FREDERICK CROSS

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. pmc Genetic analysis of the relationship between activation loop phosphorylation and cyclin binding in the activation of the Saccharomyces cerevisiae Cdc28p cyclin-dependent kinase
    F R Cross
    The Rockefeller University, New York, NY 10021, USA
    Genetics 154:1549-59. 2000
  2. pmc Conservation and function of a potential substrate-binding domain in the yeast Clb5 B-type cyclin
    F R Cross
    The Rockefeller University, New York, NY 10021, USA
    Mol Cell Biol 20:4782-90. 2000
  3. ncbi Specialization and targeting of B-type cyclins
    F R Cross
    Rockefeller University New York, New York 10021, USA
    Mol Cell 4:11-9. 1999
  4. ncbi Starting the cell cycle: what's the point?
    F R Cross
    Rockefeller University, New York, USA
    Curr Opin Cell Biol 7:790-7. 1995
  5. pmc Molecular evolution allows bypass of the requirement for activation loop phosphorylation of the Cdc28 cyclin-dependent kinase
    F R Cross
    The Rockefeller University, New York, New York 10021, USA
    Mol Cell Biol 18:2923-31. 1998
  6. pmc Analysis of the mitotic exit control system using locked levels of stable mitotic cyclin
    Benjamin J Drapkin
    Laboratory of Yeast Molecular Genetics, The Rockefeller University, New York, NY 10021, USA
    Mol Syst Biol 5:328. 2009
  7. pmc Rising cyclin-CDK levels order cell cycle events
    Catherine Oikonomou
    Laboratory of Cell Cycle Genetics, The Rockefeller University, New York, New York, United States of America
    PLoS ONE 6:e20788. 2011
  8. pmc Evolution of networks and sequences in eukaryotic cell cycle control
    Frederick R Cross
    The Rockefeller University, New York, NY 10065, USA
    Philos Trans R Soc Lond B Biol Sci 366:3532-44. 2011
  9. pmc Quantitative characterization of a mitotic cyclin threshold regulating exit from mitosis
    Frederick R Cross
    The Rockefeller University, New York, NY 10021, USA
    Mol Biol Cell 16:2129-38. 2005
  10. pmc Phosphorylation of the Sic1 inhibitor of B-type cyclins in Saccharomyces cerevisiae is not essential but contributes to cell cycle robustness
    Frederick R Cross
    The Rockefeller University, New York, New York 10021, USA
    Genetics 176:1541-55. 2007

Collaborators

Detail Information

Publications73

  1. pmc Genetic analysis of the relationship between activation loop phosphorylation and cyclin binding in the activation of the Saccharomyces cerevisiae Cdc28p cyclin-dependent kinase
    F R Cross
    The Rockefeller University, New York, NY 10021, USA
    Genetics 154:1549-59. 2000
    ..This conclusion was supported by analysis of suppressors of a mutation in the Cdk phosphothreonine-binding pocket created by cyclin binding...
  2. pmc Conservation and function of a potential substrate-binding domain in the yeast Clb5 B-type cyclin
    F R Cross
    The Rockefeller University, New York, NY 10021, USA
    Mol Cell Biol 20:4782-90. 2000
    ..These results support the idea of a modular, structurally conserved cyclin domain involved in substrate targeting...
  3. ncbi Specialization and targeting of B-type cyclins
    F R Cross
    Rockefeller University New York, New York 10021, USA
    Mol Cell 4:11-9. 1999
    ..Mutagenesis of a potential substrate-targeting domain of CLB5 reduced biological activity without reducing Clb5p-associated kinase activity. Thus, Clb5p may have targeting domains required for CLB5-specific biological activity...
  4. ncbi Starting the cell cycle: what's the point?
    F R Cross
    Rockefeller University, New York, USA
    Curr Opin Cell Biol 7:790-7. 1995
    ..Cln-Cdc28 kinases may directly regulate many cell cycle processes, including some classically considered to be 'post-Start'. Specialization of function among the three genetically redundant CLN genes is becoming apparent...
