VADIM GENNADYEVICH CHEREZOV

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. pmc High resolution structure of the ba3 cytochrome c oxidase from Thermus thermophilus in a lipidic environment
    Theresa Tiefenbrunn
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America
    PLoS ONE 6:e22348. 2011
  2. pmc Lipidic cubic phase technologies for membrane protein structural studies
    Vadim Cherezov
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Curr Opin Struct Biol 21:559-66. 2011
  3. pmc Rastering strategy for screening and centring of microcrystal samples of human membrane proteins with a sub-10 microm size X-ray synchrotron beam
    Vadim Cherezov
    Department of Molecular Biology, Scripps Research Institute, La Jolla, CA 92037, USA
    J R Soc Interface 6:S587-97. 2009
  4. pmc Analysis of full and partial agonists binding to beta2-adrenergic receptor suggests a role of transmembrane helix V in agonist-specific conformational changes
    VSEVOLOD KATRITCH
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Mol Recognit 22:307-18. 2009
  5. pmc High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor
    Vadim Cherezov
    Department of Molecular Biology, Scripps Research Institute, La Jolla, CA 92037, USA
    Science 318:1258-65. 2007
  6. pmc The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist
    Veli Pekka Jaakola
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037 USA
    Science 322:1211-7. 2008
  7. pmc Insights into the mode of action of a putative zinc transporter CzrB in Thermus thermophilus
    Vadim Cherezov
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Structure 16:1378-88. 2008
  8. pmc A specific cholesterol binding site is established by the 2.8 A structure of the human beta2-adrenergic receptor
    Michael A Hanson
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Structure 16:897-905. 2008
  9. pmc Conserved binding mode of human beta2 adrenergic receptor inverse agonists and antagonist revealed by X-ray crystallography
    Daniel Wacker
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Am Chem Soc 132:11443-5. 2010
  10. pmc Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist
    Ellen Y T Chien
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 330:1091-5. 2010

Research Grants

Collaborators

Detail Information

Publications15

  1. pmc High resolution structure of the ba3 cytochrome c oxidase from Thermus thermophilus in a lipidic environment
    Theresa Tiefenbrunn
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America
    PLoS ONE 6:e22348. 2011
    ..The development of a robust system for production of ba(3)-oxidase crystals diffracting to high resolution, together with an established expression system for generating mutants, opens the door for systematic structure-function studies...
  2. pmc Lipidic cubic phase technologies for membrane protein structural studies
    Vadim Cherezov
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Curr Opin Struct Biol 21:559-66. 2011
    ..This wider acceptance should translate to an increased number of otherwise difficult-to-crystallize membrane protein structures, shedding light on their functional mechanisms and on structural details of lipid-protein interactions...
  3. pmc Rastering strategy for screening and centring of microcrystal samples of human membrane proteins with a sub-10 microm size X-ray synchrotron beam
    Vadim Cherezov
    Department of Molecular Biology, Scripps Research Institute, La Jolla, CA 92037, USA
    J R Soc Interface 6:S587-97. 2009
    ..We anticipate that further innovations of the technologies applied to microcrystallography will enable the solving of structures of ever more challenging targets...
  4. pmc Analysis of full and partial agonists binding to beta2-adrenergic receptor suggests a role of transmembrane helix V in agonist-specific conformational changes
    VSEVOLOD KATRITCH
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Mol Recognit 22:307-18. 2009
    ....
  5. pmc High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor
    Vadim Cherezov
    Department of Molecular Biology, Scripps Research Institute, La Jolla, CA 92037, USA
    Science 318:1258-65. 2007
    ....
  6. pmc The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist
    Veli Pekka Jaakola
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037 USA
    Science 322:1211-7. 2008
    ....
  7. pmc Insights into the mode of action of a putative zinc transporter CzrB in Thermus thermophilus
    Vadim Cherezov
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Structure 16:1378-88. 2008
    ..The latter requires that zinc binding becomes uncoupled from the creation of a metallochaperone-docking site on CzrB...
  8. pmc A specific cholesterol binding site is established by the 2.8 A structure of the human beta2-adrenergic receptor
    Michael A Hanson
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Structure 16:897-905. 2008
    ....
  9. pmc Conserved binding mode of human beta2 adrenergic receptor inverse agonists and antagonist revealed by X-ray crystallography
    Daniel Wacker
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Am Chem Soc 132:11443-5. 2010
    ....
  10. pmc Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist
    Ellen Y T Chien
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 330:1091-5. 2010
    ..This difference provides direction to the design of D3R-selective agents for treating drug abuse and other neuropsychiatric indications...
  11. pmc Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists
    Beili Wu
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 330:1066-71. 2010
    ..These structures provide new clues about the interactions between CXCR4 and its natural ligand CXCL12, and with the HIV-1 glycoprotein gp120...
  12. pmc Recent progress in the structure determination of GPCRs, a membrane protein family with high potential as pharmaceutical targets
    Vadim Cherezov
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA, USA
    Methods Mol Biol 654:141-68. 2010
    ..The process remains risky and these protocols do not necessarily guarantee success...
  13. pmc LCP-Tm: an assay to measure and understand stability of membrane proteins in a membrane environment
    Wei Liu
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, USA
    Biophys J 98:1539-48. 2010
    ..This assay has the potential to guide protein engineering efforts and identify stabilizing conditions that may improve the chances of obtaining high-resolution structures of intrinsically unstable membrane proteins...
  14. ncbi request reprint Membrane protein crystallization in lipidic mesophases. A mechanism study using X-ray microdiffraction
    Vadim Cherezov
    Department of Molecular Biology, The Scripps Research Institute, La Jolla CA 92037, USA
    Faraday Discuss 136:195-212; discussion 213-29. 2007
    ..This result supports the proposal that the protein uses a lamellar portal on its way from the bulk mesophase up and into the face of the crystal...

Research Grants1

  1. Molecular Mechanism of Allosteric Modulation of the Oxytocin Receptor by Sterols
    VADIM GENNADYEVICH CHEREZOV; Fiscal Year: 2010
    ..High resolution crystal structures give insights into mechanism of signal transduction and provide necessary templates for the rational design of a new generation of more efficient and safe drugs. ..