Jerold Chun

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. pmc Normal human pluripotent stem cell lines exhibit pervasive mosaic aneuploidy
    Suzanne E Peterson
    Department of Molecular Biology, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, California, United States of America
    PLoS ONE 6:e23018. 2011
  2. pmc Role of lysophosphatidic acid receptor LPA2 in the development of allergic airway inflammation in a murine model of asthma
    Yutong Zhao
    Department of Medicine, The University of Chicago, Chicago, Illinois, USA
    Respir Res 10:114. 2009
  3. pmc Autotaxin and lysophosphatidic acid1 receptor-mediated demyelination of dorsal root fibers by sciatic nerve injury and intrathecal lysophosphatidylcholine
    Jun Nagai
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    Mol Pain 6:78. 2010
  4. pmc Involvement of LPA1 receptor signaling in the reorganization of spinal input through Abeta-fibers in mice with partial sciatic nerve injury
    Weijiao Xie
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8521, Japan
    Mol Pain 4:46. 2008
  5. pmc Loss of spinal substance P pain transmission under the condition of LPA1 receptor-mediated neuropathic pain
    Makoto Inoue
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    Mol Pain 2:25. 2006
  6. pmc Autotaxin, a synthetic enzyme of lysophosphatidic acid (LPA), mediates the induction of nerve-injured neuropathic pain
    Makoto Inoue
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University, Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    Mol Pain 4:6. 2008
  7. pmc Lysophosphatidic acid-3 receptor-mediated feed-forward production of lysophosphatidic acid: an initiator of nerve injury-induced neuropathic pain
    Lin Ma
    Nagasaki University Graduate School of Biomedical Sciences, Japan
    Mol Pain 5:64. 2009
  8. pmc Mechanism of action of oral fingolimod (FTY720) in multiple sclerosis
    Jerold Chun
    Department of Molecular Biology, Helen L Dorris Child and Adolescent Neuropsychiatric Disorder Institute, The Scripps Research Institute, La Jolla, CA, USA
    Clin Neuropharmacol 33:91-101. 2010
  9. ncbi request reprint Lysophospholipids in the nervous system
    Jerold Chun
    Department of Molecular Biology, The Helen L, Dorris Institute for Neurological and Psychiatric Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, ICND 118, La Jolla, CA 92037, USA
    Prostaglandins Other Lipid Mediat 77:46-51. 2005
  10. pmc International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid receptor nomenclature
    Jerold Chun
    Department of Molecular Biology, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Pharmacol Rev 62:579-87. 2010

Collaborators

Detail Information

Publications102 found, 100 shown here

  1. pmc Normal human pluripotent stem cell lines exhibit pervasive mosaic aneuploidy
    Suzanne E Peterson
    Department of Molecular Biology, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, California, United States of America
    PLoS ONE 6:e23018. 2011
    ..The karyotypic heterogeneity generated by mosaic aneuploidy may contribute to the reported functional and phenotypic heterogeneity of hPSCs lines, as well as their therapeutic efficacy and safety following transplantation...
  2. pmc Role of lysophosphatidic acid receptor LPA2 in the development of allergic airway inflammation in a murine model of asthma
    Yutong Zhao
    Department of Medicine, The University of Chicago, Chicago, Illinois, USA
    Respir Res 10:114. 2009
    ..We have demonstrated that LPA induced cytokine and lipid mediator release in human bronchial epithelial cells. Here we provide evidence for the role of LPA and LPA receptors in Th2-dominant airway inflammation...
  3. pmc Autotaxin and lysophosphatidic acid1 receptor-mediated demyelination of dorsal root fibers by sciatic nerve injury and intrathecal lysophosphatidylcholine
    Jun Nagai
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    Mol Pain 6:78. 2010
    ..Previously, we found that lysophosphatidic acid receptor (LPA1) signaling initiates sciatic nerve injury-induced neuropathic pain and demyelination...
  4. pmc Involvement of LPA1 receptor signaling in the reorganization of spinal input through Abeta-fibers in mice with partial sciatic nerve injury
    Weijiao Xie
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8521, Japan
    Mol Pain 4:46. 2008
    ..These results suggest that LPA(1) receptor-mediated signaling mechanisms also participate in functional cross-talk between Abeta- and C- or Adelta-fibers...
  5. pmc Loss of spinal substance P pain transmission under the condition of LPA1 receptor-mediated neuropathic pain
    Makoto Inoue
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    Mol Pain 2:25. 2006
    ..All these results suggest that the loss of pain transmission through polymodal C-fiber neurons is also mediated by the LPA1 activation following nerve injury...
  6. pmc Autotaxin, a synthetic enzyme of lysophosphatidic acid (LPA), mediates the induction of nerve-injured neuropathic pain
    Makoto Inoue
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University, Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    Mol Pain 4:6. 2008
    ..Therefore, targeted inhibition of ATX-mediated LPA biosynthesis as well as LPA1 receptor and its downstream pathways may represent a novel way to prevent nerve injury-induced neuropathic pain...
  7. pmc Lysophosphatidic acid-3 receptor-mediated feed-forward production of lysophosphatidic acid: an initiator of nerve injury-induced neuropathic pain
    Lin Ma
    Nagasaki University Graduate School of Biomedical Sciences, Japan
    Mol Pain 5:64. 2009
    ..We previously reported that intrathecal injection of lysophosphatidylcholine (LPC) induced neuropathic pain through activation of the lysophosphatidic acid (LPA)-1 receptor, possibly via conversion to LPA by autotaxin (ATX)...
  8. pmc Mechanism of action of oral fingolimod (FTY720) in multiple sclerosis
    Jerold Chun
    Department of Molecular Biology, Helen L Dorris Child and Adolescent Neuropsychiatric Disorder Institute, The Scripps Research Institute, La Jolla, CA, USA
    Clin Neuropharmacol 33:91-101. 2010
    ..Therapeutic efficacy observed in animal studies has been substantiated in phase 2 and 3 trials involving patients with relapsing or relapsing-remitting MS...
  9. ncbi request reprint Lysophospholipids in the nervous system
    Jerold Chun
    Department of Molecular Biology, The Helen L, Dorris Institute for Neurological and Psychiatric Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, ICND 118, La Jolla, CA 92037, USA
    Prostaglandins Other Lipid Mediat 77:46-51. 2005
    ..While influencing a large number of biologically important systems, this discussion will focus on the nervous system, including areas of future research...
