Research Topics
| R S ColemanSummaryAffiliation: The Ohio State University Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
A direct and efficient total synthesis of the tubulin-binding agents ceratamine A and B; use of IBX for a remarkable heterocycle dehydrogenationRobert S Coleman
Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210, USA
Org Lett 11:2133-6. 2009..Final dehydrogenation proved remarkably facile using IBX...
Total synthesis of eupomatilones 4 and 6: structurally rearranged and atropisomerically fluxional lignan natural productsRobert S Coleman
Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210, USA
Org Lett 6:4025-8. 2004..The structure of eupomatilone 6 is revised...- Asymmetric synthesis of the dibenzocyclooctadiene lignans interiotherin a and gomisin RRobert S Coleman
Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210, USA
Org Lett 7:1849-52. 2005.... - Tandem Stille/Suzuki-Miyaura coupling of a hetero-bis-metalated diene. Rapid, one-pot assembly of polyene systemsRobert S Coleman
Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210, USA
Org Lett 7:2289-91. 2005.... - Asymmetric total synthesis of dibenzocyclooctadiene lignan natural productsRobert S Coleman
Department of Chemistry, The Ohio State University, Columbus, 43210, USA
J Org Chem 70:8932-41. 2005..The syntheses were achieved in six to eight steps from simple aromatic precursors... - Total synthesis of lucilactaene, a cell cycle inhibitor active in p53-inactive cellsRobert S Coleman
Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210 1185, USA
J Am Chem Soc 127:16038-9. 2005..Sequential Stille and Suzuki-Miyaura couplings interpolate this unique boron/tin diene into the pentaene chain. The total synthesis of lucilactaene was accomplished efficiently, in just eight linear steps... - Total synthesis of gymnoconjugatins A and BRobert S Coleman
Department of Chemistry, The Ohio State University, Columbus, Ohio 43210, USA
J Org Chem 71:9841-4. 2006..Convergent and efficient syntheses of the microbial natural products gymnoconjugatin A and B are reported and were based on a linchpin coupling strategy using a boron/tin hetero-bis-metallated butadiene system... - Total synthesis of 2'-O-methylmyxalamide D and (6E)-2'-O-methylmyxalamide DRobert S Coleman
Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, OH 43210-1185, USA
J Am Chem Soc 129:3826-7. 2007 - Dependence of DNA sequence selectivity and cell cytotoxicity on azinomycin A and B epoxyamide stereochemistryRobert S Coleman
Department of Chemistry, The Ohio State University, Columbus, OH 43210, USA
Org Lett 9:1891-4. 2007..Both species were found to have unique selectivity profiles and alkylate DNA in a manner distinct from azinomycin B. Computational docking experiments support altered binding modes for the enantiomers... - Synthesis of functional "top-half" partial structures of azinomycin a and BRobert S Coleman
Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210, USA
J Org Chem 72:7726-35. 2007..The design and synthesis of a detailed series of functional "top-half" substructures of azinomycin A and B is described... - Mitomycin synthetic studies: stereocontrolled and convergent synthesis of a fully elaborated aziridinomitosaneRobert S Coleman
Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210, USA
J Org Chem 69:7309-16. 2004.... - Divergent and stereocontrolled synthesis of the enamide side chains of oximidines I/II/III, salicylihalamides A/B, lobatamides A/D, and CJ-12,950Robert S Coleman
Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210, USA
Org Lett 6:577-80. 2004.... - A convergent approach to the mitomycin ring systemR S Coleman
Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210 1185, USA
Org Lett 3:1141-4. 2001.... - Stereocontrolled synthesis of the diene and triene macrolactones of oximidines I and II: organometallic coupling versus standard macrolactonizationR S Coleman
Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210, USA
Org Lett 3:3487-90. 2001..A comparison of the effectiveness of this protocol is made with standard macrolactonization... - Studies on the mechanism of action of azinomycin B: definition of regioselectivity and sequence selectivity of DNA cross-link formation and clarification of the role of the naphthoateRobert S Coleman
Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210 1185, USA
J Am Chem Soc 124:13008-17. 2002..A kinetic assay for agent regioselectivity was used to determine the orientation of binding and covalent cross-link formation... - Total synthesis of natural product DNA cross-linking agentsR S Coleman
Department of Chemistry, Ohio State University, 100 West 18th Avenue, Columbus, OH 43210, USA
Curr Opin Drug Discov Devel 4:435-49. 2001..This review describes recent progress on the total synthesis of four natural product families, including the mitomycins, the structurally and functionally related agent FR-900482, the bis-pyrrole isochrysohermidine and the azinomycins... - Role of the azinomycin naphthoate and central amide in sequence-dependent DNA alkylation and cytotoxicity of epoxide-bearing substructuresRobert S Coleman
Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210, USA
Org Lett 4:3545-8. 2002..g., 2). Compounds were evaluated for cytotoxicity against two breast cancer cell lines. [structure: see text].. 