  5. pmc Molecular evolution allows bypass of the requirement for activation loop phosphorylation of the Cdc28 cyclin-dependent kinase
    F R Cross
    The Rockefeller University, New York, New York 10021, USA
    Mol Cell Biol 18:2923-31. 1998
    ..Some growth defects remain in suppressed cak1 cdc28 strains carrying the mutant CDC28 genes, consistent with additional nonessential roles for CAK1...
  6. pmc Analysis of the mitotic exit control system using locked levels of stable mitotic cyclin
    Benjamin J Drapkin
    Laboratory of Yeast Molecular Genetics, The Rockefeller University, New York, NY 10021, USA
    Mol Syst Biol 5:328. 2009
    ..Although our results are inconsistent with the aforementioned ODE model, revision of the model to allow Cdc14/Clb2 balance to control mitotic exit corrects these discrepancies, providing theoretical support for our conclusions...
  7. pmc Rising cyclin-CDK levels order cell cycle events
    Catherine Oikonomou
    Laboratory of Cell Cycle Genetics, The Rockefeller University, New York, New York, United States of America
    PLoS ONE 6:e20788. 2011
    ....
  8. pmc Evolution of networks and sequences in eukaryotic cell cycle control
    Frederick R Cross
    The Rockefeller University, New York, NY 10065, USA
    Philos Trans R Soc Lond B Biol Sci 366:3532-44. 2011
    ....
  9. pmc Quantitative characterization of a mitotic cyclin threshold regulating exit from mitosis
    Frederick R Cross
    The Rockefeller University, New York, NY 10021, USA
    Mol Biol Cell 16:2129-38. 2005
    ..The loss of robustness of the Clb2 overexpressing system is also predicted by the model. These results provide strong confirmation of the model's predictive ability...
  10. pmc Phosphorylation of the Sic1 inhibitor of B-type cyclins in Saccharomyces cerevisiae is not essential but contributes to cell cycle robustness
    Frederick R Cross
    The Rockefeller University, New York, New York 10021, USA
    Genetics 176:1541-55. 2007
    ....
  11. pmc Mutations in SID2, a novel gene in Saccharomyces cerevisiae, cause synthetic lethality with sic1 deletion and may cause a defect during S phase
    M D Jacobson
    The Rockefeller University, New York, New York 10021, USA
    Genetics 159:17-33. 2001
    ..Consistent with this hypothesis, sid2-1 rad9 cells are dead or very slow growing even when SIC1 is expressed...
  12. ncbi Mutations in CDC14 result in high sensitivity to cyclin gene dosage in Saccharomyces cerevisiae
    M Yuste-Rojas
    Rockefeller University, New York, NY 10021, USA
    Mol Gen Genet 263:60-72. 2000
    ..We also describe genetic interactions between CDC28 and CDC14...
  13. ncbi Cyclin-specific START events and the G1-phase specificity of arrest by mating factor in budding yeast
    L J Oehlen
    The Rockefeller University, New York, NY 10021, USA
    Mol Gen Genet 258:183-98. 1998
    ....
  14. pmc Role of Swi4 in cell cycle regulation of CLN2 expression
    F R Cross
    Rockefeller University, New York, New York 10021
    Mol Cell Biol 14:4779-87. 1994
    ..Swi4 may bind to nonconsensus sequences in the CLN2 promoter (possibly in addition to consensus sites), or it may act indirectly to regulate CLN2 expression...
  15. pmc Genetic analysis of Cln/Cdc28 regulation of cell morphogenesis in budding yeast
    B K Benton
    Rockefeller University, New York, NY 10021
    EMBO J 12:5267-75. 1993
    ..These results suggest direct regulation of diverse aspects of bud morphogenesis by Cln/Cdc28p activity...
  16. pmc Testing cyclin specificity in the exit from mitosis
    M D Jacobson
    The Rockefeller University, New York, NY 10021, USA
    Mol Cell Biol 20:4483-93. 2000
    ....