  10. pmc International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid receptor nomenclature
    Jerold Chun
    Department of Molecular Biology, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Pharmacol Rev 62:579-87. 2010
    ..This review incorporates IUPHAR Nomenclature Committee guidelines in updating the nomenclature for lysophospholipid receptors ( http://www.iuphar-db.org/DATABASE/FamilyMenuForward?familyId=36)...
  11. ncbi request reprint Lysophospholipid receptors as potential drug targets in tissue transplantation and autoimmune diseases
    Jerold Chun
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Curr Pharm Des 12:161-71. 2006
    ..Here we provide a brief introduction to receptor-mediated lysophospholipid signaling and discuss its basic and potential therapeutic roles in autoimmune-related diseases...
  12. ncbi request reprint Immunology. The sources of a lipid conundrum
    Jerold Chun
    Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 316:208-10. 2007
  13. pmc Aneuploid cells are differentially susceptible to caspase-mediated death during embryonic cerebral cortical development
    Suzanne E Peterson
    Department of Molecular Biology, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 32:16213-22. 2012
    ....
  14. pmc Diversity of lysophosphatidic acid receptor-mediated intracellular calcium signaling in early cortical neurogenesis
    Adrienne E Dubin
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 30:7300-9. 2010
    ..Compared with other known factors, lysophospholipids represent the major activator of calcium signaling identified within NPCs at this early stage in corticogenesis...
  15. ncbi request reprint Failed clearance of aneuploid embryonic neural progenitor cells leads to excess aneuploidy in the Atm-deficient but not the Trp53-deficient adult cerebral cortex
    Michael J McConnell
    The Salk Institute for Biological Studies, Laboratory of Genetics, La Jolla, California 92037, USA
    J Neurosci 24:8090-6. 2004
    ..These data lend increasing support to the hypothesis that hereditary mutations such as ATM-deficiency, which render abnormal cells resistant to developmental clearance, can lead to late-manifesting human neurological disorders...
  16. ncbi request reprint Constitutional aneuploidy in the normal human brain
    Stevens K Rehen
    Helen L Dorris Child and Adolescent Neuropsychiatric Disorder Institute, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 25:2176-80. 2005
    ..6%. Together, these data demonstrate that human brain cells (both neurons and non-neuronal cells) can be aneuploid and that the resulting genetic mosaicism is a normal feature of the human CNS...
  17. pmc FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation
    Ji Woong Choi
    Department of Molecular Biology, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 108:751-6. 2011
    ..These data identify nonimmunological CNS mechanisms of FTY720 efficacy and implicate S1P signaling pathways within the CNS as targets for multiple sclerosis therapies...
  18. ncbi request reprint Aneuploid mosaicism in the developing and adult cerebellar cortex
    Jurjen W Westra
    Helen L Dorris Child and Adolescent Neuropsychiatric Disorder Institute, The Scripps Research Institute, La Jolla, California 92037, USA
    J Comp Neurol 507:1944-51. 2008
    ....
  19. ncbi request reprint Non-proliferative effects of lysophosphatidic acid enhance cortical growth and folding
    Marcy A Kingsbury
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, ICND 118, La Jolla, California 92037, USA
    Nat Neurosci 6:1292-9. 2003
    ..Our results implicate extracellular lipid signals as new influences on brain formation during embryonic development...
  20. ncbi request reprint LPA(4)/GPR23 is a lysophosphatidic acid (LPA) receptor utilizing G(s)-, G(q)/G(i)-mediated calcium signaling and G(12/13)-mediated Rho activation
    Chang Wook Lee
    Department of Molecular Biology, Helen L Dorris Institute for Neurological and Psychiatric Disorders, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 282:4310-7. 2007
    ....
  21. pmc Age-dependent loss of sperm production in mice via impaired lysophosphatidic acid signaling
    Xiaoqin Ye
    Department of Molecular Biology, The Helen L Dorris Child and Adolescent Neuropsychiatric Disorder Institute, The Scripps Research Institute, La Jolla, California 92037, USA
    Biol Reprod 79:328-36. 2008
    ..Germ cell apoptosis led to a reduction in germ cell proliferation. These data demonstrate a novel in vivo function for LPA signaling as a germ cell survival factor during spermatogenesis...
  22. pmc Lysophosphatidic acid (LPA) and its receptor, LPA1 , influence embryonic schwann cell migration, myelination, and cell-to-axon segregation
    Brigitte Anliker
    Molecular and Cellular Neuroscience Department, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, California
    Glia 61:2009-22. 2013
    ..These results identify receptor mediated LPA signaling between neurons and SCs that promote SC migration and contribute to the normal development of peripheral nerves through effects on SC-axon segregation and myelination...
  23. ncbi request reprint Lysophospholipid activation of G protein-coupled receptors
    Tetsuji Mutoh
    Department of Molecular Biology, Helen L Dorris Child and Adolescent Neuropsychiatric Disorder Institute, The Scripps Research Institute, 10550 North Torrey Pines Rd, ICND 118, La Jolla, CA 92037, USA
    Subcell Biochem 49:269-97. 2008
    ..Here we provide a brief introduction to receptor-mediated lysophospholipid signaling and physiology, and then discuss potential therapeutic roles in human diseases...
  24. ncbi request reprint Sphingosine 1-phosphate (S1P) signaling is required for maintenance of hair cells mainly via activation of S1P2
    Deron R Herr
    Department of Molecular Biology, Helen L Dorris Institute for Neurological and Psychiatric Disorders, La Jolla, California 92037, USA
    J Neurosci 27:1474-8. 2007
    ..This study reveals the previously unknown role of S1P signaling in the maintenance of cochlear and vestibular integrity and suggests a means for therapeutic intervention in degenerative hearing loss...
  25. ncbi request reprint LPA receptors: subtypes and biological actions
    Ji Woong Choi
    Department of Molecular Biology, Helen L Dorris Institute for Neurological and Psychiatric Disorders, The Scripps Research Institute, La Jolla, California 92037, USA
    Annu Rev Pharmacol Toxicol 50:157-86. 2010
    ....
