D E Cohn

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. ncbi request reprint Bevacizumab and weekly taxane chemotherapy demonstrates activity in refractory ovarian cancer
    David E Cohn
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, The Ohio State University College of Medicine and Comprehensive Cancer Center, 320 West 10th Avenue, M 210 Starling Loving Hall, Columbus, OH 43210, USA
    Gynecol Oncol 102:134-9. 2006
  2. ncbi request reprint Prospective evaluation of positron emission tomography for the detection of groin node metastases from vulvar cancer
    David E Cohn
    Division of Gynecologic Oncology, Washington University School of Medicine, St Louis, Missouri, USA
    Gynecol Oncol 85:179-84. 2002
  3. ncbi request reprint HER-2 is an independent prognostic factor in endometrial cancer: association with outcome in a large cohort of surgically staged patients
    Carl Morrison
    Department of Pathology, Division of Gynecologic Oncology Center for Biostatistics, The Arthur James Cancer Hospital, and the Richard Solove Research Institute, The Ohio State University Medical School Columbus, OH 43210, USA
    J Clin Oncol 24:2376-85. 2006
  4. ncbi request reprint Screening for Lynch syndrome (hereditary nonpolyposis colorectal cancer) among endometrial cancer patients
    Heather Hampel
    Human Cancer Genetics Program, The Ohio State University Comprehensive Cancer Center, 420 West 12th Avenue, Columbus, OH 43210, USA
    Cancer Res 66:7810-7. 2006
  5. ncbi request reprint Correlation between patient weight and defects in DNA mismatch repair: is this the link between an increased risk of previous cancer in thinner women with endometrial cancer?
    D E Cohn
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, The Ohio State University College of Medicine, Columbus, Ohio, USA
    Int J Gynecol Cancer 18:136-40. 2008
  6. pmc Safe and targeted anticancer therapy for ovarian cancer using a novel class of curcumin analogs
    Kellie S Rath
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The Ohio State University, Columbus, OH 43210, USA
    J Ovarian Res 6:35. 2013
  7. pmc Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers
    Antonis C Antoniou
    Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Worts Causeway, Cambridge CB1 8RN, UK
    Breast Cancer Res 14:R33. 2012
  8. doi request reprint Reporting of quality measures in gynecologic oncology programs at Prospective Payment System (PPS)-Exempt Cancer Hospitals: An early glimpse into a challenging initiative
    David E Cohn
    The Ohio State University, Columbus, OH, USA Electronic address
    Gynecol Oncol 130:403-6. 2013
  9. doi request reprint Novel perioperative imaging with 18F-FDG PET/CT and intraoperative 18F-FDG detection using a handheld gamma probe in recurrent ovarian cancer
    David E Cohn
    The Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, Columbus, OH 43210 1228, USA
    Gynecol Oncol 110:152-7. 2008
  10. ncbi request reprint Residents' perspectives on surgical training and the resident-fellow relationship: comparing residency programs with and without gynecological oncology fellowships
    D E Cohn
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, Columbus, Ohio, USA
    Int J Gynecol Cancer 18:199-204. 2008

Detail Information

Publications79

  1. ncbi request reprint Bevacizumab and weekly taxane chemotherapy demonstrates activity in refractory ovarian cancer
    David E Cohn
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, The Ohio State University College of Medicine and Comprehensive Cancer Center, 320 West 10th Avenue, M 210 Starling Loving Hall, Columbus, OH 43210, USA
    Gynecol Oncol 102:134-9. 2006
    ..To determine the ability of patients to be treated with biweekly bevacizumab and weekly taxane chemotherapy in women with advanced, refractory ovarian cancer...
  2. ncbi request reprint Prospective evaluation of positron emission tomography for the detection of groin node metastases from vulvar cancer
    David E Cohn
    Division of Gynecologic Oncology, Washington University School of Medicine, St Louis, Missouri, USA
    Gynecol Oncol 85:179-84. 2002
    ..We set out to determine the ability of positron emission tomography with fluorodeoxyglucose to detect groin lymph node metastases from vulvar cancer...
  3. ncbi request reprint HER-2 is an independent prognostic factor in endometrial cancer: association with outcome in a large cohort of surgically staged patients
    Carl Morrison
    Department of Pathology, Division of Gynecologic Oncology Center for Biostatistics, The Arthur James Cancer Hospital, and the Richard Solove Research Institute, The Ohio State University Medical School Columbus, OH 43210, USA
    J Clin Oncol 24:2376-85. 2006
    ..To evaluate HER-2 expression and amplification in a large cohort of endometrial cancer with complete surgical staging and outcome data...
