Research Topics
| C W ColwellSummaryAffiliation: The Scripps Research Institute Country: USA Publications
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Detail Information
Publications
An in vivo evaluation of bone response to three implant surfaces using a rabbit intramedullary rod modelJuan C Hermida
Orthopaedic Research Laboratories, Shiley Center for Orthopaedic Research and Education at Scripps Clinic, 11025 North Torrey Pines Road, Suite 140, La Jolla, CA, 92037, USA
J Orthop Surg Res 5:57. 2010..The results of this in vivo lapine study suggest that the presence of an hydroxyapatite coating enhances osseointegration despite similarities in average surface roughness...
Ceramic-on-ceramic total hip arthroplasty early dislocation rateClifford W Colwell
Shiley Center for Orthopaedic Research and Education at Scripps Clinic, La Jolla, CA 92037, USA
Clin Orthop Relat Res 465:155-8. 2007..1%). All were treated successfully, one with a revision and 17 with closed reduction under general anesthesia. Ceramic-on-ceramic total hip arthroplasty can be a good alternative bearing surface with a low dislocation rate...- Randomized study of aprotinin effect on transfusions and blood loss in primary THAClifford W Colwell
Shiley Center for Orthopaedic Research and Education at Scripps Clinic, La Jolla, CA 92037, USA
Clin Orthop Relat Res 465:189-95. 2007..Serious complications were similar in the two groups (placebo, 11%; aprotinin, 10%). Our data suggest full-dose aprotinin is safe and effective in decreasing blood transfusion in total hip arthroplasty... - Erythrocyte viability in blood salvaged during total joint arthroplasty with cementClifford W Colwell
Scripps Clinic, La Jolla, CA 92037, USA
J Bone Joint Surg Am 84:23-5. 2002..The purpose of this study was to determine the viability of salvaged erythrocytes from patients undergoing primary total joint arthroplasty with cement... - Comparison of ximelagatran, an oral direct thrombin inhibitor, with enoxaparin for the prevention of venous thromboembolism following total hip replacement. A randomized, double-blind studyC W Colwell
Scripps Clinic Center for Orthopaedic Research and Education, 11025 North Torrey Pines Road, Suite 140, La Jolla, CA 92037 1030, USA
J Thromb Haemost 1:2119-30. 2003..We compared the efficacy and safety of ximelagatran with those of enoxaparin for the prevention of VTE in patients undergoing THR... 
Thrombosis prevention after total hip arthroplasty: a prospective, randomized trial comparing a mobile compression device with low-molecular-weight heparinClifford W Colwell
Shiley Center for Orthopaedic Research and Education at Scripps Clinic, 11025 North Torrey Pines Road, Suite 140, La Jolla, CA 92037, USA
J Bone Joint Surg Am 92:527-35. 2010..The purpose of this study was to compare a new mobile compression device with low-molecular-weight heparin with regard to their safety and effectiveness for the prevention of venous thromboembolic disease...- Oral direct thrombin inhibitor ximelagatran compared with warfarin for the prevention of venous thromboembolism after total knee arthroplastyClifford W Colwell
Orthopaedic Surgery, Scripps Clinic, 11025 North Torrey Pines Road, Suite 140, La Jolla, CA 92037, USA
J Bone Joint Surg Am 87:2169-77. 2005.... - Rationale for low-molecular-weight heparin prophylaxis after total knee arthroplastyClifford W Colwell
Shiley Center for Orthopaedic Research and Education, Scripps Clinic, La Jolla, CA 92037, USA
Clin Orthop Relat Res 452:181-5. 2006..As with all treatments, the benefit must be considered against the risk when using these anticoagulants... - The effect of the orientation of the acetabular and femoral components on the range of motion of the hip at different head-neck ratiosD D D'Lima
Division of Orthopaedic Surgery, Scripps Clinic, La Jolla, California 92037, USA
