Ennio Chiocca

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. pmc Deciphering the Multifaceted Relationship between Oncolytic Viruses and Natural Killer Cells
    Christopher A Alvarez-Breckenridge
    Medical Scientist Training Program, The Ohio State University, Columbus, OH 43210, USA
    Adv Virol 2012:702839. 2012
  2. pmc The Gs-linked receptor GPR3 inhibits the proliferation of cerebellar granule cells during postnatal development
    Shigeru Tanaka
    Dardinger Laboratory for Neuro oncology and Neurosciences, Department of Neurological Surgery, The Ohio State University, Columbus, OH, USA
    PLoS ONE 4:e5922. 2009
  3. pmc The histone deacetylase inhibitor valproic acid lessens NK cell action against oncolytic virus-infected glioblastoma cells by inhibition of STAT5/T-BET signaling and generation of gamma interferon
    Christopher A Alvarez-Breckenridge
    Medical Scientist Training Program, The Ohio State University Medical Center and The James Cancer Hospital and Solove Research Institute, Columbus, Ohio, USA
    J Virol 86:4566-77. 2012
  4. doi request reprint A phase I trial of Ad.hIFN-beta gene therapy for glioma
    E Antonio Chiocca
    Department of Neurosurgery, Dardinger Neuro oncology Center, James Comprehensive Cancer Center, The Ohio State University Medical Center, Columbus, Ohio 43210 1240, USA
    Mol Ther 16:618-26. 2008
  5. pmc Phase IB study of gene-mediated cytotoxic immunotherapy adjuvant to up-front surgery and intensive timing radiation for malignant glioma
    E Antonio Chiocca
    James Cancer Hospital Ohio State University Medical Center, N 1017 Doan Hall, 410 W 10th Ave, Columbus, OH 43210, USA
    J Clin Oncol 29:3611-9. 2011
  6. ncbi request reprint The host response to cancer virotherapy
    E Antonio Chiocca
    The Ohio State University Medical Center, Dardinger Neuro oncology Center, Department of Neurosurgery, James Comprehensive Cancer Center, N 1017 Doan Hall, 410 West 10th Avenue, Columbus, OH 43210 1240, USA
    Curr Opin Mol Ther 10:38-45. 2008
  7. doi request reprint Solitary pituitary sarcoidosis with normal endocrine function: case report
    Promod Pillai
    Department of Neurological Surgery, The Ohio State University Medical Center, Columbus, OH 43210, USA
    J Neurosurg 108:591-4. 2008
  8. doi request reprint Spinal angiography and epidural venography in juvenile muscular atrophy of the distal arm "Hirayama disease"
    Bakri Elsheikh
    Department of Neurology, 421 Means Hall, 1654 Upham Drive, Ohio State University, Columbus, Ohio 43210, USA
    Muscle Nerve 40:206-12. 2009
  9. pmc Gene- and viral-based therapies for brain tumors
    Kaveh Asadi-Moghaddam
    Department of Neurological Surgery, Dardinger Center for Neuro oncology and Neurosciences, James Cancer Hospital Solove Research Institute, The Ohio State University Medical Center, Columbus, Ohio, USA
    Neurotherapeutics 6:547-57. 2009
  10. doi request reprint Emerging functions of microRNAs in glioblastoma
    Sean Lawler
    Dardinger Laboratory for Neuro oncology and Neurosciences, Department of Neurological Surgery, The Ohio State University Medical Center and James Comprehensive Cancer Center, Columbus, OH 43210, USA
    J Neurooncol 92:297-306. 2009

Research Grants

  1. Interdisciplinary Tumor Complexity Modeling
    Ennio Chiocca; Fiscal Year: 2003
  2. Biology of Tauopathies Studied with HSV Amplicons
    E Antonio Chiocca; Fiscal Year: 2007
  3. Interdisciplinary Tumor Complexity Modeling
    E Antonio Chiocca; Fiscal Year: 2006
  4. Interdisciplinary Tumor Complexity Modeling
    Ennio Chiocca; Fiscal Year: 2004
  5. Imaging Transcriptional Activation of Gliomas
    E Antonio Chiocca; Fiscal Year: 2006
  6. Interdisciplinary Tumor Complexity Modeling
    Ennio Chiocca; Fiscal Year: 2005
  7. Biology of Tauopathies Studied with HSV Amplicons
    Ennio Chiocca; Fiscal Year: 2006
  8. HSV Amplicon Vectors for Cerebral Ischemia
    Ennio Chiocca; Fiscal Year: 2002
  9. Interdisciplinary Tumor Complexity Modeling
    Ennio Chiocca; Fiscal Year: 2004
  10. Dose Response/Dynamics Ultrasound Mediated BBB Opening
    Ennio Chiocca; Fiscal Year: 2005

