J L Clifford

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. ncbi request reprint Suppression of type I interferon signaling proteins is an early event in squamous skin carcinogenesis
    John L Clifford
    Departments of Clinical Cancer Prevention, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 8:2067-72. 2002
  2. ncbi request reprint Effects of novel phenylretinamides on cell growth and apoptosis in bladder cancer
    J L Clifford
    Department of Clinical Cancer Prevention The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Epidemiol Biomarkers Prev 10:391-5. 2001
  3. ncbi request reprint Dominant negative signal transducer and activator of transcription 2 (STAT2) protein: stable expression blocks interferon alpha action in skin squamous cell carcinoma cells
    John L Clifford
    Department of Clinical Cancer Prevention, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Cancer Ther 2:453-9. 2003
  4. ncbi request reprint Expression of protein mediators of type I interferon signaling in human squamous cell carcinoma of the skin
    J L Clifford
    Department of Clinical Cancer Prevention, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Cancer Epidemiol Biomarkers Prev 9:993-7. 2000
  5. ncbi request reprint Retinoid receptor-dependent and -independent effects of N-(4-hydroxyphenyl)retinamide in F9 embryonal carcinoma cells
    J L Clifford
    Department of Clinical Cancer Prevention, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Cancer Res 59:14-8. 1999
  6. ncbi request reprint Cloning and characterization of the human retinoid X receptor alpha gene: conservation of structure with the mouse homolog
    G Li
    Department of Clinical Cancer Prevention, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Biochem Biophys Res Commun 269:54-7. 2000
  7. pmc Active Stat3 is required for survival of human squamous cell carcinoma cells in serum-free conditions
    Weihong Yin
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Science Center School of Medicine in Shreveport and Feist Weiller Cancer Center, Shreveport, LA 71130, USA
    Mol Cancer 5:15. 2006
  8. ncbi request reprint Retinoids and skin: microarrays shed new light on chemopreventive action of all-trans retinoic acid
    Satish B Cheepala
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
    Mol Carcinog 46:634-9. 2007
  9. ncbi request reprint Chemoprevention of skin carcinogenesis by phenylretinamides: retinoid receptor-independent tumor suppression
    Hui Xu
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center Shreveport and the Feist Weiller Cancer Center, Shreveport, Louisiana 17730, USA
    Clin Cancer Res 12:969-79. 2006
  10. ncbi request reprint Retinoid receptor-dependent and independent biological activities of novel fenretinide analogues and metabolites
    Anita L Sabichi
    Department of Clinical Cancer Prevention, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 9:4606-13. 2003

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Suppression of type I interferon signaling proteins is an early event in squamous skin carcinogenesis
    John L Clifford
    Departments of Clinical Cancer Prevention, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 8:2067-72. 2002
    ..Our previous preliminary studies suggested suppression of some or all of the ISGF-3 proteins in skin SCC...
  2. ncbi request reprint Effects of novel phenylretinamides on cell growth and apoptosis in bladder cancer
    J L Clifford
    Department of Clinical Cancer Prevention The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Epidemiol Biomarkers Prev 10:391-5. 2001
    ..These in vitro findings warrant further study of these novel phenylretinamides, which may have potential as preventive or therapeutic agents in transitional cell cancer...
  3. ncbi request reprint Dominant negative signal transducer and activator of transcription 2 (STAT2) protein: stable expression blocks interferon alpha action in skin squamous cell carcinoma cells
    John L Clifford
    Department of Clinical Cancer Prevention, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Cancer Ther 2:453-9. 2003
    ..Furthermore, we propose that these dnSTAT2-expressing cells provide a novel in vitro model for the study of type I IFN action in human skin cells...
  4. ncbi request reprint Expression of protein mediators of type I interferon signaling in human squamous cell carcinoma of the skin
    J L Clifford
    Department of Clinical Cancer Prevention, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Cancer Epidemiol Biomarkers Prev 9:993-7. 2000
    ..These data have led to the hypothesis that the loss of IFN sensitivity may contribute to the development and progression of skin SCC...
  5. ncbi request reprint Retinoid receptor-dependent and -independent effects of N-(4-hydroxyphenyl)retinamide in F9 embryonal carcinoma cells
    J L Clifford
    Department of Clinical Cancer Prevention, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Cancer Res 59:14-8. 1999
    ..Therefore, two distinct effects of 4HPR were identified in this system: a rapid induction of cell death and a slower induction of differentiation, which are likely to be receptor independent and dependent, respectively...
  6. ncbi request reprint Cloning and characterization of the human retinoid X receptor alpha gene: conservation of structure with the mouse homolog
    G Li
    Department of Clinical Cancer Prevention, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Biochem Biophys Res Commun 269:54-7. 2000
    ..These results provide information necessary to generate constructs for targeting the RXRalpha gene in human cell lines, which may eventually lead to an understanding of the function of RXRalpha in human cancer...