  26. ncbi request reprint Embryonic brain expression analysis of lysophospholipid receptor genes suggests roles for s1p(1) in neurogenesis and s1p(1-3) in angiogenesis
    Christine McGiffert
    Neurosciences Graduate Program, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0636, USA
    FEBS Lett 531:103-8. 2002
    ..The punctate pattern colocalized with vascular endothelial markers. Together, these results suggest that s1p(1) influences neurogenesis and s1p(1-3) influence angiogenesis in the developing brain...
  27. doi request reprint Chromosomal mosaicism in neural stem cells
    Suzanne E Peterson
    Department of Molecular Biology, Child and Adolescent Neuropsychiatric Disorder Institute, The Scripps Research Institute, La Jolla, CA, USA
    Methods Mol Biol 438:197-204. 2008
    ..SKY offers superior speed and sensitivity in its ability to detect many types of chromosomal defects, including deletions, insertions, translocations, and aneuploidy...
  28. pmc Neuronal DNA content variation (DCV) with regional and individual differences in the human brain
    Jurjen W Westra
    Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, California 92037, USA
    J Comp Neurol 518:3981-4000. 2010
    ....
  29. pmc Lysophosphatidic acid signaling may initiate fetal hydrocephalus
    Yun C Yung
    Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA
    Sci Transl Med 3:99ra87. 2011
    ..Administration of an LPA(1) receptor antagonist blocked development of FH. These findings implicate the LPA signaling pathway in the etiology of FH and suggest new potential targets for developing new treatments for FH...
  30. pmc Sphingosine 1-phosphate receptors are essential mediators of eyelid closure during embryonic development
    Deron R Herr
    From the Department of Molecular and Cellular Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, California 92037 and
    J Biol Chem 288:29882-9. 2013
    ..Fibroblasts derived from double-null embryos have a deficient response to epidermal growth factor, suggesting that S1P2 and S1P3 modulate this essential signaling pathway during eyelid closure. ..
  31. doi request reprint Roles for lysophospholipid S1P receptors in multiple sclerosis
    Kyoko Noguchi
    Department of Molecular Biology, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA
    Crit Rev Biochem Mol Biol 46:2-10. 2011
    ..These data implicate lysophospholipid signaling--via S1P(1) and perhaps other lysophospholipid receptors--in therapeutic approaches to MS and potentially other diseases with immunological and/or neurological components...
  32. ncbi request reprint Lysophosphatidic acid in neural signaling
    Xiaoqin Ye
    Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA 92093 0636, USA
    Neuroreport 13:2169-75. 2002
    ..This review provides a current summary of LPA-induced effects in neural cells in vitro or in vivo in combination with our current understanding of the signaling pathways responsible for these effects...
  33. pmc S1P3 receptor-induced reorganization of epithelial tight junctions compromises lung barrier integrity and is potentiated by TNF
    Yasuhiro Gon
    Department of Immunology, Core Microscopy Facility, Helen L Dorris Child and Adolescent Neuro Psychiatric Disorder Institute, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 102:9270-5. 2005
    ..Because S1P3-null mice are resistant to S1P-induced pulmonary leakage, either alone or in the presence of TNF, S1P3 antagonism may be useful in protecting epithelial integrity in pulmonary disease...
  34. pmc Stereotyped fetal brain disorganization is induced by hypoxia and requires lysophosphatidic acid receptor 1 (LPA1) signaling
    Keira Joann Herr
    Department of Molecular Biology, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 108:15444-9. 2011
    ....
  35. ncbi request reprint Sphingosine 1-phosphate S1P2 and S1P3 receptor-mediated Akt activation protects against in vivo myocardial ischemia-reperfusion injury
    Christopher K Means
    Department of Pharmacology, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0636, USA
    Am J Physiol Heart Circ Physiol 292:H2944-51. 2007
    ..Our data demonstrate that activation of S1P(2) and S1P(3) receptors plays a significant role in protecting cardiomyocytes from I/R damage in vivo and implicate the release of S1P and receptor-mediated Akt activation in this process...
  36. ncbi request reprint Emerging medicinal roles for lysophospholipid signaling
    Shannon E Gardell
    Department of Molecular Biology, Helen L Dorris Child and Adolescent Neuropsychiatric Disorder Institute, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Trends Mol Med 12:65-75. 2006
    ..Recent genetic and pharmacological studies on LP signaling in animal disease models have identified new areas in which interventions in LP signaling might provide novel therapeutic approaches for the treatment of human diseases...
  37. ncbi request reprint Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate
    M Germana Sanna
    Department of Immunology, The Center for Mass Spectrometry, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 279:13839-48. 2004
    ....
  38. doi request reprint Neurological S1P signaling as an emerging mechanism of action of oral FTY720 (fingolimod) in multiple sclerosis
    Chang Wook Lee
    Department of Molecular Biology, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA
    Arch Pharm Res 33:1567-74. 2010
    ....
  39. ncbi request reprint Lysophosphatidic acid as a novel cell survival/apoptotic factor
    Xiaoqin Ye
    Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA 92093 0636, USA
    Biochim Biophys Acta 1585:108-13. 2002
    ..The effects of LPA on both cell survival and apoptosis underscore important roles for this lipid in normal development and pathological processes...
  40. ncbi request reprint A new method of embryonic culture for assessing global changes in brain organization
    Stevens K Rehen
    Helen L Dorris Child and Adolescent Neuropsychiatric Disorder Institute, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Neurosci Methods 158:100-8. 2006
    ..This method should thus be helpful for assessing a wide range of soluble molecules for their systemic effects on the embryonic brain...
  41. pmc A reevaluation of tetraploidy in the Alzheimer's disease brain
    Jurjen W Westra
    Helen L Dorris Child and Adolescent Neuropsychiatric Disorder Institute, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neurodegener Dis 6:221-9. 2009
    ..Our findings demonstrate that neuronal tetraploidy is nonexistent in the AD brain and intimate a reevaluation of neuronal cell cycle re-entry as a therapeutic target for AD...
  42. pmc Ser18 and 23 phosphorylation is required for p53-dependent apoptosis and tumor suppression
    Connie Chao
    Section of Molecular Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093 0322, USA
    EMBO J 25:2615-22. 2006
    ..Therefore, Ser18 and Ser23 phosphorylation is important for p53-dependent suppression of tumorigenesis in certain physiological context...