  17. pmc Genes that can bypass the CLN requirement for Saccharomyces cerevisiae cell cycle START
    C B Epstein
    Rockefeller University, New York, New York 10021
    Mol Cell Biol 14:2041-7. 1994
    ..Thus, factors implicated in CLN1 and CLN2 expression and/or function are also required for BYC1 function in the absence of all three CLN genes; this may suggest the involvement of other targets of Swi4, Swi6, and Bck2 in START...
  18. ncbi Directed evolution to bypass cyclin requirements for the Cdc28p cyclin-dependent kinase
    K Levine
    Rockefeller University, New York, New York, USA
    Mol Cell 4:353-63. 1999
    ..Thus, the mutants' CLN bypass activity might result from constitutive, cyclin-independent activity, suggesting that Cdk targeting by cyclins is not required for cell cycle initiation...
  19. pmc Distinct subcellular localization patterns contribute to functional specificity of the Cln2 and Cln3 cyclins of Saccharomyces cerevisiae
    M E Miller
    The Rockefeller University, New York, New York 10021, USA
    Mol Cell Biol 20:542-55. 2000
    ..The data presented here support the idea that cyclin function is regulated at the level of subcellular localization and that subcellular localization contributes to the functional specificity of Cln2p and Cln3p...
  20. ncbi Potential regulation of Ste20 function by the Cln1-Cdc28 and Cln2-Cdc28 cyclin-dependent protein kinases
    L J Oehlen
    Rockefeller University, New York, New York 10021, USA
    J Biol Chem 273:25089-97. 1998
    ....
  21. ncbi The role of Cdc42 in signal transduction and mating of the budding yeast Saccharomyces cerevisiae
    L J Oehlen
    Rockefeller University, New York, New York 10021, USA
    J Biol Chem 273:8556-9. 1998
    ..These results show that Cdc42 is not required for transduction of the mating factor signal per se but that it is essential for proper mating factor-induced morphogenesis...
  22. ncbi G1 cyclins CLN1 and CLN2 repress the mating factor response pathway at Start in the yeast cell cycle
    L J Oehlen
    Rockefeller University, New York, New York 10021
    Genes Dev 8:1058-70. 1994
    ..The repression at Start of pheromone signaling by Cln1-Cdc28p or Cln2-Cdc28p kinase complexes may contribute to the acquisition of pheromone resistance as cells execute Start...
  23. pmc Cla4p, a Saccharomyces cerevisiae Cdc42p-activated kinase involved in cytokinesis, is activated at mitosis
    B K Benton
    The Rockefeller University, New York, New York 10021, USA
    Mol Cell Biol 17:5067-76. 1997
    ..Cla4p kinase activity was not reduced by mutational inactivation of gin4, suggesting that Gin4p may be downstream or parallel to Cla4p in the regulation of cytokinesis...
  24. pmc Ste12 and Mcm1 regulate cell cycle-dependent transcription of FAR1
    L J Oehlen
    Rockefeller University, New York, New York 10021, USA
    Mol Cell Biol 16:2830-7. 1996
    ..This indicates that transcription of FAR1 in the G1 phase is essential for accumulation of the protein and for pheromone-induced cell cycle arrest...
  25. pmc The yeast Cln3 protein is an unstable activator of Cdc28
    F R Cross
    Rockefeller University, New York, New York 10021
    Mol Cell Biol 13:3266-71. 1993
    ..These and other results strongly support the idea that Cln proteins function to activate Cdc28 at START...
  26. pmc Saccharomyces cerevisiae G1 cyclins differ in their intrinsic functional specificities
    K Levine
    The Rockefeller University, New York, New York 10021, USA
    Mol Cell Biol 16:6794-803. 1996
    ..Consistent with the idea that Cln3 may be the primary transcriptional activator of CLN1, CLN2, and other genes, the activation of CLN2 transcription was found to be sensitive to the gene dosage of CLN3 but not to the gene dosage of CLN2...
