Research Topics
Species | Paul CornSummaryAffiliation: The University of Texas Country: USA Publications
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Publications
Tat-binding protein-1, a component of the 26S proteasome, contributes to the E3 ubiquitin ligase function of the von Hippel-Lindau proteinPaul G Corn
Department of Medicine, Howard Hughes Medical Institute and Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Nat Genet 35:229-37. 2003..Thus, the ability of pVHL to degrade Hif1 alpha depends in part on its interaction with TBP-1 and suggests a new mechanism for Hif1 alpha stabilization in some pVHL-deficient tumors...- Genome-wide profiling of methylated promoters in pancreatic adenocarcinoma: defining the pancreatic pancer epigenomePaul Corn
MD Anderson Cancer Center, Department of Genitourinary Medical Oncology, Houston, Texas 77030, USA
Cancer Biol Ther 7:1157-9. 2008 
Novel therapies for metastatic castrate-resistant prostate cancerFarshid Dayyani
Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
J Natl Cancer Inst 103:1665-75. 2011..The rationale to disrupt this "two-compartment" crosstalk has led to the development of drugs that target tumor stromal elements in addition to the cancer epithelial cell...- Hypoxic regulation of miR-210: shrinking targets expand HIF-1's influencePaul G Corn
MD Anderson Cancer Center, Department of Genitourinary Medical Oncology, Houston, Texas 77030, USA
Cancer Biol Ther 7:265-7. 2008 - Microarray analysis of p53-dependent gene expression in response to hypoxia and DNA damagePaul G Corn
MD Anderson Cancer Center, Houston, Texas, USA
Cancer Biol Ther 6:1858-66. 2007..These data suggest a hypothesis that the combination of hypoxia and DNA damage promotes resistance to therapy by eliciting a transcriptional response that favors cell cycle arrest over apoptosis... 
Role of the ubiquitin proteasome system in renal cell carcinomaPaul G Corn
MD Anderson Cancer Center, GU Medical Oncology, Box 1374, 1515 Holcombe Boulevard, Houston, TX 77030, USA
BMC Biochem 8:S4. 2007..Publication history: Republished from Current BioData's Targeted Proteins database (TPdb; http://www.targetedproteinsdb.com)...- Reactivation of p53 function with a demethylating agentPaul G Corn
MD Anderson Cancer Center, Genitourinary Medical Oncology Department, Houston, Texas 77030, USA
Cancer Biol Ther 5:1161-2. 2006 - Upfront, randomized, phase 2 trial of sorafenib versus sorafenib and low-dose interferon alfa in patients with advanced renal cell carcinoma: clinical and biomarker analysisEric Jonasch
Department of Genitourinary Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Cancer 116:57-65. 2010..The objective of this study was to independently evaluate the objective response rate of sorafenib and sorafenib plus low-dose interferon-alfa 2b (IFN) as frontline therapy in patients with metastatic renal cell carcinoma (mRCC)... - Inhibition of RNA-dependent protein kinase (PKR) leads to cancer cell death and increases chemosensitivityAbujiang Pataer
Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Cancer Biol Ther 8:245-52. 2009..Our results suggest a rationale to develop therapeutic strategies that target PKR signaling in human cancer cells... - Phase II presurgical feasibility study of bevacizumab in untreated patients with metastatic renal cell carcinomaEric Jonasch
Department ofGenitourinary Medical Oncology, The University of Texas M D Anderson Cancer Center, PO Box 301439, Houston, TX 77230 1439, USA
J Clin Oncol 27:4076-81. 2009.... - Dasatinib inhibits both osteoclast activation and prostate cancer PC-3-cell-induced osteoclast formationJohn C Araujo
Department of Genitourinary Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
Cancer Biol Ther 8:2153-9. 2009..Since Src kinase has been shown to be necessary for osteoclast function, we hypothesized that dasatinib, a Src family kinase inhibitor, would reduce osteoclast activity and prostate cancer (PC-3) cell-induced osteoclast formation... - Inhibition of Mxi1 suppresses HIF-2alpha-dependent renal cancer tumorigenesisChun Chui Tsao
Department of Genitourinary Medical Oncology, MD Anderson Cancer Center, Houston, Texas 77030, USA
Cancer Biol Ther 7:1619-27. 2008..Compared to Mxi1-proficient tumors, Mxi1-deficient tumors display reduced cellular proliferation. These results establish Mxi1 as an important downstream target of HIF that contributes to pVHL-deficient renal cancer tumorigenesis... - 5-Aza-2'-deoxycytidine sensitizes busulfan-resistant myeloid leukemia cells by regulating expression of genes involved in cell cycle checkpoint and apoptosisBenigno C Valdez
Department of Stem Cell Transplantation and Cellular Therapy, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
Leuk Res 34:364-72. 2010..Our results suggest that, depending on tumor p53 status, incorporation of DAC might synergistically improve the cytoreductive efficacy of Bu-based pretransplant regimen in patients with ML... - Caspase 10 levels are increased following DNA damage in a p53-dependent mannerBart Rikhof
Laboratory of Molecular Oncology and Cell Cycle Regulation, Howard Hughes Medical Institute, Departments of Medicine, Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Cancer Biol Ther 2:707-12. 2003..Upregulation of caspase 10 may represent one factor that determines how p53 activation leads to cellular apoptosis following DNA damage... - Frequent hypermethylation of the 5' CpG island of the mitotic stress checkpoint gene Chfr in colorectal and non-small cell lung cancerPaul G Corn
University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
Carcinogenesis 24:47-51. 2003..These results suggest that epigenetic inactivation of Chfr may be responsible for many of the checkpoint defects observed in human cancers... - Hypoxic regulation of mRNA expressionLawrence B Gardner
New York University School of Medicine and MD Anderson Cancer Center, USA
Cell Cycle 7:1916-24. 2008..Recent data from our laboratory demonstrate that nonsense mediated RNA decay is also regulated in hypoxic cells and thus may play an important role in hypoxic gene regulation and hypoxic phenotypes... - Mxi1 is induced by hypoxia in a HIF-1-dependent manner and protects cells from c-Myc-induced apoptosisPaul G Corn
University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Cancer Biol Ther 4:1285-94. 2005..The results suggest a coordinated mechanism for opposing c-Myc signaling during hypoxia that is mediated by a reduction in c-Myc levels, the induction of Mxi1, and a dominant effect of HIF-1 transcriptional activity... - Derangement of growth and differentiation control in oncogenesisPaul G Corn
Department of Medicine, Division of Hematology/Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA
Bioessays 24:83-90. 2002..Insights into what distinguishes the regulation of growth and differentiation in a normal cell versus a cancer cell have led to the development of novel anticancer therapies...
Research Grants
- Regulation of the von Hippel-Lindau ProteinPaul Corn; Fiscal Year: 2007..abstract_text> ..