Research Topics
Genomes and Genes
| Jerold ChunSummaryAffiliation: The Scripps Research Institute Country: USA Publications
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Publications
Role of lysophosphatidic acid receptor LPA2 in the development of allergic airway inflammation in a murine model of asthmaYutong Zhao
Department of Medicine, The University of Chicago, Chicago, Illinois, USA
Respir Res 10:114. 2009..We have demonstrated that LPA induced cytokine and lipid mediator release in human bronchial epithelial cells. Here we provide evidence for the role of LPA and LPA receptors in Th2-dominant airway inflammation...- Autotaxin and lysophosphatidic acid1 receptor-mediated demyelination of dorsal root fibers by sciatic nerve injury and intrathecal lysophosphatidylcholineJun Nagai
Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
Mol Pain 6:78. 2010..Previously, we found that lysophosphatidic acid receptor (LPA1) signaling initiates sciatic nerve injury-induced neuropathic pain and demyelination... - Involvement of LPA1 receptor signaling in the reorganization of spinal input through Abeta-fibers in mice with partial sciatic nerve injuryWeijiao Xie
Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8521, Japan
Mol Pain 4:46. 2008..These results suggest that LPA(1) receptor-mediated signaling mechanisms also participate in functional cross-talk between Abeta- and C- or Adelta-fibers... - Loss of spinal substance P pain transmission under the condition of LPA1 receptor-mediated neuropathic painMakoto Inoue
Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
Mol Pain 2:25. 2006..All these results suggest that the loss of pain transmission through polymodal C-fiber neurons is also mediated by the LPA1 activation following nerve injury... - Autotaxin, a synthetic enzyme of lysophosphatidic acid (LPA), mediates the induction of nerve-injured neuropathic painMakoto Inoue
Division of Molecular Pharmacology and Neuroscience, Nagasaki University, Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
Mol Pain 4:6. 2008..Therefore, targeted inhibition of ATX-mediated LPA biosynthesis as well as LPA1 receptor and its downstream pathways may represent a novel way to prevent nerve injury-induced neuropathic pain... - Lysophosphatidic acid-3 receptor-mediated feed-forward production of lysophosphatidic acid: an initiator of nerve injury-induced neuropathic painLin Ma
Nagasaki University Graduate School of Biomedical Sciences, Japan
Mol Pain 5:64. 2009..We previously reported that intrathecal injection of lysophosphatidylcholine (LPC) induced neuropathic pain through activation of the lysophosphatidic acid (LPA)-1 receptor, possibly via conversion to LPA by autotaxin (ATX)... - International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid receptor nomenclatureJerold Chun
Department of Molecular Biology, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
Pharmacol Rev 62:579-87. 2010..This review incorporates IUPHAR Nomenclature Committee guidelines in updating the nomenclature for lysophospholipid receptors ( http://www.iuphar-db.org/DATABASE/FamilyMenuForward?familyId=36)... 
Lysophospholipids in the nervous systemJerold Chun
Department of Molecular Biology, The Helen L, Dorris Institute for Neurological and Psychiatric Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, ICND 118, La Jolla, CA 92037, USA
Prostaglandins Other Lipid Mediat 77:46-51. 2005..While influencing a large number of biologically important systems, this discussion will focus on the nervous system, including areas of future research...- Mechanism of action of oral fingolimod (FTY720) in multiple sclerosisJerold Chun
Department of Molecular Biology, Helen L Dorris Child and Adolescent Neuropsychiatric Disorder Institute, The Scripps Research Institute, La Jolla, CA, USA
Clin Neuropharmacol 33:91-101. 2010..Therapeutic efficacy observed in animal studies has been substantiated in phase 2 and 3 trials involving patients with relapsing or relapsing-remitting MS... - Lysophospholipid receptors as potential drug targets in tissue transplantation and autoimmune diseasesJerold Chun
Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
Curr Pharm Des 12:161-71. 2006..Here we provide a brief introduction to receptor-mediated lysophospholipid signaling and discuss its basic and potential therapeutic roles in autoimmune-related diseases... - Immunology. The sources of a lipid conundrumJerold Chun
Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Science 316:208-10. 2007 
Aneuploid cells are differentially susceptible to caspase-mediated death during embryonic cerebral cortical developmentSuzanne E Peterson
Department of Molecular Biology, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, California 92037, USA
J Neurosci 32:16213-22. 2012....- Diversity of lysophosphatidic acid receptor-mediated intracellular calcium signaling in early cortical neurogenesisAdrienne E Dubin
Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
J Neurosci 30:7300-9. 2010..Compared with other known factors, lysophospholipids represent the major activator of calcium signaling identified within NPCs at this early stage in corticogenesis... - Constitutional aneuploidy in the normal human brainStevens K Rehen
