Elissa J Chesler

Summary

Affiliation: The Jackson Laboratory
Country: USA

Publications

  1. pmc Accelerating discovery for complex neurological and behavioral disorders through systems genetics and integrative genomics in the laboratory mouse
    Jason A Bubier
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Neurotherapeutics 9:338-48. 2012
  2. pmc GeneWeaver: a web-based system for integrative functional genomics
    Erich J Baker
    School of Engineering and Computer Science, Baylor University, Waco, TX 76798, USA
    Nucleic Acids Res 40:D1067-76. 2012
  3. pmc High-precision genetic mapping of behavioral traits in the diversity outbred mouse population
    R W Logan
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Genes Brain Behav 12:424-37. 2013
  4. pmc High-throughput behavioral phenotyping in the expanded panel of BXD recombinant inbred strains
    V M Philip
    Systems Genetics Group, Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN, USA
    Genes Brain Behav 9:129-59. 2010
  5. pmc Out of the bottleneck: the Diversity Outcross and Collaborative Cross mouse populations in behavioral genetics research
    Elissa J Chesler
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, 04609, USA
    Mamm Genome 25:3-11. 2014
  6. pmc Genetic variation in hippocampal microRNA expression differences in C57BL/6 J X DBA/2 J (BXD) recombinant inbred mouse strains
    Michael J Parsons
    Mammalian Genetics Unit, Medical Research Council Harwell Oxfordshire, United Kingdom
    BMC Genomics 13:476. 2012
  7. doi request reprint Opportunities for bioinformatics in the classification of behavior and psychiatric disorders
    Elissa J Chesler
    The Jackson Laboratory, Bar Harbor, Maine, USA
    Int Rev Neurobiol 104:183-211. 2012
  8. pmc Quantitative trait loci for sensitivity to ethanol intoxication in a C57BL/6J×129S1/SvImJ inbred mouse cross
    Elissa J Chesler
    The Jackson Laboratory, 600 Main St, Bar Harbor, ME 04609, USA
    Mamm Genome 23:305-21. 2012
  9. pmc Comparison of threshold selection methods for microarray gene co-expression matrices
    Bhavesh R Borate
    Department of Animal Science, University of Tennessee, Knoxville, Tennessee, USA
    BMC Res Notes 2:240. 2009
  10. ncbi request reprint The importance of open-source integrative genomics to drug discovery
    Elissa J Chesler
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Curr Opin Drug Discov Devel 13:310-6. 2010

