Stephanie Constant

Summary

Affiliation: The George Washington University
Country: USA

Publications

  1. pmc Resident lung antigen-presenting cells have the capacity to promote Th2 T cell differentiation in situ
    Stephanie L Constant
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA
    J Clin Invest 110:1441-8. 2002
  2. pmc The level of CD147 expression correlates with cyclophilin-induced signalling and chemotaxis
    Alexander Trachtenberg
    The George Washington University, Washington, DC 20037, USA
    BMC Res Notes 4:396. 2011
  3. pmc MyD88-dependent induction of allergic Th2 responses to intranasal antigen
    Damani A Piggott
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA
    J Clin Invest 115:459-67. 2005
  4. pmc Mechanism of transforming growth factor beta-induced inhibition of T helper type 1 differentiation
    Leonid Gorelik
    Yale University School of Medicine, New Haven, CT 06520, USA
    J Exp Med 195:1499-505. 2002
  5. pmc Leishmania pifanoi pathogenesis: selective lack of a local cutaneous response in the absence of circulating antibody
    Maria Colmenares
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520 8034, USA
    Infect Immun 70:6597-605. 2002
  6. pmc A nonproliferating parvovirus vaccine vector elicits sustained, protective humoral immunity following a single intravenous or intranasal inoculation
    Gene A Palmer
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Virol 78:1101-8. 2004
  7. pmc Blocking cyclophilins in the chronic phase of asthma reduces the persistence of leukocytes and disease reactivation
    Erik J Stemmy
    Department of Microbiology, Immunology, and Tropical Medicine, George Washington University Medical Center, Washington, DC 20037, USA
    Am J Respir Cell Mol Biol 45:991-8. 2011

Collaborators

Detail Information

Publications7

  1. pmc Resident lung antigen-presenting cells have the capacity to promote Th2 T cell differentiation in situ
    Stephanie L Constant
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA
    J Clin Invest 110:1441-8. 2002
    ..Furthermore, these pulmonary APCs demonstrated a marked expression of IL-6 and IL-10 within hours of antigen uptake, suggesting that resident tissue APCs have the capacity to promote Th2 T cell differentiation in situ...
  2. pmc The level of CD147 expression correlates with cyclophilin-induced signalling and chemotaxis
    Alexander Trachtenberg
    The George Washington University, Washington, DC 20037, USA
    BMC Res Notes 4:396. 2011
    ..abstract:..
  3. pmc MyD88-dependent induction of allergic Th2 responses to intranasal antigen
    Damani A Piggott
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA
    J Clin Invest 115:459-67. 2005
    ..Furthermore, the dependence of Th2 responses on MyD88 is governed by the initial route of antigen exposure; this demonstrates what we believe are novel site-specific innate mechanisms for control of adaptive Th2 immunity...
  4. pmc Mechanism of transforming growth factor beta-induced inhibition of T helper type 1 differentiation
    Leonid Gorelik
    Yale University School of Medicine, New Haven, CT 06520, USA
    J Exp Med 195:1499-505. 2002
    ..Furthermore, we show that the direct inhibitory effect of TGF-beta on T cells is responsible, at least in part, for the inability of BALB/c mice to mount a Leishmania-specific Th1 response and to clear Leishmanial infection...
  5. pmc Leishmania pifanoi pathogenesis: selective lack of a local cutaneous response in the absence of circulating antibody
    Maria Colmenares
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520 8034, USA
    Infect Immun 70:6597-605. 2002
    ..These data, taken together, suggest that one possible mechanism for the role of antibody in pathogenesis may be to mediate parasite uptake and regulate the immune response at the local cutaneous site of infection...
  6. pmc A nonproliferating parvovirus vaccine vector elicits sustained, protective humoral immunity following a single intravenous or intranasal inoculation
    Gene A Palmer
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Virol 78:1101-8. 2004
    ..Both humoral and cell-mediated Th(1) immunity was induced, as shown by anti-OspA immunoglobulin G2a antibody and preferential gamma interferon production by OspA-specific CD4(+) T cells...
  7. pmc Blocking cyclophilins in the chronic phase of asthma reduces the persistence of leukocytes and disease reactivation
    Erik J Stemmy
    Department of Microbiology, Immunology, and Tropical Medicine, George Washington University Medical Center, Washington, DC 20037, USA
    Am J Respir Cell Mol Biol 45:991-8. 2011
    ..These findings suggest that blocking the function of cyclophilins during the chronic phase of asthma may provide a novel therapeutic strategy for regulating disease chronicity and severity...

Research Grants10

  1. Regulation of leukocyte trafficking by cyclophilins
    Stephanie Constant; Fiscal Year: 2005
    ..This will be examined using both in vitro and in vivo approaches, the latter using a mouse model of lung inflammation. ..
  2. Role of hookworm secretions in host immunomodulation
    Stephanie Constant; Fiscal Year: 2009
    ..In turn these have the potential to provide novel targets for therapeutic and/or preventative strategies for infections by hookworms, as well as other types of pathogens. ..
  3. Contribution of cyclophilins to leukocyte recruitment in lung inflammation
    Stephanie Constant; Fiscal Year: 2007
    ..In addition, we plan to establish whether blocking the activity of extracellular cyclophilins can also reduce inflammatory responses that are ongoing. ..
  4. Role of hookworm secretions in host immunomodulation
    Stephanie Constant; Fiscal Year: 2007
    ..In turn these have the potential to provide novel targets for therapeutic and/or preventative strategies for infections by hookworms, as well as other types of pathogens. ..
  5. Role of cyclophilins in leukocyte recruitment in asthma
    Stephanie Constant; Fiscal Year: 2005
    ..The findings from these studies are the first step in identifying a novel target for therapeutic intervention in diseases mediated by inflammation. ..
  6. Contribution of cyclophilins to leukocyte recruitment in lung inflammation
    Stephanie Constant; Fiscal Year: 2009
    ..In addition, we plan to establish whether blocking the activity of extracellular cyclophilins can also reduce inflammatory responses that are ongoing. ..