  43. doi request reprint Lysophosphatidic acid-induced c-fos up-regulation involves cyclic AMP response element-binding protein activated by mitogen- and stress-activated protein kinase-1
    Chang Wook Lee
    Department of Molecular Biology, Helen L Dorris Child and Adolescent Neuropsychiatric Disorder Institute, The Scripps Research Institute, La Jolla, California 92037, USA
    J Cell Biochem 104:785-94. 2008
    ..Taken together, our results suggest that CREB plays an important role in up-regulation of c-fos mRNA level in LPA-stimulated Rat-2 fibroblast cells...
  44. pmc Targeted deletion of LPA5 identifies novel roles for lysophosphatidic acid signaling in development of neuropathic pain
    Mu En Lin
    Scripps Research Institute, Molecular Biology Department, Dorris Neuroscience Center, La Jolla, California 92037, USA
    J Biol Chem 287:17608-17. 2012
    ..These data expand the influences of LPA signaling in neuropathic pain through a second LPA receptor subtype, LPA(5), involving a mechanistically distinct downstream signaling pathway compared with LPA(1)...
  45. pmc Mathematical modeling supports substantial mouse neural progenitor cell death
    Michael J McConnell
    Crick Jacobs Center for Theoretical and Computational Biology, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Neural Dev 4:28. 2009
    ..Existing quantitative models of mouse cerebral cortical development are not fully constrained by experimental data...
  46. ncbi request reprint Lysophosphatidic acid in vascular development and disease
    Siew T Teo
    Department of Molecular Biology, Helen L Dorris Child and Adolescent Neuropsychiatric Disorder Institute, The Scripps Research Institute, ICND 118, La Jolla, CA 92037, USA
    IUBMB Life 61:791-9. 2009
    ....
  47. doi request reprint Dendritic cell PAR1-S1P3 signalling couples coagulation and inflammation
    Frank Niessen
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nature 452:654-8. 2008
    ..Thus, activation of dendritic cells by coagulation in the lymphatics emerges as a previously unknown mechanism that promotes systemic inflammation and lethality in decompensated innate immune responses...
  48. ncbi request reprint Cell surface receptors in lysophospholipid signaling
    Brigitte Anliker
    Department of Molecular Biology, Helen L Dorris Institute for Neurological and Psychiatric Disorders, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Semin Cell Dev Biol 15:457-65. 2004
    ..Finally, in vivo effects of LP receptor gene deletion in mice will be discussed...
  49. pmc Fingolimod: direct CNS effects of sphingosine 1-phosphate (S1P) receptor modulation and implications in multiple sclerosis therapy
    Aran Groves
    The Scripps Research Institute, Molecular and Cellular Neuroscience Department, Dorris Neuroscience Center, 10550 N Torrey Pines Rd, DNC 118, La Jolla, CA 92037, USA
    J Neurol Sci 328:9-18. 2013
    ..Additionally, we briefly outline other existing and investigational MS therapies that may also have effects in the CNS...
  50. pmc LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing
    Xiaoqin Ye
    Department of Molecular Biology, Helen L Dorris Child and Adolescent Neuropsychiatric Disorder Institute, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 435:104-8. 2005
    ..These data identify LPA3 receptor-mediated signalling as having an influence on implantation, and further indicate linkage between LPA signalling and prostaglandin biosynthesis...
  51. doi request reprint Lysophosphatidic acid (LPA) and its receptors
    Kyoko Noguchi
    The Department of Molecular Biology, Helen L Dorris Institute for Neurological and Psychiatric Disorders, The Scripps Research Institute, La Jolla, CA 92037, United States
    Curr Opin Pharmacol 9:15-23. 2009
    ..In addition, small molecule agonists and antagonists have been reported. Here we review recent data on the nervous system functions of LPA signaling, and summarize data on reported agonists and antagonists of LPA receptors...
  52. pmc The genomically mosaic brain: aneuploidy and more in neural diversity and disease
    Diane M Bushman
    Molecular and Cellular Neuroscience Department, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA, USA
    Semin Cell Dev Biol 24:357-69. 2013
    ..Here we discuss genomic mosaicism as a feature of the normal brain as well as a possible factor in the weak or complex genetic linkages observed for many of the most common forms of neurological and psychiatric diseases...
  53. ncbi request reprint FISH analysis of human pluripotent stem cells
    Suzanne E Peterson
    Jeanne Loring Lab, Chemical Physiology, The Scripps Research Institute, La Jolla, CA, USA
    Methods Mol Biol 767:191-200. 2011
    ..Here we will describe a cytogenetic method for screening human PSCs using FISH...
  54. pmc Biological roles of lysophospholipid receptors revealed by genetic null mice: an update
    Ji Woong Choi
    Department of Molecular Biology, Helen L Dorris Child and Adolescent Neuropsychiatric Disorder Institute, The Scripps Research Institute, 10550 North Torrey Pines Rd, ICND 118, La Jolla, CA 92037, USA
    Biochim Biophys Acta 1781:531-9. 2008
    ..This review will focus on findings from in vivo as well as in vitro studies using genetic null mice for the LP receptors, LPA1,2,3 and S1P1,2,3,5, and for the LP producing enzymes, autotaxin and sphingosine kinase 1/2...
  55. pmc A mechanistically novel, first oral therapy for multiple sclerosis: the development of fingolimod (FTY720, Gilenya)
    Jerold Chun
    Department of Molecular Biology and Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, California 92037, USA
    Discov Med 12:213-28. 2011
    ..This duality may herald a paradigm shift in the treatment of MS and other neurological disorders...
  56. pmc Lysophosphatidic acid (LPA) receptors: signaling properties and disease relevance
    Mu En Lin
    Department of Molecular Biology, Helen L Dorris Institute for Neurological and Psychiatric Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Prostaglandins Other Lipid Mediat 91:130-8. 2010
    ..Modulation of LPA signaling may thus provide therapeutic inroads for the treatment of human disease...
