DOUGLAS COULTER

Summary

Affiliation: The Children's Hospital of Philadelphia
Country: USA

Publications

  1. ncbi request reprint Functional regulation of the dentate gyrus by GABA-mediated inhibition
    Douglas A Coulter
    The Children s Hospital of Philadelphia, Abramson Pediatric Research Center, Philadelphia, PA 19104 4318, USA
    Prog Brain Res 163:235-43. 2007
  2. pmc Hippocampal microcircuit dynamics probed using optical imaging approaches
    Douglas A Coulter
    Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Physiol 589:1893-903. 2011
  3. pmc Animal models of limbic epilepsies: what can they tell us?
    Douglas A Coulter
    Department of Neuroscience, University of Pennsylvania School of Medicine, Children s Hospital of Philadelphia, 19104 4318, USA
    Brain Pathol 12:240-56. 2002
  4. pmc Massive and specific dysregulation of direct cortical input to the hippocampus in temporal lobe epilepsy
    Chyze W Ang
    Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 26:11850-6. 2006
  5. pmc Deficits in phosphorylation of GABA(A) receptors by intimately associated protein kinase C activity underlie compromised synaptic inhibition during status epilepticus
    Miho Terunuma
    Department of Neuroscience, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 28:376-84. 2008
  6. pmc Selective induction of astrocytic gliosis generates deficits in neuronal inhibition
    Pavel I Ortinski
    Division of Neurology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Nat Neurosci 13:584-91. 2010
  7. pmc Dentate granule cell GABA(A) receptors in epileptic hippocampus: enhanced synaptic efficacy and altered pharmacology
    Akiva S Cohen
    Pediatric Regional Epilepsy Program, Pennsylvania, USA
    Eur J Neurosci 17:1607-16. 2003
  8. ncbi request reprint Heterogeneous GABAA receptor subunit expression in pediatric epilepsy patients
    Brenda E Porter
    Division of Neurology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Neurobiol Dis 18:484-91. 2005
  9. pmc Disrupted dentate granule cell chloride regulation enhances synaptic excitability during development of temporal lobe epilepsy
    Hemal R Pathak
    Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 27:14012-22. 2007
  10. pmc Increased expression of the neuronal glutamate transporter (EAAT3/EAAC1) in hippocampal and neocortical epilepsy
    Peter B Crino
    PENN Epilepsy Center, Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Epilepsia 43:211-8. 2002

Research Grants

  1. PHYSIOLOGY OF STATUS EPILEPTICUS IN VITRO
    DOUGLAS COULTER; Fiscal Year: 2009
  2. PHYSIOLOGY OF STATUS EPILEPTICUS IN VITRO
    Douglas A Coulter; Fiscal Year: 2010
  3. Transcriptional Repression as a Therapeutic Target in Epileptogenesis
    DOUGLAS COULTER; Fiscal Year: 2006
  4. GABA RECEPTOR ALTERATIONS DURING STATUS EPILEPTICUS
    DOUGLAS COULTER; Fiscal Year: 2007
  5. PHYSIOLOGY OF STATUS EPILEPTICUS IN VITRO
    DOUGLAS COULTER; Fiscal Year: 2007
  6. PHYSIOLOGY OF STATUS EPILEPTICUS IN VITRO
    DOUGLAS COULTER; Fiscal Year: 2009
  7. PHYSIOLOGY OF STATUS EPILEPTICUS IN VITRO
    Douglas A Coulter; Fiscal Year: 2010
  8. PHYSIOLOGY OF THALAMOCORTICAL RHYTHMICITY IN VITRO
    DOUGLAS COULTER; Fiscal Year: 2001
  9. PHYSIOLOGY OF STATUS EPILEPTICUS IN VITRO
    DOUGLAS COULTER; Fiscal Year: 2001
  10. GABA RECEPTOR ALTERATIONS DURING STATUS EPILEPTICUS
    DOUGLAS COULTER; Fiscal Year: 2002