  4. ncbi request reprint Screening for Lynch syndrome (hereditary nonpolyposis colorectal cancer) among endometrial cancer patients
    Heather Hampel
    Human Cancer Genetics Program, The Ohio State University Comprehensive Cancer Center, 420 West 12th Avenue, Columbus, OH 43210, USA
    Cancer Res 66:7810-7. 2006
    ..Studying all endometrial cancer patients for Lynch syndrome using a combination of MSI and immunohistochemistry for molecular prescreening followed by gene sequencing and deletion analysis is feasible and may be desirable...
  5. ncbi request reprint Correlation between patient weight and defects in DNA mismatch repair: is this the link between an increased risk of previous cancer in thinner women with endometrial cancer?
    D E Cohn
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, The Ohio State University College of Medicine, Columbus, Ohio, USA
    Int J Gynecol Cancer 18:136-40. 2008
    ....
  6. pmc Safe and targeted anticancer therapy for ovarian cancer using a novel class of curcumin analogs
    Kellie S Rath
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The Ohio State University, Columbus, OH 43210, USA
    J Ovarian Res 6:35. 2013
    ..This article reviews some of the key findings of our work with the DAP compounds, and compares this to some of the targeted therapies currently used in ovarian cancer therapy...
  7. pmc Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers
    Antonis C Antoniou
    Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Worts Causeway, Cambridge CB1 8RN, UK
    Breast Cancer Res 14:R33. 2012
    ..2)...
  8. doi request reprint Reporting of quality measures in gynecologic oncology programs at Prospective Payment System (PPS)-Exempt Cancer Hospitals: An early glimpse into a challenging initiative
    David E Cohn
    The Ohio State University, Columbus, OH, USA Electronic address
    Gynecol Oncol 130:403-6. 2013
    ..Given this reporting mandate, we set out to determine whether the PPS-exempt gynecologic oncology programs could identify quality measures specific to the care of our patients...
  9. doi request reprint Novel perioperative imaging with 18F-FDG PET/CT and intraoperative 18F-FDG detection using a handheld gamma probe in recurrent ovarian cancer
    David E Cohn
    The Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, Columbus, OH 43210 1228, USA
    Gynecol Oncol 110:152-7. 2008
    ..We describe an innovative approach for intraoperative tumor localization and verification of tumor resection utilizing (18)F-FDG for perioperative PET/CT imaging and intraoperative gamma probe detection in ovarian cancer...
  10. ncbi request reprint Residents' perspectives on surgical training and the resident-fellow relationship: comparing residency programs with and without gynecological oncology fellowships
    D E Cohn
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, Columbus, Ohio, USA
    Int J Gynecol Cancer 18:199-204. 2008
    ..While fellows are often thought of as a detracting factor to residency training, they do not appear to affect the perception of the quality of resident surgical training...
  11. doi request reprint Comprehensive miRNA profiling of surgically staged endometrial cancer
    David E Cohn
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, Columbus, OH, USA
    Am J Obstet Gynecol 202:656.e1-8. 2010
    ..We sought to determine a microRNA (miRNA) profile of surgically staged endometrial cancers...
  12. doi request reprint At what cost does a potential survival advantage of bevacizumab make sense for the primary treatment of ovarian cancer? A cost-effectiveness analysis
    David E Cohn
    The Ohio State University College of Medicine, Columbus, OH, USA
    J Clin Oncol 29:1247-51. 2011
    ..To determine whether the addition of bevacizumab to paclitaxel and carboplatin for the primary treatment of advanced ovarian cancer can be cost effective...
  13. ncbi request reprint Non-Hodgkin's lymphoma mimicking gynecological malignancies of the vagina and cervix: a report of four cases
    D E Cohn
    Departments of Obstetrics and Gynecology, Division of Gynecologic Oncology, The Ohio State University College of Medicine, 320 West 10th Avenue, Columbus, OH 43210, USA
    Int J Gynecol Cancer 17:274-9. 2007
    ..A correct diagnosis leads to the appropriate therapy, and radical gynecological surgery can be avoided for primary cervical and vaginal lymphoma...
  14. ncbi request reprint Improved survival with an intact DNA mismatch repair system in endometrial cancer
    David E Cohn
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, The Ohio State University College of Medicine and Comprehensive Cancer Center, Columbus, Ohio 43210, USA
    Obstet Gynecol 108:1208-15. 2006
    ..To correlate survival and surgical-pathologic factors with DNA mismatch repair status in patients with endometrial cancer...
