Barry Coller

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. pmc Traversing the valley of death: a guide to assessing prospects for translational success
    Barry S Coller
    The Rockefeller University, New York, NY, USA
    Sci Transl Med 1:10cm9. 2009
  2. pmc The physician-scientist, the state, and the oath: thoughts for our times
    Barry S Coller
    Laboratory of Blood and Vascular Biology, Rockefeller University, New York, New York 10021, USA
    J Clin Invest 116:2567-70. 2006
  3. ncbi request reprint Leukocytosis and ischemic vascular disease morbidity and mortality: is it time to intervene?
    Barry S Coller
    The Rockefeller University, 1230 York Ave, New York, NY 10021, USA
    Arterioscler Thromb Vasc Biol 25:658-70. 2005
  4. pmc The GPIIb/IIIa (integrin alphaIIbbeta3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend
    Barry S Coller
    Laboratory of Blood and Vascular Biology, The Rockefeller University, New York, NY, USA
    Blood 112:3011-25. 2008
  5. ncbi request reprint Mechanistic insights from a refined three-dimensional model of integrin alphaIIbbeta3
    Marta Filizola
    Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Biol Chem 279:24624-30. 2004
  6. pmc Structural and therapeutic insights from the species specificity and in vivo antithrombotic activity of a novel alphaIIb-specific alphaIIbbeta3 antagonist
    Robert Blue
    Laboratory of Blood and Vascular Biology, Rockefeller University, New York, NY 10065, USA
    Blood 114:195-201. 2009
  7. pmc Functional and computational studies of the ligand-associated metal binding site of beta3 integrins
    Marta Murcia
    Department of Structural and Chemical Biology, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Proteins 71:1779-91. 2008
  8. ncbi request reprint Dynamics of GPIIb/IIIa-mediated platelet-platelet interactions in platelet adhesion/thrombus formation on collagen in vitro as revealed by videomicroscopy
    Dipti Patel
    Laboratory of Blood and Vascular Biology, The Rockefeller University, New York, NY 10021, USA
    Blood 101:929-36. 2003
  9. ncbi request reprint Two novel mutations in the alpha IIb calcium-binding domains identify hydrophobic regions essential for alpha IIbbeta 3 biogenesis
    W Beau Mitchell
    Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Blood 101:2268-76. 2003
  10. pmc Ligand density dramatically affects integrin alpha IIb beta 3-mediated platelet signaling and spreading
    Marketa Jirouskova
    Laboratory of Blood and Vascular Biology, Rockefeller University, New York, NY 10021, USA
    Blood 109:5260-9. 2007