Covalent cross-linking of duplex DNA using 4-thio-2'-deoxyuridine as a readily modifiable platform for introduction of reactive functionality into oligonucleotidesR S Coleman
Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, OH 43210 1185, USA
Nucleic Acids Res 25:4771-7. 1997..The sequence selectivity of cross-link formation as a function of tether topology and rigidity was examined, and the thermal stability of the modified duplexes was measured by UV melting experiments...- Cellular effects induced by the antitumor agent azinomycin BGilbert T Kelly
Department of Chemistry, Texas A and M University, College Station, Texas 77843, USA
Chem Biol 13:485-92. 2006..RT-PCR analysis validated the gene changes, and flow cytometry of azinomycin-treated yeast cells demonstrated a phenotypic S phase shift consistent with transcriptional effects... - Total synthesis of the eupomatilonesSoumya Mitra
Department of Chemistry, The Ohio State University, Columbus, OH 43210, USA
J Org Chem 72:8724-36. 2007..Full details of the total syntheses of five members of the eupomatilone family of lignans are reported... - Use of electrophilic substitution to form site-specific cross-links in DNAR M Pires
The Ohio State University, Columbus, Ohio, USA
Curr Protoc Nucleic Acid Chem . 2001.... - DNA cross-linking by azinomycin B: Monte Carlo simulations in the evaluation of sequence selectivityStefano Alcaro
Dipartimento di Scienze Farmaco Biologiche, Università di Catanzaro Magna Graecia, 88021 Roccelletta di Borgia, Catanzaro, Italy
J Med Chem 45:861-70. 2002..Synthetic work on the azinomycins and the information coming from this computational study will be important for the design of more potent or DNA sequence-selective agents based on the azinomycin skeleton... - Molecular modeling of DNA cross-linking analogues based on the azinomycin scaffoldStefano Alcaro
Dipartimento di Scienze Farmacobiologiche, Universita Magna Graecia di Catanzaro, I 88021 Roccelletta di Borgia, Catanzaro, Italy
J Chem Inf Model 45:602-9. 2005..As a result, some interesting SAR considerations have been highlighted and a cross-linking conformation different from that of the azinomycin was identified in a less potent, simplified analogue... - Complex local dynamics in DNA on the picosecond and nanosecond time scalesEric B Brauns
Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, USA
Phys Rev Lett 88:158101. 2002..Sequence dependence of the localized dynamics of DNA does not appear within this time range. We infer that 30%-50% of the relaxation is faster than 40 ps, has a nonlogarithmic decay and has a sequence dependent amplitude... - Nanoscale structure and dynamics of DNAMark A Berg
Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC 29208, USA
Phys Chem Chem Phys 10:1229-42. 2008.... - Sodium-ion binding to DNA: detection by ultrafast time-resolved stokes-shift spectroscopyLatha A Gearheart
Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, USA
J Am Chem Soc 125:11812-3. 2003..Our interpretation is that a subpopulation of helices have sodium cations bound in a fashion that slows the normal dynamics... - Power-law solvation dynamics in DNA over six decades in timeDaniele Andreatta
Department of Chemistry and Biochemistry, University of South Carolina, Columbia, 29208, USA
J Am Chem Soc 127:7270-1. 2005..The various subcomponents may be so strongly coupled that their motions cannot be treated separately... - Role of monovalent counterions in the ultrafast dynamics of DNASobhan Sen
Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, USA
J Phys Chem B 110:13248-55. 2006..The lack of change in the spectral shape of the emission shows that neither the broadly distributed power-law relaxation nor the extra nanosecond dynamics are due to heterogeneity in the relaxation rates of different helices... - Effect of protein binding on ultrafast DNA dynamics: characterization of a DNA:APE1 complexSobhan Sen
Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, USA
Biophys J 89:4129-38. 2005..Stokes-shift measurements of the complex show surprisingly little change in the dynamics within the 40 ps-40 ns time range... - Ultrafast dynamics in DNA: "fraying" at the end of the helixDaniele Andreatta
Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC 29208, USA
J Am Chem Soc 128:6885-92. 2006..In addition, a new relaxation with a well-defined relaxation time of 5 ps appears. This process is assigned to the rapid component of "fraying" at the end of the helix... - Effect of lesions on the dynamics of DNA on the picosecond and nanosecond timescales using a polarity sensitive probeMark M Somoza
Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC 29208, USA
Nucleic Acids Res 32:2494-507. 2004....
Research Grants
- Asymmetric Synthesis of Cytotoxic Natural ProductsRobert Coleman; Fiscal Year: 2005..abstract_text> ..
- AZINOMYCINS--TOTAL SYNTHESIS AND MECHANISM OF ACTIONRobert Coleman; Fiscal Year: 2001....
- Azinomycins - Total Synthesis and Mechanism of ActionRobert Coleman; Fiscal Year: 2007..abstract_text> ..