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Functional regulation of the dentate gyrus by GABA-mediated inhibition
    Douglas A Coulter
    The Children s Hospital of Philadelphia, Abramson Pediatric Research Center, Philadelphia, PA 19104 4318, USA
    Prog Brain Res 163:235-43. 2007
    ..Both synaptic and extrasynaptic GABA(A) receptors exhibit profound dysregulation in animal models of temporal lobe epilepsy, which may contribute to the hippocampal hyperexcitability that defines this disorder...
  2. pmc Hippocampal microcircuit dynamics probed using optical imaging approaches
    Douglas A Coulter
    Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Physiol 589:1893-903. 2011
    ....
  3. pmc Animal models of limbic epilepsies: what can they tell us?
    Douglas A Coulter
    Department of Neuroscience, University of Pennsylvania School of Medicine, Children s Hospital of Philadelphia, 19104 4318, USA
    Brain Pathol 12:240-56. 2002
    ..We have also provided a brief introduction into how animal models of temporal lobe epilepsy facilitate use of modern state-of-the-art techniques in neurobiology to address critical questions in the pathogenesis of epilepsy...
  4. pmc Massive and specific dysregulation of direct cortical input to the hippocampus in temporal lobe epilepsy
    Chyze W Ang
    Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 26:11850-6. 2006
    ..This dysregulated temporoammonic pathway is critically positioned to mediate generation and/or propagation of seizure activity in the hippocampus...
  5. pmc Deficits in phosphorylation of GABA(A) receptors by intimately associated protein kinase C activity underlie compromised synaptic inhibition during status epilepticus
    Miho Terunuma
    Department of Neuroscience, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 28:376-84. 2008
    ..Thus, enhancing phosphorylation of GABA(A)Rs or selectively blocking their interaction with AP2 may provide novel therapeutic strategies to ameliorate SE...
  6. pmc Selective induction of astrocytic gliosis generates deficits in neuronal inhibition
    Pavel I Ortinski
    Division of Neurology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Nat Neurosci 13:584-91. 2010
    ..Thus, reactive astrocytosis could generate local synaptic perturbations, leading to broader functional deficits associated with neurologic disease...
  7. pmc Dentate granule cell GABA(A) receptors in epileptic hippocampus: enhanced synaptic efficacy and altered pharmacology
    Akiva S Cohen
    Pediatric Regional Epilepsy Program, Pennsylvania, USA
    Eur J Neurosci 17:1607-16. 2003
    ....
  8. ncbi request reprint Heterogeneous GABAA receptor subunit expression in pediatric epilepsy patients
    Brenda E Porter
    Division of Neurology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Neurobiol Dis 18:484-91. 2005
    ..Patient-specific GABAAR expression might contribute to variability in anti-epileptic drug efficacy, side-effect profiles, and seizure susceptibility...
  9. pmc Disrupted dentate granule cell chloride regulation enhances synaptic excitability during development of temporal lobe epilepsy
    Hemal R Pathak
    Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 27:14012-22. 2007
    ..This pathophysiological process may constitute a significant mechanism linking injury to the subsequent development of epilepsy...
  10. pmc Increased expression of the neuronal glutamate transporter (EAAT3/EAAC1) in hippocampal and neocortical epilepsy
    Peter B Crino
    PENN Epilepsy Center, Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Epilepsia 43:211-8. 2002
    ..To define the changes in gene and protein expression of the neuronal glutamate transporter (EAAT3/EAAC1) in a rat model of temporal lobe epilepsy as well as in human hippocampal and neocortical epilepsy...
  11. ncbi request reprint Shift of intracellular chloride concentration in ganglion and amacrine cells of developing mouse retina
    Ling Li Zhang
    Deaprtment of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6058, USA
    J Neurophysiol 95:2404-16. 2006
    ..Our results support the hypothesis that a shift from high [Cl-]i to low causes GABA to switch from excitatory to inhibitory...
  12. pmc Axonal α7 nicotinic ACh receptors modulate presynaptic NMDA receptor expression and structural plasticity of glutamatergic presynaptic boutons
    Hong Lin
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 107:16661-6. 2010
    ....
  13. pmc Developmental and cell-selective variations in N-methyl-D-aspartate receptor degradation by calpain
    Yi Na Dong
    Department of Neurology and Pediatrics, University of Pennsylvania and The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4318, USA
    J Neurochem 99:206-17. 2006
    ..Our data suggest that the susceptibility of the NMDA receptor to cleavage by calpain varies with neuronal maturity in a manner that may alter its electrophysiological properties...
  14. pmc Enhanced astrocytic Ca2+ signals contribute to neuronal excitotoxicity after status epilepticus
    Shinghua Ding