  15. ncbi request reprint Cost-effectiveness analysis of strategies for the surgical management of grade 1 endometrial adenocarcinoma
    David E Cohn
    Division of Gynecologic Oncology, Ohio State University College of Medicine, Columbus, Ohio, USA
    Obstet Gynecol 109:1388-95. 2007
    ..To estimate the costs and outcomes of various strategies used for the management of grade 1 endometrial cancer...
  16. doi request reprint Sustained progression-free survival with weekly paclitaxel and bevacizumab in recurrent ovarian cancer
    J D Hurt
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, M 210 Starling Loving Hall, 320 West 10th Avenue, Columbus, OH 43210, USA
    Gynecol Oncol 115:396-400. 2009
    ..To determine efficacy, toxicity, and survival in patients with recurrent epithelial ovarian cancer (EOC) receiving combination of weekly paclitaxel and biweekly bevacizumab (PB)...
  17. ncbi request reprint Atypical clustering of gynecologic malignancies: A family study including molecular analysis of candidate genes
    D E Cohn
    Division of Gynecologic Oncology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Gynecol Oncol 77:18-25. 2000
    ..We set out to determine whether hereditary nonpolyposis colorectal cancer (HNPCC) was responsible for cancer susceptibility in a family with gynecologic malignancies in three consecutive generations...
  18. doi request reprint Which factors predict bowel complications in patients with recurrent epithelial ovarian cancer being treated with bevacizumab?
    D L Richardson
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, M 210 Starling Loving Hall, 320 West 10th Avenue, Columbus, OH 43210, USA
    Gynecol Oncol 118:47-51. 2010
    ..We sought to identify factors associated with bowel perforation and fistula formation in recurrent EOC patients treated with bevacizumab...
  19. ncbi request reprint Radical hysterectomy for cervical cancer in obese women
    D E Cohn
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri, USA
    Obstet Gynecol 96:727-31. 2000
    ..To estimate the morbidity, adequacy of surgery, and survival of obese women undergoing radical hysterectomy and pelvic lymphadenectomy...
  20. doi request reprint Multicenter analysis of recurrence and survival in stage IIIA endometrial cancer
    Laura J Havrilesky
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Duke University Medical Cente, Durham, North Carolina 27710, USA
    Gynecol Oncol 114:279-83. 2009
    ..To determine factors related to recurrence and survival in women with stage IIIA endometrial cancer; to examine outcomes of women with IIIA1 disease...
  21. ncbi request reprint Absence of PTEN repeat tract mutation in endometrial cancers with microsatellite instability
    D E Cohn
    Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Gynecol Oncol 79:101-6. 2000
    ..We set out to investigate the relationship between MSI and PTEN mutation in a large series of primary endometrial carcinomas...
  22. ncbi request reprint Surgical staging for patients presenting with grade 1 endometrial carcinoma
    Inbar Ben-Shachar
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Arthur G James Cancer Hospital and Solove Research Institute, The Ohio State University College of Medicine and Public Health, USA
    Obstet Gynecol 105:487-93. 2005
    ..To examine the impact of surgical staging of patients presenting with grade 1 endometrial cancer...
  23. doi request reprint Outcomes following percutaneous upper gastrointestinal decompressive tube placement for malignant bowel obstruction in ovarian cancer
    K S Rath
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, The Wexner Medical Center at Ohio State University, Columbus, OH 43210, USA
    Gynecol Oncol 129:103-6. 2013
    ..The objective of this study was to evaluate peri-operative and survival outcomes of ovarian cancer patients undergoing percutaneous upper gastrointestinal decompression for malignant bowel obstruction (MBO)...
  24. doi request reprint Is selective lymphadenectomy more cost-effective than routine lymphadenectomy in patients with endometrial cancer?
    A E Clements
    Divisions of Gynecologic Oncology, Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, Columbus, OH, USA
    Gynecol Oncol 128:166-70. 2013
    ..The objective of this study is to determine the cost-effectiveness of two strategies in women undergoing surgery for newly diagnosed endometrial cancer...
  25. doi request reprint Outpatient platinum-taxane intraperitoneal chemotherapy regimen for ovarian cancer
    Leigh G Seamon
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The Ohio State University College of Medicine and Arthur G James Cancer Hospital and Solove Research Institute, Columbus, OH 43210 1228, USA
    Int J Gynecol Cancer 19:1195-8. 2009
    ..We describe the toxicity profile of an outpatient regimen of an intravenous (IV) and IP taxane-platinum chemotherapy...