Collaborators

Detail Information

Publications35

  1. pmc Traversing the valley of death: a guide to assessing prospects for translational success
    Barry S Coller
    The Rockefeller University, New York, NY, USA
    Sci Transl Med 1:10cm9. 2009
    ..Although this preliminary tool will require validation and adjustment, we offer it to stimulate a discussion about more rigorous methods for selecting and conducting translational projects...
  2. pmc The physician-scientist, the state, and the oath: thoughts for our times
    Barry S Coller
    Laboratory of Blood and Vascular Biology, Rockefeller University, New York, New York 10021, USA
    J Clin Invest 116:2567-70. 2006
    ..Careful analysis of historical examples of abuses of human rights committed in the name of medical science or the state is an important mechanism to safeguard current and future human participants...
  3. ncbi request reprint Leukocytosis and ischemic vascular disease morbidity and mortality: is it time to intervene?
    Barry S Coller
    The Rockefeller University, 1230 York Ave, New York, NY 10021, USA
    Arterioscler Thromb Vasc Biol 25:658-70. 2005
    ....
  4. pmc The GPIIb/IIIa (integrin alphaIIbbeta3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend
    Barry S Coller
    Laboratory of Blood and Vascular Biology, The Rockefeller University, New York, NY, USA
    Blood 112:3011-25. 2008
    ....
  5. ncbi request reprint Mechanistic insights from a refined three-dimensional model of integrin alphaIIbbeta3
    Marta Filizola
    Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Biol Chem 279:24624-30. 2004
    ..In addition, it suggests mechanistic hypotheses pertaining to both naturally occurring mutations responsible for Glanzmann thrombasthenia and to point mutations that affect ligand binding...
  6. pmc Structural and therapeutic insights from the species specificity and in vivo antithrombotic activity of a novel alphaIIb-specific alphaIIbbeta3 antagonist
    Robert Blue
    Laboratory of Blood and Vascular Biology, Rockefeller University, New York, NY 10065, USA
    Blood 114:195-201. 2009
    ..Collectively, these data support RUC-1's specificity for alphaIIb, provide new insights into the alphaIIb binding pocket, and establish RUC-1's antithrombotic effects in vivo...
  7. pmc Functional and computational studies of the ligand-associated metal binding site of beta3 integrins
    Marta Murcia
    Department of Structural and Chemical Biology, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Proteins 71:1779-91. 2008
    ..Our computational results indicate that the LIMBS plays a crucial role in ligand binding to alphaIIbeta3 by virtue of its effects on the coordination of the MIDAS...
  8. ncbi request reprint Dynamics of GPIIb/IIIa-mediated platelet-platelet interactions in platelet adhesion/thrombus formation on collagen in vitro as revealed by videomicroscopy
    Dipti Patel
    Laboratory of Blood and Vascular Biology, The Rockefeller University, New York, NY 10021, USA
    Blood 101:929-36. 2003
    ..Thus, in this model system, absence or blockade of GPIIb/IIIa receptors interferes with thrombus formation and alters the pattern of platelet deposition...
  9. ncbi request reprint Two novel mutations in the alpha IIb calcium-binding domains identify hydrophobic regions essential for alpha IIbbeta 3 biogenesis
    W Beau Mitchell
    Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Blood 101:2268-76. 2003
    ..These data suggest that the alphaIIb calcium-binding domains play a key structural role in the beta-propeller, and that the structural integrity of the calcium-binding domains is critical for integrin biogenesis...
  10. pmc Ligand density dramatically affects integrin alpha IIb beta 3-mediated platelet signaling and spreading
    Marketa Jirouskova
    Laboratory of Blood and Vascular Biology, Rockefeller University, New York, NY 10021, USA
    Blood 109:5260-9. 2007
    ..We conclude that 2 fundamentally different signaling mechanisms can be initiated by a single integrin receptor interacting with the same ligand when it is immobilized at different densities...
  11. doi request reprint Creating an ontology-based human phenotyping system: The Rockefeller University bleeding history experience
    Andreas C Mauer
    The Rockefeller University, New York, New York, USA
    Clin Transl Sci 2:382-5. 2009
    ..Thus, this system can increase the power to detect genotype-phenotype-environment relationships and help new investigators begin their studies. We anticipate that this approach may be applicable to other disorders...
  12. pmc In vitro and in vivo evidence for shear-induced activation of latent transforming growth factor-beta1
    Jasimuddin Ahamed
    Laboratory of Blood and Vascular Biology, The Rockefeller University, New York, NY 10065, USA
    Blood 112:3650-60. 2008
    ..Release and activation of latent TGF-beta1 in vivo was demonstrated in a mouse model 5 minutes after thrombus formation. These data potentially provide a novel mechanism for in vivo activation of TGF-beta1...
  13. ncbi request reprint Antibody blockade or mutation of the fibrinogen gamma-chain C-terminus is more effective in inhibiting murine arterial thrombus formation than complete absence of fibrinogen
    Marketa Jirouskova
    Rockefeller University, Box 309, 1230 York Ave, New York, NY 10021, USA
    Blood 103:1995-2002. 2004
    ....
  14. pmc In vitro and in vivo evidence that thrombospondin-1 (TSP-1) contributes to stirring- and shear-dependent activation of platelet-derived TGF-beta1
    Jasimuddin Ahamed
    Laboratory of Blood and Vascular Biology, The Rockefeller University, New York, NY, USA
    PLoS ONE 4:e6608. 2009
    ....
  15. pmc alphaIIbbeta3 biogenesis is controlled by engagement of alphaIIb in the calnexin cycle via the N15-linked glycan
    W Beau Mitchell
    Mount Sinai School of Medicine, Rockefeller University, New York, NY 10021, USA
    Blood 107:2713-9. 2006
    ..Our findings suggest that pro-alphaIIb engages the calnexin cycle via the N15 glycan and that failure of pro-alphaIIb to complex normally with beta3 results in proteasomal degradation...
  16. pmc Morphological and functional platelet abnormalities in Berkeley sickle cell mice
    Arun S Shet
    The Laboratory of Blood and Vascular Biology, Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Blood Cells Mol Dis 41:109-18. 2008
    ..Thus, additional studies are needed to assess whether large platelets contribute either to pulmonary hypertension or the large vessel arterial occlusion that produces stroke in some children with sickle cell disease...
  17. ncbi request reprint Two new beta3 integrin mutations in Indian patients with Glanzmann thrombasthenia: localization of mutations affecting cysteine residues in integrin beta3
    Sona Nair
    Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Thromb Haemost 88:503-9. 2002
    ..Patient 2 had an insertion mutation resulting in a frameshift and premature termination. Both mutations affect biogenesis of platelet alphaIIbbeta3 receptors...
