Jean Francois Cote

Summary

Affiliation: The Burnham Institute
Country: USA

Publications

  1. ncbi PSTPIP is a substrate of PTP-PEST and serves as a scaffold guiding PTP-PEST toward a specific dephosphorylation of WASP
    Jean Francois Cote
    Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Biol Chem 277:2973-86. 2002
  2. pmc Essential function of PTP-PEST during mouse embryonic vascularization, mesenchyme formation, neurogenesis and early liver development
    Jacinthe Sirois
    McGill Cancer Center and Biochemistry Department, McGill University, 3655 Sir William Osler Promenade, Montreal, Que, Canada H3G 1Y6
    Mech Dev 123:869-80. 2006
  3. pmc ELMO recruits actin cross-linking family 7 (ACF7) at the cell membrane for microtubule capture and stabilization of cellular protrusions
    Yoran Margaron
    Institut de Recherches Cliniques de Montreal, Montreal, Quebec H2W 1R7, Canada
    J Biol Chem 288:1184-99. 2013
  4. pmc An evolutionarily conserved autoinhibitory molecular switch in ELMO proteins regulates Rac signaling
    Manishha Patel
    Institut de Recherches Cliniques de Montreal, 110 avenue des Pins Ouest, Montreal, PQ H2W 1R7, Canada
    Curr Biol 20:2021-7. 2010
  5. pmc Axl phosphorylates Elmo scaffold proteins to promote Rac activation and cell invasion
    Afnan Abu-Thuraia
    Institut de recherches cliniques de Montreal IRCM, Montreal, QC, Canada Département de Médecine Programmes de Biologie Moléculaire, Universite de Montreal, Montreal, QC, Canada
    Mol Cell Biol 35:76-87. 2015
  6. pmc GEF what? Dock180 and related proteins help Rac to polarize cells in new ways
    Jean Francois Cote
    Cytoskeletal Organization and Cell Migration Laboratory, Institut de Recherches Cliniques de Montreal, Universite de Montreal, 110 Pine Avenue West, Montreal, PQ H2W1R7, Canada
    Trends Cell Biol 17:383-93. 2007

Collaborators

  • Yoshinori Fukui
  • Kay Hofmann
  • Yoran Margaron
  • Afnan Abu-Thuraia
  • Nadine Fradet
  • Manishha Patel
  • Jacinthe Sirois
  • Robert A Screaton
  • Rony Chidiac
  • Jean Philippe Gratton
  • Rosemarie Gauthier
  • Michel Bouvier
  • Qi Yang
  • Brian Wilkes
  • Eugene Daniels
  • Michel L Tremblay
  • Noriko Uetani
  • Stephen A Duncan
  • Alain Charest
  • Annie Bourdeau

Detail Information

Publications6

  1. ncbi PSTPIP is a substrate of PTP-PEST and serves as a scaffold guiding PTP-PEST toward a specific dephosphorylation of WASP
    Jean Francois Cote
    Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Biol Chem 277:2973-86. 2002
    ..This finding suggests a possible mechanism for PTP-PEST to directly modulate actin remodeling through the PSTPIP-WASP interaction...
  2. pmc Essential function of PTP-PEST during mouse embryonic vascularization, mesenchyme formation, neurogenesis and early liver development
    Jacinthe Sirois
    McGill Cancer Center and Biochemistry Department, McGill University, 3655 Sir William Osler Promenade, Montreal, Que, Canada H3G 1Y6
    Mech Dev 123:869-80. 2006
    ....
  3. pmc ELMO recruits actin cross-linking family 7 (ACF7) at the cell membrane for microtubule capture and stabilization of cellular protrusions
    Yoran Margaron
    Institut de Recherches Cliniques de Montreal, Montreal, Quebec H2W 1R7, Canada
    J Biol Chem 288:1184-99. 2013
    ..In conclusion, our findings support a role for ELMO in protrusion stability by acting at the interface between the actin cytoskeleton and the microtubule network...
  4. pmc An evolutionarily conserved autoinhibitory molecular switch in ELMO proteins regulates Rac signaling
    Manishha Patel
    Institut de Recherches Cliniques de Montreal, 110 avenue des Pins Ouest, Montreal, PQ H2W 1R7, Canada
    Curr Biol 20:2021-7. 2010
    ..Functionally, we found that ELMO mutants with impaired autoregulatory activity promote cell elongation. These results demonstrate an unsuspected level of regulation for Rac1 signaling via autoinhibition of ELMO...
  5. pmc Axl phosphorylates Elmo scaffold proteins to promote Rac activation and cell invasion
    Afnan Abu-Thuraia
    Institut de recherches cliniques de Montreal IRCM, Montreal, QC, Canada Département de Médecine Programmes de Biologie Moléculaire, Universite de Montreal, Montreal, QC, Canada
    Mol Cell Biol 35:76-87. 2015
    ..These results define a new mechanism by which Axl promotes cell proliferation and invasion and identifies inhibition of the Elmo-Dock pathway as a potential therapeutic target to stop Axl-induced metastases. ..
  6. pmc GEF what? Dock180 and related proteins help Rac to polarize cells in new ways
    Jean Francois Cote
    Cytoskeletal Organization and Cell Migration Laboratory, Institut de Recherches Cliniques de Montreal, Universite de Montreal, 110 Pine Avenue West, Montreal, PQ H2W1R7, Canada
    Trends Cell Biol 17:383-93. 2007
    ....