Collaborators

Detail Information

Publications34

  1. pmc Deciphering the Multifaceted Relationship between Oncolytic Viruses and Natural Killer Cells
    Christopher A Alvarez-Breckenridge
    Medical Scientist Training Program, The Ohio State University, Columbus, OH 43210, USA
    Adv Virol 2012:702839. 2012
    ..In this review we discuss the current literature on the NK response to oncolytic viral infection and how future studies clarify this intricate response...
  2. pmc The Gs-linked receptor GPR3 inhibits the proliferation of cerebellar granule cells during postnatal development
    Shigeru Tanaka
    Dardinger Laboratory for Neuro oncology and Neurosciences, Department of Neurological Surgery, The Ohio State University, Columbus, OH, USA
    PLoS ONE 4:e5922. 2009
    ..Molecular events that govern this program remain to be fully elucidated. GPR3 belongs to a family of Gs-linked receptors that activate cyclic AMP and are abundantly expressed in the adult brain...
  3. pmc The histone deacetylase inhibitor valproic acid lessens NK cell action against oncolytic virus-infected glioblastoma cells by inhibition of STAT5/T-BET signaling and generation of gamma interferon
    Christopher A Alvarez-Breckenridge
    Medical Scientist Training Program, The Ohio State University Medical Center and The James Cancer Hospital and Solove Research Institute, Columbus, Ohio, USA
    J Virol 86:4566-77. 2012
    ..These findings indicate that one of the avenues by which VPA enhances oHSV efficacy is through initial suppression of immune cell recruitment and inhibition of inflammatory cell pathways within NK cells...
  4. doi request reprint A phase I trial of Ad.hIFN-beta gene therapy for glioma
    E Antonio Chiocca
    Department of Neurosurgery, Dardinger Neuro oncology Center, James Comprehensive Cancer Center, The Ohio State University Medical Center, Columbus, Ohio 43210 1240, USA
    Mol Ther 16:618-26. 2008
    ..Direct Ad.hIFN-beta injection into the tumor and the surrounding normal brain areas after surgical removal was feasible and associated with apoptosis induction...
  5. pmc Phase IB study of gene-mediated cytotoxic immunotherapy adjuvant to up-front surgery and intensive timing radiation for malignant glioma
    E Antonio Chiocca
    James Cancer Hospital Ohio State University Medical Center, N 1017 Doan Hall, 410 W 10th Ave, Columbus, OH 43210, USA
    J Clin Oncol 29:3611-9. 2011
    ....
  6. ncbi request reprint The host response to cancer virotherapy
    E Antonio Chiocca
    The Ohio State University Medical Center, Dardinger Neuro oncology Center, Department of Neurosurgery, James Comprehensive Cancer Center, N 1017 Doan Hall, 410 West 10th Avenue, Columbus, OH 43210 1240, USA
    Curr Opin Mol Ther 10:38-45. 2008
    ..We believe that such host responses have to be circumvented, at least temporarily or partially, or both, in order to fulfill the promising anticancer effects of these agents...
  7. doi request reprint Solitary pituitary sarcoidosis with normal endocrine function: case report
    Promod Pillai
    Department of Neurological Surgery, The Ohio State University Medical Center, Columbus, OH 43210, USA
    J Neurosurg 108:591-4. 2008
    ....
  8. doi request reprint Spinal angiography and epidural venography in juvenile muscular atrophy of the distal arm "Hirayama disease"
    Bakri Elsheikh
    Department of Neurology, 421 Means Hall, 1654 Upham Drive, Ohio State University, Columbus, Ohio 43210, USA
    Muscle Nerve 40:206-12. 2009
    ..Resolution of progression is associated with cessation of body growth, after which the symptoms plateau or modestly improve. Muscle Nerve 40: 206-212, 2009...
  9. pmc Gene- and viral-based therapies for brain tumors
    Kaveh Asadi-Moghaddam
    Department of Neurological Surgery, Dardinger Center for Neuro oncology and Neurosciences, James Cancer Hospital Solove Research Institute, The Ohio State University Medical Center, Columbus, Ohio, USA
    Neurotherapeutics 6:547-57. 2009
    ..Furthermore, the problem of delivering genetic vectors into solid brain tumors and the efficiency in situ gene transfer remains one of the most significant hurdles in gene therapy...
  10. doi request reprint Emerging functions of microRNAs in glioblastoma
    Sean Lawler
    Dardinger Laboratory for Neuro oncology and Neurosciences, Department of Neurological Surgery, The Ohio State University Medical Center and James Comprehensive Cancer Center, Columbus, OH 43210, USA
    J Neurooncol 92:297-306. 2009
    ..Research in this area is quickly gathering pace and is illuminating important aspects of the disease that may ultimately lead to novel therapeutic interventions, as well as diagnostic and prognostic tools for brain tumors...
  11. pmc "Buy one get one free": armed viruses for the treatment of cancer cells and their microenvironment
    Balveen Kaur
    Dardinger Laboratory for Neuro oncology and Neurosciences, Department of Neurological Surgery, James Comprehensive Cancer Center and The Ohio State University Medical Center, 400 West 12th Avenue, Columbus, OH 43210, USA
    Curr Gene Ther 9:341-55. 2009
    ....