  57. ncbi request reprint International Union of Pharmacology. XXXIV. Lysophospholipid receptor nomenclature
    Jerold Chun
    Merck Research Laboratories, La Jolla, California 92037, USA
    Pharmacol Rev 54:265-9. 2002
    ..Herein, the molecular pharmacology of the lysophospholipid receptors is reviewed briefly, and a rational nomenclature for LPA and S1P receptors that is consistent with the International Union of Pharmacology guidelines is proposed...
  58. ncbi request reprint In vivo roles of lysophospholipid receptors revealed by gene targeting studies in mice
    Amy H Yang
    Department of Pharmacology, School of Medicine, University of California, San Diego UCSD, La Jolla, CA 92093 0636, USA
    Biochim Biophys Acta 1582:197-203. 2002
    ..Altogether, these data give insights to the importance of LPA/S1P receptors at the cellular and organismal level...
  59. pmc Massively parallel polymerase cloning and genome sequencing of single cells using nanoliter microwells
    Jeff Gole
    Department of Bioengineering, Institute for Genomic Medicine and Institute of Engineering in Medicine, University of California at San Diego, La Jolla, California, USA
    Nat Biotechnol 31:1126-32. 2013
    ..In addition, MIDAS allowed us to detect single-copy number changes in primary human adult neurons at 1- to 2-Mb resolution. MIDAS can potentially further the characterization of genomic diversity in many heterogeneous cell populations. ..
  60. pmc Lysophospholipids and their receptors in the central nervous system
    Ji Woong Choi
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Biochim Biophys Acta 1831:20-32. 2013
    ..This article is part of a Special Issue entitled Advances in Lysophospholipid Research...
  61. pmc Insights into the pharmacological relevance of lysophospholipid receptors
    Tetsuji Mutoh
    Department of Molecular Biology, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA, USA
    Br J Pharmacol 165:829-44. 2012
    ..Continued basic and translational research on LP signalling should provide novel insights into both basic biological mechanisms, as well as novel therapeutic approaches to combat a range of human diseases...
  62. ncbi request reprint Identification of neural programmed cell death through the detection of DNA fragmentation in situ and by PCR
    Yun C Yung
    Helen L Dorris Child and Adolescent Neuropsychiatric Disorder Institute, The Scripps Research Institute, La Jolla, California, USA
    Curr Protoc Neurosci . 2009
    ..A description of various current detection strategies is provided, as well as support protocols for preparing positive and negative controls and for preparing genomic DNA...
  63. ncbi request reprint Signaling mechanisms responsible for lysophosphatidic acid-induced urokinase plasminogen activator expression in ovarian cancer cells
    Hongbin Li
    Department of Immunology and Molecular Biology, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, California 92037, USA
    J Biol Chem 280:10564-71. 2005
    ..Thus these results suggest that the G(i)-Ras-Raf-NF-kappaB signaling cascade is responsible for LPA-induced uPA up-regulation in ovarian cancer cells...
  64. ncbi request reprint Tandem genomic arrangement of a G protein (Gna15) and G protein-coupled receptor (s1p(4)/lp(C1)/Edg6) gene
    James J A Contos
    Department of Pharmacology, School of Medicine, University of California at San Diego, La Jolla, CA 92093 0636, USA
    FEBS Lett 531:99-102. 2002
    ....
  65. ncbi request reprint Lysophospholipid G protein-coupled receptors
    Brigitte Anliker
    Department of Molecular Biology, Helen L Dorris Institute for Neurological and Psychiatric Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Biol Chem 279:20555-8. 2004
    ..In this brief review, we note cogent features of lysophospholipid receptors, including the current nomenclature, signaling properties, development of agonists and antagonists, and physiological functions...
  66. ncbi request reprint GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5
    Chang Wook Lee
    Department of Molecular Biology, Helen L Dorris Institute for Neurological and Psychiatric Disorders, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 281:23589-97. 2006
    ..These results support GPR92 as a fifth LPA receptor, LPA5, which likely has distinct physiological functions in view of its expression pattern...
  67. pmc Lysophospholipid receptor nomenclature review: IUPHAR Review 8
    Yasuyuki Kihara
    Molecular and Cellular Neuroscience Department, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA, USA
    Br J Pharmacol 171:3575-94. 2014
    ..This nomenclature incorporates previous recommendations from the International Union of Basic and Clinical Pharmacology, the Human Genome Organization, the Gene Nomenclature Committee, and the Mouse Genome Informatix. ..
  68. pmc Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function
    Xinyu Zhao
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:6777-82. 2003
    ..Our findings indicate that DNA methylation is important in maintaining cellular genomic stability and is crucial for normal neural stem cell and brain functions...
  69. pmc S1P1 receptor localization confers selectivity for Gi-mediated cAMP and contractile responses
    Christopher Kable Means
    Biomedical Sciences Graduate Program and Department of Pharmacology, University of California, San Diego, California 92093 0636, USA
    J Biol Chem 283:11954-63. 2008
    ..Thus localization of S1P(1) receptors to caveolae is required for the ability of this receptor to inhibit adenylyl cyclase and contractility but compromises receptor coupling to Akt and ERK...
  70. ncbi request reprint High-density lipoprotein stimulates myocardial perfusion in vivo
    Bodo Levkau
    Institute of Pathophysiology, Center of Internal Medicine, University Hospital Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Circulation 110:3355-9. 2004
    ..In vivo, administration of reconstituted HDL restored abnormal endothelial function of the brachial artery in hypercholesterolemic patients. However, no data are currently available on the effect of HDL on myocardial perfusion...
  71. ncbi request reprint Sphingosine 1-phosphate receptor agonists attenuate relapsing-remitting experimental autoimmune encephalitis in SJL mice
    Michael Webb
    Molecular Neuroscience Laboratory, Merck Research Laboratories, 3535 General Atomics Court, San Diego, CA 92121, USA
    J Neuroimmunol 153:108-21. 2004
    ..EAE produced by adoptively transferring lymph node cells from immunized mice to naïve hosts is similarly ameliorated by FTY-P. Treatment with FTY-P is accompanied by a dose-responsive peripheral lymphopoenia...
  72. ncbi request reprint Lysophospholipid receptors: signaling and biology
    Isao Ishii
    Department of Molecular Genetics, National Institute of Neuroscience, NCNP, Kodaira, Tokyo 187 8502, Japan
    Annu Rev Biochem 73:321-54. 2004
    ..The rapidly expanding literature on the LP receptors is herein reviewed...