Helen L. Dorris Child and Adolescent Neuropsychiatric Disorder Institute, The Scripps Research Institute, La Jolla, California 92037, USA
J Neurosci 25:2176-80. 2005..6%. Together, these data demonstrate that human brain cells (both neurons and non-neuronal cells) can be aneuploid and that the resulting genetic mosaicism is a normal feature of the human CNS... - FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulationJi Woong Choi
Department of Molecular Biology, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 108:751-6. 2011..These data identify nonimmunological CNS mechanisms of FTY720 efficacy and implicate S1P signaling pathways within the CNS as targets for multiple sclerosis therapies... - LPA(4)/GPR23 is a lysophosphatidic acid (LPA) receptor utilizing G(s)-, G(q)/G(i)-mediated calcium signaling and G(12/13)-mediated Rho activationChang Wook Lee
Department of Molecular Biology, Helen L Dorris Institute for Neurological and Psychiatric Disorders, The Scripps Research Institute, La Jolla, California 92037, USA
J Biol Chem 282:4310-7. 2007.... - Failed clearance of aneuploid embryonic neural progenitor cells leads to excess aneuploidy in the Atm-deficient but not the Trp53-deficient adult cerebral cortexMichael J McConnell
The Salk Institute for Biological Studies, Laboratory of Genetics, La Jolla, California 92037, USA
J Neurosci 24:8090-6. 2004..These data lend increasing support to the hypothesis that hereditary mutations such as ATM-deficiency, which render abnormal cells resistant to developmental clearance, can lead to late-manifesting human neurological disorders... - Age-dependent loss of sperm production in mice via impaired lysophosphatidic acid signalingXiaoqin Ye
Department of Molecular Biology, The Helen L Dorris Child and Adolescent Neuropsychiatric Disorder Institute, The Scripps Research Institute, La Jolla, California 92037, USA
Biol Reprod 79:328-36. 2008..Germ cell apoptosis led to a reduction in germ cell proliferation. These data demonstrate a novel in vivo function for LPA signaling as a germ cell survival factor during spermatogenesis... - Lysophospholipid activation of G protein-coupled receptorsTetsuji Mutoh
Department of Molecular Biology, Helen L Dorris Child and Adolescent Neuropsychiatric Disorder Institute, The Scripps Research Institute, 10550 North Torrey Pines Rd, ICND 118, La Jolla, CA 92037, USA
Subcell Biochem 49:269-97. 2008..Here we provide a brief introduction to receptor-mediated lysophospholipid signaling and physiology, and then discuss potential therapeutic roles in human diseases... - Non-proliferative effects of lysophosphatidic acid enhance cortical growth and foldingMarcy A Kingsbury
Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, ICND 118, La Jolla, California 92037, USA
Nat Neurosci 6:1292-9. 2003..Our results implicate extracellular lipid signals as new influences on brain formation during embryonic development... - LPA receptors: subtypes and biological actionsJi Woong Choi
Department of Molecular Biology, Helen L Dorris Institute for Neurological and Psychiatric Disorders, The Scripps Research Institute, La Jolla, California 92037, USA
Annu Rev Pharmacol Toxicol 50:157-86. 2010.... - Embryonic brain expression analysis of lysophospholipid receptor genes suggests roles for s1p(1) in neurogenesis and s1p(1-3) in angiogenesisChristine McGiffert
Neurosciences Graduate Program, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0636, USA
FEBS Lett 531:103-8. 2002..The punctate pattern colocalized with vascular endothelial markers. Together, these results suggest that s1p(1) influences neurogenesis and s1p(1-3) influence angiogenesis in the developing brain... - Aneuploid mosaicism in the developing and adult cerebellar cortexJurjen W Westra
Helen L Dorris Child and Adolescent Neuropsychiatric Disorder Institute, The Scripps Research Institute, La Jolla, California 92037, USA
J Comp Neurol 507:1944-51. 2008.... - Sphingosine 1-phosphate (S1P) signaling is required for maintenance of hair cells mainly via activation of S1P2Deron R Herr
Department of Molecular Biology, Helen L Dorris Institute for Neurological and Psychiatric Disorders, La Jolla, California 92037, USA
J Neurosci 27:1474-8. 2007..This study reveals the previously unknown role of S1P signaling in the maintenance of cochlear and vestibular integrity and suggests a means for therapeutic intervention in degenerative hearing loss... - Lysophosphatidic acid signaling may initiate fetal hydrocephalusYun C Yung
Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA
Sci Transl Med 3:99ra87. 2011..Administration of an LPA(1) receptor antagonist blocked development of FH. These findings implicate the LPA signaling pathway in the etiology of FH and suggest new potential targets for developing new treatments for FH... - Normal human pluripotent stem cell lines exhibit pervasive mosaic aneuploidySuzanne E Peterson
Department of Molecular Biology, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, California, United States of America