  27. pmc Mechanisms controlling subcellular localization of the G(1) cyclins Cln2p and Cln3p in budding yeast
    M E Miller
    The Rockefeller University, New York, New York 10021, USA
    Mol Cell Biol 21:6292-311. 2001
    ....
  28. pmc Accurate quantitation of protein expression and site-specific phosphorylation
    Y Oda
    The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 96:6591-6. 1999
    ....
  29. pmc Genetic and biochemical evaluation of the importance of Cdc6 in regulating mitotic exit
    Vincent Archambault
    The Rockefeller University, New York, New York 10021, USA
    Mol Biol Cell 14:4592-604. 2003
    ..We conclude, therefore, that although both Cdc6 and Sic1 have the potential to facilitate mitotic exit by inhibiting Clb2-Cdk, mitotic exit nevertheless does not require any identified stoichiometric inhibitor of Cdk activity...
  30. pmc Cyclin and cyclin-dependent kinase substrate requirements for preventing rereplication reveal the need for concomitant activation and inhibition
    Amy E Ikui
    The Rockefeller University, New York, New York 10021, USA
    Genetics 175:1011-22. 2007
    ....
  31. pmc Positive feedback of G1 cyclins ensures coherent cell cycle entry
    Jan M Skotheim
    Center for Studies in Physics and Biology, The Rockefeller University, New York 10065, USA
    Nature 454:291-6. 2008
    ..A similar G1/S regulatory network in mammalian cells, comprised of non-orthologous genes, suggests either conservation of regulatory architecture or convergent evolution...
  32. pmc Cln3-associated kinase activity in Saccharomyces cerevisiae is regulated by the mating factor pathway
    D I Jeoung
    The Rockefeller University, New York, New York 10021, USA
    Mol Cell Biol 18:433-41. 1998
    ....
  33. pmc Structure-function analysis of the Saccharomyces cerevisiae G1 cyclin Cln2
    K N Huang
    The Rockefeller University, New York, New York 10021, USA
    Mol Cell Biol 17:4654-66. 1997
    ..Some alleles demonstrated restricted patterns of defects, suggesting that these mutations may interfere with specific aspects of Cln2 function...
  34. ncbi APC-dependent proteolysis of the mitotic cyclin Clb2 is essential for mitotic exit
    Ralph Wasch
    The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nature 418:556-62. 2002
    ..Cdh1 and Sic1 may be required for further inactivation of Clb2-Cdk1, regulating cell size and the length of G1...
  35. ncbi Retinoblastoma protein: combating algal bloom
    F R Cross
    The Rockefeller University, 1230 York Ave, Box 237, New York, New York 10021, USA
    Curr Biol 11:R824-7. 2001
    ..The discovery of a homolog of the retinoblastoma protein (Rb) in a single-celled eukaryote--the alga Chlamydomonas--promises new and surprising insights into Rb's function in cell-cycle regulation...
  36. ncbi Over-expression of S. cerevisiae G1 cyclins restores the viability of alg1 N-glycosylation mutants
    B K Benton
    Rockefeller University, New York, NY 10021, USA
    Curr Genet 29:106-13. 1996
    ..Co-ordinate regulation of glycosylation, sugar nucleotide metabolism, and cell-cycle progression through G1 may be a feature that ensures adequate cell-wall precursors are present before bud emergence...
  37. pmc Mutations in RAD27 define a potential link between G1 cyclins and DNA replication
    E A Vallen
    Rockefeller University, New York, New York 10021 6399, USA
    Mol Cell Biol 15:4291-302. 1995
    ....
  38. pmc Isolation and characterization of new alleles of the cyclin-dependent kinase gene CDC28 with cyclin-specific functional and biochemical defects
    K Levine
    The Rockefeller University, New York, New York 10021, USA
    Mol Cell Biol 18:290-302. 1998
    ..Mutants of this sort should be useful in differentiating the function of Cdc28 complexed with different cyclin regulatory subunits...
  39. pmc High functional overlap between MluI cell-cycle box binding factor and Swi4/6 cell-cycle box binding factor in the G1/S transcriptional program in Saccharomyces cerevisiae
    James M Bean
    Rockefeller University, New York, New York 10021, USA
    Genetics 171:49-61. 2005
    ..Finally, we observe residual G1/S transcriptional regulation in the absence of Swi4 and Mbp1...
