B Conti

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. pmc Night eating and obesity in the EP3R-deficient mouse
    Manuel Sanchez-Alavez
    The Harold L Dorris Neurological Research Institute and Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 104:3009-14. 2007
  2. doi request reprint A cool way to live long
    Bruno Conti
    The Scripps Research Institute, Department of Chemical Physiology, La Jolla, CA 92037, USA
    Cell 152:671-2. 2013
  3. pmc Interleukin 18 in the CNS
    Silvia Alboni
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Italy
    J Neuroinflammation 7:9. 2010
  4. pmc Considerations on temperature, longevity and aging
    B Conti
    Molecular and Integrative Neurosciences Department, The Harold Dorris Neurological Research Institute, The Scripps Research Institute, La Jolla, CA 92037, USA
    Cell Mol Life Sci 65:1626-30. 2008
  5. ncbi request reprint Transgenic mice with a reduced core body temperature have an increased life span
    Bruno Conti
    Harold L Dorris Neurological Research Center, Scripps Research Institute, La Jolla, CA 92037, USA
    Science 314:825-8. 2006
  6. ncbi request reprint Uncoupling protein 2 protects dopaminergic neurons from acute 1,2,3,6-methyl-phenyl-tetrahydropyridine toxicity
    Bruno Conti
    Harold L Dorris Neurological Research Center, Scripps Research Institute, La Jolla, California 92037, USA
    J Neurochem 93:493-501. 2005
  7. pmc Age- and gender-specific changes of hypocretin immunopositive neurons in C57Bl/6 mice
    Sara E Brownell
    Molecular and Integrative Neurosciences Department and Harold L Dorris Neurological Research Center, The Scripps Research Institute, 10550 North Torrey Pines Road SR307, La Jolla, CA 92037, United States
    Neurosci Lett 472:29-32. 2010
  8. pmc Hypothalamic and dietary control of temperature-mediated longevity
    Iustin Tabarean
    The Scripps Research Institute, La Jolla, CA 92037, USA
    Ageing Res Rev 9:41-50. 2010
  9. ncbi request reprint Mice devoid of prion protein have cognitive deficits that are rescued by reconstitution of PrP in neurons
    Jose R Criado
    Department of Neuropharmacology TPC 10, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neurobiol Dis 19:255-65. 2005
  10. pmc Fever
    Tamas Bartfai
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA, USA
    ScientificWorldJournal 10:490-503. 2010

Research Grants

  1. Aging and hypothalamic temparature
    Bruno Conti; Fiscal Year: 2010
  2. Aging and hypothalamic temparature
    Bruno Conti; Fiscal Year: 2007

