Pietro Cottone

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. pmc Consummatory, anxiety-related and metabolic adaptations in female rats with alternating access to preferred food
    Pietro Cottone
    Committee on the Neurobiology of Addictive Disorders CNAD, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Psychoneuroendocrinology 34:38-49. 2009
  2. pmc Intermittent access to preferred food reduces the reinforcing efficacy of chow in rats
    Pietro Cottone
    Committee on the Neurobiology of Addictive Disorders, SP30 2400, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Am J Physiol Regul Integr Comp Physiol 295:R1066-76. 2008
  3. pmc Feeding microstructure in diet-induced obesity susceptible versus resistant rats: central effects of urocortin 2
    Pietro Cottone
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA or
    J Physiol 583:487-504. 2007
  4. ncbi Opioid-dependent anticipatory negative contrast and binge-like eating in rats with limited access to highly preferred food
    Pietro Cottone
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 33:524-35. 2008
  5. ncbi FG 7142 specifically reduces meal size and the rate and regularity of sustained feeding in female rats: evidence that benzodiazepine inverse agonists reduce food palatability
    Pietro Cottone
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 32:1069-81. 2007
  6. pmc CRF system recruitment mediates dark side of compulsive eating
    Pietro Cottone
    Committee on the Neurobiology of Addictive Disorders, Pearson Center for Alcoholism and Addiction Research, Harold L Dorris Neurological Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:20016-20. 2009
  7. pmc Corticotropin releasing factor-induced amygdala gamma-aminobutyric Acid release plays a key role in alcohol dependence
    Marisa Roberto
    Committee on the Neurobiology of Addictive Disorders, Scripps Research Institute, La Jolla, California 92037, USA
    Biol Psychiatry 67:831-9. 2010
  8. pmc The sigma-receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking
    Valentina Sabino
    Committee on the Neurobiology of Addictive Disorders, SP30 2400, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Neuropsychopharmacology 34:1482-93. 2009
  9. pmc Activation of σ-receptors induces binge-like drinking in Sardinian alcohol-preferring rats
    Valentina Sabino
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 36:1207-18. 2011
  10. pmc CRF-CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats
    Olivier George
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 104:17198-203. 2007