  73. ncbi request reprint Sphingosine kinase type 1 induces G12/13-mediated stress fiber formation, yet promotes growth and survival independent of G protein-coupled receptors
    Ana Olivera
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases NIH, Bethesda, MD 20891, USA
    J Biol Chem 278:46452-60. 2003
    ..Our results demonstrate a receptor-independent intracellular function of S1P, reminiscent of its action in yeast cells that lack S1PRs...
  74. pmc HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3
    Jerzy Roch Nofer
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfalische Wilhelms Universitat, Munster, Germany
    J Clin Invest 113:569-81. 2004
    ..This mechanism may contribute to the vasoactive effect of HDL and represent a novel aspect of its antiatherogenic function...
  75. ncbi request reprint Neurobiology of lysophosphatidic acid signaling
    Nobuyuki Fukushima
    Department of Biochemistry, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Neuroscientist 8:540-50. 2002
    ..Here the authors review features of the LPA receptor family and cellular responses of nervous system-derived cells, and discuss developmental and pathological roles for LPA signaling in the nervous system...
  76. pmc Characterization of lpa(2) (Edg4) and lpa(1)/lpa(2) (Edg2/Edg4) lysophosphatidic acid receptor knockout mice: signaling deficits without obvious phenotypic abnormality attributable to lpa(2)
    James J A Contos
    Department of Pharmacology, Neurosciences and Biomedical Sciences Programs, School of Medicine, University of California, San Diego, La Jolla 92093 0636, USA
    Mol Cell Biol 22:6921-9. 2002
    ..Thus, although LPA(2) is not essential for normal mouse development, it does act redundantly with LPA(1) to mediate most LPA responses in fibroblasts...
  77. pmc Dual regulation of actin rearrangement through lysophosphatidic acid receptor in neuroblast cell lines: actin depolymerization by Ca(2+)-alpha-actinin and polymerization by rho
    Nobuyuki Fukushima
    Department of Molecular Biochemistry, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Mol Biol Cell 13:2692-705. 2002
    ..This dual actin rearrangement may play a novel, important role in regulation of the neuronal morphology and motility during brain development...
  78. ncbi request reprint Immunomodulator FTY720 Induces eNOS-dependent arterial vasodilatation via the lysophospholipid receptor S1P3
    Markus Tölle
    Med Klinik IV, Charite Campus Benjamin Franklin, Berlin, Germany
    Circ Res 96:913-20. 2005
    ....
  79. ncbi request reprint The sphingosine 1-phosphate receptor S1P2 triggers hepatic wound healing
    Valérie Serrière-Lanneau
    INSERM U841, Institut Mondor de Recherche Biomedicale, Hopital Henri Mondor, 94010 Creteil, France
    FASEB J 21:2005-13. 2007
    ..These results unravel a novel major role of S1P2 in the wound healing response to acute liver injury by a mechanism involving enhanced proliferation of hMF...
  80. ncbi request reprint High-density lipoproteins and their constituent, sphingosine-1-phosphate, directly protect the heart against ischemia/reperfusion injury in vivo via the S1P3 lysophospholipid receptor
    Gregor Theilmeier
    Institute for Anatomy, Department of Anesthesiology and Intensive Care, University Hospital Munster, Vesaliusweg 2 4, 48149 Munster, Germany
    Circulation 114:1403-9. 2006
    ..We hypothesized that some of the cholesterol transport-independent biological properties of high-density lipoprotein (HDL) implied in atheroprotection may also be beneficial in settings of acute myocardial reperfusion injury...
  81. ncbi request reprint Sphingosine-1-phosphate stimulates the functional capacity of progenitor cells by activation of the CXCR4-dependent signaling pathway via the S1P3 receptor
    Dirk H Walter
    Molecular Cardiology, Department of Internal Medicine III, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Arterioscler Thromb Vasc Biol 27:275-82. 2007
    ....
  82. pmc Immunomodulator FTY720 induces myofibroblast differentiation via the lysophospholipid receptor S1P3 and Smad3 signaling
    Christina D Keller
    Institute of Pharmacy, Pharmacology and Toxicology, Freie Universitat Berlin, Konigin Luise Str 2 4, D 14195 Berlin, Germany
    Am J Pathol 170:281-92. 2007
    ..Finally, we determined that downstream of S1P3 signaling Smad3 activation is essential for myofibroblast differentiation in response to FTY720. Thus, FTY720 may have adverse fibrotic effects related to its activity on S1P3 signaling...
  83. pmc HDL-associated lysosphingolipids inhibit NAD(P)H oxidase-dependent monocyte chemoattractant protein-1 production
    Markus Tölle
    Charite Campus Benjamin Franklin, Medizinische Klinik, Berlin, Germany
    Arterioscler Thromb Vasc Biol 28:1542-8. 2008
    ..Here we investigated the influence of HDL on MCP-1 production in vascular smooth muscle cells (VSMCs) and rat aortic explants...
  84. ncbi request reprint S1P3-mediated Akt activation and cross-talk with platelet-derived growth factor receptor (PDGFR)
    Linnea M Baudhuin
    Department of Cancer Biology, The Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    FASEB J 18:341-3. 2004
    ..This is the first report demonstrating a unique interaction between S1P3 and PDGFR, in addition to demonstrating a specific role for S1P3 in S1P-induced Akt activation...
  85. ncbi request reprint Pharmacological characterization of lysophospholipid receptor signal transduction pathways in rat cerebrocortical astrocytes
    Tadimeti S Rao
    Merck Research Laboratories, 3535 General Atomics Court, Building 1, San Diego, CA 92121, USA
    Brain Res 990:182-94. 2003
    ....
  86. pmc Lysophosphatidic acid receptors 1 and 2 play roles in regulation of vascular injury responses but not blood pressure
    Manikandan Panchatcharam
    Division of Cardiovascular Medicine, The Gill Heart Institute, Lexington, KY 40536, USA
    Circ Res 103:662-70. 2008
    ..These results identify a role for LPA1 and LPA2 in regulating SMC migratory responses in the context of vascular injury but suggest that additional LPA receptor subtypes are required for other LPA-mediated effects in the vasculature...