PLoS ONE 6:e23018. 2011..The karyotypic heterogeneity generated by mosaic aneuploidy may contribute to the reported functional and phenotypic heterogeneity of hPSCs lines, as well as their therapeutic efficacy and safety following transplantation... - Lysophosphatidic acid in neural signalingXiaoqin Ye
Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA 92093-0636, USA
Neuroreport 13:2169-75. 2002..This review provides a current summary of LPA-induced effects in neural cells in vitro or in vivo in combination with our current understanding of the signaling pathways responsible for these effects... - Neuronal DNA content variation (DCV) with regional and individual differences in the human brainJurjen W Westra
Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, California 92037, USA
J Comp Neurol 518:3981-4000. 2010.... - Roles for lysophospholipid S1P receptors in multiple sclerosisKyoko Noguchi
Department of Molecular Biology, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA
Crit Rev Biochem Mol Biol 46:2-10. 2011..These data implicate lysophospholipid signaling--via S1P(1) and perhaps other lysophospholipid receptors--in therapeutic approaches to MS and potentially other diseases with immunological and/or neurological components... - S1P3 receptor-induced reorganization of epithelial tight junctions compromises lung barrier integrity and is potentiated by TNFYasuhiro Gon
Department of Immunology, Core Microscopy Facility, Helen L Dorris Child and Adolescent Neuro Psychiatric Disorder Institute, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 102:9270-5. 2005..Because S1P3-null mice are resistant to S1P-induced pulmonary leakage, either alone or in the presence of TNF, S1P3 antagonism may be useful in protecting epithelial integrity in pulmonary disease... - Stereotyped fetal brain disorganization is induced by hypoxia and requires lysophosphatidic acid receptor 1 (LPA1) signalingKeira Joann Herr
Department of Molecular Biology, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 108:15444-9. 2011.... - Sphingosine 1-phosphate S1P2 and S1P3 receptor-mediated Akt activation protects against in vivo myocardial ischemia-reperfusion injuryChristopher K Means
Department of Pharmacology, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0636, USA
Am J Physiol Heart Circ Physiol 292:H2944-51. 2007..Our data demonstrate that activation of S1P(2) and S1P(3) receptors plays a significant role in protecting cardiomyocytes from I/R damage in vivo and implicate the release of S1P and receptor-mediated Akt activation in this process... - Emerging medicinal roles for lysophospholipid signalingShannon E Gardell
Department of Molecular Biology, Helen L. Dorris Child and Adolescent Neuropsychiatric Disorder Institute, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Trends Mol Med 12:65-75. 2006..Recent genetic and pharmacological studies on LP signaling in animal disease models have identified new areas in which interventions in LP signaling might provide novel therapeutic approaches for the treatment of human diseases... - Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rateM Germana Sanna
Department of Immunology, The Center for Mass Spectrometry, The Scripps Research Institute, La Jolla, California 92037, USA
J Biol Chem 279:13839-48. 2004.... - Lysophosphatidic acid as a novel cell survival/apoptotic factorXiaoqin Ye
Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA 92093-0636, USA
Biochim Biophys Acta 1585:108-13. 2002..The effects of LPA on both cell survival and apoptosis underscore important roles for this lipid in normal development and pathological processes... - Neurological S1P signaling as an emerging mechanism of action of oral FTY720 (fingolimod) in multiple sclerosisChang Wook Lee
Department of Molecular Biology, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA
Arch Pharm Res 33:1567-74. 2010.... - Chromosomal mosaicism in neural stem cellsSuzanne E Peterson
Department of Molecular Biology, Child and Adolescent Neuropsychiatric Disorder Institute, The Scripps Research Institute, La Jolla, CA, USA
Methods Mol Biol 438:197-204. 2008..SKY offers superior speed and sensitivity in its ability to detect many types of chromosomal defects, including deletions, insertions, translocations, and aneuploidy... - Lysophosphatidic acid-induced c-fos up-regulation involves cyclic AMP response element-binding protein activated by mitogen- and stress-activated protein kinase-1Chang Wook Lee
Department of Molecular Biology, Helen L Dorris Child and Adolescent Neuropsychiatric Disorder Institute, The Scripps Research Institute, La Jolla, California 92037, USA
J Cell Biochem 104:785-94. 2008..Taken together, our results suggest that CREB plays an important role in up-regulation of c-fos mRNA level in LPA-stimulated Rat-2 fibroblast cells... - A reevaluation of tetraploidy in the Alzheimer's disease brainJurjen W Westra
Helen L Dorris Child and Adolescent Neuropsychiatric Disorder Institute, The Scripps Research Institute, La Jolla, CA 92037, USA
