C J Cohen

Summary

Affiliation: The Children's Hospital of Philadelphia
Country: USA

Publications

  1. ncbi Multiple regions within the coxsackievirus and adenovirus receptor cytoplasmic domain are required for basolateral sorting
    C J Cohen
    Division of Immunologic and Infectious Diseases, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, USA
    J Biol Chem 276:25392-8. 2001
  2. pmc The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction
    C J Cohen
    Division of Immunologic and Infectious Diseases, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 98:15191-6. 2001
  3. ncbi Chimpanzee adenovirus CV-68 adapted as a gene delivery vector interacts with the coxsackievirus and adenovirus receptor
    Christopher J Cohen
    The Children s Hospital of Philadelphia, Division of Immunologic and Infectious Diseases, Abramson 1202, 3516 Civic Center Boulevard, Philadelphia, PA 19104, USA
    J Gen Virol 83:151-5. 2002
  4. pmc A zebrafish coxsackievirus and adenovirus receptor homologue interacts with coxsackie B virus and adenovirus
    JenniElizabeth Petrella
    Division of Immunologic and Infectious Diseases, The Children s Hospital of Philadelphia, 3615 Civic Center Boulevard, Philadelphia, PA 19104, USA
    J Virol 76:10503-6. 2002
  5. pmc Novel, chimpanzee serotype 68-based adenoviral vaccine carrier for induction of antibodies to a transgene product
    Zhiquan Xiang
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    J Virol 76:2667-75. 2002

Research Grants

Collaborators

Detail Information

Publications5

  1. ncbi Multiple regions within the coxsackievirus and adenovirus receptor cytoplasmic domain are required for basolateral sorting
    C J Cohen
    Division of Immunologic and Infectious Diseases, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, USA
    J Biol Chem 276:25392-8. 2001
    ..The results suggest that multiple regions within the CAR cytoplasmic domain contain information that is necessary for basolateral targeting...
  2. pmc The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction
    C J Cohen
    Division of Immunologic and Infectious Diseases, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 98:15191-6. 2001
    ..These results indicate that CAR is a component of the tight junction and of the functional barrier to paracellular solute movement. Sequestration of CAR in tight junctions may limit virus infection across epithelial surfaces...
  3. ncbi Chimpanzee adenovirus CV-68 adapted as a gene delivery vector interacts with the coxsackievirus and adenovirus receptor
    Christopher J Cohen
    The Children s Hospital of Philadelphia, Division of Immunologic and Infectious Diseases, Abramson 1202, 3516 Civic Center Boulevard, Philadelphia, PA 19104, USA
    J Gen Virol 83:151-5. 2002
    ..These results indicate that gene delivery by C68 occurs by a CAR-dependent mechanism...
  4. pmc A zebrafish coxsackievirus and adenovirus receptor homologue interacts with coxsackie B virus and adenovirus
    JenniElizabeth Petrella
    Division of Immunologic and Infectious Diseases, The Children s Hospital of Philadelphia, 3615 Civic Center Boulevard, Philadelphia, PA 19104, USA
    J Virol 76:10503-6. 2002
    ..In contrast, CAR residues contacting the south edge of the canyon are not conserved, suggesting that receptor interaction with the viral "puff region" is not essential for attachment...
  5. pmc Novel, chimpanzee serotype 68-based adenoviral vaccine carrier for induction of antibodies to a transgene product
    Zhiquan Xiang
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    J Virol 76:2667-75. 2002
    ..This novel vaccine carrier thus offers a distinct advantage over adenoviral vaccines based on common human serotypes...

Research Grants1

  1. Expression of the coxsackievirus and adenovirus receptor
    Christopher Cohen; Fiscal Year: 2002
    ..The experiments outlined below will define CAR's function in virus infection of epithelial cells, and its contribution to the formation and structure of the epithelial tight junction. ..