Affiliation: The Burnham Institute
- Nicotinamide rescues human embryonic stem cell-derived neuroectoderm from parthanatic cell deathFlavio Cimadamore
Burnham Institute for Medical Research, La Jolla, California 92037, USA
Stem Cells 27:1772-81. 2009..We argue that small natural metabolites provide a powerful physiological tool to optimize hESC differentiation compatible with the requirements of regenerative medicine...
- Human ESC-derived neural crest model reveals a key role for SOX2 in sensory neurogenesisFlavio Cimadamore
Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Cell Stem Cell 8:538-51. 2011..We found that SOX2 binds directly to NGN1 and MASH1 promoters and is required for their expression. Our data suggest that SOX2 plays a key role for NGN1-dependent acquisition of neuronal fates in sensory ganglia...
- SOX2-LIN28/let-7 pathway regulates proliferation and neurogenesis in neural precursorsFlavio Cimadamore
Center for Neuroscience, Aging, and Stem Cell Research, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 110:E3017-26. 2013..In conclusion, we discovered the SOX2-LIN28/let-7 pathway as a unique molecular mechanism governing NPC proliferation and neurogenic potential. ..