  40. ncbi Coherence and timing of cell cycle start examined at single-cell resolution
    James M Bean
    The Rockefeller University, New York, New York 10021, USA
    Mol Cell 21:3-14. 2006
    ..Thus, multiple pathways may independently suppress qualitatively different kinds of noise at Start...
  41. pmc Novel role for Cdc14 sequestration: Cdc14 dephosphorylates factors that promote DNA replication
    Joanna Bloom
    The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Mol Cell Biol 27:842-53. 2007
    ....
  42. pmc Daughter-specific transcription factors regulate cell size control in budding yeast
    Stefano Di Talia
    The Rockefeller University, New York, New York, USA
    PLoS Biol 7:e1000221. 2009
    ..This work demonstrates mechanistically how asymmetric localization of cell fate determinants results in cell-type-specific regulation of the cell cycle...
  43. pmc Requirements and reasons for effective inhibition of the anaphase promoting complex activator CDH1
    Jonathan A Robbins
    The Rockefeller University, New York, NY 10065, USA
    Mol Biol Cell 21:914-25. 2010
    ..Thus, different spindle-regulatory pathways have distinct sensitivities to Cdh1, and ACM1 may buffer essential CDK phosphorylation of Cdh1...
  44. ncbi Two-faced cyclins with eyes on the targets
    Vincent Archambault
    Rockefeller University, New York, New York, USA
    Cell Cycle 4:125-30. 2005
    ..The evolutionary conservation of the HP motif suggests that it allows cyclins to carry out important and specialized functions...
  45. ncbi Targeted proteomic study of the cyclin-Cdk module
    Vincent Archambault
    The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Mol Cell 14:699-711. 2004
    ..Our results demonstrate that this approach can be used to detect a host of transient and dynamic protein associations within a biological module...
  46. ncbi Two redundant oscillatory mechanisms in the yeast cell cycle
    Frederick R Cross
    The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Dev Cell 4:741-52. 2003
    ..Computational modeling confirms that two such mechanisms can be linked to yield a robust cell cycle control system...
  47. ncbi 'Marker swap' plasmids: convenient tools for budding yeast molecular genetics
    F R Cross
    Rockefeller University, New York, NY 10021, USA
    Yeast 13:647-53. 1997
    ..These 'marker-swap' plasmids therefore eliminate the need for much subcloning to change markers. Marker-swapped alleles are acceptably stable mitotically and meiotically for most applications...
  48. pmc Forced periodic expression of G1 cyclins phase-locks the budding yeast cell cycle
    G Charvin
    Laboratory of Yeast Molecular Genetics and Center for Studies in Physics and Biology, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 106:6632-7. 2009
    ..Our results provide quantitative insight into how cell size is integrated with the cell cycle oscillator...
  49. pmc Mitotic exit in the absence of separase activity
    Ying Lu
    The Rockefeller University, New York, NY 10065, USA
    Mol Biol Cell 20:1576-91. 2009
    ..We also found a novel role for the MEN: activating Cdc14 nuclear export, even in the absence of Net1...
  50. ncbi Periodic cyclin-Cdk activity entrains an autonomous Cdc14 release oscillator
    Ying Lu
    The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
    Cell 141:268-79. 2010
    ..This concept may have broad implications for the structure and evolution of eukaryotic cell-cycle control...
  51. ncbi The effects of molecular noise and size control on variability in the budding yeast cell cycle
    Stefano Di Talia
    The Rockefeller University, New York, New York 10021, USA
    Nature 448:947-51. 2007
    ..This analysis decomposes the regulatory dynamics of the Start transition into two independent modules, a size sensing module and a timing module, each of which is predominantly controlled by a different G1 cyclin...
  52. ncbi Multiple levels of cyclin specificity in cell-cycle control
    Joanna Bloom
    Laboratory of Yeast Molecular Genetics, Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nat Rev Mol Cell Biol 8:149-60. 2007
    ....