  7. pmc Active Stat3 is required for survival of human squamous cell carcinoma cells in serum-free conditions
    Weihong Yin
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Science Center School of Medicine in Shreveport and Feist Weiller Cancer Center, Shreveport, LA 71130, USA
    Mol Cancer 5:15. 2006
    ..Stat3 is a mediator of numerous growth factor and cytokine signaling pathways, all of which activate it through phosphorylation of tyrosine 705...
  8. ncbi request reprint Retinoids and skin: microarrays shed new light on chemopreventive action of all-trans retinoic acid
    Satish B Cheepala
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
    Mol Carcinog 46:634-9. 2007
    ..This result has pointed the way toward the detailed study of Raf/Mek/Erk pathway signaling in skin cancer development and its potential as a target pathway for chemoprevention by ATRA and other chemopreventive drugs...
  9. ncbi request reprint Chemoprevention of skin carcinogenesis by phenylretinamides: retinoid receptor-independent tumor suppression
    Hui Xu
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center Shreveport and the Feist Weiller Cancer Center, Shreveport, Louisiana 17730, USA
    Clin Cancer Res 12:969-79. 2006
    ....
  10. ncbi request reprint Retinoid receptor-dependent and independent biological activities of novel fenretinide analogues and metabolites
    Anita L Sabichi
    Department of Clinical Cancer Prevention, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 9:4606-13. 2003
    ..Thus, 4-MPR may play a role in the clinical activity of 4-HPR. This study further reveals the mechanism of action of these novel phenylretinamides and supports continued investigation into their development as chemopreventive drugs...
  11. doi request reprint Phase III prevention trial of fenretinide in patients with resected non-muscle-invasive bladder cancer
    Anita L Sabichi
    Department of Clinical Cancer Prevention, The University of Texas M D Anderson Cancer Center, Houston, TX 77230 1439, USA
    Clin Cancer Res 14:224-9. 2008
    ..The study aims to evaluate the efficacy and toxicity of fenretinide in preventing tumor recurrence in patients with transitional cell carcinoma (TCC) of the bladder...
  12. ncbi request reprint Phase II and biologic study of interferon alfa, retinoic acid, and cisplatin in advanced squamous skin cancer
    Dong M Shin
    Department of Thoracic Head and Neck Medical Oncology, Diagnostic Imaging, Biostatistics, Head and Neck Surgery, and Clinical Cancer Prevention, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4095, USA
    J Clin Oncol 20:364-70. 2002
    ..The purpose of this study was to test interferon alfa (IFNalpha), 13-cis-retinoic acid (13cRA), and cisplatin biochemotherapy in advanced squamous cell carcinoma (SCC) of the skin...
  13. ncbi request reprint Randomized trial of adjuvant 13-cis-retinoic acid and interferon alfa for patients with aggressive skin squamous cell carcinoma
    Abenaa M Brewster
    Department of Clinical Cancer Prevention, The University of Texas M D Anderson Cancer Center, Houston, TX 77230 1439, USA
    J Clin Oncol 25:1974-8. 2007
    ....
  14. ncbi request reprint Identification of the retinoic acid-inducible Gprc5a as a new lung tumor suppressor gene
    Qingguo Tao
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Natl Cancer Inst 99:1668-82. 2007
    ..We previously cloned human G protein-coupled receptor family C type 5A (GPRC5A), whose expression is suppressed in some human lung carcinoma cells, and its mouse homolog Gprc5a...
  15. ncbi request reprint Identification and characterization of the human retinoid X receptor alpha gene promoter
    Guojun Li
    Department of Clinical Cancer Prevention, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Gene 372:118-27. 2006
    ..In addition, the 5' untranslated region of RXRalpha is highly G+C rich, resulting in a potentially stable folding pattern, that would place RXRalpha amongst a group of genes that are subject to regulation at the translational level...
  16. ncbi request reprint Identification of a novel splice variant of X-linked inhibitor of apoptosis-associated factor 1
    Weihong Yin
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Science Center School of Medicine in Shreveport and Feist Weiller Cancer Center, 1501 Kings Highway, P O Box 33932, Shreveport, LA 71130, USA
    Biochem Biophys Res Commun 339:1148-54. 2006
    ..In transfected cells, xaf1c encodes a truncated protein of 18kDa, which is distributed primarily in the nucleus...
  17. ncbi request reprint Alleviating the suppression of glycogen synthase kinase-3beta by Akt leads to the phosphorylation of cAMP-response element-binding protein and its transactivation in intact cell nuclei
    Thomas R Salas
    Departments of Clinical Cancer Prevention and Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 278:41338-46. 2003
    ....
  18. pmc Stage-specific disruption of Stat3 demonstrates a direct requirement during both the initiation and promotion stages of mouse skin tumorigenesis
    Ken Kataoka
    Department of Carcinogenesis, Science Park Research Division, The University of Texas MD Anderson Cancer Center, 1808 Park Road 1C, Smithville, TX 78957, USA
    Carcinogenesis 29:1108-14. 2008
    ..Collectively, these results directly demonstrate that Stat3 is required for skin tumor development during both the initiation and promotion stages of skin carcinogenesis in vivo...