Neurodegener Dis 6:221-9. 2009..Our findings demonstrate that neuronal tetraploidy is nonexistent in the AD brain and intimate a reevaluation of neuronal cell cycle re-entry as a therapeutic target for AD... - Ser18 and 23 phosphorylation is required for p53-dependent apoptosis and tumor suppressionConnie Chao
Section of Molecular Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093 0322, USA
EMBO J 25:2615-22. 2006..Therefore, Ser18 and Ser23 phosphorylation is important for p53-dependent suppression of tumorigenesis in certain physiological context... - Targeted deletion of LPA5 identifies novel roles for lysophosphatidic acid signaling in development of neuropathic painMu En Lin
Scripps Research Institute, Molecular Biology Department, Dorris Neuroscience Center, La Jolla, California 92037, USA
J Biol Chem 287:17608-17. 2012..These data expand the influences of LPA signaling in neuropathic pain through a second LPA receptor subtype, LPA(5), involving a mechanistically distinct downstream signaling pathway compared with LPA(1)... - Mathematical modeling supports substantial mouse neural progenitor cell deathMichael J McConnell
Crick Jacobs Center for Theoretical and Computational Biology, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
Neural Dev 4:28. 2009..Existing quantitative models of mouse cerebral cortical development are not fully constrained by experimental data... - Dendritic cell PAR1-S1P3 signalling couples coagulation and inflammationFrank Niessen
Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
Nature 452:654-8. 2008..Thus, activation of dendritic cells by coagulation in the lymphatics emerges as a previously unknown mechanism that promotes systemic inflammation and lethality in decompensated innate immune responses... - Lysophosphatidic acid in vascular development and diseaseSiew T Teo
Department of Molecular Biology, Helen L Dorris Child and Adolescent Neuropsychiatric Disorder Institute, The Scripps Research Institute, ICND 118, La Jolla, CA 92037, USA
IUBMB Life 61:791-9. 2009.... - Cell surface receptors in lysophospholipid signalingBrigitte Anliker
Department of Molecular Biology, Helen L Dorris Institute for Neurological and Psychiatric Disorders, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
Semin Cell Dev Biol 15:457-65. 2004..Finally, in vivo effects of LP receptor gene deletion in mice will be discussed... - A new method of embryonic culture for assessing global changes in brain organizationStevens K Rehen
Helen L. Dorris Child and Adolescent Neuropsychiatric Disorder Institute, The Scripps Research Institute, La Jolla, CA 92037, USA
J Neurosci Methods 158:100-8. 2006..This method should thus be helpful for assessing a wide range of soluble molecules for their systemic effects on the embryonic brain... - Biological roles of lysophospholipid receptors revealed by genetic null mice: an updateJi Woong Choi
Department of Molecular Biology, Helen L Dorris Child and Adolescent Neuropsychiatric Disorder Institute, The Scripps Research Institute, 10550 North Torrey Pines Rd, ICND 118, La Jolla, CA 92037, USA
Biochim Biophys Acta 1781:531-9. 2008..This review will focus on findings from in vivo as well as in vitro studies using genetic null mice for the LP receptors, LPA1,2,3 and S1P1,2,3,5, and for the LP producing enzymes, autotaxin and sphingosine kinase 1/2... - Lysophosphatidic acid (LPA) and its receptorsKyoko Noguchi
The Department of Molecular Biology, Helen L Dorris Institute for Neurological and Psychiatric Disorders, The Scripps Research Institute, La Jolla, CA 92037, United States
Curr Opin Pharmacol 9:15-23. 2009..In addition, small molecule agonists and antagonists have been reported. Here we review recent data on the nervous system functions of LPA signaling, and summarize data on reported agonists and antagonists of LPA receptors... - LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacingXiaoqin Ye
Department of Molecular Biology, Helen L Dorris Child and Adolescent Neuropsychiatric Disorder Institute, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Nature 435:104-8. 2005..These data identify LPA3 receptor-mediated signalling as having an influence on implantation, and further indicate linkage between LPA signalling and prostaglandin biosynthesis... - A mechanistically novel, first oral therapy for multiple sclerosis: the development of fingolimod (FTY720, Gilenya)Jerold Chun
Department of Molecular Biology and Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, California 92037, USA
Discov Med 12:213-28. 2011..This duality may herald a paradigm shift in the treatment of MS and other neurological disorders... - In vivo roles of lysophospholipid receptors revealed by gene targeting studies in miceAmy H Yang
Department of Pharmacology, School of Medicine, University of California, San Diego (UCSD, La Jolla, CA 92093-0636, USA
Biochim Biophys Acta 1582:197-203. 2002..Altogether, these data give insights to the importance of LPA/S1P receptors at the cellular and organismal level... - Lysophosphatidic acid (LPA) receptors: signaling properties and disease relevanceMu En Lin
Department of Molecular Biology, Helen L Dorris Institute for Neurological and Psychiatric Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