  18. pmc Effects of limiting extension at the alphaIIb genu on ligand binding to integrin alphaIIbbeta3
    Robert Blue
    Laboratory of Blood and Vascular Biology, The Rockefeller University, New York, New York 10021, USA
    J Biol Chem 285:17604-13. 2010
    ..Our data are consistent with alphaIIb extension resulting in increased access to the ligand-binding site and/or facilitating the conformational change(s) in beta3 that affect the intrinsic affinity of the binding pocket for ligand...
  19. pmc Application of high-throughput screening to identify a novel alphaIIb-specific small- molecule inhibitor of alphaIIbbeta3-mediated platelet interaction with fibrinogen
    Robert Blue
    Laboratory of Blood and Vascular Biology, The Rockefeller University, New York, NY 10021, USA
    Blood 111:1248-56. 2008
    ..Compound 1 provides a prototype for small molecule selective inhibition of alphaIIbbeta3, without receptor priming, via targeting alphaIIb...
  20. pmc Primary role for adherent leukocytes in sickle cell vascular occlusion: a new paradigm
    Aslihan Turhan
    Department of Medicine, Mount Sinai School of Medicine, 1 Gustave Levy Place, Box 1079, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 99:3047-51. 2002
    ....
  21. pmc Integrin beta3 regions controlling binding of murine mAb 7E3: implications for the mechanism of integrin alphaIIbbeta3 activation
    Andrea Artoni
    Laboratory of Blood and Vascular Biology, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:13114-20. 2004
    ..Thus, our data are consistent with alphaIIbbeta3 existing in variably bent conformations in equilibrium with each other on unactivated platelets, and activation resulting in alphaIIbbeta3 adopting a more extended conformation...
  22. pmc Mapping early conformational changes in alphaIIb and beta3 during biogenesis reveals a potential mechanism for alphaIIbbeta3 adopting its bent conformation
    W Beau Mitchell
    Department of Pediatrics, Mount Sinai School of Medicine, and New York Blood Center, 310 E 67th Street, New York, NY 10021, USA
    Blood 109:3725-32. 2007
    ..Our data suggest a working model in which pro-alphaIIb adopts a bent conformation soon after synthesis, and then beta3 assumes its bent conformation by virtue of its interaction with the bent pro-alphaIIb...
  23. ncbi request reprint Intravenous immune globulin prevents venular vaso-occlusion in sickle cell mice by inhibiting leukocyte adhesion and the interactions between sickle erythrocytes and adherent leukocytes
    Aslihan Turhan
    Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1079, New York, NY 10029, USA
    Blood 103:2397-400. 2004
    ..These data raise the possibility that i.v.IG may have a beneficial effect on sickle cell-associated vaso-occlusion...
  24. ncbi request reprint Science and humanism: the twin pillars of medicine
    Barry S Coller
    Laboratory of Blood and Vascular Biology, The Rockefeller University, New York, NY 10021, USA
    Mt Sinai J Med 69:277-9. 2002
  25. pmc Targeted molecular dynamics reveals overall common conformational changes upon hybrid domain swing-out in beta3 integrins
    Davide Provasi
    Department of Structural and Chemical Biology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Proteins 77:477-89. 2009
    ..Taken together, our results suggest novel testable hypotheses of intradomain and interdomain interactions responsible for beta3 integrin activation...
  26. ncbi request reprint Evidence for megakaryocyte engraftment following reduced-intensity conditioning
    Deborah L French
    Departments of Medicine and Pediatrics, Mount Sinai School of Medicine, New York, NY, USA
    Exp Hematol 32:877-80. 2004
    ..In this study we show that at 23 weeks post-RIC, a leukemia patient acquired the HPA-3 donor phenotype at the DNA and platelet RNA levels...
  27. ncbi request reprint Fibrin but not adsorbed fibrinogen supports fibronectin assembly by spread platelets. Effects of the interaction of alphaIIb beta3 with the C terminus of the fibrinogen gamma-chain
    Jaehyung Cho
    Molecular and Cellular Pharmacology Program and Department of Medicine, University of Wisconsin Madison School of Medicine, Madison, Wisconsin 53706, USA
    J Biol Chem 280:35490-8. 2005
    ..This interaction is less dominant when platelets adhere to fibrin, resulting in enhanced fibronectin assembly...
  28. ncbi request reprint Disulfide bond disruption by a beta 3-Cys549Arg mutation in six Jordanian families with Glanzmann thrombasthenia causes diminished production of constitutively active alpha IIb beta 3
    Ronit Mor-Cohen
    Amalia Biron Research Institute of Thrombosis and Hemostasis, Chaim Sheba Medical Center, Tel Hashomer, Israel 52621
    Thromb Haemost 98:1257-65. 2007
    ..In conclusion, the novel ancestral mutation found in a cluster of Jordanian GT patients disrupts a conserved Cys549-Cys558 bond which results in reduced production of constitutively active alpha IIb beta 3...
  29. ncbi request reprint Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics
    Tsan Xiao
    The CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 432:59-67. 2004
    ..Allostery in the head thus disrupts interaction between the legs in a previously described low-affinity bent integrin conformation, and leg extension positions the high-affinity head far above the cell surface...
  30. pmc Biography of Barry S. Coller
    Christen Brownlee
    Proc Natl Acad Sci U S A 101:13111-3. 2004
  31. ncbi request reprint Adjuvant treatment with a glycoprotein IIb/IIIa receptor inhibitor increases the therapeutic window for low-dose tissue plasminogen activator administration in a rat model of embolic stroke
    Li Zhang
    Department of Neurology, Henry Ford Health Sciences Center, Detroit, Mich, USA
    Circulation 107:2837-43. 2003
    ....
  32. ncbi request reprint Monocyte-derived tissue factor contributes to stent thrombosis in an in vitro system
    Tullio Palmerini
    Istituto di Cardiologia, Policlinico S Orsola, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy
    J Am Coll Cardiol 44:1570-7. 2004
    ..This study evaluated the role of circulating tissue factor (TF) in mediating thrombus formation on stents in an in vitro model of stent perfusion...
  33. ncbi request reprint Effects of abciximab on the acute pathology of blood vessels after arterial stenting in nonhuman primates
    Tullio Palmerini
    Istituto di Cardiologia, Policlinico S Orsola, University of Bologna, Bologna, Italy
    J Am Coll Cardiol 40:360-6. 2002
    ..This study was designed to assess the effect of abciximab on platelet and leukocyte deposition 60 min after stent insertion in nonhuman primates...
  34. ncbi request reprint Professing and living the oath: teaching medicine as a profession
    Barry S Coller
    Am J Med 112:744-8. 2002
  35. ncbi request reprint Molecular diversity of Glanzmann thrombasthenia in southern India: new insights into mRNA splicing and structure-function correlations of alphaIIbbeta3 integrin (ITGA2B, ITGB3)
    Hava Peretz
    Clinical Biochemistry Laboratory, Sourasky Medical Center, Tel Aviv, Israel
    Hum Mutat 27:359-69. 2006
    ....