  12. ncbi request reprint Gene therapeutics: the future of brain tumor therapy?
    Jennifer L Cutter
    Dardinger Laboratory for Neuro oncology and Neurosciences, Department of Neurological Surgery and Comprehensive Cancer Center, The Ohio State University Medical Center, 410 West 12th Avenue, Columbus, OH 43210, USA
    Expert Rev Anticancer Ther 6:1053-64. 2006
    ..Oncolytic viral strategies are summarized in this review, with a focus on therapies used in brain tumors...
  13. ncbi request reprint Cyclophosphamide allows for in vivo dose reduction of a potent oncolytic virus
    Hirokazu Kambara
    Dardinger Center for Neuro oncology and Neurosciences, Department of Neurological Surgery, The Ohio State University Comprehensive Cancer Center, Columbus, 43210, USA
    Cancer Res 65:11255-8. 2005
    ..These findings thus show that cyclophosphamide allows for dose reduction of doses of a relatively potent oncolytic virus, a finding with implications for the development of clinical trials...
  14. ncbi request reprint Gene therapy for glioblastoma
    Manish Aghi
    Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Neurosurg Focus 20:E18. 2006
    ..The authors review the principles behind these approaches and their initial results...
  15. pmc MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells
    Jakub Godlewski
    Dardinger Laboratory for Neuro oncology and Neurosciences, Department of Neurological Surgery, The Ohio State University Medical Center and James Comprehensive Cancer Center, Columbus, OH 43210, USA
    Mol Cell 37:620-32. 2010
    ..Thus, miR-451 is a regulator of the LKB1/AMPK pathway, and this may represent a fundamental mechanism that contributes to cellular adaptation in response to altered energy availability...
  16. ncbi request reprint An oncolytic HSV-1 mutant expressing ICP34.5 under control of a nestin promoter increases survival of animals even when symptomatic from a brain tumor
    Hirokazu Kambara
    Dardinger Center for Neuro oncology, Department of Neurological Surgery, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio 43210, USA
    Cancer Res 65:2832-9. 2005
    ..rQNestin34.5 treatment doubled the life span of these animals. These results show that rQNestin34.5 could be a potent agent for the treatment of malignant glioma...
  17. pmc Lithium inhibits invasion of glioma cells; possible involvement of glycogen synthase kinase-3
    Michal O Nowicki
    Dardinger Laboratory for Neuro oncology and Neurosciences, Department of Neurological Surgery, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Neuro Oncol 10:690-9. 2008
    ..These data outline previously unidentified pathways and inhibitors that may be useful for the development of novel anti-invasive therapeutics for the treatment of brain tumors...
  18. ncbi request reprint Oncolytic viruses driven by tumor-specific promoters
    Jayson Hardcastle
    Dardinger Laboratory for Neuro oncology and Neurosciences, Department of Neurological Surgery, The Ohio State University, Columbus, Ohio 43210, USA
    Curr Cancer Drug Targets 7:181-9. 2007
    ..This review will focus on the various strategies exploited to generate viruses whose virulence is governed by tumor-specific transcriptional events...
  19. pmc Cyclophosphamide enhances glioma virotherapy by inhibiting innate immune responses
    Giulia Fulci
    Dardinger Center for Neuro oncology and Neurosciences, Department of Neurological Surgery, James Cancer Hospital and Solove Research Institute, Ohio State University Medical Center, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 103:12873-8. 2006
    ..Our results reveal molecular and cellular mechanisms that inhibit intratumoral spread of HSV and suggest a therapeutic path for improving the efficacy of virotherapy as a treatment for cancer...
  20. pmc Allergy and inflammatory transcriptome is predominantly negatively correlated with CD133 expression in glioblastoma
    Judith A Schwartzbaum
    School of Public Health, Division of Epidemiology, Ohio State University, Columbus, Ohio 43210, USA
    Neuro Oncol 12:320-7. 2010
    ..However, IL-17 and NCAM-1 may play proinflammatory and immunosuppressive roles, respectively, during the late stage of glioblastoma progression. Our findings suggest that immune function continues to change as the tumor progresses...
  21. ncbi request reprint Effect of tumor microenvironment modulation on the efficacy of oncolytic virus therapy
    Kazuhiko Kurozumi
    Dardinger Laboratory for Neuro oncology and Neurosciences, Department of Neurological Surgery, The Ohio State University, Columbus, OH 43210, USA
    J Natl Cancer Inst 99:1768-81. 2007
    ..We investigated oncolytic virus (OV) therapy-induced changes in tumor blood vessels and the impact of modulating tumor vasculature on the efficacy of oncolytic virus therapy...
  22. pmc Physiological transgene regulation and functional complementation of a neurological disease gene deficiency in neurons
    Pier Paolo Peruzzi
    Department of Neurological Surgery, Dardinger Laboratory for Neuro oncology and Neurosciences, The Ohio State University Medical School, Columbus, Ohio, USA
    Mol Ther 17:1517-26. 2009