  26. doi request reprint Prospective evaluation of DNA mismatch repair protein expression in primary endometrial cancer
    Floor J Backes
    The Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, Columbus, OH 43210 1228, USA
    Gynecol Oncol 114:486-90. 2009
    ..We report our experience with the prospective evaluation of MMR protein expression in endometrial cancer...
  27. doi request reprint CA125 decline in ovarian cancer patients treated with intravenous versus intraperitoneal platinum-based chemotherapy
    Debra L Richardson
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, USA
    Gynecol Oncol 111:233-6. 2008
    ..The secondary objectives are to determine if the time to normal CA125 levels and time to nadir of CA125 differ between the groups...
  28. doi request reprint Combination gemcitabine, platinum, and bevacizumab for the treatment of recurrent ovarian cancer
    Debra L Richardson
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, The Ohio State University College of Medicine, Columbus, OH, USA
    Gynecol Oncol 111:461-6. 2008
    ..To describe the response rate (RR), progression-free survival (PFS), and toxicity profile of combination gemcitabine, platinum, and bevacizumab (GPB) for the treatment of recurrent epithelial ovarian cancer (EOC)...
  29. doi request reprint Minimally invasive comprehensive surgical staging for endometrial cancer: Robotics or laparoscopy?
    Leigh G Seamon
    The Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, Columbus, OH 43210 1228, USA
    Gynecol Oncol 113:36-41. 2009
    ..To compare outcomes between robotic versus laparoscopic hysterectomy and lymphadenectomy in patients with endometrial cancer...
  30. ncbi request reprint Should the presence of lymphvascular space involvement be used to assign patients to adjuvant therapy following hysterectomy for unstaged endometrial cancer?
    David E Cohn
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Arthur G James Cancer Hospital and Solove Research Institute, The Ohio State University College of Medicine, Columbus, Ohio 43210, USA
    Gynecol Oncol 87:243-6. 2002
    ..As such, the presence of LVSI may indicate the need for lymphadenectomy or adjuvant therapy for potential regional lymph node metastases in patients with unstaged endometrial cancer...
  31. ncbi request reprint Factors predicting subcutaneous implanted central venous port function: the relationship between catheter tip location and port failure in patients with gynecologic malignancies
    D E Cohn
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, 4911 Barnes Hospital Plaza, St. Louis, Missouri 63110, USA
    Gynecol Oncol 83:533-6. 2001
    ..Confirmation of the location of the catheter tip is imperative for the long-term function of a subcutaneous implanted central venous port...
  32. ncbi request reprint Morbid obesity and endometrial cancer: surgical, clinical, and pathologic outcomes in surgically managed patients
    James C Pavelka
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The Ohio State University College of Medicine and Public Health, 320 West 10th Avenue, Columbus, OH 43210, USA
    Gynecol Oncol 95:588-92. 2004
    ..To evaluate surgical, clinical, and pathologic outcomes of patients with endometrial cancer managed with primary surgery when stratified by body mass index (BMI)...
  33. doi request reprint Sequential chemotherapy and irradiation in advanced stage endometrial cancer: A Gynecologic Oncology Group phase I trial of doxorubicin-cisplatin followed by whole abdomen irradiation
    Jeffrey M Fowler
    The Ohio State University, Gynecologic Oncology, M210 Starling Loving Hall, 320 West Tenth Avenue, Columbus, OH 43210 1228, USA
    Gynecol Oncol 112:553-7. 2009
    ..The objective of this study was to evaluate the feasibility and toxicity of delivering sequential doxorubicin-cisplatin (AC) followed by whole abdomen irradiation (WAI)...
  34. doi request reprint The detection of differentially expressed microRNAs from the serum of ovarian cancer patients using a novel real-time PCR platform
    Kimberly E Resnick
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, The Ohio State University College of Medicine, Columbus, Ohio 43210, USA
    Gynecol Oncol 112:55-9. 2009
    ..To determine the utility of serum miRNAs as biomarkers for epithelial ovarian cancer...
  35. pmc Identification of candidate epigenetic biomarkers for ovarian cancer detection
    Yi Wen Huang
    Molecular Biology and Cancer Genetics Program, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
    Oncol Rep 22:853-61. 2009
    ..Molecular therapies, by reversing the aberrant epigenomes using inhibitory agents or by abrogating the upstream signaling pathways that convey the epigenomic perturbations, may be developed into promising treatment regimens...
  36. ncbi request reprint Vaginal evisceration during intraperitoneal chemotherapy for advanced ovarian cancer
    Amy M Burkett
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, 320 West 10th Avenue, M 210 Starling Loving Hall, The Ohio State University College of Medicine and Comprehensive Cancer Center, Columbus, OH 43210, USA
    Gynecol Oncol 104:491-3. 2007
    ..We present a case of vaginal evisceration during intraperitoneal chemotherapy for advanced ovarian cancer...
