Tong Chen

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. ncbi request reprint Black raspberries inhibit N-nitrosomethylbenzylamine (NMBA)-induced angiogenesis in rat esophagus parallel to the suppression of COX-2 and iNOS
    Tong Chen
    Cancer Chemoprevention and Support Program, Division of Hematology and Oncology, Department of Internal Medicine, College of Medicine and Public Health, The Ohio State University Columbus, OH 43210, USA
    Carcinogenesis 27:2301-7. 2006
  2. doi request reprint Randomized phase II trial of lyophilized strawberries in patients with dysplastic precancerous lesions of the esophagus
    Tong Chen
    Division of Medical Oncology, Department of Internal Medicine, The Ohio State University, 410 West 12 Avenue, Columbus, OH 43210, USA
    Cancer Prev Res (Phila) 5:41-50. 2012
  3. pmc Protection against esophageal cancer in rodents with lyophilized berries: potential mechanisms
    Gary D Stoner
    Division of Hematology and Oncology, Department of Internal Medicine, Ohio State University Comprehensive Cancer Center, Columbus 43210, USA
    Nutr Cancer 54:33-46. 2006
  4. pmc Chemopreventive properties of black raspberries in N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis: down-regulation of cyclooxygenase-2, inducible nitric oxide synthase, and c-Jun
    Tong Chen
    Cancer Chemoprevention Program, Division of Hematology and Oncology, Department of Internal Medicine, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43210, USA
    Cancer Res 66:2853-9. 2006
  5. pmc Cancer prevention with freeze-dried berries and berry components
    Gary D Stoner
    Division of Hematology and Oncology, Department of Internal Medicine, College of Medicine, The Ohio State University, Innovation Centre, 2001 Polaris Parkway, Columbus, OH 43240, USA
    Semin Cancer Biol 17:403-10. 2007
  6. ncbi request reprint Photochemoprevention of UVB-induced skin carcinogenesis in SKH-1 mice by brown algae polyphenols
    Hyejeong Hwang
    Chemoprevention and Support Program, Division of Hematology and Oncology, Department of Internal Medicine, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43210, USA
    Int J Cancer 119:2742-9. 2006
  7. ncbi request reprint The effects of L-748706, a selective cyclooxygenase-2 inhibitor, on N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis
    Gary D Stoner
    Cancer Chemoprevention and Support Program, Division of Hematology and Oncology, College of Medicine and Public Health, The Ohio State University, Columbus, OH 43210, USA
    Carcinogenesis 26:1590-5. 2005
  8. pmc Chemoprevention of esophageal squamous cell carcinoma
    Gary D Stoner
    Division of Hematology and Oncology, Department of Internal Medicine, Ohio State University College of Medicine and Comprehensive Cancer Center, Columbus, OH 43210, USA
    Toxicol Appl Pharmacol 224:337-49. 2007
  9. ncbi request reprint Inducible nitric oxide synthase expression in N-nitrosomethylbenzylamine (NMBA)-induced rat esophageal tumorigenesis
    Tong Chen
    Division of Environmental Health Sciences, School of Public Health and Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA
    Mol Carcinog 40:232-40. 2004
  10. ncbi request reprint Chemopreventive effects of a selective nitric oxide synthase inhibitor on carcinogen-induced rat esophageal tumorigenesis
    Tong Chen
    Division of Environmental Health Sciences, School of Public Health and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
    Cancer Res 64:3714-7. 2004

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Black raspberries inhibit N-nitrosomethylbenzylamine (NMBA)-induced angiogenesis in rat esophagus parallel to the suppression of COX-2 and iNOS
    Tong Chen
    Cancer Chemoprevention and Support Program, Division of Hematology and Oncology, Department of Internal Medicine, College of Medicine and Public Health, The Ohio State University Columbus, OH 43210, USA
    Carcinogenesis 27:2301-7. 2006
    ..86, P < 0.001) and iNOS (r2 = 0.81, P < 0.005). As high vascularity is a risk factor for metastasis and tumor recurrence, BRB may have cancer therapeutic effects in human esophageal cancer...
  2. doi request reprint Randomized phase II trial of lyophilized strawberries in patients with dysplastic precancerous lesions of the esophagus
    Tong Chen
    Division of Medical Oncology, Department of Internal Medicine, The Ohio State University, 410 West 12 Avenue, Columbus, OH 43210, USA
    Cancer Prev Res (Phila) 5:41-50. 2012
    ..9% (P = 0.023). Our present results indicate the potential of freeze-dried strawberry powder for preventing human esophageal cancer, supporting further clinical testing of this natural agent in this setting...
