rockefeller University, New York, New York 10021, USA
Mol Biol Cell 14:4592-604. 2003..We conclude, therefore, that although both Cdc6 and Sic1 have the potential to facilitate mitotic exit by inhibiting Clb2-Cdk, mitotic exit nevertheless does not require any identified stoichiometric inhibitor of Cdk activity... - Positive feedback of G1 cyclins ensures coherent cell cycle entryJan M Skotheim
Center for Studies in Physics and Biology, The Rockefeller University, New York 10065, USA
Nature 454:291-6. 2008..A similar G1/S regulatory network in mammalian cells, comprised of non-orthologous genes, suggests either conservation of regulatory architecture or convergent evolution... - Cyclin and cyclin-dependent kinase substrate requirements for preventing rereplication reveal the need for concomitant activation and inhibitionAmy E Ikui
The Rockefeller University, New York, New York 10021, USA
Genetics 175:1011-22. 2007.... 
APC-dependent proteolysis of the mitotic cyclin Clb2 is essential for mitotic exitRalph Wasch
The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
Nature 418:556-62. 2002..Cdh1 and Sic1 may be required for further inactivation of Clb2-Cdk1, regulating cell size and the length of G1...- High functional overlap between MluI cell-cycle box binding factor and Swi4/6 cell-cycle box binding factor in the G1/S transcriptional program in Saccharomyces cerevisiaeJames M Bean
Rockefeller University, New York, New York 10021, USA
Genetics 171:49-61. 2005..Finally, we observe residual G1/S transcriptional regulation in the absence of Swi4 and Mbp1... - Daughter-specific transcription factors regulate cell size control in budding yeastStefano Di Talia
The Rockefeller University, New York, New York, USA
PLoS Biol 7:e1000221. 2009..This work demonstrates mechanistically how asymmetric localization of cell fate determinants results in cell-type-specific regulation of the cell cycle... - Requirements and reasons for effective inhibition of the anaphase promoting complex activator CDH1Jonathan A Robbins
The Rockefeller University, New York, NY 10065, USA
Mol Biol Cell 21:914-25. 2010..Thus, different spindle-regulatory pathways have distinct sensitivities to Cdh1, and ACM1 may buffer essential CDK phosphorylation of Cdh1... - Novel role for Cdc14 sequestration: Cdc14 dephosphorylates factors that promote DNA replicationJoanna Bloom
The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
Mol Cell Biol 27:842-53. 2007.... - Coherence and timing of cell cycle start examined at single-cell resolutionJames M Bean
The Rockefeller University, New York, New York 10021, USA
Mol Cell 21:3-14. 2006..Thus, multiple pathways may independently suppress qualitatively different kinds of noise at Start... - Two-faced cyclins with eyes on the targetsVincent Archambault
Rockefeller University, New York, New York, USA
Cell Cycle 4:125-30. 2005..The evolutionary conservation of the HP motif suggests that it allows cyclins to carry out important and specialized functions... - Targeted proteomic study of the cyclin-Cdk moduleVincent Archambault
The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
Mol Cell 14:699-711. 2004..Our results demonstrate that this approach can be used to detect a host of transient and dynamic protein associations within a biological module... - Two redundant oscillatory mechanisms in the yeast cell cycleFrederick R Cross
The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
Dev Cell 4:741-52. 2003..Computational modeling confirms that two such mechanisms can be linked to yield a robust cell cycle control system... 
Periodic cyclin-Cdk activity entrains an autonomous Cdc14 release oscillatorYing Lu
The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
Cell 141:268-79. 2010..This concept may have broad implications for the structure and evolution of eukaryotic cell-cycle control...- Disruption of mechanisms that prevent rereplication triggers a DNA damage responseVincent Archambault
The Rockefeller University, 1230 York Ave, Box 237, New York, NY 10021, USA
Mol Cell Biol 25:6707-21. 2005..Our results implicate an Mre11-Mec1-dependent pathway in limiting the extent of rereplication... - The effects of molecular noise and size control on variability in the budding yeast cell cycleStefano Di Talia
The Rockefeller University, New York, New York 10021, USA
Nature 448:947-51. 2007..This analysis decomposes the regulatory dynamics of the Start transition into two independent modules, a size sensing module and a timing module, each of which is predominantly controlled by a different G1 cyclin... - Multiple levels of cyclin specificity in cell-cycle controlJoanna Bloom
Laboratory of Yeast Molecular Genetics, Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
Nat Rev Mol Cell Biol 8:149-60. 2007.... - Analysis of the mitotic exit control system using locked levels of stable mitotic cyclinBenjamin J Drapkin
Laboratory of Yeast Molecular Genetics, The Rockefeller University, New York, NY 10021, USA
Mol Syst Biol 5:328. 2009..Although our results are inconsistent with the aforementioned ODE model, revision of the model to allow Cdc14/Clb2 balance to control mitotic exit corrects these discrepancies, providing theoretical support for our conclusions... - Specific genetic interactions between spindle assembly checkpoint proteins and B-Type cyclins in Saccharomyces cerevisiaeAmy E Ikui
The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
Genetics 183:51-61. 2009..Thus, different B-type cyclins are required for distinct aspects of spindle morphogenesis and function, as revealed by differential genetic interactions with spindle checkpoint components... - Shake it, don't break it: positive feedback and the evolution of oscillator designFrederick R Cross