J Bone Joint Surg Am 82:315-21. 2000..In this study, a computer model was used to determine the effects of the positions of the acetabular and femoral components and of varying head-neck ratios on impingement and range of motion... - The Harris-Galante Porous acetabular component at intermediate follow-upA A Yashar
Division of Orthopedic Surgery, Scripps Clinic, La Jolla, Calif 92037, USA
Orthopedics 24:747-51. 2001..A potentially adverse effect of polyethylene wear on the longevity of a THA was supported by a positive correlation between polyethylene wear rate and femoral osteolysis... - Patellar tracking in total knee arthroplasty: inset versus onset designK A Ezzet
Division of Orthopaedic Surgery, Scripps Clinic, La Jolla, California 92037, USA
J Arthroplasty 16:838-43. 2001..No statistically significant differences were seen in knee kinematics between the 2 designs. The inset patella tended to shift laterally and tilt laterally more than the onset patella. This difference may be clinically significant... - Highly cross-linked polyethylene in total hip arthroplastyAlexander C Gordon
Illinoise Bone and Joint Institution, Morton Grove, IL 60053, USA
J Am Acad Orthop Surg 14:511-23. 2006.... - In vivo knee moments and shear after total knee arthroplastyDARRYL D D'LIMA
Shiley Center for Orthopaedic Research and Education, Scripps Clinic, 11025 N Torrey Pines Road, Suite 140, La Jolla, CA 92037, USA Department of Bioengineering, University of California, San Diego, CA, USA
J Biomech 40:S11-7. 2007..These findings indicate that the soft tissues around the knee absorbed most of the external shear forces. Our results highlight the importance of direct measurements of knee forces... - Correlation between the knee adduction torque and medial contact force for a variety of gait patternsDong Zhao
Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, FL, USA
J Orthop Res 25:789-97. 2007..These results support the hypothesis that the knee adduction torque is highly correlated with medial compartment contact force and medial to total force ratio during gait... - Evidence-based guidelines for venous thromboembolism prophylaxis in orthopedic surgeryClifford W Colwell
Shiley Center for Orthopaedic Research and Education at Scripps Clinic, La Jolla, Calif, USA
Orthopedics 30:129-35; quiz 136-7. 2007 - In vivo medial and lateral tibial loads during dynamic and high flexion activitiesDong Zhao
Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, Florida, USA
J Orthop Res 25:593-602. 2007..9 BW for lunge, with corresponding lateral forces of 0.1 and 0.7 BW, respectively. For this patient, a constant load split of 55% medial-45% lateral during loaded activity would be a reasonable approximation for these test conditions... - Press-fit condylar design total knee arthroplasty. Fourteen to seventeen-year follow-upDavid J Rodricks
Shiley Center for Orthopaedic Research and Education at Scripps Clinic, 11025 North Torrey Pines Road, Suite 140, La Jolla, CA 92037, USA
J Bone Joint Surg Am 89:89-95. 2007..The present study represents the fourteen to seventeen-year results for our patients who were described in our previous report on the eight to ten-year results... - Tibial forces measured in vivo after total knee arthroplastyShantanu Patil
Orthopaedic Research Laboratories, Shiley Center for Orthopaedic Research and Education at Scripps Clinic, California, USA
J Arthroplasty 21:255-62. 2006..Technical design improvements will enhance function, quality of life, and longevity of total knee arthroplasty... - Thromboprophylaxis in orthopedic surgeryClifford W Colwell
Shiley Center for Orthopaedic Research and Education at Scripps Clinic, La Jolla, California, USA
Am J Orthop . 2006..Goals of treatment are to prevent proximal and distal DVT, pulmonary death, chronic pulmonary hypertension, and postthrombotic syndrome... - e-Knee: the electronic knee prosthesisMary E Hardwick