    ..The faithful retention of gene expression and phenotype complementation by the system provides a novel method to analyze neurological disease genes...
  23. pmc Enhanced antitumor efficacy of vasculostatin (Vstat120) expressing oncolytic HSV-1
    Jayson Hardcastle
    Dardinger Laboratory for Neuro oncology and Neurosciences, Department of Neurological Surgery, James Comprehensive Cancer Center and The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    Mol Ther 18:285-94. 2010
    ..This is the first study to report the antitumor effects of Vstat120 delivery into established tumors and supports the further development of RAMBO as a possible cancer therapy...
  24. pmc Quantitative analysis of complex glioma cell migration on electrospun polycaprolactone using time-lapse microscopy
    Jed Johnson
    Department of Materials Science and Engineering, The Ohio State University, Columbus, OH 43210, USA
    Tissue Eng Part C Methods 15:531-40. 2009
    ....
  25. ncbi request reprint Contribution of bone marrow-derived cells to blood vessels in ischemic tissues and tumors
    Manish Aghi
    Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, 502 White Building, 55 Fruit Street, Boston, MA 02114, USA
    Mol Ther 12:994-1005. 2005
    ..We also take note of key issues that will need to be understood about the biology of vasculogenesis before cellular therapies utilizing vascular progenitor cells can be finally taken from the bench to the bedside...
  26. ncbi request reprint Personalizing oncolytic virotherapy?
    Balveen Kaur
    Dardinger Laboratory for Neuro oncology and Neurosciences, Comprehensive Cancer Center, and Department of Neurological Surgery, The Ohio State University Medical Center, Columbus, Ohio, USA
    Mol Ther 15:6-7. 2007
  27. ncbi request reprint Brain tumor imaging and surgical management: the neurosurgeon's perspective
    W James Thoman
    Department of Neurological Surgery, The Ohio State University Medical Center, Columbus, OH 43210 1240, USA
    Top Magn Reson Imaging 17:121-6. 2006
    ....
  28. ncbi request reprint Early STAT1 activation after systemic delivery of HSV amplicon vectors suppresses transcription of the vector-encoded transgene
    Masataka Suzuki
    Dardinger Laboratory for Neuro oncology and Neurosciences, Department of Neurological Surgery and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
    Mol Ther 15:2017-26. 2007
    ..Our results indicate that type I IFNs induced by systemic delivery of HSV amplicon vectors initiate a cascade of immune responses and suppress transgene expression at the transcriptional level by activation of STAT1...
  29. pmc C2/C3 pathologic fractures from polyostotic fibrous dysplasia of the cervical spine treated with percutaneous vertebroplasty
    David Dang
    Department of Radiology, Ohio State University, Columbus, OH, USA
    Eur Spine J 16:250-4. 2007
    ..We present a case that illustrates a potential use of PVP in the management of a patient with symptomatic spinal fibrous dysplasia with associated pathologic fractures who was poor surgical candidate...
  30. pmc Oncolytic HSV-1 infection of tumors induces angiogenesis and upregulates CYR61
    Kazuhiko Kurozumi
    Dardinger Laboratory for Neuro oncology and Neurosciences, Department of Neurological Surgery, James Comprehensive Cancer Center, The Ohio State University Medical Center, Columbus, Ohio, USA
    Mol Ther 16:1382-91. 2008
    ..Finally, we show that treatment of glioma cells with Cilengitide, known to counter CYR61-induced integrin activation, significantly suppressed the proangiogenic effect of OV treatment of gliomas (P < 0.05)...
  31. doi request reprint Stable transgene expression from HSV amplicon vectors in the brain: potential involvement of immunoregulatory signals
    Masataka Suzuki
    Dardinger Laboratory for Neuro oncology and Neurosciences, Department of Neurological Surgery, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    Mol Ther 16:1727-36. 2008
    ....
  32. doi request reprint The predictive value of low-field strength magnetic resonance imaging for intraoperative residual tumor detection. Clinical article
    Robert A Hirschl
    Dardinger Neuro oncology Center, Department of Neurological Surgery, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    J Neurosurg 111:252-7. 2009
    ..The object of this study was to determine the predictive concordance of low-strength iMR imaging with standard high-strength MR imaging for detection of residual tumor...
  33. ncbi request reprint Improved HSV-1 amplicon packaging system using ICP27-deleted, oversized HSV-1 BAC DNA
    Yoshinaga Saeki
    Molecular Neuro Oncology Lab, Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
    Methods Mol Med 76:51-60. 2003
  34. ncbi request reprint Oncolytic viruses for the therapy of brain tumors and other solid malignancies: a review
    Giulia Fulci
    Molecular Neuro oncology Laboratories, Massachusetts General Hospital East Building, CNY6, 13th Street, Charlestown, MA 02129, USA
    Front Biosci 8:e346-60. 2003
    ..We will also summarize published results from OV clinical trials and attempt to provide a perspective on research in this area...