    Silvio Conte Center for Integration at the Tripartite Synapse, Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 27:10674-84. 2007
    ..These observations support neurotoxic roles for astrocytic gliotransmission in pathological conditions and identify this process as a novel therapeutic target...
  15. pmc In vitro functional imaging in brain slices using fast voltage-sensitive dye imaging combined with whole-cell patch recording
    Greg C Carlson
    Translational Research Laboratory, University of Pennsylvania School of Medicine, Room 2226, 125 S 31st Street, Philadelphia, Pennsylvania 19104 3403, USA
    Nat Protoc 3:249-55. 2008
    ..Thus, the combined VSD imaging and whole-cell patch approach provides experimental resolution spanning single-cell electrophysiology to complex local circuit responses...
  16. ncbi request reprint AMPA glutamate receptor-mediated calcium signaling is transiently enhanced during development of oligodendrocytes
    Takayuki Itoh
    The Children s Hospital of Philadelphia, Pennsylvania, USA
    J Neurochem 81:390-402. 2002
    ..susceptibility to excitotoxicity of cells at these stages of oligodendroglial differentiation, and is likely to be important to these cells in the trans-synaptic Ca2+-signaling from glutamatergic neurons, which occurs in hippocampus..
  17. pmc Repeated neonatal handling with maternal separation permanently alters hippocampal GABAA receptors and behavioral stress responses
    Fu Chun Hsu
    The Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 100:12213-8. 2003
    ....
  18. pmc Hippocampal CA1 circuitry dynamically gates direct cortical inputs preferentially at theta frequencies
    Chyze W Ang
    Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 25:9567-80. 2005
    ....
  19. pmc Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems
    Hai Yan Wu
    Departments of Pediatrics and Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Biol Chem 282:20075-87. 2007
    ..Thus, the Fyn-controlled regulation of NMDA receptor cleavage by calpain may play critical roles in controlling NMDA receptor properties during synaptic plasticity and excitotoxicity...
  20. ncbi request reprint The incorporation of an ion channel gene mutation associated with the long QT syndrome (Q9E-hMiRP1) in a plasmid vector for site-specific arrhythmia gene therapy: in vitro and in vivo feasibility studies
    Denise Y Burton
    Division of Cardiology, Children s Hospital of Philadelphia, Civic Center Boulevard, Philadelphia, PA 19104 4318, USA
    Hum Gene Ther 14:907-22. 2003
    ....
  21. pmc Dynamic regulation of synaptic GABA release by the glutamate-glutamine cycle in hippocampal area CA1
    Shu Ling Liang
    Division of Neurology and the Pediatric Regional Epilepsy Program, Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    J Neurosci 26:8537-48. 2006
    ..We conclude that the glutamate-glutamine cycle is a major contributor to synaptic GABA release under physiological conditions, which dynamically regulates inhibitory synaptic strength...
  22. pmc A neuronal glutamate transporter contributes to neurotransmitter GABA synthesis and epilepsy
    Jehuda P Sepkuty
    Department of Neurology, Johns Hopkins University, Baltimore, Maryland 21287 7247, USA
    J Neurosci 22:6372-9. 2002
    ..EAAC1 may participate in normal GABA neurosynthesis and limbic hyperexcitability, whereas epilepsy can result from a disruption of the interaction between EAAC1 and GABA metabolism...
  23. pmc Induction of prolonged electrographic seizures in vitro has a defined threshold and is all or none: implications for diagnosis of status epilepticus
    Azhar Rafiq
    Department of Neurology and the VCU Comprehensive Epilepsy Center of Virginia Commonwealth University, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298 0599, USA
    Epilepsia 44:1034-41. 2003
    ..To study whether induction of prolonged (>30-min duration) in vitro electrographic seizure discharges resembling status epilepticus (SE) is graded or all-or-none, and to determine the critical factors mediating SE induction...
  24. ncbi request reprint Anticonvulsant actions of lamotrigine on spontaneous thalamocortical rhythms
    John W Gibbs
    Department of Anatomy, Medical College of Virginia of Virginia Commonwealth University, Richmond, Virginia, USA
    Epilepsia 43:342-9. 2002
    ....
  25. ncbi request reprint Clioquinol effects on tissue chelatable zinc in mice
    Yuval B Nitzan
    Department of Morphology, Zlotowski Center for Neuroscience, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Mol Med (Berl) 81:637-44. 2003
    ..Thus, our findings indicate that CQ has considerable potential as a versatile scientific and clinical tool used for selective modulation of zinc pools...
  26. ncbi request reprint Models for epilepsy and epileptogenesis: report from the NIH workshop, Bethesda, Maryland
    James P Stables
    National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892, USA
    Epilepsia 43:1410-20. 2002
    ..To move toward new and more effective therapies, novel approaches to therapy discovery are needed...