Prostaglandins Other Lipid Mediat 91:130-8. 2010..Modulation of LPA signaling may thus provide therapeutic inroads for the treatment of human disease... - International Union of Pharmacology. XXXIV. Lysophospholipid receptor nomenclatureJerold Chun
Merck Research Laboratories, La Jolla, California 92037, USA
Pharmacol Rev 54:265-9. 2002..Herein, the molecular pharmacology of the lysophospholipid receptors is reviewed briefly, and a rational nomenclature for LPA and S1P receptors that is consistent with the International Union of Pharmacology guidelines is proposed... - Insights into the pharmacological relevance of lysophospholipid receptorsTetsuji Mutoh
Department of Molecular Biology, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA, USA
Br J Pharmacol 165:829-44. 2012..Continued basic and translational research on LP signalling should provide novel insights into both basic biological mechanisms, as well as novel therapeutic approaches to combat a range of human diseases... - Lysophospholipid G protein-coupled receptorsBrigitte Anliker
Department of Molecular Biology, Helen L. Dorris Institute for Neurological and Psychiatric Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
J Biol Chem 279:20555-8. 2004..In this brief review, we note cogent features of lysophospholipid receptors, including the current nomenclature, signaling properties, development of agonists and antagonists, and physiological functions... - Tandem genomic arrangement of a G protein (Gna15) and G protein-coupled receptor (s1p(4)/lp(C1)/Edg6) geneJames J A Contos
Department of Pharmacology, School of Medicine, University of California at San Diego, La Jolla, CA 92093 0636, USA
FEBS Lett 531:99-102. 2002.... - Identification of neural programmed cell death through the detection of DNA fragmentation in situ and by PCRYun C Yung
Helen L Dorris Child and Adolescent Neuropsychiatric Disorder Institute, The Scripps Research Institute, La Jolla, California, USA
Curr Protoc Neurosci . 2009..A description of various current detection strategies is provided, as well as support protocols for preparing positive and negative controls and for preparing genomic DNA... - FISH analysis of human pluripotent stem cellsSuzanne E Peterson
Jeanne Loring Lab, Chemical Physiology, The Scripps Research Institute, La Jolla, CA, USA
Methods Mol Biol 767:191-200. 2011..Here we will describe a cytogenetic method for screening human PSCs using FISH... - Signaling mechanisms responsible for lysophosphatidic acid-induced urokinase plasminogen activator expression in ovarian cancer cellsHongbin Li
Department of Immunology and Molecular Biology, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, California 92037, USA
J Biol Chem 280:10564-71. 2005..Thus these results suggest that the G(i)-Ras-Raf-NF-kappaB signaling cascade is responsible for LPA-induced uPA up-regulation in ovarian cancer cells... - GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5Chang Wook Lee
Department of Molecular Biology, Helen L Dorris Institute for Neurological and Psychiatric Disorders, The Scripps Research Institute, La Jolla, California 92037, USA
J Biol Chem 281:23589-97. 2006..These results support GPR92 as a fifth LPA receptor, LPA5, which likely has distinct physiological functions in view of its expression pattern... - Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal functionXinyu Zhao
Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 100:6777-82. 2003..Our findings indicate that DNA methylation is important in maintaining cellular genomic stability and is crucial for normal neural stem cell and brain functions... - Lysophospholipids and their receptors in the central nervous systemJi Woong Choi
Department of Molecular Biology, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA Department of Pharmacology, College of Pharmacy, Gachon University, Incheon 406 799, Republic of Korea
Biochim Biophys Acta 1831:20-32. 2013..This article is part of a Special Issue entitled Advances in Lysophospholipid Research... - High-density lipoproteins and their constituent, sphingosine-1-phosphate, directly protect the heart against ischemia/reperfusion injury in vivo via the S1P3 lysophospholipid receptorGregor Theilmeier
Institute for Anatomy, Department of Anesthesiology and Intensive Care, University Hospital Munster, Vesaliusweg 2 4, 48149 Munster, Germany
Circulation 114:1403-9. 2006..We hypothesized that some of the cholesterol transport-independent biological properties of high-density lipoprotein (HDL) implied in atheroprotection may also be beneficial in settings of acute myocardial reperfusion injury... - Neurobiology of lysophosphatidic acid signalingNobuyuki Fukushima
Department of Biochemistry, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Neuroscientist 8:540-50. 2002..Here the authors review features of the LPA receptor family and cellular responses of nervous system-derived cells, and discuss developmental and pathological roles for LPA signaling in the nervous system... - Sphingosine kinase type 1 induces G12/13-mediated stress fiber formation, yet promotes growth and survival independent of G protein-coupled receptorsAna Olivera
Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases NIH, Bethesda, MD 20891, USA
J Biol Chem 278:46452-60. 2003..Our results demonstrate a receptor-independent intracellular function of S1P, reminiscent of its action in yeast cells that lack S1PRs... - Characterization of lpa(2) (Edg4) and lpa(1)/lpa(2) (Edg2/Edg4) lysophosphatidic acid receptor knockout mice: signaling deficits without obvious phenotypic abnormality attributable to lpa(2)James J A Contos
Department of Pharmacology, Neurosciences and Biomedical Sciences Programs, School of Medicine, University of California, San Diego, La Jolla 92093 0636, USA
Mol Cell Biol 22:6921-9. 2002..Thus, although LPA(2) is not essential for normal mouse development, it does act redundantly with LPA(1) to mediate most LPA responses in fibroblasts... - Dual regulation of actin rearrangement through lysophosphatidic acid receptor in neuroblast cell lines: actin depolymerization by Ca(2+)-alpha-actinin and polymerization by rhoNobuyuki Fukushima
Department of Molecular Biochemistry, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
Mol Biol Cell 13:2692-705. 2002..This dual actin rearrangement may play a novel, important role in regulation of the neuronal morphology and motility during brain development... - Immunomodulator FTY720 Induces eNOS-dependent arterial vasodilatation via the lysophospholipid receptor S1P3Markus Tölle
Med Klinik IV, Charite Campus Benjamin Franklin, Berlin, Germany
Circ Res 96:913-20. 2005.... - Sphingosine-1-phosphate stimulates the functional capacity of progenitor cells by activation of the CXCR4-dependent signaling pathway via the S1P3 receptorDirk H Walter
Molecular Cardiology, Department of Internal Medicine III, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
Arterioscler Thromb Vasc Biol 27:275-82. 2007.... - The sphingosine 1-phosphate receptor S1P2 triggers hepatic wound healingValérie Serrière-Lanneau
INSERM U841, Institut Mondor de Recherche Biomedicale, Hopital Henri Mondor, 94010 Creteil, France
FASEB J 21:2005-13. 2007..These results unravel a novel major role of S1P2 in the wound healing response to acute liver injury by a mechanism involving enhanced proliferation of hMF... - S1P1 receptor localization confers selectivity for Gi-mediated cAMP and contractile responsesChristopher Kable Means
Biomedical Sciences Graduate Program and Department of Pharmacology, University of California, San Diego, California 92093 0636, USA
J Biol Chem 283:11954-63. 2008..Thus localization of S1P(1) receptors to caveolae is required for the ability of this receptor to inhibit adenylyl cyclase and contractility but compromises receptor coupling to Akt and ERK... - Lysophospholipid receptors: signaling and biologyIsao Ishii
Department of Molecular Genetics, National Institute of Neuroscience, NCNP, Kodaira, Tokyo 187 8502, Japan
Annu Rev Biochem 73:321-54. 2004..The rapidly expanding literature on the LP receptors is herein reviewed... - Immunomodulator FTY720 induces myofibroblast differentiation via the lysophospholipid receptor S1P3 and Smad3 signalingChristina D Keller
Institute of Pharmacy, Pharmacology and Toxicology, Freie Universitat Berlin, Konigin Luise Str 2 4, D 14195 Berlin, Germany
Am J Pathol 170:281-92. 2007..Finally, we determined that downstream of S1P3 signaling Smad3 activation is essential for myofibroblast differentiation in response to FTY720. Thus, FTY720 may have adverse fibrotic effects related to its activity on S1P3 signaling... - Sphingosine 1-phosphate receptor agonists attenuate relapsing-remitting experimental autoimmune encephalitis in SJL miceMichael Webb
Molecular Neuroscience Laboratory, Merck Research Laboratories, 3535 General Atomics Court, San Diego, CA 92121, USA
J Neuroimmunol 153:108-21. 2004..EAE produced by adoptively transferring lymph node cells from immunized mice to naïve hosts is similarly ameliorated by FTY-P. Treatment with FTY-P is accompanied by a dose-responsive peripheral lymphopoenia... - High-density lipoprotein stimulates myocardial perfusion in vivoBodo Levkau
Institute of Pathophysiology, Center of Internal Medicine, University Hospital Essen, Hufelandstrasse 55, 45122 Essen, Germany
Circulation 110:3355-9. 2004..In vivo, administration of reconstituted HDL restored abnormal endothelial function of the brachial artery in hypercholesterolemic patients. However, no data are currently available on the effect of HDL on myocardial perfusion... - HDL-associated lysosphingolipids inhibit NAD(P)H oxidase-dependent monocyte chemoattractant protein-1 productionMarkus Tölle
Charite Campus Benjamin Franklin, Medizinische Klinik, Berlin, Germany
Arterioscler Thromb Vasc Biol 28:1542-8. 2008..Here we investigated the influence of HDL on MCP-1 production in vascular smooth muscle cells (VSMCs) and rat aortic explants... - HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3Jerzy Roch Nofer
Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfalische Wilhelms Universitat, Munster, Germany
J Clin Invest 113:569-81. 2004..This mechanism may contribute to the vasoactive effect of HDL and represent a novel aspect of its antiatherogenic function... - Absence of LPA1 signaling results in defective cortical developmentGuillermo Estivill-Torrus