  37. ncbi request reprint Outcome of reproductive age women with stage IA or IC invasive epithelial ovarian cancer treated with fertility-sparing therapy
    Jeanne M Schilder
    Department of Ob Gyn, Division of Gynecologic Oncology, Indiana University Medical Center, 535 Barnhill Drive, Rm 436, Indianapolis, IN 46202 6294, USA
    Gynecol Oncol 87:1-7. 2002
    ..The purpose of this study was to determine the recurrence rate, survival, and pregnancy outcome in patients with Stage IA and Stage IC invasive epithelial ovarian cancer treated with unilateral adnexectomy...
  38. ncbi request reprint Salvage of isolated vaginal recurrences in women with surgical stage I endometrial cancer: a multiinstitutional experience
    W K Huh
    Division of Gynecologic Oncology, University of Alabama at Birmingham, Birmingham, Alabama 35249, USA
    Int J Gynecol Cancer 17:886-9. 2007
    ....
  39. doi request reprint Are prediction models for Lynch syndrome valid for probands with endometrial cancer?
    Floor J Backes
    The Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, Columbus, OH 43210 1228, USA
    Fam Cancer 8:483-7. 2009
    ..Further studies are needed to develop models that include questions specific to patients with EMC with a greater age range, as well as placing increased emphasis on prediction of LS in probands with MSH6 mutations...
  40. doi request reprint A detailed analysis of the learning curve: robotic hysterectomy and pelvic-aortic lymphadenectomy for endometrial cancer
    Leigh G Seamon
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The Ohio State University, Columbus, Ohio 43210 1228, USA
    Gynecol Oncol 114:162-7. 2009
    ..To define the learning curve for robotic hysterectomy and pelvic-aortic lymphadenectomy for endometrial carcinoma...
  41. doi request reprint Comprehensive surgical staging for endometrial cancer in obese patients: comparing robotics and laparotomy
    Leigh G Seamon
    Divisions of Gynecologic Oncology, Department of Obstetrics and Gynecology, The Ohio State University, Columbus, Ohio, USA
    Obstet Gynecol 114:16-21. 2009
    ..To compare adequacy and outcomes of surgical staging for endometrial cancer in obese women by robotics or laparotomy...
  42. ncbi request reprint Clinical and pathologic correlates in surgical stage II endometrial carcinoma
    David E Cohn
    Division of Gynecologic Oncology, Ohio State University College of Medicine, Columbus, Ohio, USA
    Obstet Gynecol 109:1062-7. 2007
    ..To identify the surgical, pathologic, and therapeutic factors that influence outcome in patients with surgical stage II endometrial adenocarcinoma...
  43. doi request reprint Is the progression free survival advantage of concurrent gemcitabine plus cisplatin and radiation followed by adjuvant gemcitabine and cisplatin in patients with advanced cervical cancer worth the additional cost? A cost-effectiveness analysis
    B Smith
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The Ohio State University, Columbus, OH, USA Electronic address
    Gynecol Oncol 130:416-20. 2013
    ..The objective of this study is to determine whether concurrent and adjuvant chemoradiation with gemcitabine/cisplatin is cost-effective in patients with stage IIB to IVA cervical cancer...
  44. ncbi request reprint Meigs' syndrome with an elevated CA 125 from benign Brenner tumors
    B M Buttin
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University, St. Louis, Missouri 63110, USA
    Obstet Gynecol 98:980-2. 2001
    ..CONCLUSION: Cytologic or histologic confirmation of malignancy is imperative in patients with a pelvic mass, ascites, hydrothorax, and elevated CA 125 before initiating chemotherapy...
  45. ncbi request reprint Gestational trophoblastic diseases: new standards for therapy
    D E Cohn
    Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Curr Opin Oncol 12:492-6. 2000
    ..This review highlights these recent advancements in the epidemiology, genetics, diagnosis, and treatment of gestational trophoblastic disease...
  46. ncbi request reprint Is there a prognostic difference between depth of myometrial invasion and the tumor-free distance from the uterine serosa in endometrial cancer?
    Jaina Lindauer
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The Ohio State University College of Medicine and Public Health, Columbus, OH 43210, USA
    Gynecol Oncol 91:547-51. 2003
    ..The objective was to determine whether tumor-free distance from the uterine serosa is more predictive of patient outcome than depth of endometrial cancer invasion into the myometrium...
