Ehud Cohen

Summary

Affiliation: The Salk Institute
Country: USA

Publications

  1. pmc The insulin paradox: aging, proteotoxicity and neurodegeneration
    Ehud Cohen
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Rev Neurosci 9:759-67. 2008
  2. pmc Temporal requirements of insulin/IGF-1 signaling for proteotoxicity protection
    Ehud Cohen
    Howard Hughes Medical Institute, Glenn Center for Aging Research, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Aging Cell 9:126-34. 2010
  3. pmc A kinetic assessment of the C. elegans amyloid disaggregation activity enables uncoupling of disassembly and proteolysis
    Jan Bieschke
    Department of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Protein Sci 18:2231-41. 2009
  4. pmc A kinetic aggregation assay allowing selective and sensitive amyloid-β quantification in cells and tissues
    Deguo Du
    Howard Hughes Medical Institute, Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, United States
    Biochemistry 50:1607-17. 2011
  5. pmc Reduced IGF-1 signaling delays age-associated proteotoxicity in mice
    Ehud Cohen
    Howard Hughes Medical Institute, Glenn Center for Aging Research, Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 139:1157-69. 2009
  6. pmc Ageing and protein aggregation-mediated disorders: from invertebrates to mammals
    Andrew Dillin
    Howard Hughes Medical Institute, Glenn Center for Ageing Research, Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Philos Trans R Soc Lond B Biol Sci 366:94-8. 2011
  7. ncbi request reprint Opposing activities protect against age-onset proteotoxicity
    Ehud Cohen
    Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 313:1604-10. 2006
  8. pmc Scrapie-like prion protein accumulates in aggresomes of cyclosporin A-treated cells
    Ehud Cohen
    Department of Molecular Biology, The Hebrew University Hadassah Medical School, PO Box 12272, Jerusalem 91120, Israel
    EMBO J 22:404-17. 2003

Collaborators

Detail Information

Publications8

  1. pmc The insulin paradox: aging, proteotoxicity and neurodegeneration
    Ehud Cohen
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Rev Neurosci 9:759-67. 2008
    ..Here we review this apparent paradox and delineate the therapeutic potential of manipulating the insulin/IGF1 signalling pathway for the treatment of neurodegenerative diseases...
  2. pmc Temporal requirements of insulin/IGF-1 signaling for proteotoxicity protection
    Ehud Cohen
    Howard Hughes Medical Institute, Glenn Center for Aging Research, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Aging Cell 9:126-34. 2010
    ....
  3. pmc A kinetic assessment of the C. elegans amyloid disaggregation activity enables uncoupling of disassembly and proteolysis
    Jan Bieschke
    Department of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Protein Sci 18:2231-41. 2009
    ..Future discovery of the molecular basis of the disaggregation and proteolysis activities offers the promise of delaying the age-onset proteotoxicity that leads to neurodegeneration in a spectrum of maladies...
  4. pmc A kinetic aggregation assay allowing selective and sensitive amyloid-β quantification in cells and tissues
    Deguo Du
    Howard Hughes Medical Institute, Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, United States
    Biochemistry 50:1607-17. 2011
    ..An ion-exchange resin amyloid isolation strategy from complex biological samples is demonstrated as an alternative for improving the sensitivity and linearity of the kinetic aggregation assay...
  5. pmc Reduced IGF-1 signaling delays age-associated proteotoxicity in mice
    Ehud Cohen
    Howard Hughes Medical Institute, Glenn Center for Aging Research, Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 139:1157-69. 2009
    ....
  6. pmc Ageing and protein aggregation-mediated disorders: from invertebrates to mammals
    Andrew Dillin
    Howard Hughes Medical Institute, Glenn Center for Ageing Research, Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Philos Trans R Soc Lond B Biol Sci 366:94-8. 2011
    ..Here, we review these novel studies and discuss the potential of ageing alteration as a therapeutic approach for the treatment of late onset neurodegeneration...
  7. ncbi request reprint Opposing activities protect against age-onset proteotoxicity
    Ehud Cohen
    Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 313:1604-10. 2006
    ..Because the IIS pathway is central to the regulation of longevity and youthfulness in worms, flies, and mammals, these results suggest a mechanistic link between the aging process and aggregation-mediated proteotoxicity...
  8. pmc Scrapie-like prion protein accumulates in aggresomes of cyclosporin A-treated cells
    Ehud Cohen
    Department of Molecular Biology, The Hebrew University Hadassah Medical School, PO Box 12272, Jerusalem 91120, Israel
    EMBO J 22:404-17. 2003
    ..These results suggest mechanisms whereby abnormally folded cytosolic PrP may in some cases participate in the development of spontaneous and inherited prion diseases...