Shiley Center for Orthopaedic Research and Education at Scripps Clinic, La Jolla, CA, USA
Orthop Nurs 25:326-9. 2006..Direct measurement of knee forces can lead to a better understanding of the stresses seen following total knee arthroplasty. Information generated by the e-Knee will aid in the improvement of implant design and patient care... - Rationale for thromboprophylaxis in lower joint arthroplastyClifford W Colwell
Shiley Center for Orthopaedic Research and Education, Scripps Clinic, La Jolla, California, USA
Am J Orthop (Belle Mead NJ) 36:11-3. 2007..Data from meta-analyses and placebo-controlled, blinded, randomized clinical trials have demonstrated little or no increase in rates of clinically important bleeding with prophylaxis... - In vitro model of full-thickness cartilage defect healingHok Kei Tam
Shiley Center for Orthopaedic Research and Education at Scripps Clinic, 11025 North Torrey Pines Road, Suite 140, La Jolla, California 92037, USA
J Orthop Res 25:1136-44. 2007.... - Thromboprophylaxis in elderly patients undergoing major orthopaedic surgeryClifford W Colwell
Shiley Center for Orthopaedic Research and Education at Scripps Clinic, La Jolla, California 92037, USA
Drugs Aging 25:551-8. 2008..Adhering to published evidence-based guidelines can greatly decrease the number of thromboembolic events seen in elderly patients undergoing major orthopaedic surgery... - Prevention of venous thromboembolism: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)William H Geerts
Thromboembolism Program, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario, Canada
Chest 133:381S-453S. 2008..We recommend that, on admission to the ICU, all patients be assessed for their risk of VTE, and that most receive thromboprophylaxis (Grade 1A)... - The Mark Coventry Award: in vivo knee forces during recreation and exercise after knee arthroplastyDARRYL D D'LIMA
Shiley Center for Orthopaedic Research and Education at Scripps Clinic, La Jolla, CA 92037, USA
Clin Orthop Relat Res 466:2605-11. 2008.... - In vivo contact kinematics and contact forces of the knee after total knee arthroplasty during dynamic weight-bearing activitiesKartik M Varadarajan
Bioengineering Laboratory, Orthopaedic Surgery, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
J Biomech 41:2159-68. 2008..This in turn may help advance our understanding of factors limiting longevity of TKA implants, such as aseptic loosening and polyethylene component wear, and enable improved TKA designs... - In vivo knee loading characteristics during activities of daily living as measured by an instrumented total knee replacementAnnegret Mundermann
Department of Mechanical Engineering, Durand Building 205, 496 Lomita Mall, Stanford University, Stanford, California 94305 4038, USA
J Orthop Res 26:1167-72. 2008.... - Sensitivity of knee replacement contact calculations to kinematic measurement errorsBenjamin J Fregly
Department of Mechanical and Aerospace Engineering, University of Florida, 231 MAE A Building, Box 116250, Gainesville, Florida 32611, USA
J Orthop Res 26:1173-9. 2008.... - Extensor mechanism function in single-radius vs multiradius femoral components for total knee arthroplastyJames Hall
The Center Orthopaedic and Neurosurgical Care and Research, Bend, Oregon, USA
J Arthroplasty 23:216-9. 2008..Knee extensor mechanism function after TKA with either a single sagittal radius or multiradius implant was comparable in contemporary posterior cruciate ligament-retaining TKA designs... - Bony impingement affects range of motion after total hip arthroplasty: A subject-specific approachOliver Kessler
Scientific Affairs, Stryker Europe, Thalwil, Switzerland
J Orthop Res 26:443-52. 2008.... - An ABJS Best Paper: Dynamic intraoperative ligament balancing for total knee arthroplastyDARRYL D D'LIMA
Orthopaedic Research Laboratories, Shiley Center for Orthopaedic Research and Education at Scripps Clinic, 11025 North Torrey Pines Road, La Jolla, CA 92037, USA