Detail Information

Publications26

  1. pmc Night eating and obesity in the EP3R-deficient mouse
    Manuel Sanchez-Alavez
    The Harold L Dorris Neurological Research Institute and Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 104:3009-14. 2007
    ..The findings add to the growing literature on links between inflammatory signaling and obesity...
  2. doi request reprint A cool way to live long
    Bruno Conti
    The Scripps Research Institute, Department of Chemical Physiology, La Jolla, CA 92037, USA
    Cell 152:671-2. 2013
    ..They show that low temperatures activate a cold-sensitive cation channel, TRPA-1, which triggers a complex signaling pathway in both neurons and nonneuronal cells to extend the lifespan of Caenorhabditis elegans...
  3. pmc Interleukin 18 in the CNS
    Silvia Alboni
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Italy
    J Neuroinflammation 7:9. 2010
    ..This review summarizes current knowledge on the central role of IL-18 in health and disease...
  4. pmc Considerations on temperature, longevity and aging
    B Conti
    Molecular and Integrative Neurosciences Department, The Harold Dorris Neurological Research Institute, The Scripps Research Institute, La Jolla, CA 92037, USA
    Cell Mol Life Sci 65:1626-30. 2008
    ..Some of the possible mechanisms mediating these effects are considered here with respect to major aging models and theories...
  5. ncbi request reprint Transgenic mice with a reduced core body temperature have an increased life span
    Bruno Conti
    Harold L Dorris Neurological Research Center, Scripps Research Institute, La Jolla, CA 92037, USA
    Science 314:825-8. 2006
    ..Thus, modest, sustained reduction of core body temperature prolonged life span independent of altered diet or CR...
  6. ncbi request reprint Uncoupling protein 2 protects dopaminergic neurons from acute 1,2,3,6-methyl-phenyl-tetrahydropyridine toxicity
    Bruno Conti
    Harold L Dorris Neurological Research Center, Scripps Research Institute, La Jolla, California 92037, USA
    J Neurochem 93:493-501. 2005
    ..Our data suggest that UCP2 may represent a drug target for slowing the progression of Parkinson's disease...
  7. pmc Age- and gender-specific changes of hypocretin immunopositive neurons in C57Bl/6 mice
    Sara E Brownell
    Molecular and Integrative Neurosciences Department and Harold L Dorris Neurological Research Center, The Scripps Research Institute, 10550 North Torrey Pines Road SR307, La Jolla, CA 92037, United States
    Neurosci Lett 472:29-32. 2010
    ..Evaluation of the time-dependent decline in the number of hypocretin immunopositive neurons may help to explain the physiological changes in sleep or energy homeostasis regulation during aging...
  8. pmc Hypothalamic and dietary control of temperature-mediated longevity
    Iustin Tabarean
    The Scripps Research Institute, La Jolla, CA 92037, USA
    Ageing Res Rev 9:41-50. 2010
    ....
  9. ncbi request reprint Mice devoid of prion protein have cognitive deficits that are rescued by reconstitution of PrP in neurons
    Jose R Criado
    Department of Neuropharmacology TPC 10, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neurobiol Dis 19:255-65. 2005
    ....
  10. pmc Fever
    Tamas Bartfai
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA, USA
    ScientificWorldJournal 10:490-503. 2010
    ..We also show how fever research provided new insights into temperature and energy homeostasis, and into treatment of infection and inflammation...
  11. pmc Insulin causes hyperthermia by direct inhibition of warm-sensitive neurons
    Manuel Sanchez-Alavez
    The Harold L Dorris Neurological Research Institute, Department of Molecular and Integrative Neurosciences, The Scripps Research Institute, La Jolla, California, USA
    Diabetes 59:43-50. 2010
    ..The objective is to examine the role of the metabolic signal insulin in the control of core body temperature (CBT)...
  12. pmc Metabolic characterization of a mouse deficient in all known leptin receptor isoforms
    Olivia Osborn
    Molecular and Integrative Neurosciences Department, The Harold L Dorris Neurological Research Institute, The Scripps Research Institute, La Jolla, CA 92037, USA
    Cell Mol Neurobiol 30:23-33. 2010
    ....
  13. pmc The sigma-receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking
    Valentina Sabino
    Committee on the Neurobiology of Addictive Disorders, SP30 2400, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Neuropsychopharmacology 34:1482-93. 2009
    ....
  14. doi request reprint Insights into the roles of the inflammatory mediators IL-1, IL-18 and PGE2 in obesity and insulin resistance
    Olivia Osborn
    The Harold L Dorris Neurological Research Institute, and Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Swiss Med Wkly 138:665-73. 2008
    ..This review highlights results of studies in mice which indicate important roles for these proinflammatory cytokines during the development of obesity and insulin resistance, and in the treatment of type 2 diabetes...
  15. pmc Hypothalamic-pituitary-adrenal axis disregulation in PrPC-null mice