Research Grants20

  1. Transforming Clinical and Translational Research and Education at Rockefeller
    Barry Coller; Fiscal Year: 2007
    ..It will also eagerly adopt the best practices identified by the Consortium and adhere to the standardsset by the Consortium. ..
  2. High Throughput Screen for Novel Inhibitors of Platelet Integrin alphaIIb-beta3
    Barry Coller; Fiscal Year: 2007
    ....
  3. Transforming Clinical and Translational Research and Education at Rockefeller
    Barry Coller; Fiscal Year: 2007
    ..It will also eagerly adopt the best practices identified by the Consortium and adhere to the standards set by the Consortium...
  4. Beta-3 Integrins in Platelet and Vasoocclusive Disorders
    Barry Coller; Fiscal Year: 2007
    ..B. The impact of breeding either P-selectin deficiency or beta3 deficiency into Berkeley sickle cell mice on erythrocyte survival, organ damage, and microvascular occlusion. ..
  5. Information Technology To Enhance IRB Functions
    Barry Coller; Fiscal Year: 2002
    ..The Physician-in-Chief, Dr. Barry Coller, has led the recruitments and the University Oversight of Protection of Human Subjects Committee. Dr...
  6. Novel On-line Education in Protection of Human Subjects
    Barry Coller; Fiscal Year: 2003
    ..The Physician-in-Chief, Dr. Barry Coller, has led key recruitments and the University Oversight of Protection of Human Subjects Committee. Dr...
  7. Integrin Biogenesis in Human ES-derived Megakaryocytes
    Barry Coller; Fiscal Year: 2004
    ..Gordon Keller, who has agreed to train the key personnel in HESC culture techniques. Additionally, HESC culture protocols have been designed with the advice of Dr. Gordon Keller. ..
  8. Integrin alphaIIbbeta3 Structure, Activation, and Ligand Binding
    Barry Coller; Fiscal Year: 2010
    ..Finally, using new high throughput technology, we hope to identify new compounds that may form the basis of improved therapies for heart attack and stroke. ..