Clin Orthop Relat Res 463:208-12. 2007..Surgical navigation systems have reduced the variability in component alignment. An instrumented tibial trial can be a valuable adjunct to directly measure soft tissue balance... - Prophylaxis for the thromboembolic disease--recommendations from the American College of Chest Physicians--are they appropriate for orthopaedic surgery?Clifford W Colwell
J Arthroplasty 21:148-9; author reply 149. 2006 - Venous thrombosis prophylaxis with low-molecular-weight heparin in hip and knee arthroplastyClifford W Colwell
Division of Orthopaedic Surgery, Scripps Clinic, La Jolla, California, USA
Instr Course Lect 51:487-9. 2002 - Advances in DVT prophylaxis and management in major orthopaedic surgeryMary E Hardwick
Scripps Clinic Center for Orthopaedic Research and Education, La Jolla, California, USA
Surg Technol Int 12:265-8. 2004..With the incidence of DVT reported in the range of 41% to 85% without prophylaxis in joint replacement and hip-fracture surgery, prophylaxis is warranted in all lower-extremity joint replacement and hip-fracture patients... - Prevention of venous thromboembolism: the Seventh ACCP Conference on Antithrombotic and Thrombolytic TherapyWilliam H Geerts
Thromboembolism Program, Sunnybrook and Women's College Health Sciences Centre, Room D674, 2075 Bayview Ave, Toronto, ON, Canada M4N 3M5
Chest 126:338S-400S. 2004..We recommend, on admission to the intensive care unit, all patients be assessed for their risk of VTE. Accordingly, most patients should receive thromboprophylaxis (Grade 1A)... - Comparison of the wear rates of twenty-eight and thirty-two-millimeter femoral heads on cross-linked polyethylene acetabular cups in a wear simulatorJuan C Hermida
Scripps Clinic, 11025 North Torrey Pines Road, Suite 140, La Jolla, CA 92037, USA
J Bone Joint Surg Am 85:2325-31. 2003..001). CONCLUSION: The dramatic reduction in wear rates with polyethylene cross-linking, even with the larger head size, may increase the potential for use of 32-mm head components in total hip arthroplasty... - Impact of patellofemoral design on patellofemoral forces and polyethylene stressesDARRYL D D'LIMA
Scripps Clinic Center for Orthopaedic Research and Education, La Jolla, CA 92037, USA
J Bone Joint Surg Am 85:85-93. 2003..The presence of a functioning posterior cruciate ligament and the design parameters of a total knee arthroplasty, such as trochlear groove alignment and cam-post configuration, can have a major effect on patellar biomechanics... - Dosing and timing of low-molecular-weight heparin thromboprophylaxis in total hip arthroplastyClifford W Colwell
Scripps Clinic, La Jolla, Calif 92037, USA
Orthopedics 26:1155-61; quiz 1162-3. 2003 - Comparison of ximelagatran with warfarin for the prevention of venous thromboembolism after total knee replacementCharles W Francis
Department of Medicine, University of Rochester, Rochester, NY, USA
N Engl J Med 349:1703-12. 2003..The purpose of the present study was to determine whether a higher dose of ximelagatran is superior to warfarin... - Polyethylene cross-linking by two different methods reduces acetabular liner wear in a hip joint wear simulatorJuan C Hermida
Joint Mechanics Laboratory, Scripps Clinic Center for Orthopaedic Research and Education, 11025 N Torrey Pines Road, Ste 140, La Jolla, CA 92037, USA
J Orthop Res 21:761-6. 2003..The differences in wear rates between the two highly cross-linked polyethylene designs (9.5 EB or 10 Gamma) are probably too small to be clinically significant... - Blood conservation in primary total hip arthroplastyMatthew S Hepinstall
Lenox Hill Hospital, New York, NY, USA
J South Orthop Assoc 12:95-102. 2003.... - Polyethylene wear and acetabular component orientationShantanu Patil
Orthopaedic Research Laboratories, Scripps Clinic Center for Orthopaedic Research and Education, La Jolla, CA 92037, USA