    Manuel Sanchez-Alavez
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California 92037, USA
    Neuroreport 19:1473-7. 2008
    ..Pretreatment with corticosterone or dexamethasone inhibited stress-induced elevation of adrenocorticotropic hormone in PrP+/+ but not in PrP 0/0 mice. Thus, PrPC may play a role in the negative feedback regulation of axis...
  16. pmc A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus
    Xiaoying Lu
    Department of Neuropharmacology and The Harold L Dorris Neurological Research Center, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 102:874-9. 2005
    ....
  17. ncbi request reprint Interleukin-1 system in CNS stress: seizures, fever, and neurotrauma
    Tamas Bartfai
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, USA
    Ann N Y Acad Sci 1113:173-7. 2007
    ..Selective induction or pharmacological application of IL-1ra may be sparing neurons in seizures and neurotrauma...
  18. pmc Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency
    Eric P Zorrilla
    Harold L Dorris Neurological Research Institute, Committee on the Neurobiology of Addictive Disorders, and Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 104:11097-102. 2007
    ..The data suggest that endogenous IL-18 signaling modulates food intake, metabolism, and adiposity during adulthood and might be a central or peripheral pharmacological target for controlling energy homeostasis...
  19. pmc Contributions of neuronal prion protein on sleep recovery and stress response following sleep deprivation
    Manuel Sanchez-Alavez
    Molecular and Integrative Neuroscience Department, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Brain Res 1158:71-80. 2007
    ..They also suggest that neuronal PrP(c)-dependent hormonal regulation of HPA axis may contribute to the sleep homeostasis...
  20. pmc CRF system recruitment mediates dark side of compulsive eating
    Pietro Cottone
    Committee on the Neurobiology of Addictive Disorders, Pearson Center for Alcoholism and Addiction Research, Harold L Dorris Neurological Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:20016-20. 2009
    ....
  21. ncbi request reprint Cross-linking cellular prion protein triggers neuronal apoptosis in vivo
    Laura Solforosi
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Science 303:1514-6. 2004
    ..These findings suggest that PrPC functions in the control of neuronal survival and provides a model to explore whether cross-linking of PrPC by oligomeric PrPSc can promote neuronal loss during prion infection...
  22. ncbi request reprint Cytokines and fever
    Bruno Conti
    Harold L Dorris Neurological Research Center, Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Front Biosci 9:1433-49. 2004
    ....
  23. ncbi request reprint Neurons of the superior nucleus of the medial habenula and ependymal cells express IL-18 in rat CNS
    Shuei Sugama
    Harold L Dorris Neurological Research Center, Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, SR307, La Jolla, CA 92037, USA
    Brain Res 958:1-9. 2002
    ..They also suggest that ependymal cells may be the source of IL-18 previously reported in the cerebrospinal fluid (CSF). The role of IL-18 in the ependyma and the CSF remains to be elucidated...
  24. pmc Metabolic depression and increased reactive oxygen species production by isolated mitochondria at moderately lower temperatures
    Sameh S Ali
    Department of Medicine, University of California at San Diego, La Jolla, California 92093, USA
    J Biol Chem 285:32522-8. 2010
    ..These data indicate that reduced mitochondrial ROS production is not one of the mechanisms mediating lifespan extension at lower T. They suggest instead that increased ROS leakage may mediate mitochondrial responses to hypothermia...
  25. doi request reprint Interleukin-18 and stress
    Shuei Sugama
    Department of Physiology, Nippon Medical School, 1 1 5 Sendagi Bunkyo ku, Tokyo 113 8602, Japan
    Brain Res Rev 58:85-95. 2008
    ..This review summarizes the evidence linking stress and IL-18 and discusses the possible implication of the neuro-immuno-modulatory action of IL-18...
  26. ncbi request reprint The adrenal gland is a source of stress-induced circulating IL-18
    Shuei Sugama
    Department of Physiology, Nippon Medical School, 1 1 5 Sendagi Bunkyo ku, Tokyo 113 8602, Japan
    J Neuroimmunol 172:59-65. 2006
    ..The stress-induced increase in circulating IL-18 was abolished by adrenalectomy. These findings demonstrate that the adrenal gland is required to achieve elevation of circulating IL-18 during stress...

Research Grants5

  1. Aging and hypothalamic temparature
    Bruno Conti; Fiscal Year: 2010
    ..We propose experiments designed to characterize the mechanisms that may be responsible for the reduction of core body temperature and the prolonged life-span in Hcrt-UCP2 mice. ..
  2. Aging and hypothalamic temparature
    Bruno Conti; Fiscal Year: 2007
    ..We propose experiments designed to characterize the mechanisms that may be responsible for the reduction of core body temperature and the prolonged life-span in Hcrt-UCP2 mice. ..