Thomas Coleman

Summary

Affiliation: The Kenneth S. Warren Institute
Country: USA

Publications

  1. pmc Science review: recombinant human erythropoietin in critical illness: a role beyond anemia?
    Thomas Coleman
    The Kenneth S Warren Institute, Kitchawan, New York, USA
    Crit Care 8:337-41. 2004
  2. pmc Cytoprotective doses of erythropoietin or carbamylated erythropoietin have markedly different procoagulant and vasoactive activities
    Thomas R Coleman
    The Kenneth S Warren Institute, Warren Pharmaceuticals, Ossining, NY 10562, USA
    Proc Natl Acad Sci U S A 103:5965-70. 2006
  3. pmc Nonerythropoietic, tissue-protective peptides derived from the tertiary structure of erythropoietin
    Michael Brines
    Warren Pharmaceuticals, Ossining, NY 10562, USA
    Proc Natl Acad Sci U S A 105:10925-30. 2008
  4. pmc Erythropoietin mediates tissue protection through an erythropoietin and common beta-subunit heteroreceptor
    Michael Brines
    Kenneth S Warren Institute, Ossining, NY 10563, USA
    Proc Natl Acad Sci U S A 101:14907-12. 2004
  5. pmc Asialoerythropoietin is a nonerythropoietic cytokine with broad neuroprotective activity in vivo
    Serhat Erbayraktar
    The Kenneth S Warren Institute, Kitchawan, NY 10562, USA
    Proc Natl Acad Sci U S A 100:6741-6. 2003
  6. pmc Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis
    Pia Villa
    Mario Negri Institute for Pharmacological Research, 20157, Milan, Italy
    J Exp Med 198:971-5. 2003
  7. pmc Carbamylated erythropoietin reduces radiosurgically-induced brain injury
    Serhat Erbayraktar
    Dokuz Eylul School of Medicine, Izmir, Turkey
    Mol Med 12:74-80. 2006
  8. pmc Carbamylated erythropoietin ameliorates the metabolic stress induced in vivo by severe chronic hypoxia
    Monica Fantacci
    Department of Medicine, University of Milan, San Paolo Hospital, Milan 20142, Italy
    Proc Natl Acad Sci U S A 103:17531-6. 2006

Collaborators

  • Michael Brines
  • Giovanni Grasso
  • Christof Westenfelder
  • Livius V d'Uscio
  • Kenneth Kaushansky
  • P Ghezzi
  • Nimesh S A Patel
  • Anthony Cerami
  • Serhat Erbayraktar
  • Pia Villa
  • Monica Fantacci
  • Zubeyde Erbayraktar
  • Osman Yilmaz
  • Paola Bianciardi
  • Anna Caretti
  • Nihal de Lanerolle
  • Jonathan P S Knisely
  • Alain de Lotbiniere
  • Michele Samaja
  • Lars Østergaard Pedersen
  • Necati Gokmen
  • Paolo Bigini
  • Marina Marinovich
  • Barbara Viviani
  • Carla Cerami-Hand
  • Lone Helboe
  • Jean Paul Wuerth
  • Marcel Leist
  • Qiao wen Xie
  • Maddalena Fratelli
  • Thomas Sager
  • Teresa Laragione
  • Simona Casagrande
  • Alessandra Sfacteria
  • Davide Agnello
  • Jens Gerwein
  • Lars Torup
  • Mads Kreilgaard
  • Søren Christensen
  • Marie Aavang Geist
  • Tiziana Mennini
  • Alfredo Cagnotto

Detail Information

Publications8

  1. pmc Science review: recombinant human erythropoietin in critical illness: a role beyond anemia?
    Thomas Coleman
    The Kenneth S Warren Institute, Kitchawan, New York, USA
    Crit Care 8:337-41. 2004
    ..Here, we speculate on the potential utility of EPO as a protective cytokine in the context of acute critical illness and suggest key parameters required for a proof-of-concept clinical study...
  2. pmc Cytoprotective doses of erythropoietin or carbamylated erythropoietin have markedly different procoagulant and vasoactive activities
    Thomas R Coleman
    The Kenneth S Warren Institute, Warren Pharmaceuticals, Ossining, NY 10562, USA
    Proc Natl Acad Sci U S A 103:5965-70. 2006
    ..These preclinical findings suggest that nonerythropoietic tissue-protective ligands, which appear to elicit fewer adverse effects, may be especially useful in clinical settings for tissue protection...
  3. pmc Nonerythropoietic, tissue-protective peptides derived from the tertiary structure of erythropoietin
    Michael Brines
    Warren Pharmaceuticals, Ossining, NY 10562, USA
    Proc Natl Acad Sci U S A 105:10925-30. 2008
    ..Thus, the tissue-protective activities of EPO are mimicked by small, nonerythropoietic peptides that simulate a portion of EPO's three-dimensional structure...
  4. pmc Erythropoietin mediates tissue protection through an erythropoietin and common beta-subunit heteroreceptor
    Michael Brines
    Kenneth S Warren Institute, Ossining, NY 10563, USA
    Proc Natl Acad Sci U S A 101:14907-12. 2004
    ..These data support the concept that EpoR and betacR comprise a tissue-protective heteroreceptor...
  5. pmc Asialoerythropoietin is a nonerythropoietic cytokine with broad neuroprotective activity in vivo
    Serhat Erbayraktar
    The Kenneth S Warren Institute, Kitchawan, NY 10562, USA
    Proc Natl Acad Sci U S A 100:6741-6. 2003
    ..These data suggest that nonerythropoietic variants of rhEPO can cross the blood-brain barrier and provide neuroprotection...
  6. pmc Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis
    Pia Villa
    Mario Negri Institute for Pharmacological Research, 20157, Milan, Italy
    J Exp Med 198:971-5. 2003
    ..These findings suggest that rhEPO attenuates ischemia-induced inflammation by reducing neuronal death rather than by direct effects upon EPO-R-expressing inflammatory cells...
  7. pmc Carbamylated erythropoietin reduces radiosurgically-induced brain injury
    Serhat Erbayraktar
    Dokuz Eylul School of Medicine, Izmir, Turkey
    Mol Med 12:74-80. 2006
    ..These findings further extend the kinds of injury for which administration of a tissue-protective cytokine provides benefit...
  8. pmc Carbamylated erythropoietin ameliorates the metabolic stress induced in vivo by severe chronic hypoxia
    Monica Fantacci
    Department of Medicine, University of Milan, San Paolo Hospital, Milan 20142, Italy
    Proc Natl Acad Sci U S A 103:17531-6. 2006
    ..These observations therefore demonstrate that CEpo administration reduces the metabolic stress caused by severe CH, resulting in improved cellular survival independent of erythrocyte production...