The Rockefeller University, New York, New York 10021, USA
Dev Cell 9:309-10. 2005..In cell cycle control, a negative feedback oscillator design is shown to be reinforced with a positive feedback loop, giving a robust oscillatory architecture that is surprisingly common in biology... - Nucleosome-depleted regions in cell-cycle-regulated promoters ensure reliable gene expression in every cell cycleLu Bai
Center for Studies in Physics and Biology, The Rockefeller University, New York, NY 10065, USA
Dev Cell 18:544-55. 2010..Therefore, we propose that the NDR function in limiting stochasticity in gene expression promotes the ubiquity and conservation of promoter NDR. PAPERCLIP:.. - Protein sequestration generates a flexible ultrasensitive response in a genetic networkNicolas E Buchler
The Rockefeller University, New York, NY 10065, USA
Mol Syst Biol 5:272. 2009..The generation of flexible ultrasensitive responses is an unappreciated adaptive advantage that could explain the frequent evolutionary emergence of dominant negatives... - A microfluidic device for temporally controlled gene expression and long-term fluorescent imaging in unperturbed dividing yeast cellsGilles Charvin
Center for Studies in Physics and Biology, The Rockefeller University, New York, New York, USA
PLoS ONE 3:e1468. 2008..Yet the control and quantification of transient gene expression in unperturbed dividing cells has received less attention... - Mode locking the cell cycleFrederick R Cross
The Rockefeller University, 1230 York Avenue, New York, New York, 10021, USA
Phys Rev E Stat Nonlin Soft Matter Phys 72:021910. 2005..We determine which variables are most effective in coupling an external stimulus to the cell cycle oscillator, and speculate about whether experiments are feasible and informative for this model organism... - Testing a mathematical model of the yeast cell cycleFrederick R Cross
The Rockefeller University, New York, NY 10021, USA
Mol Biol Cell 13:52-70. 2002..Thus, the model is a strong but incomplete attempt at a realistic representation of cell cycle control. Constraints of the sort developed here will be important in development of a truly predictive model... - Mitotic exit in the absence of separase activityYing Lu
The Rockefeller University, New York, NY 10065, USA
Mol Biol Cell 20:1576-91. 2009..We also found a novel role for the MEN: activating Cdc14 nuclear export, even in the absence of Net1... - Interaction of the S-phase cyclin Clb5 with an "RXL" docking sequence in the initiator protein Orc6 provides an origin-localized replication control switchGwendolyn M Wilmes
Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Genes Dev 18:981-91. 2004..We propose that Clb5 binding to ORC provides an origin-localized replication control switch that specifically prevents reinitiation at replicated origins... - Cycling without the cyclosome: modeling a yeast strain lacking the APCBrian R Thornton
Cancer Research Institute, Department of Biochemistry and Biophysics, University of California, San Francisco, USA
Cell Cycle 3:629-33. 2004..We discuss a few minor inconsistencies between the model and experiment, and how these may inform future revisions to the model... - Integrative analysis of cell cycle control in budding yeastKatherine C Chen
Department of Biology, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061 0406, USA
Mol Biol Cell 15:3841-62. 2004.... - Ribosome biogenesis is sensed at the Start cell cycle checkpointKara A Bernstein
Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA
Mol Biol Cell 18:953-64. 2007..Thus ribosome biogenesis may be sensed at multiple steps in Start regulation. Ribosome biogenesis may thus both delay Start by increasing the cell size setpoint and independently may promote Start by inactivating Whi5... - Identification of novel and conserved functional and structural elements of the G1 cyclin Cln3 important for interactions with the CDK Cdc28 in Saccharomyces cerevisiaeMary E Miller
Rhodes College, 2000 North Parkway, Memphis, TN 38112, USA
Yeast 22:1021-36. 2005..Alanine substitutions introduced into the HPD of Cln3 and Cln2 show functional defects while maintaining physical interaction with Cdc28 as measured by co-immunoprecipitation assay...
Research Grants
- How do cyclins drive the cell cycle?FREDERICK CROSS; Fiscal Year: 2006..This oscillator is highly conserved and essential for cell cycle control throughout the eukaryotes. ..
- How do cyclins drive the cell cycle?FREDERICK CROSS; Fiscal Year: 2007..Overall, we are interested in regulation of cell cycle dynamics, and in cyclin-specific pathways promoting individual cell cycle events. ..
- Sources and Consequences of noise in cell cycle regulationFREDERICK CROSS; Fiscal Year: 2007....
- How do cyclins drive the cell cycle?FREDERICK CROSS; Fiscal Year: 2009..Overall, we are interested in regulation of cell cycle dynamics, and in cyclin-specific pathways promoting individual cell cycle events. ..
- Sources and Consequences of noise in cell cycle regulationFREDERICK CROSS; Fiscal Year: 2009....
- CONTROL OF THE START OF THE BUDDING YEAST CELL CYCLEFREDERICK CROSS; Fiscal Year: 1993..These are the issues addressed in this application...
- SPECIFICITY OF CYCLIN FUNCTION AT CELL CYCLE INITIATIONFREDERICK CROSS; Fiscal Year: 2002....
- How do cyclins drive the cell cycle?FREDERICK CROSS; Fiscal Year: 2003..This oscillator is highly conserved and essential for cell cycle control throughout the eukaryotes. ..
- How do cyclins drive the cell cycle?Frederick R Cross; Fiscal Year: 2010..Overall, we are interested in regulation of cell cycle dynamics, and in cyclin-specific pathways promoting individual cell cycle events. ..