Research Grants14

  1. Interdisciplinary Tumor Complexity Modeling
    Ennio Chiocca; Fiscal Year: 2003
    ..abstract_text> ..
  2. Biology of Tauopathies Studied with HSV Amplicons
    E Antonio Chiocca; Fiscal Year: 2007
    ....
  3. Interdisciplinary Tumor Complexity Modeling
    E Antonio Chiocca; Fiscal Year: 2006
    ..abstract_text> ..
  4. Interdisciplinary Tumor Complexity Modeling
    Ennio Chiocca; Fiscal Year: 2004
    ..abstract_text> ..
  5. Imaging Transcriptional Activation of Gliomas
    E Antonio Chiocca; Fiscal Year: 2006
    ..The conceptual scheme presented herein will also be applicable to a variety of diseases for which gene profiling analyses are available. ..
  6. Interdisciplinary Tumor Complexity Modeling
    Ennio Chiocca; Fiscal Year: 2005
    ..abstract_text> ..
  7. Biology of Tauopathies Studied with HSV Amplicons
    Ennio Chiocca; Fiscal Year: 2006
    ....
  8. HSV Amplicon Vectors for Cerebral Ischemia
    Ennio Chiocca; Fiscal Year: 2002
    ..abstract_text> ..
  9. Interdisciplinary Tumor Complexity Modeling
    Ennio Chiocca; Fiscal Year: 2004
    ..abstract_text> ..
  10. Dose Response/Dynamics Ultrasound Mediated BBB Opening
    Ennio Chiocca; Fiscal Year: 2005
    ..We aim to develop a device that will safely and reversibly open this barrier, allowing drugs to enter the brain and thereby creating an opportunity to treat diseases like brain cancer, Alzheimer's, Parkinson's, and others. ..
  11. Biology of Tauopathies Studied with HSV Amplicons
    Ennio Chiocca; Fiscal Year: 2005
    ....
  12. HSV Amplicon Vectors for Cerebral Ischemia
    Ennio Chiocca; Fiscal Year: 2004
    ..abstract_text> ..
  13. HSV Amplicon Vectors for Cerebral Ischemia
    Ennio Chiocca; Fiscal Year: 2003
    ..abstract_text> ..