Research Grants25

  1. PHYSIOLOGY OF STATUS EPILEPTICUS IN VITRO
    DOUGLAS COULTER; Fiscal Year: 2009
    ..This will broaden our understanding of how seizures are generated, and may help to develop new therapies to better treat temporal lobe epilepsy. ..
  2. PHYSIOLOGY OF STATUS EPILEPTICUS IN VITRO
    Douglas A Coulter; Fiscal Year: 2010
    ..This will broaden our understanding of how seizures are generated, and may help to develop new therapies to better treat temporal lobe epilepsy. ..
  3. Transcriptional Repression as a Therapeutic Target in Epileptogenesis
    DOUGLAS COULTER; Fiscal Year: 2006
    ..abstract_text> ..
  4. GABA RECEPTOR ALTERATIONS DURING STATUS EPILEPTICUS
    DOUGLAS COULTER; Fiscal Year: 2007
    ..Understanding of these processes is critical in developing novel, more effective strategies for controlling the deleterious pathological consequences of brain injury, including epilepsy. ..
  5. PHYSIOLOGY OF STATUS EPILEPTICUS IN VITRO
    DOUGLAS COULTER; Fiscal Year: 2007
    ..abstract_text> ..
  6. PHYSIOLOGY OF STATUS EPILEPTICUS IN VITRO
    DOUGLAS COULTER; Fiscal Year: 2009
    ..This will broaden our understanding of how seizures are generated, and may help to develop new therapies to better treat temporal lobe epilepsy. ..
  7. PHYSIOLOGY OF STATUS EPILEPTICUS IN VITRO
    Douglas A Coulter; Fiscal Year: 2010
    ..This will broaden our understanding of how seizures are generated, and may help to develop new therapies to better treat temporal lobe epilepsy. ..
  8. PHYSIOLOGY OF THALAMOCORTICAL RHYTHMICITY IN VITRO
    DOUGLAS COULTER; Fiscal Year: 2001
    ....
  9. PHYSIOLOGY OF STATUS EPILEPTICUS IN VITRO
    DOUGLAS COULTER; Fiscal Year: 2001
    ..Understanding of the nature of epileptogenic changes at both the functional and molecular levels is necessary to achieve in order to some day have the potential to develop a cure for this devastating disorder. ..
  10. GABA RECEPTOR ALTERATIONS DURING STATUS EPILEPTICUS
    DOUGLAS COULTER; Fiscal Year: 2002
    ....