Detail Information

Publications23

  1. pmc Accelerating discovery for complex neurological and behavioral disorders through systems genetics and integrative genomics in the laboratory mouse
    Jason A Bubier
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Neurotherapeutics 9:338-48. 2012
    ..Together, these model organism-based approaches can lead to a refinement of diagnostic categories and targeted treatment of neurological and psychiatric disease...
  2. pmc GeneWeaver: a web-based system for integrative functional genomics
    Erich J Baker
    School of Engineering and Computer Science, Baylor University, Waco, TX 76798, USA
    Nucleic Acids Res 40:D1067-76. 2012
    ..An empirical 'ontology' is discovered from the aggregate of experimental knowledge around user-defined areas of biological inquiry...
  3. pmc High-precision genetic mapping of behavioral traits in the diversity outbred mouse population
    R W Logan
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Genes Brain Behav 12:424-37. 2013
    ..Our results demonstrate that high-precision mapping of behavioral traits can be achieved with moderate numbers of DO animals, representing a significant advance in our ability to leverage the mouse as a tool for behavioral genetics...
  4. pmc High-throughput behavioral phenotyping in the expanded panel of BXD recombinant inbred strains
    V M Philip
    Systems Genetics Group, Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN, USA
    Genes Brain Behav 9:129-59. 2010
    ..org for quantitative trait locus (QTL) detection and genetic analysis of gene expression. Together with the results of related studies, these data form a public resource for integrative systems genetic analysis of neurobehavioral traits...
  5. pmc Out of the bottleneck: the Diversity Outcross and Collaborative Cross mouse populations in behavioral genetics research
    Elissa J Chesler
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, 04609, USA
    Mamm Genome 25:3-11. 2014
    ....
  6. pmc Genetic variation in hippocampal microRNA expression differences in C57BL/6 J X DBA/2 J (BXD) recombinant inbred mouse strains
    Michael J Parsons
    Mammalian Genetics Unit, Medical Research Council Harwell Oxfordshire, United Kingdom
    BMC Genomics 13:476. 2012
    ....
  7. doi request reprint Opportunities for bioinformatics in the classification of behavior and psychiatric disorders
    Elissa J Chesler
    The Jackson Laboratory, Bar Harbor, Maine, USA
    Int Rev Neurobiol 104:183-211. 2012
    ..With the perspective and application of bioinformatics, we can uncover the relationships among these systems and take steps forward in realizing the common and distinct bases of psychiatric disease...
  8. pmc Quantitative trait loci for sensitivity to ethanol intoxication in a C57BL/6J×129S1/SvImJ inbred mouse cross
    Elissa J Chesler
    The Jackson Laboratory, 600 Main St, Bar Harbor, ME 04609, USA
    Mamm Genome 23:305-21. 2012
    ..Uncovering candidate genes associated with variation in these phenotypes in this population could ultimately shed light on genetic factors underlying sensitivity to EtOH intoxication and risk for alcoholism in humans...
  9. pmc Comparison of threshold selection methods for microarray gene co-expression matrices
    Bhavesh R Borate
    Department of Animal Science, University of Tennessee, Knoxville, Tennessee, USA
    BMC Res Notes 2:240. 2009
    ..This study investigated threshold selection in the context of combinatorial network analysis of transcriptome data...
  10. ncbi request reprint The importance of open-source integrative genomics to drug discovery
    Elissa J Chesler
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Curr Opin Drug Discov Devel 13:310-6. 2010
    ..Current analytic approaches use the full scale and scope of data, but require data sharing, interoperability and community recognition of the value of shared information...
  11. pmc Ontological Discovery Environment: a system for integrating gene-phenotype associations
    Erich J Baker
    Department of Computer Science, Baylor University, Waco, TX, USA
    Genomics 94:377-87. 2009
    ..This approach allows data integration and hypothesis discovery across multiple experimental contexts, regardless of the face similarity and semantic annotation of the experimental systems or species domain...
  12. pmc A systematic comparison of genome-scale clustering algorithms
    Jeremy J Jay
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    BMC Bioinformatics 13:S7. 2012
    ..In the present study, a variety of parametric and graph theoretical clustering algorithms are compared using well-characterized transcriptomic data at a genome scale from Saccharomyces cerevisiae...
  13. ncbi request reprint The ldis1 lens mutation in RIIIS/J mice maps to chromosome 8 near cadherin 1
    Monica M Jablonski
    Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN, USA
    Mol Vis 10:577-87. 2004
    ..We also have fine-mapped the mutation, ldis1 (lens disrupter 1), and have evaluated positional candidate genes...
  14. ncbi request reprint Performing integrative functional genomics analysis in GeneWeaver.org
    Jeremy J Jay
    The Jackson Laboratory, Bar Harbor, ME, USA
    Methods Mol Biol 1101:13-29. 2014
    ..Users can retrieve curated gene set data, upload, store, and share their own experimental results and perform integrative analyses including novel algorithmic approaches for set-set integration of genes and functions. ..
  15. pmc The Collaborative Cross at Oak Ridge National Laboratory: developing a powerful resource for systems genetics
    Elissa J Chesler
    Systems Genetics Group, Biosciences Division, Oak Ridge National Laboratory, Bldg 1059 MS 6420, P O Box 2008, Oak Ridge, TN 37831 6420, USA
    Mamm Genome 19:382-9. 2008
    ..Herein we present a progress report of the Collaborative Cross breeding program at ORNL and a description of the kinds of investigations that this resource will support...
  16. pmc Genetic analysis in the Collaborative Cross breeding population
    Vivek M Philip
    Systems Genetics Group, Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, USA
    Genome Res 21:1223-38. 2011
    ..Despite these inescapable pressures, high diversity and precision for genetic mapping remain. These results demonstrate the potential of the CC population once completed and highlight implications for development of related populations...
  17. pmc High-resolution genetic mapping using the Mouse Diversity outbred population
    Karen L Svenson
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genetics 190:437-47. 2012
    ....
  18. ncbi request reprint Genetic correlates of gene expression in recombinant inbred strains: a relational model system to explore neurobehavioral phenotypes
    Elissa J Chesler
    Department of Anatomy and Neurobiology, Center for Genomics and Bioinformatics, University of Tennessee Health Science Center, Memphis, TN, USA
    Neuroinformatics 1:343-57. 2003
    ..By repeatedly studying the same panel of mice, early data can be re-examined in light of technological advances unforeseen at the time of their initial collection...
  19. pmc Autism candidate genes via mouse phenomics
    Terrence F Meehan
    The Jackson Laboratory, 600 Main St, Bar Harbor, ME 04609, USA
    J Biomed Inform 44:S5-11. 2011
    ..2010). Prediction and characterization of autistic mutant mouse alleles assists researchers in studying the complex nature of ASD and provides a generalizable approach to candidate gene prioritization...
  20. pmc Precise genetic mapping and integrative bioinformatics in Diversity Outbred mice reveals Hydin as a novel pain gene
    Jill M Recla
    IGERT Program in Functional Genomics, Graduate School of Biomedical Sciences and Engineering, The University of Maine, Orono, ME, 04469, USA
    Mamm Genome 25:211-22. 2014
    ..Real-time quantitative-PCR analysis showed no expression differences in Hydin transcript levels between pain-sensitive and pain-resistant mice, suggesting that Hydin may influence hot-plate behavior through other biological mechanisms. ..
  21. ncbi request reprint Identifying genetic loci and spleen gene coexpression networks underlying immunophenotypes in BXD recombinant inbred mice
    Rachel M Lynch
    Systems Genetics Group, Oak Ridge National Laboratory, Oak Ridge
    Physiol Genomics 41:244-53. 2010
    ....
  22. pmc Extracting gene networks for low-dose radiation using graph theoretical algorithms
    Brynn H Voy
    Life Sciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA
    PLoS Comput Biol 2:e89. 2006
    ..We present several examples of multiple gene interactions that are altered by radiation exposure and thus represent potential molecular pathways that mediate the radiation response...
  23. ncbi request reprint The Collaborative Cross, a community resource for the genetic analysis of complex traits
    Gary A Churchill
    The Jackson Laboratory, 600 Main Street Bar Harbor, Maine 04609, USA
    Nat Genet 36:1133-7. 2004
    ..The Collaborative Cross will provide a common reference panel specifically designed for the integrative analysis of complex systems and will change the way we approach human health and disease...