  53. pmc Disruption of mechanisms that prevent rereplication triggers a DNA damage response
    Vincent Archambault
    The Rockefeller University, 1230 York Ave, Box 237, New York, NY 10021, USA
    Mol Cell Biol 25:6707-21. 2005
    ..Our results implicate an Mre11-Mec1-dependent pathway in limiting the extent of rereplication...
  54. ncbi Cyclin specificity: how many wheels do you need on a unicycle?
    M E Miller
    The Rockefeller University, New York, NY 10021, USA
    J Cell Sci 114:1811-20. 2001
    ..Such targeting might occur through a combination of factors, including temporal expression, protein associations, and subcellular localization...
  55. ncbi Mode locking the cell cycle
    Frederick R Cross
    The Rockefeller University, 1230 York Avenue, New York, New York, 10021, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 72:021910. 2005
    ..We determine which variables are most effective in coupling an external stimulus to the cell cycle oscillator, and speculate about whether experiments are feasible and informative for this model organism...
  56. pmc Nucleosome-depleted regions in cell-cycle-regulated promoters ensure reliable gene expression in every cell cycle
    Lu Bai
    Center for Studies in Physics and Biology, The Rockefeller University, New York, NY 10065, USA
    Dev Cell 18:544-55. 2010
    ..Therefore, we propose that the NDR function in limiting stochasticity in gene expression promotes the ubiquity and conservation of promoter NDR. PAPERCLIP:..
  57. pmc Specific genetic interactions between spindle assembly checkpoint proteins and B-Type cyclins in Saccharomyces cerevisiae
    Amy E Ikui
    The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Genetics 183:51-61. 2009
    ..Thus, different B-type cyclins are required for distinct aspects of spindle morphogenesis and function, as revealed by differential genetic interactions with spindle checkpoint components...
  58. pmc Protein sequestration generates a flexible ultrasensitive response in a genetic network
    Nicolas E Buchler
    The Rockefeller University, New York, NY 10065, USA
    Mol Syst Biol 5:272. 2009
    ..The generation of flexible ultrasensitive responses is an unappreciated adaptive advantage that could explain the frequent evolutionary emergence of dominant negatives...
  59. pmc Testing a mathematical model of the yeast cell cycle
    Frederick R Cross
    The Rockefeller University, New York, NY 10021, USA
    Mol Biol Cell 13:52-70. 2002
    ..Thus, the model is a strong but incomplete attempt at a realistic representation of cell cycle control. Constraints of the sort developed here will be important in development of a truly predictive model...
  60. pmc A microfluidic device for temporally controlled gene expression and long-term fluorescent imaging in unperturbed dividing yeast cells
    Gilles Charvin
    Center for Studies in Physics and Biology, The Rockefeller University, New York, New York, USA
    PLoS ONE 3:e1468. 2008
    ..Yet the control and quantification of transient gene expression in unperturbed dividing cells has received less attention...
  61. ncbi Shake it, don't break it: positive feedback and the evolution of oscillator design
    Frederick R Cross
    The Rockefeller University, New York, New York 10021, USA
    Dev Cell 9:309-10. 2005
    ..In cell cycle control, a negative feedback oscillator design is shown to be reinforced with a positive feedback loop, giving a robust oscillatory architecture that is surprisingly common in biology...
  62. pmc Cell cycle arrest caused by CLN gene deficiency in Saccharomyces cerevisiae resembles START-I arrest and is independent of the mating-pheromone signalling pathway
    F R Cross
    Rockefeller University, New York, New York 10021 6399
    Mol Cell Biol 10:6482-90. 1990
    ..These results are consistent with a specific CLN requirement for START transit...