J Bone Joint Surg Am 85:56-63. 2003..CONCLUSION: All three studies presented here underlined the importance of optimizing the position of the acetabular component. Careful attention to acetabular position may help to minimize wear... - Ximelagatran versus warfarin for the prevention of venous thromboembolism after total knee arthroplasty. A randomized, double-blind trialCharles W Francis
University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
Ann Intern Med 137:648-55. 2002..Ximelagatran, an oral direct thrombin inhibitor, has shown promising efficacy and tolerability in patients undergoing total hip or knee arthroplasty... - Venous thromboembolic disease prophylaxis in patients undergoing orthopedic surgery of the lower extremityClifford W Colwell
Musculoskeletal Center, Scripps Clinic, La Jolla, California, USA
Am J Orthop 31:2-3. 2002 - Efficacy of fondaparinux for thromboprophylaxis in hip fracture patientsBengt I Eriksson
Sahlgrenska Univesrity Hospital/Ostra, , Sweden
J Arthroplasty 19:78-81. 2004..063). Risk of VTE was continued following short course fondaparinux in hip fracture patients, but was significantly reduced by extending prophylaxis, without significant risk of major bleeding... - The efficacy of a single daily dose of enoxaparin for deep vein thrombosis prophylaxis following total knee arthroplastyPamela A Pulido
Scripps Center for Orthopaedic Research and Education, La Jolla, CA 92037, USA
Orthopedics 27:1185-7. 2004..7% (7) on postoperative day 21. No new DVT or propagation of distal to proximal DVT were noted. For this small cohort, enoxaparin 40 mg daily demonstrates effective prophylaxis for DVT in TKA patients... - An implantable telemetry device to measure intra-articular tibial forcesChristopher P Townsend
Orthopaedic Research Laboratories, Scripps Clinic Center for Orthopaedic Research and Education, CA 92037, USA
J Biomech 38:299-304. 2005..Reasonable accuracy was obtained in measuring loads applied through a polyethylene insert. The implant was also able to detect unicondylar loading with liftoff... - Fatal vascular outcomes following major orthopedic surgeryOla E Dahl
Thrombosis Research Institute, London, UK
Thromb Haemost 93:860-6. 2005..In conclusion, although prophylaxis results in a reduction in overall mortality and fatal pulmonary embolism, vascular events continue to be a common cause of mortality... - The Chitranjan Ranawat Award: in vivo knee forces after total knee arthroplastyDARRYL D D'LIMA
Orthopaedic Research Laboratories, Shiley Center for Orthopaedic Research and Education at Scripps Clinic, La Jolla, CA 92037, USA
Clin Orthop Relat Res 440:45-9. 2005..This should lead to refined surgical techniques and to enhanced prosthetic designs that will improve patient function, patient quality of life, and longevity of total knee arthroplasty implants... - Patient compliance with outpatient prophylaxis: an observational studyClifford W Colwell
Scripps Clinic, La Jolla, CA 92037, USA
Orthopedics 28:143-7. 2005..With shorter hospital stays, self-administration of low molecular weight heparin may optimize the clinical outcomes of orthopedic patients... - Patellofemoral forces after total knee arthroplasty: effect of extensor moment armChristopher Browne
Orthopaedic Research Laboratories, Scripps Clinic Center for Orthopaedic Research and Education, 11025 N Torrey Pines Road, Suite 140, La Jolla, CA 92037, USA
Knee 12:81-8. 2005..Reduction in patellofemoral forces could reduce patellar complications such as anterior knee pain, component wear, and loosening... - Prevention of venous thromboembolismWilliam Geerts
Chest 128:3775-6. 2005 - Can normal knee kinematics be restored with unicompartmental knee replacement?Shantanu Patil
Orthopaedic Research Laboratories, Scripps Clinic Center for Orthopaedic Research and Education, 11025 North Torrey Pines Road, Suite 140, La Jolla, CA 92037, USA