Unidad de Investigacion, Fundacion IMABIS, Hospital Carlos Haya, E 29010 Malaga, Spain
Cereb Cortex 18:938-50. 2008..These data support LPA(1) function in normal cortical development and suggest that the presence of genetic modifiers of LPA(1) influences cerebral cortical development... - Lysophosphatidic acid influences the morphology and motility of young, postmitotic cortical neuronsNobuyuki Fukushima
Department of Pharmacology, University of California, San Diego, La Jolla 92093 0636, USA
Mol Cell Neurosci 20:271-82. 2002..Taken together, these results implicate LPA as an extracellular lipid signal affecting process outgrowth and migration of early postmitotic neurons during development... - The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leakAndrew M Tager
Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, CNY149 8301, 149 13th Street, Charlestown, Massachusetts 02129 USA
Nat Med 14:45-54. 2008..LPA1 therefore represents a new therapeutic target for diseases in which aberrant responses to injury contribute to fibrosis, such as idiopathic pulmonary fibrosis... - LPA1 receptor activation promotes renal interstitial fibrosisJean Philippe Pradere
INSERM, U858 I2MR, Department of Metabolism and Obesity, Team 3, Toulouse, France
J Am Soc Nephrol 18:3110-8. 2007..In conclusion, LPA, likely acting through LPA1, is involved in obstruction-induced TIF. Therefore, the LPA1 receptor might be a pharmaceutical target to treat renal fibrosis... - Initiation of neuropathic pain requires lysophosphatidic acid receptor signalingMakoto Inoue
Division of Molecular Pharmacology and Neuroscience, Nagasaki University, Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki, 852 8521, Japan
Nat Med 10:712-8. 2004..Inhibitors of Rho and Rho kinase also prevented these signs of neuropathic pain. These results imply that receptor-mediated LPA signaling is crucial in the initiation of neuropathic pain... - The S1P2 receptor negatively regulates platelet-derived growth factor-induced motility and proliferationSravan K Goparaju
Department of Biochemistry, Virginia Commonwealth University Medical Center, 1101 E Marshall Street, Room 2 011, Sanger Hall, Richmond, VA 23298 0614, USA
Mol Cell Biol 25:4237-49. 2005..Thus, S1P(2) serves as a negative regulator of PDGF-induced migration and proliferation as well as SphK1 expression. Our results suggest that a complex interplay between PDGFR and S1P receptors determines their functions... - Lysophosphatidic acid stimulates astrocyte proliferation through LPA1Shinya Shano
Division of Molecular Neurobiology, Department of Life Sciences, School of Science and Engineering, Kinki University, Kowakae 3 4 1, Higashiosaka 577 8502, Japan
Neurochem Int 52:216-20. 2008..Taken together, these observations demonstrate that LPA1 mediates LPA-induced stimulation of cell proliferation but not inhibition of glutamate uptake in astrocytes... - LPA3 receptor mediates chemotaxis of immature murine dendritic cells to unsaturated lysophosphatidic acid (LPA)Liana C Chan
Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
J Leukoc Biol 82:1193-200. 2007..In summary, our results indicate that immature mouse DCs migrate preferentially in response to unsaturated LPA and that LPA(3) is important in this response... - Lysophosphatidic acid receptor-dependent secondary effects via astrocytes promote neuronal differentiationTânia Cristina Sampaio Spohr
Departamento de Anatomia, Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, 21949 590 Rio de Janeiro RJ, Brazil
J Biol Chem 283:7470-9. 2008..These data demonstrate that receptor-mediated LPA signaling in astrocytes can induce LPA-dependent, indirect effects on neuronal differentiation... - Lysophosphatidic acid stimulates neuronal differentiation of cortical neuroblasts through the LPA1-G(i/o) pathwayNobuyuki Fukushima
Molecular Neurobiology, Department of Life Sciences, School of Science and Engineering, Kinki University, Kowakae 3 4 1, Higashiosaka 577 8502, Japan
Neurochem Int 50:302-7. 2007..These results suggest that LPA promotes the commitment of neuroblasts to the neural lineage through the LPA(1)-G(i/o) pathway... - The sphingosine-1-phosphate (S1P) lysophospholipid receptor S1P3 regulates MAdCAM-1+ endothelial cells in splenic marginal sinus organizationIrute Girkontaite
Department of Physiological Chemistry, University of Ulm, Albert Einstein Allee 11, D 89069 Ulm, Germany
J Exp Med 200:1491-501. 2004..These data identify lysophospholipids and the S1P(3) receptor as essential regulators of the MZ sinus and its role as a barrier to the follicle... - S1P3-mediated Akt activation and cross-talk with platelet-derived growth factor receptor (PDGFR)Linnea M Baudhuin
Department of Cancer Biology, The Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
FASEB J 18:341-3. 2004..This is the first report demonstrating a unique interaction between S1P3 and PDGFR, in addition to demonstrating a specific role for S1P3 in S1P-induced Akt activation... - Pharmacological characterization of lysophospholipid receptor signal transduction pathways in rat cerebrocortical astrocytesTadimeti S Rao