  87. ncbi request reprint The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak
    Andrew M Tager
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, CNY149 8301, 149 13th Street, Charlestown, Massachusetts 02129 USA
    Nat Med 14:45-54. 2008
    ..LPA1 therefore represents a new therapeutic target for diseases in which aberrant responses to injury contribute to fibrosis, such as idiopathic pulmonary fibrosis...
  88. pmc The S1P2 receptor negatively regulates platelet-derived growth factor-induced motility and proliferation
    Sravan K Goparaju
    Department of Biochemistry, Virginia Commonwealth University Medical Center, 1101 E Marshall Street, Room 2 011, Sanger Hall, Richmond, VA 23298 0614, USA
    Mol Cell Biol 25:4237-49. 2005
    ..Thus, S1P(2) serves as a negative regulator of PDGF-induced migration and proliferation as well as SphK1 expression. Our results suggest that a complex interplay between PDGFR and S1P receptors determines their functions...
  89. pmc Lysophosphatidic acid receptor-dependent secondary effects via astrocytes promote neuronal differentiation
    Tânia Cristina Sampaio Spohr
    Departamento de Anatomia, Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, 21949 590 Rio de Janeiro RJ, Brazil
    J Biol Chem 283:7470-9. 2008
    ..These data demonstrate that receptor-mediated LPA signaling in astrocytes can induce LPA-dependent, indirect effects on neuronal differentiation...
  90. ncbi request reprint Absence of LPA1 signaling results in defective cortical development
    Guillermo Estivill-Torrus
    Unidad de Investigacion, Fundacion IMABIS, Hospital Carlos Haya, E 29010 Malaga, Spain
    Cereb Cortex 18:938-50. 2008
    ..These data support LPA(1) function in normal cortical development and suggest that the presence of genetic modifiers of LPA(1) influences cerebral cortical development...
  91. ncbi request reprint Lysophosphatidic acid influences the morphology and motility of young, postmitotic cortical neurons
    Nobuyuki Fukushima
    Department of Pharmacology, University of California, San Diego, La Jolla 92093 0636, USA
    Mol Cell Neurosci 20:271-82. 2002
    ..Taken together, these results implicate LPA as an extracellular lipid signal affecting process outgrowth and migration of early postmitotic neurons during development...
  92. ncbi request reprint Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA1
    Kotaro Hama
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Biol Chem 279:17634-9. 2004
    ..The present study suggests that ATX and LPA(1) represent potential targets for cancer therapy...
  93. ncbi request reprint LPA1 receptor activation promotes renal interstitial fibrosis
    Jean Philippe Pradere
    INSERM, U858 I2MR, Department of Metabolism and Obesity, Team 3, Toulouse, France
    J Am Soc Nephrol 18:3110-8. 2007
    ..In conclusion, LPA, likely acting through LPA1, is involved in obstruction-induced TIF. Therefore, the LPA1 receptor might be a pharmaceutical target to treat renal fibrosis...
  94. ncbi request reprint Lysophosphatidic acid inhibits adipocyte differentiation via lysophosphatidic acid 1 receptor-dependent down-regulation of peroxisome proliferator-activated receptor gamma2
    Marie Francoise Simon
    INSERM U586, Institut Louis Bugnard, Rangueil Hospital, BP84225, 31432 Toulouse, Cedex 4, France
    J Biol Chem 280:14656-62. 2005
    ..The local production of LPA may exert a tonic inhibitory effect on the development of adipose tissue...
  95. ncbi request reprint Lysophosphatidic acid stimulates neuronal differentiation of cortical neuroblasts through the LPA1-G(i/o) pathway
    Nobuyuki Fukushima
    Molecular Neurobiology, Department of Life Sciences, School of Science and Engineering, Kinki University, Kowakae 3 4 1, Higashiosaka 577 8502, Japan
    Neurochem Int 50:302-7. 2007
    ..These results suggest that LPA promotes the commitment of neuroblasts to the neural lineage through the LPA(1)-G(i/o) pathway...
  96. ncbi request reprint Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate (S1P) receptors, S1P(2)/LP(B2)/EDG-5 and S1P(3)/LP(B3)/EDG-3
    Isao Ishii
    Department of Pharmacology, School of Medicine, University of California at San Diego, La Jolla 92093 0636, USA
    J Biol Chem 277:25152-9. 2002
    ..Although either receptor subtype supports embryonic development, deletion of both produces marked perinatal lethality, demonstrating an essential role for combined S1P signaling by these receptors...
  97. ncbi request reprint Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling
    Makoto Inoue
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University, Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki, 852 8521, Japan
    Nat Med 10:712-8. 2004
    ..Inhibitors of Rho and Rho kinase also prevented these signs of neuropathic pain. These results imply that receptor-mediated LPA signaling is crucial in the initiation of neuropathic pain...
  98. pmc Lysophosphatidic acid stimulates astrocyte proliferation through LPA1
    Shinya Shano
    Division of Molecular Neurobiology, Department of Life Sciences, School of Science and Engineering, Kinki University, Kowakae 3 4 1, Higashiosaka 577 8502, Japan
    Neurochem Int 52:216-20. 2008
    ..Taken together, these observations demonstrate that LPA1 mediates LPA-induced stimulation of cell proliferation but not inhibition of glutamate uptake in astrocytes...
  99. ncbi request reprint Growth factor pre-treatment differentially regulates phosphoinositide turnover downstream of lysophospholipid receptor and metabotropic glutamate receptors in cultured rat cerebrocortical astrocytes
    Tadimeti S Rao
    Merck Research Laboratories San Diego, 3535 General Atomics Court, Bldg 1, San Diego, CA 92121, USA
    Int J Dev Neurosci 22:131-5. 2004
    ....
  100. ncbi request reprint LPA3 receptor mediates chemotaxis of immature murine dendritic cells to unsaturated lysophosphatidic acid (LPA)
    Liana C Chan
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    J Leukoc Biol 82:1193-200. 2007
    ..In summary, our results indicate that immature mouse DCs migrate preferentially in response to unsaturated LPA and that LPA(3) is important in this response...
  101. ncbi request reprint Embryo spacing and implantation timing are differentially regulated by LPA3-mediated lysophosphatidic acid signaling in mice
    Kotaro Hama
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113 0033, Japan
    Biol Reprod 77:954-9. 2007
    ..Because the uterine contraction is critical for embryo spacing, our results suggest that LPA3 signaling controls embryo spacing via uterine contraction around E3.5...