J Bone Joint Surg Am 87:332-8. 2005..To test this hypothesis, knee kinematics and quadriceps tension were recorded before and after replacement with a unicompartmental design and then with a tricompartmental design... - Hydroxyapatite-coated femoral stem survivorship at 10 yearsGregory Y Lee
Shiley Center for Orthopedic Research and Education at Scripps Clinic, Department of Orthopedic Surgery, La Jolla, California 92037, USA
J Arthroplasty 20:57-62. 2005..24 mm/y. Lysis was noted in 23% of the cups. No patient developed femoral lysis distally. This hydroxyapatite-coated stem continues to perform well and appears to protect against the migration of wear debris along the femoral stem... - Flexibility in administration of fondaparinux for prevention of symptomatic venous thromboembolism in orthopaedic surgeryClifford W Colwell
Shiley Center for Orthopaedic Research and Education at Scripps Clinic, La Jolla, California 92037-1030, USA
J Arthroplasty 21:36-45. 2006..2% and 0.7% [P = .19], and 1.4% and 2.0% [P = .31], respectively). Delaying initiation of fondaparinux prophylaxis provides an option after total joint arthroplasty with preserved efficacy and safety... - Managing thromboembolic risk in hip and knee arthroplasty: state of the artClifford W Colwell
Scripps Clinic, Torrey Pines, La Jolla, Calif, USA
Orthopedics 26:s231-6. 2003..Supporting medical evidence for these recommendations is described. A summary of current prophylactic regimens and discussion of duration of therapy are also presented... - Bilateral vs unilateral total knee arthroplasty: a patient-based comparison of pain levels and recovery of ambulatory skillsRobert S Powell
Scripps Clinic, Division of Orthopaedic Surgery, La Jolla, California 92037, USA
J Arthroplasty 21:642-9. 2006..Ambulatory milestones lagged behind by 36 hours. Patients wishing to pursue bilateral TKA can proceed without pain, use of narcotics, and walking distance significantly different than unilateral TKA... - A multiaxial force-sensing implantable tibial prosthesisBryan Kirking
Orthopaedic Research Laboratories, Shiley Center for Orthopaedic Research and Education at Scripps Clinic, CA, USA
J Biomech 39:1744-51. 2006..Additional uses are intraoperative measurement of forces to determine soft-tissue balancing and to evaluate the effects of rehabilitation, external bracing, and athletic activities, and activities of daily living... - What's new in orthopaedic rehabilitationMichael J Botte
Division of Orthopaedic Surgery, Scripps Clinic, La Jolla California 92037, USA
J Bone Joint Surg Am 84:2312-20. 2002 - The use of the pain pump and patient-controlled analgesia in joint reconstructionClifford W Colwell
Musculoskeletal Center, Scripps Clinic, La Jolla, California, USA
Am J Orthop 33:10-2. 2004..Continuous infusion of bupivacaine via pain pump is also an effective modality for reducing postoperative pain and decreasing postoperative consumption of opioid analgesics... - Improving tibial component coronal alignment during total knee arthroplasty with use of a tibial planing deviceShantanu Patil
Shiley Center for Orthopaedic Research and Education at Scripps Clinic, 11025 North Torrey Pines Road, Suite 140, La Jolla, CA 92037, USA
J Bone Joint Surg Am 89:381-7. 2007..However, there are outliers representing >3 degrees of varus or valgus alignment with respect to the anatomic tibial shaft axis. We measured the efficacy of a custom tibial planing device for reducing the outliers in tibial alignment... - Outcome of an acetabular design with hydroxyapatite coating on a rough substrateJuan C Hermida
Shiley Center for Orthopaedic Research and Education, Scripps Clinic, La Jolla, CA 92037, USA
Clin Orthop Relat Res 441:298-304. 2005..Level of Evidence: Therapeutic study, Level IV (case series). See the Guidelines for Authors for a complete description of levels of evidence...