Research Grants

Detail Information

Publications17

  1. pmc Consummatory, anxiety-related and metabolic adaptations in female rats with alternating access to preferred food
    Pietro Cottone
    Committee on the Neurobiology of Addictive Disorders CNAD, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Psychoneuroendocrinology 34:38-49. 2009
    ..The present diet cycling procedure may model consummatory, anxiety-related, and metabolic effects of qualitative dieting in humans...
  2. pmc Intermittent access to preferred food reduces the reinforcing efficacy of chow in rats
    Pietro Cottone
    Committee on the Neurobiology of Addictive Disorders, SP30 2400, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Am J Physiol Regul Integr Comp Physiol 295:R1066-76. 2008
    ..The results suggest that intermittent access to highly preferred food, as practiced by many restrained eaters, may progressively decrease the acceptability of less palatable foods, and may promote relapse to more rewarding alternatives...
  3. pmc Feeding microstructure in diet-induced obesity susceptible versus resistant rats: central effects of urocortin 2
    Pietro Cottone
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA or
    J Physiol 583:487-504. 2007
    ..Because central CRF(2) stimulation retains full anorectic efficacy at higher doses in the DIO model, manipulating this neuropeptidergic system might yield new therapeutic approaches for diet-induced obesity...
  4. ncbi Opioid-dependent anticipatory negative contrast and binge-like eating in rats with limited access to highly preferred food
    Pietro Cottone
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 33:524-35. 2008
    ..Such rats show changes in ingestive, metabolic, endocrine, and anxiety-related measures, which resemble features of binge eating disorders or obesity...
  5. ncbi FG 7142 specifically reduces meal size and the rate and regularity of sustained feeding in female rats: evidence that benzodiazepine inverse agonists reduce food palatability
    Pietro Cottone
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 32:1069-81. 2007
    ..5 mg/kg) female rats (n=48) in the elevated plus-maze. Thus, benzodiazepine receptor inverse agonists preferentially lessen the maintenance of feeding in female rats, effects opposite to those of palatable food...
  6. pmc CRF system recruitment mediates dark side of compulsive eating
    Pietro Cottone
    Committee on the Neurobiology of Addictive Disorders, Pearson Center for Alcoholism and Addiction Research, Harold L Dorris Neurological Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:20016-20. 2009
    ....
  7. pmc Corticotropin releasing factor-induced amygdala gamma-aminobutyric Acid release plays a key role in alcohol dependence
    Marisa Roberto
    Committee on the Neurobiology of Addictive Disorders, Scripps Research Institute, La Jolla, California 92037, USA
    Biol Psychiatry 67:831-9. 2010
    ..Ethanol augments CeA GABA release in ethanol-naive rats and mice...
  8. pmc The sigma-receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking
    Valentina Sabino
    Committee on the Neurobiology of Addictive Disorders, SP30 2400, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Neuropsychopharmacology 34:1482-93. 2009
    ....
  9. pmc Activation of σ-receptors induces binge-like drinking in Sardinian alcohol-preferring rats
    Valentina Sabino
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 36:1207-18. 2011
    ..These results suggest a key facilitatory role for σ-receptors in the reinforcing effects of alcohol and identify a potential mechanism that contributes to binge-like and excessive drinking...
  10. pmc CRF-CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats
    Olivier George
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 104:17198-203. 2007
    ..Overactivation of the CRF-CRF(1) system may contribute to nicotine dependence and may represent a prominent target for investigating the vulnerability to tobacco addiction...
  11. pmc Corticotropin-releasing factor-1 receptor antagonists decrease heroin self-administration in long- but not short-access rats
    Thomas N Greenwell
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, USA
    Addict Biol 14:130-43. 2009
    ..The results demonstrate that blockade of the CRF-CRF(1) receptor system attenuates the increased heroin intake of rats with extended access to the drug...
  12. ncbi 14-Methoxymetopon, a highly potent mu opioid agonist, biphasically affects ethanol intake in Sardinian alcohol-preferring rats
    Valentina Sabino
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 192:537-46. 2007
    ..14-methoxymetopon is a centrally acting, selective micro opioid receptor agonist with greater systemic antinociceptive potency than morphine and a putatively improved therapeutic index...
  13. pmc The alpha1 adrenergic receptor antagonist prazosin reduces heroin self-administration in rats with extended access to heroin administration
    Thomas N Greenwell
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30 2400, La Jolla, CA 92037, United States
    Pharmacol Biochem Behav 91:295-302. 2009
    ..The data suggest that the alpha1 adrenergic system may contribute to mechanisms that promote dependence in rats with extended access...
  14. pmc Effects of CB1 and CRF1 receptor antagonists on binge-like eating in rats with limited access to a sweet fat diet: lack of withdrawal-like responses
    Sarah L Parylak
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Physiol Behav 107:231-42. 2012
    ..The results suggest that CB(1)-dependent positive reinforcement rather than CRF(1)-dependent negative reinforcement mechanisms predominantly maintain excessive intake in this limited access model of sweet-fat diet binges...
  15. pmc Sigma-1 receptor knockout mice display a depressive-like phenotype
    Valentina Sabino
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Behav Brain Res 198:472-6. 2009
    ..The results further suggest that Sig-1Rs inversely modulate depressive-like behavior...
  16. ncbi Dissociation between opioid and CRF1 antagonist sensitive drinking in Sardinian alcohol-preferring rats
    Valentina Sabino
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 189:175-86. 2006
    ..The role of positive vs negative ethanol reinforcement in ethanol intake of Sardinian alcohol-preferring (sP) rats is unclear...
  17. pmc A potential role for adiponectin receptor 2 (AdipoR2) in the regulation of alcohol intake
    Vez Repunte-Canonigo
    Molecular and Integrative Neuroscience Department, The Scripps Research Institute, La Jolla, CA 92037, USA
    Brain Res 1339:11-7. 2010
    ..Altogether, the data implicate K-ras-regulated pathways involving AdipoR2 in the cellular and behavioral actions of alcohol that may contribute to overactivity of the ACC during withdrawal and excessive alcohol drinking...

Research Grants2

  1. The dark side of preferred food addiction: role of CRF systems
    Pietro Cottone; Fiscal Year: 2007
    The application proposes a career development plan for Dr. Pietro Cottone, a pharmacologically trained post-doctoral fellow committed to a research career in understanding the molecular bases of food and drug addiction...