  63. pmc Pheromone-dependent G1 cell cycle arrest requires Far1 phosphorylation, but may not involve inhibition of Cdc28-Cln2 kinase, in vivo
    A Gartner
    Institute for Biochemistry and Molecular Cell Biology and Ludwig Boltzmann Forschungsstelle, University of Vienna, Vienna, Austria
    Mol Cell Biol 18:3681-91. 1998
    ..Surprisingly, Far1-associated Cdc28-Cln2 complexes are at best moderately inhibited in immunoprecipitation kinase assays, suggesting unconventional inhibitory mechanisms of Far1...
  64. ncbi Further characterization of a size control gene in Saccharomyces cerevisiae
    F R Cross
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98104
    J Cell Sci Suppl 12:117-27. 1989
    ....
  65. pmc The pheromone receptors inhibit the pheromone response pathway in Saccharomyces cerevisiae by a process that is independent of their associated G alpha protein
    J P Hirsch
    Department of Cell Biology and Anatomy, Mount Sinai Medical Center, New York, New York 10029
    Genetics 135:943-53. 1993
    ..The ability of the pheromone receptors to block the pheromone response signal in the absence of the G alpha subunit indicates that these receptors interact with another component of the signal transduction pathway...
  66. ncbi CLB5-dependent activation of late replication origins in S. cerevisiae
    A D Donaldson
    Department of Genetics, University of Washington, Seattle 98195 7360, USA
    Mol Cell 2:173-82. 1998
    ..In clb5 clb6 mutants, the other B-type cyclins (Clb1-4p) promote an S phase during which both early and late replication origins fire...
  67. pmc Interaction between the MEC1-dependent DNA synthesis checkpoint and G1 cyclin function in Saccharomyces cerevisiae
    E A Vallen
    Department of Biology, Swarthmore College, Swarthmore, Pennsylvania 19081, USA
    Genetics 151:459-71. 1999
    ..Thus deletion of CLN1 and CLN2 could function similarly to overexpression of RNR1 in suppressing mec1 lethality...
  68. pmc Ribosome biogenesis is sensed at the Start cell cycle checkpoint
    Kara A Bernstein
    Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA
    Mol Biol Cell 18:953-64. 2007
    ..Thus ribosome biogenesis may be sensed at multiple steps in Start regulation. Ribosome biogenesis may thus both delay Start by increasing the cell size setpoint and independently may promote Start by inactivating Whi5...
  69. pmc Interaction of the S-phase cyclin Clb5 with an "RXL" docking sequence in the initiator protein Orc6 provides an origin-localized replication control switch
    Gwendolyn M Wilmes
    Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Genes Dev 18:981-91. 2004
    ..We propose that Clb5 binding to ORC provides an origin-localized replication control switch that specifically prevents reinitiation at replicated origins...
  70. pmc Integrative analysis of cell cycle control in budding yeast
    Katherine C Chen
    Department of Biology, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061 0406, USA
    Mol Biol Cell 15:3841-62. 2004
    ....
  71. ncbi Identification of novel and conserved functional and structural elements of the G1 cyclin Cln3 important for interactions with the CDK Cdc28 in Saccharomyces cerevisiae
    Mary E Miller
    Rhodes College, 2000 North Parkway, Memphis, TN 38112, USA
    Yeast 22:1021-36. 2005
    ..Alanine substitutions introduced into the HPD of Cln3 and Cln2 show functional defects while maintaining physical interaction with Cdc28 as measured by co-immunoprecipitation assay...
  72. ncbi Cycling without the cyclosome: modeling a yeast strain lacking the APC
    Brian R Thornton
    Cancer Research Institute, Department of Biochemistry and Biophysics, University of California, San Francisco, USA
    Cell Cycle 3:629-33. 2004
    ..We discuss a few minor inconsistencies between the model and experiment, and how these may inform future revisions to the model...
  73. pmc DAF1, a mutant gene affecting size control, pheromone arrest, and cell cycle kinetics of Saccharomyces cerevisiae
    F R Cross
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
    Mol Cell Biol 8:4675-84. 1988
    ..5-fold; thus, DAF1-1 may be a hyperactive or deregulated allele of a nonessential gene involved in G1 size control. Multiple copies of DAF1-1 also greatly reduced the duration of the G1 phase of the cell cycle...