  47. ncbi request reprint Correlation of cyclooxygenase-2 (COX-2) and aromatase expression in human endometrial cancer: tissue microarray analysis
    Jeffrey M Fowler
    Division of Gynecologic Oncology, The Ohio State University Medical School, Columbus, OH 43210, USA
    Am J Obstet Gynecol 192:1262-71; discussion 1271-3. 2005
    ....
  48. doi request reprint Robotic pelvic and aortic lymphadenectomy for endometrial cancer: the console surgeon's perspectives on surgical technique and directing the assistant
    Leigh G Seamon
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, Columbus, Ohio 43210 1228, USA
    J Minim Invasive Gynecol 17:180-5. 2010
    ..Our purpose is to describe and demonstrate basic console dissection techniques in robotic hysterectomy, aortic and pelvic lymphadenectomy for endometrial carcinoma, and efficient methods to direct the assistant...
  49. doi request reprint Mismatch repair status and outcomes after adjuvant therapy in patients with surgically staged endometrial cancer
    Kimberly E Resnick
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, The Ohio State University College of Medicine and Comprehensive Cancer Center, Columbus, OH 43210, USA
    Gynecol Oncol 117:234-8. 2010
    ..To determine whether DNA mismatch repair (MMR) modifies the response to chemotherapy or radiotherapy in patients with endometrial cancer...
  50. doi request reprint Prospective evaluation of prognostic significance of the tumor-free distance from uterine serosa in surgically staged endometrial adenocarcinoma
    Katherine V Schwab
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Ohio State University College of Medicine, Columbus, Ohio 43210, USA
    Gynecol Oncol 112:146-9. 2009
    ....
  51. doi request reprint The prognostic significance of the triple negative phenotype in endometrial cancer
    Rajul Kothari
    Division of Gynecologic Oncology, University of Minnesota Medical Center, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Gynecol Oncol 118:172-5. 2010
    ..To determine if the triple negative phenotype (TNP) has prognostic significance in endometrial cancer with respect to various surgicopathologic outcomes and survival...
  52. ncbi request reprint Panniculectomy concurrent with anterior pelvic exenteration for recurrent cervical cancer
    Debra L Richardson
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, Columbus, OH, USA
    Gynecol Oncol 108:449-51. 2008
    ..Panniculectomy concurrent with gynecologic cancer surgery is safe and facilitates pelvic exposure in the morbidly obese patient...
  53. ncbi request reprint Advanced endometrial cancer with serous metastasis in a 17-year-old
    David E Cohn
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, The Ohio State University College of Medicine, 320 West 10th Avenue, M 210 Starling Loving Hall, Columbus, OH 43210, USA
    Gynecol Oncol 101:356-9. 2006
    ..We present a case of stage IIIC endometrial cancer with serous histology in a 17-year-old...
  54. ncbi request reprint Genotypic and phenotypic progression in endometrial tumorigenesis: determining when defects in DNA mismatch repair and KRAS2 occur
    D E Cohn
    Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri, USA
    Genes Chromosomes Cancer 32:295-301. 2001
    ..These discordant genotypes suggest genetic heterogeneity in endometrial hyperplasia and concomitant cancer...
  55. ncbi request reprint Association between serum levels of soluble tumor necrosis factor receptors/CA 125 and disease progression in patients with epithelial ovarian malignancy: a gynecologic oncology group study
    Robert A Burger
    Department of Obstetrics and Gynecology, University of California Irvine Medical Center, Orange, CA, USA
    Cancer 101:106-15. 2004
    ....
  56. doi request reprint Lynch syndrome screening strategies among newly diagnosed endometrial cancer patients
    Kimberly Resnick
    Division of Gynecologic Oncology, Department of Internal Medicine, Ohio State University College of Medicine, Columbus, OH 43210, USA
    Obstet Gynecol 114:530-6. 2009
    ..To estimate the cost-effectiveness of screening strategies for Lynch syndrome among newly diagnosed endometrial cancer patients...
  57. ncbi request reprint Liquid-based cytology for the postirradiation surveillance of women with gynecologic malignancies
    Jason D Wright
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO 63110, USA
    Gynecol Oncol 91:134-8. 2003
    ..To determine the performance of liquid-based cytology using ThinPrep in the postirradiation surveillance of women with gynecologic malignancies...
  58. doi request reprint Robotic hysterectomy and pelvic-aortic lymphadenectomy for endometrial cancer
    Leigh G Seamon
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, and the Center for Biostatistics, The Ohio State University College of Medicine, Columbus, Ohio 43210 1228, USA
    Obstet Gynecol 112:1207-13. 2008
    ..To report the learning curve and outcomes after our first 105 patients underwent robotic hysterectomy and pelvic-aortic lymphadenectomy for the comprehensive staging of endometrial cancer...