  3. pmc Protection against esophageal cancer in rodents with lyophilized berries: potential mechanisms
    Gary D Stoner
    Division of Hematology and Oncology, Department of Internal Medicine, Ohio State University Comprehensive Cancer Center, Columbus 43210, USA
    Nutr Cancer 54:33-46. 2006
    ..Based upon the preclinical data on rodents, we have initiated prevention trials in humans to determine if berries might exhibit chemopreventive effects in the esophagus...
  4. pmc Chemopreventive properties of black raspberries in N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis: down-regulation of cyclooxygenase-2, inducible nitric oxide synthase, and c-Jun
    Tong Chen
    Cancer Chemoprevention Program, Division of Hematology and Oncology, Department of Internal Medicine, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43210, USA
    Cancer Res 66:2853-9. 2006
    ..Prostaglandin E(2) and total nitrite levels were also decreased by BRB in papillomas. These results suggest a novel tumor suppressive role of BRB through inhibition of COX-2, iNOS, and c-Jun...
  5. pmc Cancer prevention with freeze-dried berries and berry components
    Gary D Stoner
    Division of Hematology and Oncology, Department of Internal Medicine, College of Medicine, The Ohio State University, Innovation Centre, 2001 Polaris Parkway, Columbus, OH 43240, USA
    Semin Cancer Biol 17:403-10. 2007
    ..e., Barrett's esophagus, esophageal dysplasia and colonic polyps, to determine if berries will modulate various histological and molecular biomarkers of development of these diseases...
  6. ncbi request reprint Photochemoprevention of UVB-induced skin carcinogenesis in SKH-1 mice by brown algae polyphenols
    Hyejeong Hwang
    Chemoprevention and Support Program, Division of Hematology and Oncology, Department of Internal Medicine, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43210, USA
    Int J Cancer 119:2742-9. 2006
    ..These observations show that brown algae polyphenols have an antiphotocarcinogenic effect which may be associated with the prevention of UVB-induced oxidative stress, inflammation, and cell proliferation in the skin...
  7. ncbi request reprint The effects of L-748706, a selective cyclooxygenase-2 inhibitor, on N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis
    Gary D Stoner
    Cancer Chemoprevention and Support Program, Division of Hematology and Oncology, College of Medicine and Public Health, The Ohio State University, Columbus, OH 43210, USA
    Carcinogenesis 26:1590-5. 2005
    ....
  8. pmc Chemoprevention of esophageal squamous cell carcinoma
    Gary D Stoner
    Division of Hematology and Oncology, Department of Internal Medicine, Ohio State University College of Medicine and Comprehensive Cancer Center, Columbus, OH 43210, USA
    Toxicol Appl Pharmacol 224:337-49. 2007
    ..These observations have led to a clinical trial in China to evaluate the ability of freeze-dried strawberries to influence the progression of esophageal dysplasia to SCC...
  9. ncbi request reprint Inducible nitric oxide synthase expression in N-nitrosomethylbenzylamine (NMBA)-induced rat esophageal tumorigenesis
    Tong Chen
    Division of Environmental Health Sciences, School of Public Health and Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA
    Mol Carcinog 40:232-40. 2004
    ..Our data suggest, therefore, that the production of iNOS by the epithelium of the esophagus is associated with the development of NMBA-induced esophageal tumorigenesis in rats...
  10. ncbi request reprint Chemopreventive effects of a selective nitric oxide synthase inhibitor on carcinogen-induced rat esophageal tumorigenesis
    Tong Chen
    Division of Environmental Health Sciences, School of Public Health and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
    Cancer Res 64:3714-7. 2004
    ..These observations suggest that iNOS plays a role in tumor development and that its selective inhibitor, PBIT, significantly inhibits esophageal tumor progression presumably through reducing the production of NO...
  11. ncbi request reprint Molecular characterization of a novel dipeptidyl peptidase like 2-short form (DPL2-s) that is highly expressed in the brain and lacks dipeptidyl peptidase activity
    Tong Chen
    School of Biological Sciences, Flinders University, GPO Box 2100, Adelaide, South Australia 5001, Australia
    Biochim Biophys Acta 1764:33-43. 2006
    ....
  12. doi request reprint Alkaloids from stems and leaves of Stemona japonica and their insecticidal activities
    Chun Ping Tang
    State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, People s Republic of China
    J Nat Prod 71:112-6. 2008
    ....
  13. pmc Novel retroviral vectors to facilitate expression screens in mammalian cells
    Eugene Y Koh
    Whitehead Institute, Nine Cambridge Center, Cambridge, MA 02142, USA
    Nucleic Acids Res 30:e142. 2002
    ..These vectors have proven useful to identify genes linked to cell proliferation, senescence and apoptosis...