Merck Research Laboratories, 3535 General Atomics Court, Building 1, San Diego, CA 92121, USA
Brain Res 990:182-94. 2003.... - Lysophosphatidic acid receptors 1 and 2 play roles in regulation of vascular injury responses but not blood pressureManikandan Panchatcharam
Division of Cardiovascular Medicine, The Gill Heart Institute, Lexington, KY 40536, USA
Circ Res 103:662-70. 2008..These results identify a role for LPA1 and LPA2 in regulating SMC migratory responses in the context of vascular injury but suggest that additional LPA receptor subtypes are required for other LPA-mediated effects in the vasculature... - Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate (S1P) receptors, S1P(2)/LP(B2)/EDG-5 and S1P(3)/LP(B3)/EDG-3Isao Ishii
Department of Pharmacology, School of Medicine, University of California at San Diego, La Jolla 92093 0636, USA
J Biol Chem 277:25152-9. 2002..Although either receptor subtype supports embryonic development, deletion of both produces marked perinatal lethality, demonstrating an essential role for combined S1P signaling by these receptors... - Lysophosphatidic acid inhibits adipocyte differentiation via lysophosphatidic acid 1 receptor-dependent down-regulation of peroxisome proliferator-activated receptor gamma2Marie Francoise Simon
INSERM U586, Institut Louis Bugnard, Rangueil Hospital, BP84225, 31432 Toulouse, Cedex 4, France
J Biol Chem 280:14656-62. 2005..The local production of LPA may exert a tonic inhibitory effect on the development of adipose tissue... - Growth factor pre-treatment differentially regulates phosphoinositide turnover downstream of lysophospholipid receptor and metabotropic glutamate receptors in cultured rat cerebrocortical astrocytesTadimeti S Rao
Merck Research Laboratories San Diego, 3535 General Atomics Court, Bldg 1, San Diego, CA 92121, USA
Int J Dev Neurosci 22:131-5. 2004.... - Embryo spacing and implantation timing are differentially regulated by LPA3-mediated lysophosphatidic acid signaling in miceKotaro Hama
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113 0033, Japan
Biol Reprod 77:954-9. 2007..Because the uterine contraction is critical for embryo spacing, our results suggest that LPA3 signaling controls embryo spacing via uterine contraction around E3.5... - Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA1Kotaro Hama
Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
J Biol Chem 279:17634-9. 2004..The present study suggests that ATX and LPA(1) represent potential targets for cancer therapy...
Research Grants
- Lysophospholipids roles for Schwann cell & myelinationJerold Chun; Fiscal Year: 2007..studies have demonstrated that lysophospholipid receptors are "druggable" targets, raising the prospect that data from this proposal could help in the development of strategies to treat disorders of peripheral myelination ..
- Interactions of LPA and prostaglandins in implantationJerold Chun; Fiscal Year: 2007..Work from this proposal will lay the groundwork towards realizing this possible therapeutic potential. ..
- Functional studies on normal neural aneuploidyJerold Chun; Fiscal Year: 2007..This proposal will provide a framework for, and data towards, understanding the functional importance of neural aneuploidy in the nervous system. ..
- Receptor-mediated S1P signaling in the embryonic brainJerold Chun; Fiscal Year: 2007..It is notable that the small size of these lipid molecules makes them attractive targets for drug design, and results from this proposal could serve as a foundation for new therapies based upon lysophospholipid-mimetic drugs. ..
- Receptor-mediated S1P signaling in the embryonic brainJerold Chun; Fiscal Year: 2009..It is notable that the small size of these lipid molecules makes them attractive targets for drug design, and results from this proposal could serve as a foundation for new therapies based upon lysophospholipid-mimetic drugs. ..
- Interactions of LPA and prostaglandins in implantationJerold Chun; Fiscal Year: 2010..Work from this proposal will lay the groundwork towards realizing this possible therapeutic potential. ..
- Receptor-mediated S1P signaling in the embryonic brainJerold Chun; Fiscal Year: 2010..It is notable that the small size of these lipid molecules makes them attractive targets for drug design, and results from this proposal could serve as a foundation for new therapies based upon lysophospholipid-mimetic drugs. ..
- RECEPTOR-MEDIATED LPA SIGNALING IN CORTICAL DEVELOPMENTJerold Chun; Fiscal Year: 2009..It may also lead to rational approaches, based on LPA receptor modulation, for preventing or treating mental health disorders with developmental etiologies. ..
- RECEPTOR-MEDIATED LPA SIGNALING IN CORTICAL DEVELOPMENTJerold Chun; Fiscal Year: 2007..abstract_text> ..
- EMBRYONIC CORTICAL APOPTOSIS ROLES AND REGULATIONSJerold Chun; Fiscal Year: 2001..Years 1-5). This information will provide new insights into the mechanisms behind developmental neurological disorders, especially those affecting the normal functions of the cerebral cortex. ..
- ROLES FOR LPA SIGNALING IN CEREBRAL CORTICAL DEVELOPMENTJerold Chun; Fiscal Year: 2005....