  59. ncbi request reprint The mucin expression profile of endometrial carcinoma and correlation with clinical-pathologic parameters
    Carl Morrison
    Department of Pathology, Center for Biostatistics, The Ohio State University, Columbus, OH, USA
    Appl Immunohistochem Mol Morphol 15:426-31. 2007
    ..0% vs. 39/52, 75.0%, P=0.01). No significant differences in any of the mucins were noted among the other end points evaluated. Mucin expression did not correlate with tumor grade, stage, or patient outcome...
  60. ncbi request reprint CDX2 is a useful marker of intestinal-type differentiation: a tissue microarray-based study of 629 tumors from various sites
    Lindsey B De Lott
    Department of Pathology, The Ohio State University Medical Center, Columbus, OH, USA
    Arch Pathol Lab Med 129:1100-5. 2005
    ..CDX2, a critical nuclear transcription factor for intestinal development, is expressed in intestinal epithelium and adenocarcinomas...
  61. ncbi request reprint A multi-institutional review of outcomes of endometrial stromal sarcoma
    Charles A Leath
    Department of Obstetrics, Division of Gynecologic Oncology, The University of Alabama at Birmingham, Birmingham, AL, USA
    Gynecol Oncol 105:630-4. 2007
    ..To compare the clinical behavior and outcomes of low- and high-grade endometrial stromal sarcomas (LGESS and HGESS), respectively...
  62. ncbi request reprint Invasive cervical adenocarcinoma immediately following a cone biopsy for adenocarcinoma in situ with negative margins
    David E Cohn
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, The Ohio State University College of Medicine and Public Health, 320 West 10th Avenue, M 210 Starling Loving Hall, Columbus, OH 43210, USA
    Gynecol Oncol 98:158-60. 2005
    ..This case challenges the concept of conservative management of cervical adenocarcinoma in situ...
  63. ncbi request reprint Pre-emptive analgesia in gynecologic surgical procedures: preoperative wound infiltration with ropivacaine in patients who undergo laparotomy through a midline vertical incision
    Glenn M Updike
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Ohio State University, Columbus, USA
    Am J Obstet Gynecol 188:901-5. 2003
    ..We tested the hypothesis that local anesthetic that is injected before a vertical midline abdominal incision would decrease the use of postoperative opioids...
  64. doi request reprint Immunization with synthetic VEGF peptides in ovarian cancer
    Bing Wang
    College of Biological Sciences, Department of Microbiology and Medicinal Biochemistry, The Ohio State University College of Medicine and Comprehensive Cancer Center, Columbus, OH 43210, USA
    Gynecol Oncol 119:564-70. 2010
    ..To assess the role of active immunotherapy targeting VEGF with a peptide vaccine as a potential treatment for ovarian cancer...
  65. doi request reprint Metastatic squamous cell carcinoma of the vulva to the lung confirmed with allelotyping
    Shelly M Seward
    Division of Gynecologic Oncology, Pathology, The Ohio State University College of Medicine, Columbus, OH, USA
    Int J Gynecol Pathol 28:497-501. 2009
    ..Allelotyping for loss of heterozygosity is an effective tool to establish metastasis versus synchronous primary tumors in the presence of multiple lesions, helping to direct appropriate clinical management...
  66. doi request reprint Local correction of extreme stomal prolapse following transverse loop colostomy
    Leigh G Seamon
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, The Ohio State University College of Medicine, Columbus, OH, USA
    Gynecol Oncol 111:549-51. 2008
    ..Although rarely required, surgical correction is associated with potential morbidity. We describe a novel surgical approach to repair stomal herniation that aims to decrease perioperative morbidity...
  67. ncbi request reprint Gynecologic malignancies in adolescents
    Marshall Stepanian
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The Ohio State University College of Medicine and Public Health, Columbus, OH 43210, USA
    Adolesc Med Clin 15:549-68. 2004
    ..This article focuses on the most common gynecologic cancers in pediatric and adolescent girls, with a special emphasis on treatment that maintain fertility and positive body image...
  68. pmc Current and emerging trends in Lynch syndrome identification in women with endometrial cancer
    Kimberly E Resnick
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, Columbus, OH 43210, USA
    Gynecol Oncol 114:128-34. 2009
    ..Lynch syndrome is a heritable, cancer susceptibility syndrome. This study aims to review current and emerging trends in the identification of Lynch syndrome in the endometrial cancer patient population...