Research Grants33

  1. Lysophospholipids roles for Schwann cell & myelination
    Jerold Chun; Fiscal Year: 2007
    ..studies have demonstrated that lysophospholipid receptors are "druggable" targets, raising the prospect that data from this proposal could help in the development of strategies to treat disorders of peripheral myelination ..
  2. RECEPTOR-MEDIATED LPA SIGNALING IN CORTICAL DEVELOPMENT
    Jerold Chun; Fiscal Year: 2005
    ..abstract_text> ..
  3. EMBRYONIC CORTICAL APOPTOSIS ROLES AND REGULATIONS
    Jerold Chun; Fiscal Year: 1999
    ..Years 1-5). This information will provide new insights into the mechanisms behind developmental neurological disorders, especially those affecting the normal functions of the cerebral cortex. ..
  4. Receptor-mediated S1P signaling in the embryonic brain
    Jerold Chun; Fiscal Year: 2010
    ..It is notable that the small size of these lipid molecules makes them attractive targets for drug design, and results from this proposal could serve as a foundation for new therapies based upon lysophospholipid-mimetic drugs. ..
  5. Interactions of LPA and prostaglandins in implantation
    Jerold Chun; Fiscal Year: 2007
    ..Work from this proposal will lay the groundwork towards realizing this possible therapeutic potential. ..
  6. Functional studies on normal neural aneuploidy
    Jerold Chun; Fiscal Year: 2007
    ..This proposal will provide a framework for, and data towards, understanding the functional importance of neural aneuploidy in the nervous system. ..
  7. Receptor-mediated S1P signaling in the embryonic brain
    Jerold Chun; Fiscal Year: 2007
    ..It is notable that the small size of these lipid molecules makes them attractive targets for drug design, and results from this proposal could serve as a foundation for new therapies based upon lysophospholipid-mimetic drugs. ..
  8. Interactions of LPA and prostaglandins in implantation
    Jerold Chun; Fiscal Year: 2009
    ..Work from this proposal will lay the groundwork towards realizing this possible therapeutic potential. ..
  9. Receptor-mediated S1P signaling in the embryonic brain
    Jerold Chun; Fiscal Year: 2009
    ..It is notable that the small size of these lipid molecules makes them attractive targets for drug design, and results from this proposal could serve as a foundation for new therapies based upon lysophospholipid-mimetic drugs. ..
  10. RECEPTOR-MEDIATED LPA SIGNALING IN CORTICAL DEVELOPMENT
    Jerold Chun; Fiscal Year: 2009
    ..It may also lead to rational approaches, based on LPA receptor modulation, for preventing or treating mental health disorders with developmental etiologies. ..
  11. Interactions of LPA and prostaglandins in implantation
    Jerold Chun; Fiscal Year: 2010
    ..Work from this proposal will lay the groundwork towards realizing this possible therapeutic potential. ..
  12. RECEPTOR-MEDIATED LPA SIGNALING IN CORTICAL DEVELOPMENT
    Jerold Chun; Fiscal Year: 2007
    ..abstract_text> ..
  13. Lysophospholipids roles for Schwann cell & myelination
    Jerold Chun; Fiscal Year: 2006
    ..studies have demonstrated that lysophospholipid receptors are "druggable" targets, raising the prospect that data from this proposal could help in the development of strategies to treat disorders of peripheral myelination ..
  14. EMBRYONIC CORTICAL APOPTOSIS ROLES AND REGULATIONS
    Jerold Chun; Fiscal Year: 2000
    ..Years 1-5). This information will provide new insights into the mechanisms behind developmental neurological disorders, especially those affecting the normal functions of the cerebral cortex. ..
  15. EMBRYONIC CORTICAL APOPTOSIS ROLES AND REGULATIONS
    Jerold Chun; Fiscal Year: 2001
    ..Years 1-5). This information will provide new insights into the mechanisms behind developmental neurological disorders, especially those affecting the normal functions of the cerebral cortex. ..
  16. RECEPTOR-MEDIATED LPA SIGNALING IN CORTICAL DEVELOPMENT
    Jerold Chun; Fiscal Year: 2004
    ..abstract_text> ..
  17. Lysophospholipids roles for Schwann cell & myelination
    Jerold Chun; Fiscal Year: 2004
    ..studies have demonstrated that lysophospholipid receptors are "druggable" targets, raising the prospect that data from this proposal could help in the development of strategies to treat disorders of peripheral myelination ..
  18. ROLES FOR LPA SIGNALING IN CEREBRAL CORTICAL DEVELOPMENT
    Jerold Chun; Fiscal Year: 2005
    ....
  19. Lysophospholipids roles for Schwann cell & myelination
    Jerold Chun; Fiscal Year: 2005
    ..studies have demonstrated that lysophospholipid receptors are "druggable" targets, raising the prospect that data from this proposal could help in the development of strategies to treat disorders of peripheral myelination ..
  20. Receptor-mediated S1P signaling in the embryonic brain
    Jerold Chun; Fiscal Year: 2006
    ..It is notable that the small size of these lipid molecules makes them attractive targets for drug design, and results from this proposal could serve as a foundation for new therapies based upon lysophospholipid-mimetic drugs. ..
  21. RECEPTOR-MEDIATED LPA SIGNALING IN CORTICAL DEVELOPMENT
    Jerold Chun; Fiscal Year: 2006
    ..abstract_text> ..
  22. Lysophospholipids roles for Schwann cell & myelination
    Jerold Chun; Fiscal Year: 2006
    ..studies have demonstrated that lysophospholipid receptors are "druggable" targets, raising the prospect that data from this proposal could help in the development of strategies to treat disorders of peripheral myelination ..
  23. Interactions of LPA and prostaglandins in implantation
    Jerold Chun; Fiscal Year: 2006
    ..Work from this proposal will lay the groundwork towards realizing this possible therapeutic potential. ..
  24. Interactions of LPA and prostaglandins in implantation
    Jerold Chun; Fiscal Year: 2009
    ..Work from this proposal will lay the groundwork towards realizing this possible therapeutic potential. ..