  69. ncbi request reprint The role of MRI in the conservative management of endometrial cancer
    Inbar Ben-Shachar
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The Ohio State University College of Medicine and Public Health, Columbus, OH 43210, USA
    Gynecol Oncol 93:233-7. 2004
    ..Proper candidates should have disease confined to the uterus and a well-differentiated tumor. One of the evolving techniques to evaluate the extent of the disease and myometrial or cervical invasion is magnetic resonance imaging (MRI)...
  70. doi request reprint Robotic trocar site small bowel evisceration after gynecologic cancer surgery
    Leigh G Seamon
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, Columbus, OH, USA
    Obstet Gynecol 112:462-4. 2008
    ..Trocar site hernia is a known, rare complication after laparoscopic surgery. We describe a case of bowel herniation, evisceration, and bowel obstruction through an 8-mm robotic port site...
  71. ncbi request reprint Uterine papillary serous carcinoma: comparisons of outcomes in surgical Stage I patients with and without adjuvant therapy
    Warner K Huh
    University of Alabama at Birmingham, Birmingham, AL 35249, USA
    Gynecol Oncol 91:470-5. 2003
    ..Our aim was to determine the outcomes of Stage I uterine papillary serous carcinoma (UPSC) patients with and without adjuvant therapy after comprehensive surgical staging...
  72. pmc A gynecologic oncology group randomized phase III trial of whole abdominal irradiation (WAI) vs. cisplatin-ifosfamide and mesna (CIM) as post-surgical therapy in stage I-IV carcinosarcoma (CS) of the uterus
    Aaron H Wolfson
    Sylvester Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA
    Gynecol Oncol 107:177-85. 2007
    ..This study was designed to compare patient outcome following treatment with adjuvant whole abdominal irradiation (WAI) versus (vs.) chemotherapy for patients with this rare group of female pelvic malignancies...
  73. ncbi request reprint A comparison of stages IB1 and IB2 cervical cancers treated with radical hysterectomy. Is size the real difference?
    Teresa L Rutledge
    University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Gynecol Oncol 95:70-6. 2004
    ..To compare stages IB1 and IB2 cervical cancers treated with radical hysterectomy (RH) and to define predictors of nodal status and recurrence...
  74. ncbi request reprint Clinical activity of pertuzumab (rhuMAb 2C4), a HER dimerization inhibitor, in advanced ovarian cancer: potential predictive relationship with tumor HER2 activation status
    Michael S Gordon
    Arizona Cancer Center, Tuscon and Scottsdale, AZ, USA
    J Clin Oncol 24:4324-32. 2006
    ..Pertuzumab, a humanized antibody that prevents HER2 dimerization and inhibits multiple HER-mediated pathways, was studied in a phase II, multicenter trial in advanced, refractory OC...
  75. ncbi request reprint Surgical-pathological predictors of disease-free survival and risk groupings for IB2 cervical cancer: do the traditional models still apply?
    Scott A Kamelle
    Oklahoma Health Sciences Center, USA
    Gynecol Oncol 94:249-55. 2004
    ..To evaluate how the independent predictors of recurrence for stage IB2 cervical cancers treated with up-front radical hysterectomy apply to established risk models...
  76. ncbi request reprint Comment on: Screening for Lynch Syndrome (Hereditary Nonpolyposis Colorectal Cancer) among Endometrial Cancer Patients
    Heather Hampel
    Cancer Res 67:9603. 2007
  77. ncbi request reprint Evaluation of gemcitabine in previously treated patients with non-squamous cell carcinoma of the cervix: a phase II study of the Gynecologic Oncology Group
    Russell J Schilder
    Department of Medical Oncology, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Gynecol Oncol 96:103-7. 2005
    ..A multicenter study was conducted to evaluate the activity and toxicity of gemcitabine in patients with previously treated non-squamous cell carcinoma of the uterine cervix...
  78. ncbi request reprint Randomized trial results of quality of life comparing whole abdominal irradiation and combination chemotherapy in advanced endometrial carcinoma: A gynecologic oncology group study
    Deborah Watkins Bruner
    Department of Population Science and Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA
    Qual Life Res 16:89-100. 2007
    ..To prospectively compare quality of life (QOL) outcomes in patients with advanced endometrial cancer treated with whole abdominal irradiation (WAI) or doxorubicin-cisplatin (AP) chemotherapy...
  79. ncbi request reprint Profiling microdissected epithelium and stroma to model genomic signatures for cervical carcinogenesis accommodating for covariates
    David Gius
    Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 67:7113-23. 2007
    ....